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The impact of ketogenic diets on cognitive behavior, motor function, and blood lipids

“[…] intermittent ketogenic diet (IKD) or ketogenic diet (KD) intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats;…

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“[…] intermittent ketogenic diet (IKD) or ketogenic diet (KD) intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats; however, both IKD and KD positively impacted circulating lipids.”

Credit: 2024 Rutkowsky et al.

“[…] intermittent ketogenic diet (IKD) or ketogenic diet (KD) intervention did not improve measures of cognitive or motor behavior in TgF344-AD rats; however, both IKD and KD positively impacted circulating lipids.”

BUFFALO, NY- April 17, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 7, entitled, “The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats.”

Studies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer’s disease (AD). In this new study, researchers Jennifer M. Rutkowsky, Zabrisky Roland, Anthony Valenzuela, An B. Nguyen, Heui Hye Park, Natalie Six, Ilknur Dursun, Kyoungmi Kim, Pamela J. Lein, and Jon J. Ramsey from the University of California Davis and Istinye University determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. 

“[…] it remains to be determined whether long-term consumption of a ketogenic diet can mitigate declines in cognitive or motor behavior in a rat model of AD. Therefore, the current study aimed to determine whether a KD improves cognitive or motor behavior in the TgF344-AD rat.”

At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating β-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. 

TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and impaired motor coordination at 12 months of age. Neither KD nor IKD improved performance compared to CD. At 12 months of age, TgF344-AD animals had elevated blood lipids. IKD reduced lipids to WT levels with KD further reducing cholesterol below WT levels. 

“[…] the IKD or KD did not improve motor coordination or spatial learning memory compared to the control diet. However, KD, and to a lesser extent IKD, mitigated elevations in plasma lipids in the TgF344-AD rats. Furthermore, the KD diet decreased plasma levels of total Tau in females.”
 

Read the full paper: DOI: https://doi.org/10.18632/aging.205741 

Corresponding Author: Jennifer M. Rutkowsky

Corresponding Email: jrutkowsky@ucdavis.edu 

Keywords: ketogenic diet, Alzheimer’s disease, cognitive behavior, motor function, lipids

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About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at www.Aging-US.com​​ and connect with us:

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For media inquiries, please contact media@impactjournals.com.

 

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National Comprehensive Cancer Network awards Champions for Excellence and Outstanding Contributions in Cancer Care

PLYMOUTH MEETING, PA [April 17, 2024] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—is announcing…

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PLYMOUTH MEETING, PA [April 17, 2024] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—is announcing 2024 award recipients that include individuals and groups who have made significant and noteworthy impacts on improving cancer care and supporting NCCN’s mission to help all people with cancer to live better lives.

Credit: NCCN

PLYMOUTH MEETING, PA [April 17, 2024] — The National Comprehensive Cancer Network® (NCCN®)—an alliance of leading cancer centers—is announcing 2024 award recipients that include individuals and groups who have made significant and noteworthy impacts on improving cancer care and supporting NCCN’s mission to help all people with cancer to live better lives.

The 2024 NCCN Award Recipients are:

  • The NCCN COVID-19 Vaccination Advisory Committee
    • NCCN Outstanding Contribution Award
  • Darcie Green, Executive Director, Latinas Contra Cancer
    • NCCN Partners in Cancer Care Award
  • Shaji K. Kumar, MD, Consultant, Division of Hematology, Professor of Medicine, Medical Director, Cancer Center Research Office, Mayo Clinic Comprehensive Cancer Center
    • NCCN Excellence in Engagement Award
  • Donna Black, Senior Guidelines Administrative Manager, NCCN
    • NCCN Employee of the Year Award

The Outstanding Contribution Award recognizes passion for improving the care of people with cancer and exceeding expectations in service of NCCN’s mission. The NCCN COVID-19 Vaccination Advisory Committee included 36 members from NCCN Member Institutions with expertise in hematology and oncology, infectious disease, and medical ethics. They worked very quickly to provide evidence and consensus-based guidance during a time of uncertainty. Their first meeting was conducted on Jan 11, 2021, and Version 1 of the COVID-19 Vaccination Recommendations was published just 11 days later. Over the next two years, the Committee updated the recommendations seven times as new data became available and new vaccines were approved. The latest recommendations are now included in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) on Prevention and Treatment of Cancer-Related Infections.

Lindsey Baden, MD, from the Dana-Farber Cancer Institute, Chair of the NCCN Guidelines® Panel for Prevention and Treatment of Cancer-Related Infections accepted the award on behalf of fellow committee co-leads Steven A. Pergam, MD, MPH, from Fred Hutchinson Cancer Center and Brahm Segal, MD, from Roswell Park Comprehensive Cancer Center, and the entire committee.

“The emergence of SARS-CoV-2 four years ago changed the world,” said Dr. Baden. “Our patients were most at risk. The creation of the COVID-19 Vaccine Advisory Committee with broad representation across our communities, allowed us to respond thoughtfully and rapidly to care for our patients and each other in the shadow of rapidly evolving data. The committee is proud of its work in providing aggregated, streamlined, and actionable recommendations for COVID-19 vaccinations in persons with cancer.”

The Partners in Cancer Care Award goes to people outside of NCCN Member Institutions who are instrumental in helping NCCN achieve its mission. As Executive Director of Latinas Contra Cancer, Green oversees efforts to build the capacity of Latino communities to advocate effectively for themselves in healthcare settings. She leads a team of health educators and advocates to provide culturally and linguistically sensitive cancer education, navigation, and survivor support. Through her advocacy, Green has worked relentlessly to eliminate disparities in cancer prevention, diagnosis, and treatment. This includes several collaborations with NCCN, such as co-chairing the Health Equity Report Card (HERC) Community Working Group, presenting on webinars for the Alliance for Cancer Care Equity (ACCE), and participating in environmental scans and oncology policy summits.

Green stated: “I would like to express deep gratitude to NCCN not only for this acknowledgement of our work but also for the space NCCN holds for the voice of patients most impacted by race-based health inequities in cancer care and the social inequalities that impact access to and the quality of cancer care. It is an honor to be a part of this network. I look forward to our continuing partnership.”

The Excellence in Engagement Award goes to an NCCN Guidelines Panel Member who exemplifies leadership, drive, and commitment. Dr. Kumar’s leadership as Chair of the NCCN Guidelines Panel for Plasma Cell Neoplasms showcases that and more. He is being honored for his role in significantly expanding the guidelines that he oversees. He is also actively involved with NCCN’s Global Program and Continuing Education Program. Dr. Kumar’s recognition highlighted his dedication, responsiveness, thoughtfulness, and collegiality.

“This is truly an amazing honor, one that belongs to the entire panel,” said Dr. Kumar. “The NCCN role has been a highlight of my career, and I always look forward to the meetings with my friends and colleagues, the in-depth discussions, and the ability to come to a consensus on virtually every issue. The opportunity to make a difference to the patients is at the same time a humbling experience as well as a great honor and privilege. I am very grateful for the constant help and guidance from the amazing NCCN staff, who makes it all possible.”

NCCN Senior Guidelines Administrative Manager, Donna Black, was voted Employee of the Year by her peers. Black serves in a leadership role for the administrative team for the NCCN Guidelines Program. She provides essential support for the NCCN Guidelines, including scheduling panel meetings, coordinating institutional reviews, overseeing submission requests, and much more.

Black said: “I am honored to be selected as the recipient of the Employee of the Year Award. It is a privilege to be a member of the Clinical Information Team that assists clinicians, patients, and caregivers to navigate the cancer care continuum. I am immensely thankful for this recognition, and in turn want to express my appreciation for the dedication and tremendous work of all my team members.”

“We are so grateful for everyone who helps NCCN achieve our mission of improving and facilitating quality, effective, equitable, and accessible cancer care so all patients can live better lives,” said Crystal S. Denlinger, MD, Chief Executive Officer, NCCN. “All of this year’s award recipients have demonstrated incredible leadership, commitment, and dedication in service to people with cancer everywhere. We thank them for everything they do to encourage and uphold the values of NCCN.”

The awards were given out during the NCCN 2024 Annual Conference in Orlando, Florida. Visit NCCN.org/conference to learn more.

# # #

About the National Comprehensive Cancer Network

The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, equitable, and accessible cancer care so all patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information.


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Johnson & Johnson Shares Drop After Mixed Results

The share price dropped by more than 2%, while the overall S&P 500 declined by just 0.2% on the same day. JNJ reported sales of $21.38bn in the first…

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The share price dropped by more than 2%, while the overall S&P 500 declined by just 0.2% on the same day. JNJ reported sales of $21.38bn in the first quarter of 2024, which represents a 2% increase on a year-on-year basis. The firm’s net income rose by close to 4%, giving a total of $6.58bn, which is $2.71 per share.


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While these results are reasonably good, analysts were left disappointed that the company failed to hit the $21.40bn sales figure estimated beforehand. On the other hand, JNJ beat the $2.64 that was predicted as the net income per share. The firm’s chief executive officer Joaquin Duato said:

Johnson & Johnson’s solid first quarter performance reflects our sharpened focus and the progress in our portfolio and pipeline.

Sales in medical devices rebounded in the last quarter, with older adults programming non-urgent surgeries that had been deferred due to the COVID-19 pandemic.

The company’s full-year forecast now has sales of $88bn and $88.4bn, changing from the previous expectation of between $87.8bn and $88.6bn. It has also altered the full-year adjusted earnings estimate from between $10.55 and $10.75 per share to a new forecast of $10.57 to $10.72.

 

 

 

 

The post Johnson & Johnson Shares Drop After Mixed Results appeared first on LeapRate.

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Red States Fight Growing Efforts To Give “Basic Income” Cash To Residents

Red States Fight Growing Efforts To Give "Basic Income" Cash To Residents

By Kevin Hardy of Stateline

South Dakota state Sen. John Wiik likes…

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Red States Fight Growing Efforts To Give "Basic Income" Cash To Residents

By Kevin Hardy of Stateline

South Dakota state Sen. John Wiik likes to think of himself as a lookout of sorts — keeping an eye on new laws, programs and ideas brewing across the states.

“I don’t bring a ton of legislation,” said Wiik, a Republican. “The main thing I like to do is try and stay ahead of trends and try and prevent bad things from coming into our state.”

This session, that meant sponsoring successful legislation banning cities or counties from creating basic income programs, which provide direct, regular cash payments to low-income residents to help alleviate poverty.

While Wiik isn’t aware of any local governments publicly floating the idea in South Dakota, he describes such programs as “bureaucrats trying to hand out checks to make sure that your party registration matches whoever signed the checks for the rest of your life.”

The economic gut punch of the pandemic and related assistance efforts such as the expanded child tax credit popularized the idea of directly handing cash to people in need. Advocates say the programs can be administered more efficiently than traditional government assistance programs, and research suggests they increase not only financial stability but also mental and physical health.

Still, Wiik and other Republicans argue handing out no-strings-attached cash disincentivizes work — and having fewer workers available is especially worrisome in a state with the nation’s second-lowest unemployment rate.

South Dakota is among at least six states where GOP officials have looked to ban basic income programs.

The basic income concept has been around for decades, but a 2019 experiment in Stockton, California, set off a major expansion. There, 125 individuals received $500 per month with no strings attached for two years. Independent researchers found the program improved financial stability and health, but concluded that the pandemic dampened those effects.

GOP lawmakers like Wiik fear that even experimental programs could set a dangerous precedent.

“What did Ronald Reagan say, ‘The closest thing to eternal life on this planet is a government program’?” Wiik said. “So, if you get people addicted to just getting a check from the government, it’s going to be really hard to take that away.”

The debate over basic income programs is likely to intensify as blue state lawmakers seek to expand pilot programs. Minnesota, for example, could become the nation’s first to fund a statewide program. But elected officials in red states are working to thwart such efforts — not only by fighting statewide efforts but also by preventing local communities from starting their own basic income programs.

Democratic governors in Arizona and Wisconsin recently vetoed Republican legislation banning basic income programs.

Last week, Texas Attorney General Ken Paxton sued Harris County to block a pilot program that would provide $500 per month to 1,900 low-income people in the state’s largest county, home to Houston.

Paxton, a Republican, argued the program is illegal because it violates a state constitutional provision that says local governments cannot grant public money to individuals.

Harris County Attorney Christian Menefee, a Democrat, called Paxton’s move “nothing more than an attack on local government and an attempt to make headlines.”

Meanwhile, several blue states are pushing to expand these programs.

Washington state lawmakers debated a statewide basic income bill during this year’s short session. And Minnesota lawmakers are debating whether to spend $100 million to roll out one of the nation’s first statewide pilot programs.

“We’re definitely seeing that shift from pilot to policy,” said Sukhi Samra, the director of Mayors for a Guaranteed Income, which formed after the Stockton experiment.

So far, that organization has helped launch about 60 pilot programs across the country that will provide $250 million in unconditional aid, she said.

Despite pushback in some states, Samra said recent polling commissioned by the group shows broad support of basic income programs. And the programs have shown success in supplementing — not replacing — social safety net programs, she said.

The extra cash gives recipients freedom of choice. People can fix a flat tire, cover school supplies or celebrate a child’s birthday for the first time.

“There’s no social safety net program that allows you to do that.” she said. “ … This is an effective policy that helps our families, and this can radically change the way that we address poverty in this country.”

Basic Income Experiments

The proliferation of basic income projects has been closely studied by researchers.

Though many feared that free cash would dissuade people from working, that hasn’t been the case, said Sara Kimberlin, the executive director and senior research scholar at Stanford University’s Center on Poverty and Inequality.

Stanford’s Basic Income Lab has tracked more than 150 basic income pilots across the country. Generally, those offer $500 or $1,000 per month over a short period.

“There isn’t anywhere in the United States where you can live off of $500 a month,” she said. “At the same time, $500 a month really makes a tremendous difference for someone who is living really close to the edge.”

Kimberlin said the research on basic income programs has so far been promising, though it’s unclear how long the benefits may persist once programs conclude. Still, she said, plenty of research shows how critical economic stability in childhood is to stability in adulthood — something both the basic income programs and the pandemic-era child tax credit can address.

Over the past five years, basic income experiments have varied across the country.

Last year, California launched the nation’s first state-funded pilot programs targeting former foster youth.

In Colorado, the Denver Basic Income Project aimed to help homeless individuals. After early successes, the Denver City Council awarded funding late last year to extend that program, which provides up to $1,000 per month to hundreds of participants.

A 2021 pilot launched in Cambridge, Massachusetts, provided $500 a month over 18 months to 130 single caregivers. Research from the University of Pennsylvania found the Cambridge program increased employment, the ability to cover a $400 emergency expense, and food and housing security among participants.

Children in participating families were more likely to enroll in Advanced Placement courses, earned higher grades and had reduced absenteeism.

“It was really reaffirming to hear that when families are not stressed out, they are able to actually do much better,” said Geeta Pradhan, president of the Cambridge Community Foundation, which worked on the project.

Pradhan said basic income programs are part of a national trend in “trust-based philanthropy,” which empowers individuals rather than imposing top-down solutions to fight poverty.

“There is something that I think it does to people’s sense of empowerment, a sense of agency, the freedom that you feel,” she said. “I think that there’s some very important aspects of humanity that are built into these programs.”

While the pilot concluded, the Cambridge City Council committed $22 million in federal pandemic aid toward a second round of funding. Now, nearly 2,000 families earning at or below 250% of the federal poverty level are receiving $500 monthly payments, said Sumbul Siddiqui, a city council member.

Siddiqui, a Democrat, pushed for the original pilot when she was mayor during the pandemic. While she said the program has proven successful, it’s unclear whether the city can find a sustainable source of funding to keep it going long term.

States look to expand pilots

Tomas Vargas Jr. was among the 125 people who benefited from the Stockton, California, basic income program that launched in 2019.

At the time, he heard plenty of criticism from people who said beneficiaries would blow their funds on drugs and alcohol or quit their jobs.

“Off of $500 a month, which amazed me,” said Vargas, who worked part time at UPS.

But he said the cash gave him breathing room. He had felt stuck at his job, but the extra money gave him the freedom to take time off to interview for better jobs.

Unlike other social service programs like food stamps, he didn’t have to worry about losing out if his income went up incrementally. The cash allowed him to be a better father, he said, as well as improved his confidence and mental health.

The experience prompted him to get into the nonprofit sector. Financially stable, he now works at Mayors for a Guaranteed Income.

“The person I was five years ago is not the person that I am now,” he said.

Washington state Sen. Claire Wilson, a Democrat, said basic income is a proactive way to disrupt the status quo maintained by other anti-poverty efforts.

“I have a belief that our systems in our country have never been put in place to get people out of them,” she said. “They kept people right where they are.”

Wilson chairs the Human Services Committee, which considered a basic income bill this session that would have created a pilot program to offer 7,500 people a monthly amount equivalent to the fair market rent for a two-bedroom apartment in their area.

The basic income bill didn’t progress during Washington’s short legislative session this year, but Wilson said lawmakers would reconsider the idea next year. While she champions the concept, she said there’s a lot of work to be done convincing skeptics.

In Minnesota, where lawmakers are considering a $100 million statewide basic income pilot program, some Republicans balked at the concept of free cash and its cost to taxpayers.

“Just the cost alone should be a concern,” Republican state Rep. Jon Koznick said during a committee meeting this month.

State Rep. Athena Hollins, a Democrat who sponsored the legislation, acknowledged the hefty request, but said backers would support a scaled-down version and “thought it was really important to get this conversation started.”

Much of the conversation in committee centered on local programs in cities such as Minneapolis and St. Paul. St. Paul Mayor Melvin Carter, a Democrat, told lawmakers the city’s 2020 pilot saw “groundbreaking” results.

After scraping by for years, some families were able to put money into savings for the first time, he said. Families experienced less anxiety and depression. And the pilot disproved the “disparaging tropes” from critics about people living in poverty, the mayor said.

Carter told lawmakers that the complex issue of economic insecurity demands statewide solutions.

“I am well aware that the policy we’re proposing today is a departure from what we’re all used to,” he said. “In fact, that’s one of my favorite things about it.”

Tyler Durden Tue, 04/16/2024 - 22:20

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