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Geraniol attenuates oxidative stress and cognitive impairment in mouse aging model

“Our data demonstrated, for the first time, the antioxidant activity of geraniol and its function to attenuate brain hippocampus injury induced in vivo…

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“Our data demonstrated, for the first time, the antioxidant activity of geraniol and its function to attenuate brain hippocampus injury induced in vivo by D-galactose.”

Credit: 2024 Rajendran et al.

“Our data demonstrated, for the first time, the antioxidant activity of geraniol and its function to attenuate brain hippocampus injury induced in vivo by D-galactose.”

BUFFALO, NY- April 10, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 6, entitled, “Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model.”

D-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents’ models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. In this new study, researchers Peramaiyan Rajendran, Fatma J. Al-Saeedi, Rebai Ben Ammar, Basem M. Abdallah, Enas M. Ali, Najla Khaled Al Abdulsalam, Sujatha Tejavat, Duaa Althumairy, Vishnu Priya Veeraraghavan, Sarah Abdulaziz Alamer, Gamal M. Bekhet, and Emad A. Ahmed from King Faisal University, Kuwait University, Center of Biotechnology of Borj-Cedria, Saveetha University, Alexandria University, and Assiut University examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice. 

“Life expectancy in the 21st century is rising, resulting in more age-related illnesses, such as memory impairment and Alzheimer’s disease. In this study, GNL was studied for its protective effect on D-gal-induced aging in mice.”

The study was conducted using six groups of mice (6 mice per group). The first group received normal saline, then D-gal (150 mg/wt) dissolved in normal saline solution (0.9%, w/v) was given orally for 9 weeks to the second group. In the III group, from the second week until the 10th week, mice were treated orally (without anesthesia) with D-gal (150 mg/kg body wt) and GNL weekly twice (40 mg/kg body wt) four hours later. Mice in Group IV were treated with GNL from the second week up until the end of the experiment. For comparison of young versus elderly mice, 4 month old (Group V) and 16-month-old (Group VI) control mice were used. 

“We evaluated the changes in antioxidant levels, PI3K/Akt levels, and Nrf2 levels. We also examined how D-gal and GNL treated pathological aging changes.”

Administration of GNL induced a significant increase in spatial learning and memory with spontaneously altered behavior. Enhancing anti-oxidant and anti-inflammatory effects and activating PI3K/Akt were the mechanisms that mediated this effect. Further, GNL treatment upregulated Nrf2 and HO-1 to reduce oxidative stress and apoptosis. This was confirmed using 99mTc-HMPAO brain flow gamma bioassays. 

“Thus, our data suggested GNL as a promising agent for treating neuroinflammation-induced cognitive impairment.”

 

Read the full paper: DOI: https://doi.org/10.18632/aging.205677 

Corresponding Authors: Peramaiyan Rajendran, Fatma J. Al-Saeedi

Corresponding Emails: prajendran@kfu.edu.sa, fatma.alsaeedi@ku.edu.kw 

Keywords: D-galactose, geraniol, cognitive disorder, Nrf2, 99mTc-HMPAO, apoptosis

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About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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Trendy sneaker company receives a dire Nasdaq warning

The trendy label seems to have lost its luster with a once-enthusiastic consumer base.

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It seems like almost every day you check on the newest business headlines, a new company is either liquidating, filing for bankruptcy protection, getting delisting warnings, or somehow spiraling into what seems like a hopeless death of despair. 

This is thanks in part to the continued Covid consolidation, whereby brands at anything less than their best performance over the past year have been forced to fold under the immense pressure of current market conditions. 

Related: Kroger launches trendy new brand Costco doesn't have

As Covid forced — or expedited — seemingly unnatural migration patterns, many previously high-foot traffic metropolitan areas were largely abandoned for months or even years on end. High rents in these places were no longer justifiable, and a lack of incoming revenue forced many stores to shutter suddenly and ask for help. 

To be sure, some retailers thrived during this period of consolidation. Giants like Walmart  (WMT) , Target  (TGT) , and Amazon  (AMZN)  rapidly gobbled up smaller competition and it now seems like every plaza has at least one of the five largest retailers in the U.S. 

Other retailers like TJ Maxx, thrived as consumers finally returned to stores seeking deals and off-mall accessibility. So while retailers like Macy's  (M)  shuttered and crumbled, TJX was happy to sell some of its overstock labels for a fraction of the price.

Popular sneaker label gets a warning

One such company that thrived before the pandemic was Allbirds  (BIRD) , a smaller brand that built comfortable shoes made of sustainable materials best suited for walking and commuting.

The entrance of Allbirds seen from Hayes St. in San Francisco, Calif.

San Francisco Chronicle/Hearst Newspapers via Getty Images/Getty Images

A darling during the late 2010s when almost everybody went into the office every day, Allbirds catered to the crowd who wanted to look presentable at work but feel good in their feet -- and good about what they were doing for the planet. Allbirds' best-selling shoe, the Runners, are made from either wool or sustainable eucalyptus with cushioned midsoles for the perfect all-day temperature and support. They start at $98. 

But Allbirds has struggled with declining sales and profit in recent years, as upscale and presentable commuters are no longer in vogue and shoppers instead opt for comfort over everything else, as is the case with Crocs  (CROX)  and Birkenstock. 

The company tried to make a pivot to other activewear, as with women's leggings but soon found out that was a slippery slope with incumbents like Lululemon  (LULU)  ready to eat any newcomers' lunch — sustainable or not

So in April, Allbirds received a noncompliance warning from Nasdaq, where it is currently listed and trades for under $1. Since the stock has traded below $1 for over 30 days, Nasdaq warned Allbirds it must get its stock price up — or be at risk of being delisted from the exchange. 

It has 180 days, or until September 30, to make that change. In order to avoid delisting, it must trade for above $1 for at least 10 business days straight. 

Allbirds said it "will consider actions," to take in order to avoid delisting, "but no decisions about a response have been made at this time."

Earlier in 2024, Allbirds said it will shutter between 10-15 brick-and-mortar locations in the U.S., but it still expects revenue to decline 25% or more in the fiscal year. 

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Part 1: Current State of the Housing Market; Overview for mid-April 2024

Today, in the Calculated Risk Real Estate Newsletter: Part 1: Current State of the Housing Market; Overview for mid-April 2024
A brief excerpt: This 2-part overview for mid-April provides a snapshot of the current housing market.

I always like to star…

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Today, in the Calculated Risk Real Estate Newsletter: Part 1: Current State of the Housing Market; Overview for mid-April 2024

A brief excerpt:
This 2-part overview for mid-April provides a snapshot of the current housing market.

I always like to start with inventory, since inventory usually tells the tale!
...
Here is a graph of new listing from Realtor.com’s March 2024 Monthly Housing Market Trends Report showing new listings were 15.5% year-over-year in March. This is still well below pre-pandemic levels. From Realtor.com:

However, providing a boost to overall inventory, sellers turned out in higher numbers this March as newly listed homes were 15.5% above last year’s levels. This marked the fifth month of increasing listing activity after a 17-month streak of decline. 
Note the seasonality for new listings. December and January are seasonally the weakest months of the year for new listings, followed by February and November. New listings will be up year-over-year in 2024, but still below normal levels.

There are always people that need to sell due to the so-called 3 D’s: Death, Divorce, and Disease. Also, in certain times, some homeowners will need to sell due to unemployment or excessive debt (neither is much of an issue right now).

And there are homeowners who want to sell for a number of reasons: upsizing (more babies), downsizing, moving for a new job, or moving to a nicer home or location (move-up buyers). It is some of the “want to sell” group that has been locked in with the golden handcuffs over the last couple of years, since it is financially difficult to move when your current mortgage rate is around 3%, and your new mortgage rate will be in the 6 1/2% to 7 1/2% range.

But time is a factor for this “want to sell” group, and eventually some of them will take the plunge. That is probably why we are seeing more new listings now.
There is much more in the article.

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Popular shoe company gets a dire warning

The trendy label seems to have lost its luster with a once-enthusiastic consumer base.

Published

on

It seems like almost every day you check on the newest business headlines, a new company is either liquidating, filing for bankruptcy protection, getting delisting warnings, or somehow spiraling into what seems like a hopeless death of despair. 

This is thanks in part to the continued Covid consolidation, whereby brands at anything less than their best performance over the past year have been forced to fold under the immense pressure of current market conditions. 

Related: Kroger launches trendy new brand Costco doesn't have

As Covid forced — or expedited — seemingly unnatural migration patterns, many previously high-foot traffic metropolitan areas were largely abandoned for months or even years on end. High rents in these places were no longer justifiable, and a lack of incoming revenue forced many stores to shutter suddenly and ask for help. 

To be sure, some retailers thrived during this period of consolidation. Giants like Walmart  (WMT) , Target  (TGT) , and Amazon  (AMZN)  rapidly gobbled up smaller competition and it now seems like every plaza has at least one of the five largest retailers in the U.S. 

Other retailers like TJ Maxx, thrived as consumers finally returned to stores seeking deals and off-mall accessibility. So while retailers like Macy's  (M)  shuttered and crumbled, TJX was happy to sell some of its overstock labels for a fraction of the price.

Popular sneaker label gets a warning

One such company that thrived before the pandemic was Allbirds  (BIRD) , a smaller brand that built comfortable shoes made of sustainable materials best suited for walking and commuting.

The entrance of Allbirds seen from Hayes St. in San Francisco, Calif.

San Francisco Chronicle/Hearst Newspapers via Getty Images/Getty Images

A darling during the late 2010s when almost everybody went into the office every day, Allbirds catered to the crowd who wanted to look presentable at work but feel good in their feet -- and good about what they were doing for the planet. Allbirds' best-selling shoe, the Runners, are made from either wool or sustainable eucalyptus with cushioned midsoles for the perfect all-day temperature and support. They start at $98. 

But Allbirds has struggled with declining sales and profit in recent years, as upscale and presentable commuters are no longer in vogue and shoppers instead opt for comfort over everything else, as is the case with Crocs  (CROX)  and Birkenstock. 

The company tried to make a pivot to other activewear, as with women's leggings but soon found out that was a slippery slope with incumbents like Lululemon  (LULU)  ready to eat any newcomers' lunch — sustainable or not

So in April, Allbirds received a noncompliance warning from Nasdaq, where it is currently listed and trades for under $1. Since the stock has traded below $1 for over 30 days, Nasdaq warned Allbirds it must get its stock price up — or be at risk of being delisted from the exchange. 

It has 180 days, or until September 30, to make that change. In order to avoid delisting, it must trade for above $1 for at least 10 business days straight. 

Allbirds said it "will consider actions," to take in order to avoid delisting, "but no decisions about a response have been made at this time."

Earlier in 2024, Allbirds said it will shutter between 10-15 brick-and-mortar locations in the U.S., but it still expects revenue to decline 25% or more in the fiscal year. 

Read More

Continue Reading

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