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For many who are suffering with prolonged grief, the holidays can be a time to reflect and find meaning in loss

A trauma-informed therapist discusses how grief affects the brain and highlights the role of a sixth stage of grief – finding meaning – in the healing…

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In the post-pandemic world, many people are facing the holidays without their loved ones by their side. Douglas Sacha/Moment via Getty Images

The holiday season is meant to be filled with joy, connection and celebration of rituals. Many people, however, are starkly reminded of their grief this time of year and of whom – or what – they have lost.

The added stress of the holiday season doesn’t help. Studies show that the holidays negatively affect many people’s mental health.

While COVID-19-related stressors may have lessened, the grief from change and loss that so many endured during the pandemic persists. This can cause difficult emotions to resurface when they are least expected.

I am a licensed therapist and trauma-sensitive yoga instructor. For the last 12 years, I’ve helped clients and families manage grief, depression, anxiety and complex trauma. This includes many health care workers and first responders who have recounted endless stories to me about how the pandemic increased burnout and affected their mental health and quality of life.

I developed an online program that research shows has improved their well-being. And I’ve observed firsthand how much grief and sadness can intensify during the holidays.

Grief expert David Kessler discusses five coping mechanisms to get through the holidays.

Post-pandemic holidays and prolonged grief

During the pandemic, family dynamics, close relationships and social connections were strained, mental health problems increased or worsened, and most people’s holiday traditions and routines were upended.

Those who lost a loved one during the pandemic may not have been able to practice rituals such as holding a memorial service, further delaying the grieving process. As a result, holiday traditions may feel more painful now for some. Time off from school or work can also trigger more intense feelings of grief and contribute to feelings of loneliness, isolation or depression.

Sometimes feelings of grief are so persistent and severe that they interfere with daily life. For the past several decades, researchers and clinicians have been grappling with how to clearly define and treat complicated grief that does not abate over time.

In March 2022, a new entry to describe complicated grief was added to the Diagnostic and Statistical Manual of Mental Disorders, or DSM, which classifies a spectrum of mental health disorders and problems to better understand people’s symptoms and experiences in order to treat them.

This newly defined condition is called prolonged grief disorder. About 10% of bereaved adults are at risk, and those rates appear to have increased in the aftermath of the pandemic.

People with prolonged grief disorder experience intense emotions, longing for the deceased, or troublesome preoccupation with memories of their loved one. Some also find it difficult to reengage socially and may feel emotionally numb. They commonly avoid reminders of their loved one and may experience a loss of identity and feel bleak about their future. These symptoms persist nearly every day for at least a month. Prolonged grief disorder can be diagnosed at least one year after a significant loss for adults and at least six months after a loss for children.

I am no stranger to complicated grief: A close friend of mine died by suicide when I was in college, and I was one of the last people he spoke to before he ended his life. This upended my sense of predictability and control in my life and left me untangling the many existential themes that suicide loss survivors often face.

How grieving alters brain chemistry

Research suggests that grief not only has negative consequences for a person’s physical health, but for brain chemistry too.

The feeling of grief and intense yearning may disrupt the neural reward systems in the brain. When bereaved individuals seek connection to their lost loved one, they are craving the chemical reward they felt before their loss when they connected with that person. These reward-seeking behaviors tend to operate on a feedback loop, functioning similar to substance addiction, and could be why some people get stuck in the despair of their grief.

A podcast on understanding grief and loss.

One study showed an increased activation of the amygdala when showing death-related images to people who are dealing with complicated grief, compared to adults who are not grieving a loss. The amygdala, which initiates our fight or flight response for survival, is also associated with managing distress when separated from a loved one. These changes in the brain might explain the great impact prolonged grief has on someone’s life and their ability to function.

Recognizing prolonged grief disorder

Experts have developed scales to help measure symptoms of prolonged grief disorder. If you identify with some of these signs for at least one year, it may be time to reach out to a mental health professional.

Grief is not linear and doesn’t follow a timeline. It is a dynamic, evolving process that is different for everyone. There is no wrong way to grieve, so be compassionate to yourself and don’t make judgments on what you should or shouldn’t be doing.

Increasing your social supports and engaging in meaningful activities are important first steps. It is critical to address any preexisting or co-occurring mental health concerns such as anxiety, depression or post-traumatic stress.

It can be easy to confuse grief with depression, as some symptoms do overlap, but there are critical differences.

If you are experiencing symptoms of depression for longer than a few weeks and it is affecting your everyday life, work and relationships, it may be time to talk with your primary care doctor or therapist.

A sixth stage of grief

I have found that naming the stage of grief that someone is experiencing helps diminish the power it might have over them, allowing them to mourn their loss.

For decades, most clinicians and researchers have recognized five stages of grief: denial/shock, anger, depression, bargaining and acceptance.

But “accepting” your grief doesn’t sit well for many. That is why a sixth stage of grief, called “finding meaning,” adds another perspective. Honoring a loss by reflecting on its meaning and the weight of its impact can help people discover ways to move forward. Recognizing how one’s life and identity are different while making space for your grief during the holidays might be one way to soften the despair.

When my friend died by suicide, I found a deeper appreciation for what he brought into my life, soaking up the moments he would have enjoyed, in honor of him. After many years, I was able to find meaning by spreading mental health awareness. I spoke as an expert presenter for suicide prevention organizations, wrote about suicide loss and became certified to teach my local community how to respond to someone experiencing signs of mental health distress or crisis through Mental Health First Aid courses. Finding meaning is different for everyone, though.

Sometimes, adding a routine or holiday tradition can ease the pain and allow a new version of life, while still remembering your loved one. Take out that old recipe or visit your favorite restaurant you enjoyed together. You can choose to stay open to what life has to offer, while grieving and honoring your loss. This may offer new meaning to what – and who – is around you.

If you need emotional support or are in a mental health crisis, dial 988 or chat online with a crisis counselor.

Mandy Doria's position with the University of Colorado is partially funded by the Colorado Department of Public Health and Environment (CDPHE) for her work with the CO-CARES initiative, which offers resources at no cost to Colorado health care and public health workers.

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AstraZeneca advances Fasenra’s marketing with new campaign that’s on TikTok for first time

People living with severe asthma are literally stepping away from social media and into active outdoor lives in AstraZeneca’s newest campaign for its…

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People living with severe asthma are literally stepping away from social media and into active outdoor lives in AstraZeneca’s newest campaign for its asthma medication Fasenra.

A video optical effect shows people climbing out of their homes into scenes where they are hiking or playing basketball in the “Stepping Back Out” TV, digital and social effort.

The use of scene-changing videos was driven by insights from patients who want to engage in the activities they see on social media while they’re stuck inside feeling sick or worried about asthma triggers, said Matt Gray, AstraZeneca’s executive director of US marketing for Fasenra.

Matt Gray

“You’re scrolling through social media and seeing your friends doing things or places you want to be, and yet you’re just scrolling,” he said. The message is, “OK, Fasenra can help you get back into that.”

AstraZeneca is also marketing Fasenra on TikTok for the first time. The initial TikTok video is shortened from the longer TV ad, and it focuses on basketball. By adding TikTok, the goal is to reach a younger age demographic and an expanding multi-generational one in addition to using a city as the background, Gray said.

“We realized that we were missing a bit of our demographic, so we’ve done a bit more to bring back in this city setting, and using the basketball imagery, which is not a bad thing this time of year,” Gray said, referring to the March Madness NCAA college basketball tournament currently underway.

It seems to be working. In the four weeks since the basketball TikTok was posted, the ad has almost six million impressions.

AstraZeneca’s been promoting both the condition of eosinophilic asthma and its Fasenra treatment  for six years. The brand work began with a TV scientist explainer campaign, followed by a whispered-voice campaign during the Covid-19 years. Last year’s “Move Forward” work aimed to emphasize condition control for both patients and healthcare providers. Its unbranded work included personified eosinophils “Behaving Badly” and celebrity social media work with actor Tony Hale, best known for “Arrested Development.” The “Behaving Badly” campaign is still running, but the Hale campaign is not.

Gray said the campaigns have helped raise awareness of eosinophilic asthma and Fasenra. About 25 million people in the US have asthma, with an estimated 1.3 million having severe uncontrolled asthma, and the majority (about 20%) of those with eosinophilic asthma.

Fasenra sales topped $1.55 billion in 2023, up 11% from $1.4 billion the previous year.

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Measuring Fed Inflation Credibility

What do households (not economists) think inflation will be in three years? I use the deviation of forecast from target as a proxy measure for credibility…

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What do households (not economists) think inflation will be in three years? I use the deviation of forecast from target as a proxy measure for credibility regarding inflation.

Figure 1: Median 3 year CPI inflation forecast (black), 25th, 75th percentile (gray), in %. CPI inflation consistent with 2% PCE inflation target (red dashed line). NBER defined peak-to-trough recession dates shaded gray. Source: NY Fed, NBER, and author’s calculations.

As of February 2024, the inflation rate expected 3 years out is lower than it was in January 2021. While expected CPI inflation has declined, dispersion of forecasts has increased slightly.

Figure 2: Median 3 year CPI inflation forecast deviation from  CPI inflation consistent with 2% PCE inflation target (black), interquartile range (sky bule), in %.. NBER defined peak-to-trough recession dates shaded gray. Source: NY Fed, NBER, and author’s calculations.

Maximal uncertainty, as measured by the interquartile range in 3 year inflation was reached in mid-2022. It’s now dropped to to rates last seen at the exit from the pandemic-induced recession.

Note that some have questioned the use of the earlier framework,  pre-New Monetary Strategy laid out in August 2020 (see here for one reader’s critique). I’ll note that as far as I can tell, market commentators are still using the target in the old sense of the word (a sense that seems buttressed by Papell and Prodan-Boul’s recent examination of the various vintages of the SEP), rather than FAIT with, say, a 3 year window, as that would imply we should be seeing an implied target rate of deflation at about 0.8% per annum.

 

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Common household chemicals pose new threat to brain health

CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common…

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CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological diseases like multiple sclerosis and autism spectrum disorders.

Credit: Case Western Reserve University

CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological diseases like multiple sclerosis and autism spectrum disorders.

Neurological problems impact millions of people, but only a fraction of cases can be attributed to genetics alone, indicating that unknown environmental factors are important contributors to neurological disease.

The new study published today in the journal Nature Neuroscience, discovered that some common home chemicals specifically affect the brain’s oligodendrocytes, a specialized cell type that generates the protective insulation around nerve cells.

“Loss of oligodendrocytes underlies multiple sclerosis and other neurological diseases,” said the study’s principal investigator, Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics and director of the Institute for Glial Sciences at the School of Medicine. “We now show that specific chemicals in consumer products can directly harm oligodendrocytes, representing a previously unrecognized risk factor for neurological disease.” 

On the premise that not enough thorough research has been done on the impact of chemicals on brain health, the researchers analyzed over 1,800 chemicals that may be exposed to humans. They identified chemicals that selectively damaged oligodendrocytes belong to two classes: organophosphate flame retardants and quaternary ammonium compounds. Since quaternary ammonium compounds are present in many personal-care products and disinfectants, which are being used more frequently since the COVID-19 pandemic began, humans are regularly exposed to these chemicals. And many electronics and furniture include organophosphate flame retardants.

The researchers used cellular and organoid systems in the laboratory to show that quaternary ammonium compounds cause oligodendrocytes to die, while organophosphate flame retardants prevented the maturation of oligodendrocytes. 

They demonstrated how the same chemicals damage oligodendrocytes in the developing brains of mice. The researchers also linked exposure to one of the chemicals to poor neurological outcomes in children nationally.

“We found that oligodendrocytes—but not other brain cells—are surprisingly vulnerable to quaternary ammonium compounds and organophosphate flame retardants,” said Erin Cohn, lead author and graduate student in the School of Medicine’s Medical Scientist Training Program. “Understanding human exposure to these chemicals may help explain a missing link in how some neurological diseases arise.” 

The association between human exposure to these chemicals and effects on brain health requires further investigation, the experts warned. Future research must track the chemical levels in the brains of adults and children to determine the amount and length of exposure needed to cause or worsen disease.

“Our findings suggest that more comprehensive scrutiny of the impacts of these common household chemicals on brain health is necessary,” Tesar said. “We hope our work will contribute to informed decisions regarding regulatory measures or behavioral interventions to minimize chemical exposure and protect human health.”

Additional contributing researchers from Case Western Reserve School of Medicine and from the U.S. Environmental Protection Agency included Benjamin Clayton, Mayur Madhavan, Kristin Lee, Sara Yacoub, Yuriy Fedorov, Marissa Scavuzzo, Katie Paul Friedman and Timothy Shafer. 

The research was supported by grants from the National Institutes of Health, National Multiple Sclerosis Society, Howard Hughes Medical Institute and New York Stem Cell Foundation, and philanthropic support by sTF5 Care and the Long, Walter, Peterson, Goodman and Geller families.

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Case Western Reserve University is one of the country’s leading private research institutions. Located in Cleveland, we offer a unique combination of forward-thinking educational opportunities in an inspiring cultural setting. Our leading-edge faculty engage in teaching and research in a collaborative, hands-on environment. Our nationally recognized programs include arts and sciences, dental medicine, engineering, law, management, medicine, nursing and social work. About 6,000 undergraduate and 6,300 graduate students comprise our student body. Visit case.edu to see how Case Western Reserve thinks beyond the possible.

 


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