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Common household chemicals pose new threat to brain health

CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common…

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CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological diseases like multiple sclerosis and autism spectrum disorders.

Credit: Case Western Reserve University

CLEVELAND—A team of researchers from the Case Western Reserve University School of Medicine has provided fresh insight into the dangers some common household chemicals pose to brain health. They suggest that chemicals found in a wide range of items, from furniture to hair products, may be linked to neurological diseases like multiple sclerosis and autism spectrum disorders.

Neurological problems impact millions of people, but only a fraction of cases can be attributed to genetics alone, indicating that unknown environmental factors are important contributors to neurological disease.

The new study published today in the journal Nature Neuroscience, discovered that some common home chemicals specifically affect the brain’s oligodendrocytes, a specialized cell type that generates the protective insulation around nerve cells.

“Loss of oligodendrocytes underlies multiple sclerosis and other neurological diseases,” said the study’s principal investigator, Paul Tesar, the Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics and director of the Institute for Glial Sciences at the School of Medicine. “We now show that specific chemicals in consumer products can directly harm oligodendrocytes, representing a previously unrecognized risk factor for neurological disease.” 

On the premise that not enough thorough research has been done on the impact of chemicals on brain health, the researchers analyzed over 1,800 chemicals that may be exposed to humans. They identified chemicals that selectively damaged oligodendrocytes belong to two classes: organophosphate flame retardants and quaternary ammonium compounds. Since quaternary ammonium compounds are present in many personal-care products and disinfectants, which are being used more frequently since the COVID-19 pandemic began, humans are regularly exposed to these chemicals. And many electronics and furniture include organophosphate flame retardants.

The researchers used cellular and organoid systems in the laboratory to show that quaternary ammonium compounds cause oligodendrocytes to die, while organophosphate flame retardants prevented the maturation of oligodendrocytes. 

They demonstrated how the same chemicals damage oligodendrocytes in the developing brains of mice. The researchers also linked exposure to one of the chemicals to poor neurological outcomes in children nationally.

“We found that oligodendrocytes—but not other brain cells—are surprisingly vulnerable to quaternary ammonium compounds and organophosphate flame retardants,” said Erin Cohn, lead author and graduate student in the School of Medicine’s Medical Scientist Training Program. “Understanding human exposure to these chemicals may help explain a missing link in how some neurological diseases arise.” 

The association between human exposure to these chemicals and effects on brain health requires further investigation, the experts warned. Future research must track the chemical levels in the brains of adults and children to determine the amount and length of exposure needed to cause or worsen disease.

“Our findings suggest that more comprehensive scrutiny of the impacts of these common household chemicals on brain health is necessary,” Tesar said. “We hope our work will contribute to informed decisions regarding regulatory measures or behavioral interventions to minimize chemical exposure and protect human health.”

Additional contributing researchers from Case Western Reserve School of Medicine and from the U.S. Environmental Protection Agency included Benjamin Clayton, Mayur Madhavan, Kristin Lee, Sara Yacoub, Yuriy Fedorov, Marissa Scavuzzo, Katie Paul Friedman and Timothy Shafer. 

The research was supported by grants from the National Institutes of Health, National Multiple Sclerosis Society, Howard Hughes Medical Institute and New York Stem Cell Foundation, and philanthropic support by sTF5 Care and the Long, Walter, Peterson, Goodman and Geller families.

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Case Western Reserve University is one of the country’s leading private research institutions. Located in Cleveland, we offer a unique combination of forward-thinking educational opportunities in an inspiring cultural setting. Our leading-edge faculty engage in teaching and research in a collaborative, hands-on environment. Our nationally recognized programs include arts and sciences, dental medicine, engineering, law, management, medicine, nursing and social work. About 6,000 undergraduate and 6,300 graduate students comprise our student body. Visit case.edu to see how Case Western Reserve thinks beyond the possible.

 


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As mortgage rates remain rangebound, so do new home sales

  – by New Deal democratLet’s begin this post by putting why I am watching new home sales in context.The economy was kept out of recession last year,…

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 - by New Deal democrat


Let’s begin this post by putting why I am watching new home sales in context.

The economy was kept out of recession last year, despite aggressive Fed rate hikes, in large part by commodity price deflation, much or most of which was triggered by the un-kinking of supply chains after the pandemic. That gale force economic tailwind is gone, but the Fed rate hikes remain. So the big question for this year is whether the effects of the Fed rate hikes have just been delayed, or whether, because the rate hikes have stopped, so has the headwind they normally produce. Watching manufacturing and construction, especially housing construction, is what I expect to supply the answer.

So, to the data, starting with my usual caveat: while new home sales (blue in the graphs below) are the most leading of the housing metrics, they are noisy and heavily revised. There was little this month, as January was only revised higher by 3,000 to 664,000. February gave back -2,000 of that, coming in at 662,000 annualized. In the below graph I also show th slightly less leading but much less noisy single family permits (red, right scale):



Before I discuss this graph a little further, let’s compare sales with the even more leading metric of mortgage rates. Both are shown YoY (rates inverted, and *100 for scale):



Except for the distortion created by the pandemic shutdowns in spring 2020 and the YoY comparisons in spring 2021, we see that new home sales have almost simultaneously followed the trajectory of mortgage rates: the higher the mortgage rate YoY, the lower new home sales YoY. Because mortgage rates remain slightly elevated compared with one year ago, the progress YoY in new home sales has almost completely stopped. As a result, I expect single family permits to follow the more noisy downward trend in month over month comparisons in sales in the immediate future.

In other words, so long as mortgage rates remain in the 6%-7% range, I expect new housing sales and construction to stall out as well, but not to decline significantly either.

Finally, as I always reiterate, prices lag sales. So here’s the YoY update on median prices (red), which are not seasonally adjusted (red) compared with YoY sales:



Again, aside from the spring 2020 and 2021 YoY distortions due to the pandemic lockdowns, we see that prices followed sales higher, and then in 2023 followed sales lower. We will probably continue see negative YoY comparisons in prices for a few months more before they follow sales back higher YoY probably by late this year.

But the big takeaway remains that, generally speaking, I am not expecting much in the way of big moves in new home sales or prices until there is a significant change in mortgage rates.

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New Home Sales at 662,000 Annual Rate in February

The Census Bureau reports New Home Sales in February were at a seasonally adjusted annual rate (SAAR) of 662 thousand.

The previous three months were revised up slightly.

Sales of new single‐family houses in February 2024 were at a seasonally adjuste…

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The Census Bureau reports New Home Sales in February were at a seasonally adjusted annual rate (SAAR) of 662 thousand.

The previous three months were revised up slightly.
Sales of new single‐family houses in February 2024 were at a seasonally adjusted annual rate of 662,000, according to estimates released jointly today by the U.S. Census Bureau and the Department of Housing and Urban Development. This is 0.3 percent below the revised January rate of 664,000, but is 5.9 percent above the February 2023 estimate of 625,000.
emphasis added
Click on graph for larger image.

The first graph shows New Home Sales vs. recessions since 1963. The dashed line is the current sales rate.

New home sales were close to pre-pandemic levels.

The second graph shows New Home Months of Supply.

New Home Sales, Months of SupplyThe months of supply increased in February to 8.4 months from 8.3 months in January.

The all-time record high was 12.2 months of supply in January 2009. The all-time record low was 3.3 months in August 2020.

This is well above the top of the normal range (about 4 to 6 months of supply is normal).
"The seasonally‐adjusted estimate of new houses for sale at the end of February was 463,000. This represents a supply of 8.4 months at the current sales rate."
Sales were below expectations of 673 thousand SAAR, however, sales for the three previous months were revised up slightly. I'll have more later today.

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Excessively high rents are a major burden for immigrants in US cities

The US economy relies on immigrants to fill jobs, but many of them are struggling with high rent burdens that make it harder to build productive lives…

Nashville is one of the fastest-growing U.S. cities and increasingly a destination for immigrants. Joe Sohm/Visions of America/Universal Images Group via Getty Images

Rents across the U.S. have climbed to staggering levels in recent years. Millions of renters spend more than 30% of their income on rent and utilities, a situation that housing experts call being cost burdened.

High rents affect almost all segments of the population but are an especially heavy burden for immigrants, particularly those who have not yet become U.S. citizens. Immigrants, both documented and undocumented, play important roles in the U.S. economy. They often provide the cheapest labor in the riskiest of industries. Yet they are still not broadly accepted or supported in many U.S. cities.

We are geographers who study housing market issues, including racial-ethnic diversity and housing affordability. Our research on Nashville, which has emerged as an immigrant metropolis in the Southern U.S., suggests that foreign-born residents who are not yet citizens are far more burdened by high rents than other groups.

Many immigrant workers in Nashville spend more than 50% of their incomes on rent. This makes it hard for them to afford education and job training, healthy food, health care and other necessities that can help them participate as productive residents. Heavy rent burdens undermine their ability to have a higher standard of living and to be included in mainstream society.

As immigrants increasingly fan out across the U.S., we believe cities receiving new foreign-born residents should anticipate a growing need for affordable housing.

A 2022 study found that immigrant families in San Diego faced some of the highest rent burdens in the surrounding county.

Hard times for renters

The past 15 years have been challenging for renters across the U.S.. In the 2008-09 recession, which was triggered by a collapse in the housing market, millions lost their homes to foreclosure and became renters. Tighter financing made it harder for others to buy homes. By 2015, almost 43 million households had been pushed into renting.

Today about 37% of U.S. homes are occupied by renters. By 2020, almost 46% of U.S. renters paid more than 30% of their household income toward rent. As of June 2021, the median monthly rent in the 50 largest U.S. cities was $1,575 – an 8.1% increase from June 2020.

The heaviest rent burdens fall disproportionately on minorities. Almost 46% of African American-led renter households are rent burdened, compared with 34% of white households.

The COVID-19 pandemic worsened housing insecurity for people of color because of longstanding racially targeted policies and widespread health and economic disparities. Renters of color faced higher cost burdens and eviction rates. In Nashville, this was especially true in Latino and Somali communities.

Why immigrant housing matters

Immigration is the main driver of population growth in the U.S., which is important for filling jobs and boosting tax revenues. After dipping because of pandemic-era restrictions in 2020-22, immigration to the U.S. started growing again, adding 1.1 million new residents in 2023.

Foreign-born residents make up 7.15% of the U.S. population today. Most of these immigrants are not citizens, although more than 878,000 people became citizens in 2023. The median length of time these new citizens spent in the U.S. before becoming naturalized was seven years.

Nashville is the largest metropolis in Tennessee and one of the fastest-growing immigrant gateways in the South. It is home to over 37% of Tennessee’s Latino population and has been a major destination for Latinos and other foreign-born residents since the early 2000s.

For our research, we used census data estimates for 2015-19 from the National Historical Geographic Information System covering metro Nashville’s 13 counties, which contain 372 census tracts. We found that Nashville’s most racially and ethnically diverse neighborhoods had the highest levels of rent burden.

This includes census tracts with high shares of foreign-born residents who are not yet citizens, especially if those residents are Black or Latino. Our analysis of the 37 census tracts (10% of the region’s total) with the largest shares of foreign-born residents who are not yet citizens shows that the average monthly rent paid by a household in these tracts was $1,306.20, compared with $1,288.70 metrowide.

In the 37 tracts with the largest shares of Latino residents and Black residents, we found that about 21% of households spent more than 50% of their household income on rent.

Our findings corroborate other scholarly analyses of Nashville’s Somali refugees, who tend to be clustered in communities that also house other diverse groups, including Egyptians and other African immigrants. In these areas, gentrification and urban renewal have forced several Black and Somali communities from ownership into renting.

We believe specific groups of foreign-born residents may either have been ineligible or didn’t know how to apply for government-funded housing and rental assistance programs and may have had to rent from predatory landlords as a result. Some Muslim immigrants also avoid applying for bank loans because of a concept in Islamic banking called ribā, which views charging interest on loans as unjust and exploitative.

More encouragingly, we found that tracts with newer housing stock, built since 2000, have relatively lower rent burdens even though those tracts are home to many Black and non-Asian minority residents. This suggests that newer development has an important role to play in mitigating rent, especially in suburban, relatively affordable locations. In the 37 census tracts with the most foreign-born residents who are not yet citizens, about 28% of the total housing stock was built in 2000 or later, compared with 23% across Nashville.

A row of men in hard hats, shoveling dirt.
Federal, state and city officials break ground in 2022 on a mixed-income residential development at Cayce Place, Nashville’s largest subsidized housing property. The city is replacing aging structures on the site, built between 1941 and 1954. Metropolitan Development and Housing Agency, CC BY-ND

Easing rent burdens

One of the best ways to mitigate rent burdens is to build more housing and create affordable housing. However, communities sometimes oppose affordable housing projects and pro-development zoning because of fears of crime, traffic congestion or populations viewed as undesirable. Nashville is not immune to this syndrome.

The cost of housing has been a heated topic in the Nashville region since the mid-2010s. A 2023 Urban Institute report recommended creating more affordable housing in Nashville by promoting partnerships among academic, faith-based and health care institutions that own land that could be developed for housing. And the Metropolitan Council for the Nashville region plans to substantially revamp building codes to promote new housing construction.

However, critics argue that the council gives too much weight to anti-development arguments. And there is little discussion of specific ways to help groups that are ineligible for benefits and assistance that are available to U.S. citizens.

A crowded meeting room with speakers clustered at a podium.
Members of the Tennessee Immigrant & Refugee Rights Coalition celebrate on March 26, 2019, after the defeat of a state bill that would have barred most landlords from renting housing to people in the U.S. illegally. AP Photo/Jonathan Mattise

A priority for cities

Our research shows that creating more rental opportunities can help reduce rent burdens for all. We see great potential to take this research further through community-based investigations of local nuances that may add to rent burdens, especially factors and processes that can’t be adequately captured in quantitative data analysis. Many local actors have important roles to play, including elected officials and local nonprofits and community organizations that work to promote rights for immigrants and refugees.

Given the important role that immigrants play in filling jobs and contributing to local economies, we believe that helping them afford housing is a smart strategy, especially for growth-oriented cities.

The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond their academic appointment.

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