Government
Fauci’s NIAID Shielded Wuhan Bat Research Grant From Government Oversight
Fauci’s NIAID Shielded Wuhan Bat Research Grant From Government Oversight
In 2017, a subagency of the National Institutes of Health (NIH) – headed by Dr. Anthony Fauci – resumed funding a controversial grant to genetically modify bat coronavi
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In 2017, a subagency of the National Institutes of Health (NIH) - headed by Dr. Anthony Fauci - resumed funding a controversial grant to genetically modify bat coronaviruses in Wuhan, China without the approval of a government oversight body, according to the Daily Caller.
For context, in 2014, the Obama administration temporarily suspended federal funding for gain-of-function research into manipulating bat COVID to be more transmissible to humans. Four months prior to that decision, the NIH effectively shifted this research to the Wuhan Institute of Virology (WIV) via a grant to nonprofit group EcoHealth Alliance, headed by Peter Daszak.
The first $666,442 installment of EcoHealth's $3.7 million NIH grant was paid in June 2014, with similar annual payments through May 2019 under the "Understanding The Risk Of Bat Coronavirus Emergence" project.
Notably, the WIV "had openly participated in gain-of-function research in partnership with U.S. universities and institutions" for years under the leadership of Dr. Shi 'Batwoman' Zhengli, according to the Washington Post's Josh Rogin.
In 2017, however, the "Potential Pandemic Pathogens Control and Oversight (P3CO) Framework was formed within the Department of Health and Human Services (HHS)," which was tasked with evaluating the risks involved with enhancing dangerous pathogens, as well as whether proper safeguards are in place, before a grant into 'gain-of-function' or similarly risky research can be issued.
Fauci's National Institute of Allergy and Infectious Diseases (NIAID) - the subagency which funded EcoHealth - didn't think the grant needed review, and resumed their relationship with Daszak without flagging it for the P3CO committee, an NIH spokesperson told the Caller.
"This is a systemic problem," says Rutgers University professor of chemical biology, Richard H. Ebright, referring to the loophole in the review process - and adding that NIAID and NIH have "systematically thwarted–indeed systematically nullified–the HHS P3CO Framework by declining to flag and forward proposals for review."
The NIH, however, says that the grant wasn't flagged for review because "NIAID determined research in the grant was not gain-of-function research because it did not involve the enhancement of the pathogenicity or transmissibility of the viruses studied," the spokesperson told the Caller, adding: "We would not submit research proposals that did not meet the definition, because otherwise we would need to submit everything."
We'll just have to take their word for it, as the P3CO framework didn't require the HHS review committee to take a second look at the NIAID's claim that the EcoHealth grant doesn't cover gain-of-function research.
More via The Daily Caller (emphasis ours)
How Federal Oversight Of Gain-Of-Function Research Is Bypassed
The Wuhan Institute of Virology (WIV) is at the center of widespread speculation that COVID-19 could have accidentally leaked from a lab into the human population. EcoHealth’s grant to study bat-based coronaviruses in China included the transfer of $600,000 to the WIV.
Had EcoHealth’s grant been subjected to P3CO review, an HHS panel would have independently evaluated the grant and, if necessary, recommended additional biocontainment measures to prevent potential lab leaks — or even recommended that the grant be denied entirely.
The WIV is a biosafety level 4 laboratory, the highest level biocontainment certification, but U.S. Embassy officials issued two diplomatic cables warning about inadequate safety at the lab after a visit in 2018. One of the cables warned that the lab’s work on bat-based coronaviruses represented the risk of a new SARS-like pandemic, according to The Washington Post.
An annex to the World Health Organization’s COVID-19 origin report released Tuesday describes the WIV’s work using “recombinant viruses” in tests involving bat coronaviruses, which Ebright said are descriptions of gain-of-function research.
The U.S. government paused funding of gain-of-function research in 2014 after lab workers were accidentally exposed to anthrax by the Centers for Disease Control, according to The New York Times. The incident came on the heels of widespread scientific outcry in 2011 when it was revealed that laboratories in Wisconsin and the Netherlands were intentionally modifying the H5N1 bird flu virus so it could more effectively jump between ferrets.
Federally funded gain-of-function research resumed in 2017 after new oversight procedures were implemented. The review framework split oversight responsibilities between two groups — the funding agency (the NIAID in the case of the EcoHealth grant) and the P3CO Review Committee, an interdisciplinary group convened by HHS.
The committee is responsible for recommending whether a research grant involving gain-of-function needs to include any additional risk mitigation measures, an HHS spokesperson told the DCNF. But the committee is kept in the dark on any grant until the funding agency flags one for its review.
The P3CO Framework doesn’t require the HHS review committee to take a second look at the NIAID’s determination following its review that the EcoHealth grant did not involve gain-of-function research.
The NIH spokesperson said it would be “misleading and inaccurate” to suggest NIAID was required to notify the HHS review committee of its determination.
An HHS spokesperson confirmed that the department’s P3CO Review Committee only reviews research grants that are flagged for additional review by funding agencies such as NIAID. The spokesperson did not answer when asked if the review committee had knowledge of the EcoHealth grant.
Ecohealth has a history of manipulating bat-based coronaviruses. The group’s president, Peter Daszak, said as much during a podcast interview filmed in Singapore just weeks before the first reported cases of COVID-19 in Wuhan in December 2019.
“You can manipulate them in the lab pretty easily,” Daszak said. “Spike protein drives a lot of what happens with the coronavirus. Zoonotic risk. So you can get the sequence, you can build the protein — and we work with Ralph Baric at [the University of North Carolina] to do this — and insert the backbone of another virus and do some work in the lab.”
Ebright told the DCNF that NIAID was wrong to determine that the EcoHealth grant did not involve enhancing the transmissibility of Chinese bat-based coronaviruses. He said the project’s abstract for the 2019 fiscal year, which referenced “in vitro and in vivo infection experiments” on coronaviruses, “*unequivocally* required risk-benefit review under the HHS P3CO Framework.”
Other scientists have said EcoHealth’s NIH-funded work in China involved gain-of-function research on bat-based coronaviruses.
“It is hard to overemphasize that the central logic of this grant was to test the pandemic potential of SARS-related bat coronaviruses by making ones with pandemic potential, either through genetic engineering or passaging, or both,” Drs. Jonathan Latham and Allison Wilson wrote in June.
The NIH terminated the EcoHealth grant in April 2020. NIH deputy director for extramural research, Michael Lauer, told the group in a letter that the agency “does not believe that the current project outcomes align with the program goals and agency priorities.”
Fauci said during a hearing before the House Energy & Commerce Committee in June that the EcoHealth grant was canceled “because the NIH was told to cancel it.”
“I don’t know the reason, but we were told to cancel it,” Fauci said.
Fauci told Politico following the hearing that former President Donald Trump’s White House ordered the NIH to cancel the grant.
* * *
Read the rest of the report here.
Government
Low Iron Levels In Blood Could Trigger Long COVID: Study
Low Iron Levels In Blood Could Trigger Long COVID: Study
Authored by Amie Dahnke via The Epoch Times (emphasis ours),
People with inadequate…
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Authored by Amie Dahnke via The Epoch Times (emphasis ours),
People with inadequate iron levels in their blood due to a COVID-19 infection could be at greater risk of long COVID.
A new study indicates that problems with iron levels in the bloodstream likely trigger chronic inflammation and other conditions associated with the post-COVID phenomenon. The findings, published on March 1 in Nature Immunology, could offer new ways to treat or prevent the condition.
Long COVID Patients Have Low Iron Levels
Researchers at the University of Cambridge pinpointed low iron as a potential link to long-COVID symptoms thanks to a study they initiated shortly after the start of the pandemic. They recruited people who tested positive for the virus to provide blood samples for analysis over a year, which allowed the researchers to look for post-infection changes in the blood. The researchers looked at 214 samples and found that 45 percent of patients reported symptoms of long COVID that lasted between three and 10 months.
In analyzing the blood samples, the research team noticed that people experiencing long COVID had low iron levels, contributing to anemia and low red blood cell production, just two weeks after they were diagnosed with COVID-19. This was true for patients regardless of age, sex, or the initial severity of their infection.
According to one of the study co-authors, the removal of iron from the bloodstream is a natural process and defense mechanism of the body.
But it can jeopardize a person’s recovery.
“When the body has an infection, it responds by removing iron from the bloodstream. This protects us from potentially lethal bacteria that capture the iron in the bloodstream and grow rapidly. It’s an evolutionary response that redistributes iron in the body, and the blood plasma becomes an iron desert,” University of Oxford professor Hal Drakesmith said in a press release. “However, if this goes on for a long time, there is less iron for red blood cells, so oxygen is transported less efficiently affecting metabolism and energy production, and for white blood cells, which need iron to work properly. The protective mechanism ends up becoming a problem.”
The research team believes that consistently low iron levels could explain why individuals with long COVID continue to experience fatigue and difficulty exercising. As such, the researchers suggested iron supplementation to help regulate and prevent the often debilitating symptoms associated with long COVID.
“It isn’t necessarily the case that individuals don’t have enough iron in their body, it’s just that it’s trapped in the wrong place,” Aimee Hanson, a postdoctoral researcher at the University of Cambridge who worked on the study, said in the press release. “What we need is a way to remobilize the iron and pull it back into the bloodstream, where it becomes more useful to the red blood cells.”
The research team pointed out that iron supplementation isn’t always straightforward. Achieving the right level of iron varies from person to person. Too much iron can cause stomach issues, ranging from constipation, nausea, and abdominal pain to gastritis and gastric lesions.
1 in 5 Still Affected by Long COVID
COVID-19 has affected nearly 40 percent of Americans, with one in five of those still suffering from symptoms of long COVID, according to the U.S. Centers for Disease Control and Prevention (CDC). Long COVID is marked by health issues that continue at least four weeks after an individual was initially diagnosed with COVID-19. Symptoms can last for days, weeks, months, or years and may include fatigue, cough or chest pain, headache, brain fog, depression or anxiety, digestive issues, and joint or muscle pain.
Government
Walmart joins Costco in sharing key pricing news
The massive retailers have both shared information that some retailers keep very close to the vest.
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As we head toward a presidential election, the presumed candidates for both parties will look for issues that rally undecided voters.
The economy will be a key issue, with Democrats pointing to job creation and lowering prices while Republicans will cite the layoffs at Big Tech companies, high housing prices, and of course, sticky inflation.
The covid pandemic created a perfect storm for inflation and higher prices. It became harder to get many items because people getting sick slowed down, or even stopped, production at some factories.
Related: Popular mall retailer shuts down abruptly after bankruptcy filing
It was also a period where demand increased while shipping, trucking and delivery systems were all strained or thrown out of whack. The combination led to product shortages and higher prices.
You might have gone to the grocery store and not been able to buy your favorite paper towel brand or find toilet paper at all. That happened partly because of the supply chain and partly due to increased demand, but at the end of the day, it led to higher prices, which some consumers blamed on President Joe Biden's administration.
Biden, of course, was blamed for the price increases, but as inflation has dropped and grocery prices have fallen, few companies have been up front about it. That's probably not a political choice in most cases. Instead, some companies have chosen to lower prices more slowly than they raised them.
However, two major retailers, Walmart (WMT) and Costco, have been very honest about inflation. Walmart Chief Executive Doug McMillon's most recent comments validate what Biden's administration has been saying about the state of the economy. And they contrast with the economic picture being painted by Republicans who support their presumptive nominee, Donald Trump.
Image source: Joe Raedle/Getty Images
Walmart sees lower prices
McMillon does not talk about lower prices to make a political statement. He's communicating with customers and potential customers through the analysts who cover the company's quarterly-earnings calls.
During Walmart's fiscal-fourth-quarter-earnings call, McMillon was clear that prices are going down.
"I'm excited about the omnichannel net promoter score trends the team is driving. Across countries, we continue to see a customer that's resilient but looking for value. As always, we're working hard to deliver that for them, including through our rollbacks on food pricing in Walmart U.S. Those were up significantly in Q4 versus last year, following a big increase in Q3," he said.
He was specific about where the chain has seen prices go down.
"Our general merchandise prices are lower than a year ago and even two years ago in some categories, which means our customers are finding value in areas like apparel and hard lines," he said. "In food, prices are lower than a year ago in places like eggs, apples, and deli snacks, but higher in other places like asparagus and blackberries."
McMillon said that in other areas prices were still up but have been falling.
"Dry grocery and consumables categories like paper goods and cleaning supplies are up mid-single digits versus last year and high teens versus two years ago. Private-brand penetration is up in many of the countries where we operate, including the United States," he said.
Costco sees almost no inflation impact
McMillon avoided the word inflation in his comments. Costco (COST) Chief Financial Officer Richard Galanti, who steps down on March 15, has been very transparent on the topic.
The CFO commented on inflation during his company's fiscal-first-quarter-earnings call.
"Most recently, in the last fourth-quarter discussion, we had estimated that year-over-year inflation was in the 1% to 2% range. Our estimate for the quarter just ended, that inflation was in the 0% to 1% range," he said.
Galanti made clear that inflation (and even deflation) varied by category.
"A bigger deflation in some big and bulky items like furniture sets due to lower freight costs year over year, as well as on things like domestics, bulky lower-priced items, again, where the freight cost is significant. Some deflationary items were as much as 20% to 30% and, again, mostly freight-related," he added.
bankruptcy pandemic trumpGovernment
Walmart has really good news for shoppers (and Joe Biden)
The giant retailer joins Costco in making a statement that has political overtones, even if that’s not the intent.
Share this:
As we head toward a presidential election, the presumed candidates for both parties will look for issues that rally undecided voters.
The economy will be a key issue, with Democrats pointing to job creation and lowering prices while Republicans will cite the layoffs at Big Tech companies, high housing prices, and of course, sticky inflation.
The covid pandemic created a perfect storm for inflation and higher prices. It became harder to get many items because people getting sick slowed down, or even stopped, production at some factories.
Related: Popular mall retailer shuts down abruptly after bankruptcy filing
It was also a period where demand increased while shipping, trucking and delivery systems were all strained or thrown out of whack. The combination led to product shortages and higher prices.
You might have gone to the grocery store and not been able to buy your favorite paper towel brand or find toilet paper at all. That happened partly because of the supply chain and partly due to increased demand, but at the end of the day, it led to higher prices, which some consumers blamed on President Joe Biden's administration.
Biden, of course, was blamed for the price increases, but as inflation has dropped and grocery prices have fallen, few companies have been up front about it. That's probably not a political choice in most cases. Instead, some companies have chosen to lower prices more slowly than they raised them.
However, two major retailers, Walmart (WMT) and Costco, have been very honest about inflation. Walmart Chief Executive Doug McMillon's most recent comments validate what Biden's administration has been saying about the state of the economy. And they contrast with the economic picture being painted by Republicans who support their presumptive nominee, Donald Trump.
Image source: Joe Raedle/Getty Images
Walmart sees lower prices
McMillon does not talk about lower prices to make a political statement. He's communicating with customers and potential customers through the analysts who cover the company's quarterly-earnings calls.
During Walmart's fiscal-fourth-quarter-earnings call, McMillon was clear that prices are going down.
"I'm excited about the omnichannel net promoter score trends the team is driving. Across countries, we continue to see a customer that's resilient but looking for value. As always, we're working hard to deliver that for them, including through our rollbacks on food pricing in Walmart U.S. Those were up significantly in Q4 versus last year, following a big increase in Q3," he said.
He was specific about where the chain has seen prices go down.
"Our general merchandise prices are lower than a year ago and even two years ago in some categories, which means our customers are finding value in areas like apparel and hard lines," he said. "In food, prices are lower than a year ago in places like eggs, apples, and deli snacks, but higher in other places like asparagus and blackberries."
McMillon said that in other areas prices were still up but have been falling.
"Dry grocery and consumables categories like paper goods and cleaning supplies are up mid-single digits versus last year and high teens versus two years ago. Private-brand penetration is up in many of the countries where we operate, including the United States," he said.
Costco sees almost no inflation impact
McMillon avoided the word inflation in his comments. Costco (COST) Chief Financial Officer Richard Galanti, who steps down on March 15, has been very transparent on the topic.
The CFO commented on inflation during his company's fiscal-first-quarter-earnings call.
"Most recently, in the last fourth-quarter discussion, we had estimated that year-over-year inflation was in the 1% to 2% range. Our estimate for the quarter just ended, that inflation was in the 0% to 1% range," he said.
Galanti made clear that inflation (and even deflation) varied by category.
"A bigger deflation in some big and bulky items like furniture sets due to lower freight costs year over year, as well as on things like domestics, bulky lower-priced items, again, where the freight cost is significant. Some deflationary items were as much as 20% to 30% and, again, mostly freight-related," he added.
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