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UMass Amherst-UT Austin team awarded $27.5 million by CDC to help establish nation’s first disease outbreak response network

A team from the University of Massachusetts Amherst and The University of Texas at Austin is among 13 institutional partners chosen by the CDC’s Center…

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A team from the University of Massachusetts Amherst and The University of Texas at Austin is among 13 institutional partners chosen by the CDC’s Center for Forecasting and Outbreak Analytics (CFA) to establish the nation’s first outbreak response and disease modeling network.

Credit: UMass Amherst

A team from the University of Massachusetts Amherst and The University of Texas at Austin is among 13 institutional partners chosen by the CDC’s Center for Forecasting and Outbreak Analytics (CFA) to establish the nation’s first outbreak response and disease modeling network.

The CDC on Tuesday, Sept. 19, announced the $250 million effort that grew out of the needs and lessons of the COVID-19 pandemic. The emerging national network will use data to support decision makers during public health emergencies. 

Led by renowned infectious-disease researchers, integrative biologist Lauren Ancel Meyers, director of the Center for Pandemic Decision Science, and biostatistician Nicholas Reich, director of the UMass COVID-19 Forecast Hub, the UMass-UT team was awarded $27.5 million from the CFA to help implement forecasting and disease-modeling efforts over the next five years. 

In addition to the “implementation” category under which the UMass-UT team applied for and was funded as one of three centers in the nation, the other categories for funding are innovation and integration.

“Implementation is where the rubber meets the road,” says Reich, who is also director of the CDC-designated Influenza Forecasting Center of Excellence and professor in the School of Public Health and Health Sciences. “We want to take what worked from the collaborations between public health officials and the modeling community during COVID and improve upon it.”

Meyers was an integral player in the local analysis of and response to COVID-19 in the Austin area, where she directed the UT Austin COVID-19 Modeling Consortium. She was given a key to the city earlier this year for her lab’s round-the-clock contribution to the community during the pandemic. 

“Our models have provided critical information and saved lives during COVID-19 and other public health emergencies,” says Meyers, a professor of integrative biology, statistics and data sciences, and population health at UT Austin. “However, with each new threat, we scrambled to build predictive analytics and to communicate the results to decision makers. This project represents a huge national investment in data and analytics for pandemic preparedness. It will allow us, and teams like ours, to ensure that our tools are poised to rapidly detect, forecast and combat new threats and that public health officials across the U.S. are equipped to use them.” 

Reich’s forecast hub, which created a weekly “ensemble” forecast of COVID deaths and hospitalizations from dozens of models developed by teams of highly respected infectious-disease forecasters, served as the source for the CDC’s short-term forecasts for counties, states and the nation during the pandemic. These predictions were used by the White House to inform public communications as well as by healthcare and university systems in planning for coming waves, and by vaccine manufacturers in designing and siting clinical trials.

Reich says the collaboration with Meyers at UT Austin will take advantage of the strengths of both of their groups’ experiences collaborating with public health officials. The goal will be to take pilot projects that have proven successful and design them for use across jurisdictions.

“We’re looking forward to using this new partnership to take the best of what modeling and outbreak analytics have to offer and building tools and systems that can provide valuable insights to a wide range of stakeholders, from decision-makers at the local, state and federal levels to the general public,” Reich says.

Reich and Meyers will partner with two dozen academic groups and public health agencies in Texas and Massachusetts; each has received subawards under the UMass-UT plan. In Massachusetts, the Department of Public Health’s senior informatics epidemiologist Meagan Burns will work with Reich and Meyers to strengthen the team’s academic-public health core and develop strategies for decision support during crises.

“We are excited to continue our work with UMass Amherst as well as engage with UT Austin,” says Dr. Catherine M. Brown, state epidemiologist. “This collaboration will allow us to leverage the expertise of our partners and result in critical tools to respond to public health threats. DPH will help inform the development of those tools and will use them to enhance our implementation of modeling and analytics to support public health.”

Also as part of the award, the UT-UMass group will receive $500,000 a year to develop staffing and data-sharing plans when emergency activation needs to happen. “The plan is to have this network of academic and industry partners that are standing by ready to be activated when another outbreak emergency occurs, and not necessarily just the once-in-a-century pandemic,” Reich says. “Once every couple of years there’s something like an Ebola or monkey pox outbreak, or SARS or pandemic flu.”

The national network will move the U.S. forward in efforts to better prepare for and respond to disease outbreaks, says Dylan George, director of the CFA. “We are committed to working alongside these outstanding partners to achieve our goal of using data and advanced analytics to support decision-makers at every level of government,” he says. 


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Low Iron Levels In Blood Could Trigger Long COVID: Study

Low Iron Levels In Blood Could Trigger Long COVID: Study

Authored by Amie Dahnke via The Epoch Times (emphasis ours),

People with inadequate…

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Low Iron Levels In Blood Could Trigger Long COVID: Study

Authored by Amie Dahnke via The Epoch Times (emphasis ours),

People with inadequate iron levels in their blood due to a COVID-19 infection could be at greater risk of long COVID.

(Shutterstock)

A new study indicates that problems with iron levels in the bloodstream likely trigger chronic inflammation and other conditions associated with the post-COVID phenomenon. The findings, published on March 1 in Nature Immunology, could offer new ways to treat or prevent the condition.

Long COVID Patients Have Low Iron Levels

Researchers at the University of Cambridge pinpointed low iron as a potential link to long-COVID symptoms thanks to a study they initiated shortly after the start of the pandemic. They recruited people who tested positive for the virus to provide blood samples for analysis over a year, which allowed the researchers to look for post-infection changes in the blood. The researchers looked at 214 samples and found that 45 percent of patients reported symptoms of long COVID that lasted between three and 10 months.

In analyzing the blood samples, the research team noticed that people experiencing long COVID had low iron levels, contributing to anemia and low red blood cell production, just two weeks after they were diagnosed with COVID-19. This was true for patients regardless of age, sex, or the initial severity of their infection.

According to one of the study co-authors, the removal of iron from the bloodstream is a natural process and defense mechanism of the body.

But it can jeopardize a person’s recovery.

When the body has an infection, it responds by removing iron from the bloodstream. This protects us from potentially lethal bacteria that capture the iron in the bloodstream and grow rapidly. It’s an evolutionary response that redistributes iron in the body, and the blood plasma becomes an iron desert,” University of Oxford professor Hal Drakesmith said in a press release. “However, if this goes on for a long time, there is less iron for red blood cells, so oxygen is transported less efficiently affecting metabolism and energy production, and for white blood cells, which need iron to work properly. The protective mechanism ends up becoming a problem.”

The research team believes that consistently low iron levels could explain why individuals with long COVID continue to experience fatigue and difficulty exercising. As such, the researchers suggested iron supplementation to help regulate and prevent the often debilitating symptoms associated with long COVID.

It isn’t necessarily the case that individuals don’t have enough iron in their body, it’s just that it’s trapped in the wrong place,” Aimee Hanson, a postdoctoral researcher at the University of Cambridge who worked on the study, said in the press release. “What we need is a way to remobilize the iron and pull it back into the bloodstream, where it becomes more useful to the red blood cells.”

The research team pointed out that iron supplementation isn’t always straightforward. Achieving the right level of iron varies from person to person. Too much iron can cause stomach issues, ranging from constipation, nausea, and abdominal pain to gastritis and gastric lesions.

1 in 5 Still Affected by Long COVID

COVID-19 has affected nearly 40 percent of Americans, with one in five of those still suffering from symptoms of long COVID, according to the U.S. Centers for Disease Control and Prevention (CDC). Long COVID is marked by health issues that continue at least four weeks after an individual was initially diagnosed with COVID-19. Symptoms can last for days, weeks, months, or years and may include fatigue, cough or chest pain, headache, brain fog, depression or anxiety, digestive issues, and joint or muscle pain.

Tyler Durden Sat, 03/09/2024 - 12:50

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Walmart joins Costco in sharing key pricing news

The massive retailers have both shared information that some retailers keep very close to the vest.

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As we head toward a presidential election, the presumed candidates for both parties will look for issues that rally undecided voters. 

The economy will be a key issue, with Democrats pointing to job creation and lowering prices while Republicans will cite the layoffs at Big Tech companies, high housing prices, and of course, sticky inflation.

The covid pandemic created a perfect storm for inflation and higher prices. It became harder to get many items because people getting sick slowed down, or even stopped, production at some factories.

Related: Popular mall retailer shuts down abruptly after bankruptcy filing

It was also a period where demand increased while shipping, trucking and delivery systems were all strained or thrown out of whack. The combination led to product shortages and higher prices.

You might have gone to the grocery store and not been able to buy your favorite paper towel brand or find toilet paper at all. That happened partly because of the supply chain and partly due to increased demand, but at the end of the day, it led to higher prices, which some consumers blamed on President Joe Biden's administration.

Biden, of course, was blamed for the price increases, but as inflation has dropped and grocery prices have fallen, few companies have been up front about it. That's probably not a political choice in most cases. Instead, some companies have chosen to lower prices more slowly than they raised them.

However, two major retailers, Walmart (WMT) and Costco, have been very honest about inflation. Walmart Chief Executive Doug McMillon's most recent comments validate what Biden's administration has been saying about the state of the economy. And they contrast with the economic picture being painted by Republicans who support their presumptive nominee, Donald Trump.

Walmart has seen inflation drop in many key areas.

Image source: Joe Raedle/Getty Images

Walmart sees lower prices

McMillon does not talk about lower prices to make a political statement. He's communicating with customers and potential customers through the analysts who cover the company's quarterly-earnings calls.

During Walmart's fiscal-fourth-quarter-earnings call, McMillon was clear that prices are going down.

"I'm excited about the omnichannel net promoter score trends the team is driving. Across countries, we continue to see a customer that's resilient but looking for value. As always, we're working hard to deliver that for them, including through our rollbacks on food pricing in Walmart U.S. Those were up significantly in Q4 versus last year, following a big increase in Q3," he said.

He was specific about where the chain has seen prices go down.

"Our general merchandise prices are lower than a year ago and even two years ago in some categories, which means our customers are finding value in areas like apparel and hard lines," he said. "In food, prices are lower than a year ago in places like eggs, apples, and deli snacks, but higher in other places like asparagus and blackberries."

McMillon said that in other areas prices were still up but have been falling.

"Dry grocery and consumables categories like paper goods and cleaning supplies are up mid-single digits versus last year and high teens versus two years ago. Private-brand penetration is up in many of the countries where we operate, including the United States," he said.

Costco sees almost no inflation impact

McMillon avoided the word inflation in his comments. Costco  (COST)  Chief Financial Officer Richard Galanti, who steps down on March 15, has been very transparent on the topic.

The CFO commented on inflation during his company's fiscal-first-quarter-earnings call.

"Most recently, in the last fourth-quarter discussion, we had estimated that year-over-year inflation was in the 1% to 2% range. Our estimate for the quarter just ended, that inflation was in the 0% to 1% range," he said.

Galanti made clear that inflation (and even deflation) varied by category.

"A bigger deflation in some big and bulky items like furniture sets due to lower freight costs year over year, as well as on things like domestics, bulky lower-priced items, again, where the freight cost is significant. Some deflationary items were as much as 20% to 30% and, again, mostly freight-related," he added.

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Walmart has really good news for shoppers (and Joe Biden)

The giant retailer joins Costco in making a statement that has political overtones, even if that’s not the intent.

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As we head toward a presidential election, the presumed candidates for both parties will look for issues that rally undecided voters. 

The economy will be a key issue, with Democrats pointing to job creation and lowering prices while Republicans will cite the layoffs at Big Tech companies, high housing prices, and of course, sticky inflation.

The covid pandemic created a perfect storm for inflation and higher prices. It became harder to get many items because people getting sick slowed down, or even stopped, production at some factories.

Related: Popular mall retailer shuts down abruptly after bankruptcy filing

It was also a period where demand increased while shipping, trucking and delivery systems were all strained or thrown out of whack. The combination led to product shortages and higher prices.

You might have gone to the grocery store and not been able to buy your favorite paper towel brand or find toilet paper at all. That happened partly because of the supply chain and partly due to increased demand, but at the end of the day, it led to higher prices, which some consumers blamed on President Joe Biden's administration.

Biden, of course, was blamed for the price increases, but as inflation has dropped and grocery prices have fallen, few companies have been up front about it. That's probably not a political choice in most cases. Instead, some companies have chosen to lower prices more slowly than they raised them.

However, two major retailers, Walmart (WMT) and Costco, have been very honest about inflation. Walmart Chief Executive Doug McMillon's most recent comments validate what Biden's administration has been saying about the state of the economy. And they contrast with the economic picture being painted by Republicans who support their presumptive nominee, Donald Trump.

Walmart has seen inflation drop in many key areas.

Image source: Joe Raedle/Getty Images

Walmart sees lower prices

McMillon does not talk about lower prices to make a political statement. He's communicating with customers and potential customers through the analysts who cover the company's quarterly-earnings calls.

During Walmart's fiscal-fourth-quarter-earnings call, McMillon was clear that prices are going down.

"I'm excited about the omnichannel net promoter score trends the team is driving. Across countries, we continue to see a customer that's resilient but looking for value. As always, we're working hard to deliver that for them, including through our rollbacks on food pricing in Walmart U.S. Those were up significantly in Q4 versus last year, following a big increase in Q3," he said.

He was specific about where the chain has seen prices go down.

"Our general merchandise prices are lower than a year ago and even two years ago in some categories, which means our customers are finding value in areas like apparel and hard lines," he said. "In food, prices are lower than a year ago in places like eggs, apples, and deli snacks, but higher in other places like asparagus and blackberries."

McMillon said that in other areas prices were still up but have been falling.

"Dry grocery and consumables categories like paper goods and cleaning supplies are up mid-single digits versus last year and high teens versus two years ago. Private-brand penetration is up in many of the countries where we operate, including the United States," he said.

Costco sees almost no inflation impact

McMillon avoided the word inflation in his comments. Costco  (COST)  Chief Financial Officer Richard Galanti, who steps down on March 15, has been very transparent on the topic.

The CFO commented on inflation during his company's fiscal-first-quarter-earnings call.

"Most recently, in the last fourth-quarter discussion, we had estimated that year-over-year inflation was in the 1% to 2% range. Our estimate for the quarter just ended, that inflation was in the 0% to 1% range," he said.

Galanti made clear that inflation (and even deflation) varied by category.

"A bigger deflation in some big and bulky items like furniture sets due to lower freight costs year over year, as well as on things like domestics, bulky lower-priced items, again, where the freight cost is significant. Some deflationary items were as much as 20% to 30% and, again, mostly freight-related," he added.

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