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Think like a virus to understand why the pandemic isn’t over yet – and what the US needs to do to help other countries

Viruses want to pass on their genetic material. Recognizing this about SARS-CoV-2 provides insight into how the world is still vulnerable to COVID-19.

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To stop the spread of COVID-19 across the globe, it's important to understand the evolutionary imperative that viruses have to spread their genetic material. Dazeley/Getty Images

Kill every human on the planet.

This is the first assignment I give students in my public health classes, filled with do-gooders passionate about saving the world. Their homework is to play a game called Plague, in which they pretend to be pathogens bent on infecting everyone on the globe before humans can develop a cure or a vaccine.

Why this assignment? Because as a professor of infectious disease epidemiology, I aim to teach students to think like pathogens so they can learn how to control them.

With COVID-19, thinking like a pathogen leads to an inevitable conclusion: Getting the vaccine out to everyone in the world as quickly as possible is not just an ethical imperative, but also a selfish one.

Viruses use their hosts to replicate their genetic material.

Passing on genetic material a key goal

While many wealthy countries soon will offer vaccines to their entire populations, people in poorer countries might have to wait years for their shots. About half of U.S. residents are now at least partially vaccinated. Many other countries have yet to reach 1% vaccination coverage.

In the interim, SARS-CoV-2 will take advantage of this opening.

In reality, pathogens don’t actually want to kill all of their human hosts, because they would eventually have nowhere to live. Their goal is to pass on their genetic material to the next generation. They will do what they can to answer their evolutionary call.

A virus to-do list

Of course, viruses and bacteria don’t have brains so they don’t “think,” per se. But like all life forms, these particular living creatures are trying to maximize their chances of reproducing and having their offspring survive and reproduce.

As a single virus particle, you have two key items on the to-do list. First, you need a place to propagate. You need to reproduce yourself in large numbers, to increase the chances that one of your kids will do the right thing and provide you with some grandchildren. As a virus you are very good at this bit. No need to visit Tinder and find the perfect match, as you reproduce asexually. Instead you use the cellular machinery of your host – the human you infect – to reproduce yourself.

Second, you need a way to get from your current host to the next host that you will infect, otherwise known as transmission. For that you need both a portal of exit – the way to get out of your current host – and a portal of entry – the way to get into your next host. You need a susceptible host. And you need a way to travel to your next host.

Susceptible hosts? That was easy for SARS-CoV-2 when it first came on the scene. Because it was a novel pathogen, the entire global population was susceptible. No humans had full immunity to this particular virus from previous exposure, because it didn’t exist in human populations before 2019. Now, with each person who gets exposed or vaccinated, the number of susceptible hosts dwindles.

For a portal of exit, SARS-CoV-2 has a few options – mostly exhalation through breathing, but also through pooping and expelling other bodily fluids. For a portal of entry it has inhalation – the new host breathes it in – and to a lesser extent ingestion – the new host consumes it orally.

This means that transmission of this virus is relatively easy, involving an activity that people of all ages do all day: breathing. Other viruses require more specific activities or conditions, such as sexual intercourse or needle-sharing for HIV, or being bitten by a particular species of mosquito for Zika.

A woman inserting a swab into her mouth.
A woman at a testing site for asymptomatic COVID-19 in Portsmouth, England, on Feb. 22, 2021. Finnbarr Webster/Getty Images

SARS-CoV-2 is one smart virus

SARS-CoV-2 has had a lot of things playing in its favor, aside from having a global population naïve to it. Several other characteristics make it particularly successful.

First, while it does kill, it can also cause mild or asymptomatic infections in others. When pathogens kill most of their hosts, they are not so successful in spreading, because humans change their behavior in response to the perceived threat of the disease.

Ebola is a perfect example. College students would have been more likely to cancel their spring break plans to Florida in 2020 if they had expected that it might cause them to bleed out of their eyeballs, as happens in some people infected with the Ebola virus.

SARS-CoV-2 also has a long incubation period – the time between its infection of a new host and the start of the host’s symptoms. Yet it can be transmitted during the time before symptoms occur, which allows it to spread unnoticed.

Grieving women hugging one another.
Family members of a COVID-19 victim mourn as they wait outside Maulana Azad Medical College mortuary to collect the body on May 24, 2021, in New Delhi, India. Sanjeev Verma/Hindustan Times via Getty Images

More transmission, more new variants

If you’re thinking like the SARS-CoV-2 pathogen now, you’re furiously searching for a way around current vaccine formulations. The more cases you cause, the more chances you have for new variants that can break through the vaccines. You don’t care whether these cases occur in Montana or Mumbai. This is why no human is safe from the pandemic until transmission is controlled everywhere.

Thinking like a pathogen requires thinking over an evolutionary time scale, which for a virus is very short, sometimes the course of a single human infection. SARS-CoV-2 and other viruses have astonishing powers to adapt to changing conditions.

One of their survival strategies is the built-in mistakes in their reproduction machinery that cause mutations. Occasionally, a mutation occurs that improves the ability of a virus to survive and spread.

This leads to new variants, like those we have seen emerge recently. So far, available vaccines appear effective against the variants. But new variants may reduce vaccine effectiveness, or lead to a need for booster shots. The increased transmissibility of the new variants has already likely made chances of reaching herd immunity through vaccination out of reach.

We watch in horror as the virus ravages India, and to some it may seem like a distant threat. But every new case offers another opportunity for a new variant to emerge and spread worldwide.

A woman receiving a vaccine in Ecuador.
Grace Macias, a fieldworker who works on the author’s projects, gets vaccinated in Quito, Ecuador, on May 23, 2021. Grace Macias, CC BY-ND

To outsmart the virus, we need shots in arms everywhere

That is why global access to vaccines is not only a moral imperative but also the only way to outsmart the virus. The U.S. can do a lot right now to ensure global access to vaccines even as we step up vaccination here.

The U.S. has already made substantial commitments to COVAX, a global collaboration to accelerate the development and manufacture of COVID-19 vaccines and guarantee equitable distribution.

The U.S. could channel additional funds now and pressure other countries to do the same. Funding commitments to COVAX may be hollow without a concurrent plan to quickly distribute the vaccine stockpile the U.S. has amassed as we raced to buy up the first available doses.

In addition to vaccination, the U.S. and other well-resourced countries can help increase the availability of testing in all countries. These countries can also provide technical and logistics assistance to improve vaccine rollout efforts and work to coordinate and improve global genomic surveillance so new variants are quickly identified.

[Get facts about coronavirus and the latest research. Sign up for The Conversation’s newsletter.]

If this all seems expensive, think of the crushing economic costs of going back into lockdown. This is no time to be cheap.

To avoid jeopardizing the effectiveness of the millions of shots going into arms in rich countries, we must get shots into the arms of people in all countries.

Karen Levy receives funding from the National Institutes of Health and the Bill & Melinda Gates Foundation.

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United Airlines adds new flights to faraway destinations

The airline said that it has been working hard to "find hidden gem destinations."

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5 hours ago

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March 8, 2024

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Since countries started opening up after the pandemic in 2021 and 2022, airlines have been seeing demand soar not just for major global cities and popular routes but also for farther-away destinations.

Numerous reports, including a recent TripAdvisor survey of trending destinations, showed that there has been a rise in U.S. traveler interest in Asian countries such as Japan, South Korea and Vietnam as well as growing tourism traction in off-the-beaten-path European countries such as Slovenia, Estonia and Montenegro.

Related: 'No more flying for you': Travel agency sounds alarm over risk of 'carbon passports'

As a result, airlines have been looking at their networks to include more faraway destinations as well as smaller cities that are growing increasingly popular with tourists and may not be served by their competitors.

The Philippines has been popular among tourists in recent years.

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United brings back more routes, says it is committed to 'finding hidden gems'

This week, United Airlines  (UAL)  announced that it will be launching a new route from Newark Liberty International Airport (EWR) to Morocco's Marrakesh. While it is only the country's fourth-largest city, Marrakesh is a particularly popular place for tourists to seek out the sights and experiences that many associate with the country — colorful souks, gardens with ornate architecture and mosques from the Moorish period.

More Travel:

"We have consistently been ahead of the curve in finding hidden gem destinations for our customers to explore and remain committed to providing the most unique slate of travel options for their adventures abroad," United's SVP of Global Network Planning Patrick Quayle, said in a press statement.

The new route will launch on Oct. 24 and take place three times a week on a Boeing 767-300ER  (BA)  plane that is equipped with 46 Polaris business class and 22 Premium Plus seats. The plane choice was a way to reach a luxury customer customer looking to start their holiday in Marrakesh in the plane.

Along with the new Morocco route, United is also launching a flight between Houston (IAH) and Colombia's Medellín on Oct. 27 as well as a route between Tokyo and Cebu in the Philippines on July 31 — the latter is known as a "fifth freedom" flight in which the airline flies to the larger hub from the mainland U.S. and then goes on to smaller Asian city popular with tourists after some travelers get off (and others get on) in Tokyo.

United's network expansion includes new 'fifth freedom' flight

In the fall of 2023, United became the first U.S. airline to fly to the Philippines with a new Manila-San Francisco flight. It has expanded its service to Asia from different U.S. cities earlier last year. Cebu has been on its radar amid growing tourist interest in the region known for marine parks, rainforests and Spanish-style architecture.

With the summer coming up, United also announced that it plans to run its current flights to Hong Kong, Seoul, and Portugal's Porto more frequently at different points of the week and reach four weekly flights between Los Angeles and Shanghai by August 29.

"This is your normal, exciting network planning team back in action," Quayle told travel website The Points Guy of the airline's plans for the new routes.

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Walmart launches clever answer to Target’s new membership program

The retail superstore is adding a new feature to its Walmart+ plan — and customers will be happy.

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5 hours ago

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March 8, 2024

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It's just been a few days since Target  (TGT)  launched its new Target Circle 360 paid membership plan. 

The plan offers free and fast shipping on many products to customers, initially for $49 a year and then $99 after the initial promotional signup period. It promises to be a success, since many Target customers are loyal to the brand and will go out of their way to shop at one instead of at its two larger peers, Walmart and Amazon.

Related: Walmart makes a major price cut that will delight customers

And stop us if this sounds familiar: Target will rely on its more than 2,000 stores to act as fulfillment hubs. 

This model is a proven winner; Walmart also uses its more than 4,600 stores as fulfillment and shipping locations to get orders to customers as soon as possible.

Sometimes, this means shipping goods from the nearest warehouse. But if a desired product is in-store and closer to a customer, it reduces miles on the road and delivery time. It's a kind of logistical magic that makes any efficiency lover's (or retail nerd's) heart go pitter patter. 

Walmart rolls out answer to Target's new membership tier

Walmart has certainly had more time than Target to develop and work out the kinks in Walmart+. It first launched the paid membership in 2020 during the height of the pandemic, when many shoppers sheltered at home but still required many staples they might ordinarily pick up at a Walmart, like cleaning supplies, personal-care products, pantry goods and, of course, toilet paper. 

It also undercut Amazon  (AMZN)  Prime, which costs customers $139 a year for free and fast shipping (plus several other benefits including access to its streaming service, Amazon Prime Video). 

Walmart+ costs $98 a year, which also gets you free and speedy delivery, plus access to a Paramount+ streaming subscription, fuel savings, and more. 

An employee at a Merida, Mexico, Walmart. (Photo by Jeffrey Greenberg/Universal Images Group via Getty Images)

Jeff Greenberg/Getty Images

If that's not enough to tempt you, however, Walmart+ just added a new benefit to its membership program, ostensibly to compete directly with something Target now has: ultrafast delivery. 

Target Circle 360 particularly attracts customers with free same-day delivery for select orders over $35 and as little as one-hour delivery on select items. Target executes this through its Shipt subsidiary.

We've seen this lightning-fast delivery speed only in snippets from Amazon, the king of delivery efficiency. Who better to take on Target, though, than Walmart, which is using a similar store-as-fulfillment-center model? 

"Walmart is stepping up to save our customers even more time with our latest delivery offering: Express On-Demand Early Morning Delivery," Walmart said in a statement, just a day after Target Circle 360 launched. "Starting at 6 a.m., earlier than ever before, customers can enjoy the convenience of On-Demand delivery."

Walmart  (WMT)  clearly sees consumers' desire for near-instant delivery, which obviously saves time and trips to the store. Rather than waiting a day for your order to show up, it might be on your doorstep when you wake up. 

Consumers also tend to spend more money when they shop online, and they remain stickier as paying annual members. So, to a growing number of retail giants, almost instant gratification like this seems like something worth striving for.

Related: Veteran fund manager picks favorite stocks for 2024

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President Biden Delivers The “Darkest, Most Un-American Speech Given By A President”

President Biden Delivers The "Darkest, Most Un-American Speech Given By A President"

Having successfully raged, ranted, lied, and yelled through…

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7 hours ago

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March 8, 2024

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President Biden Delivers The "Darkest, Most Un-American Speech Given By A President"

Having successfully raged, ranted, lied, and yelled through the State of The Union, President Biden can go back to his crypt now.

Whatever 'they' gave Biden, every American man, woman, and the other should be allowed to take it - though it seems the cocktail brings out 'dark Brandon'?

Tl;dw: Biden's Speech tonight ...

  • Fund Ukraine.

  • Trump is threat to democracy and America itself.

  • Abortion is good.

  • American Economy is stronger than ever.

  • Inflation wasn't Biden's fault.

  • Illegals are Americans too.

  • Republicans are responsible for the border crisis.

  • Trump is bad.

  • Biden stands with trans-children.

  • J6 was the worst insurrection since the Civil War.

(h/t @TCDMS99)

Tucker Carlson's response sums it all up perfectly:

"that was possibly the darkest, most un-American speech given by an American president. It wasn't a speech, it was a rant..."

Carlson continued: "The true measure of a nation's greatness lies within its capacity to control borders, yet Bid refuses to do it."

"In a fair election, Joe Biden cannot win"

And concluded:

“There was not a meaningful word for the entire duration about the things that actually matter to people who live here.”

Victor Davis Hanson added some excellent color, but this was probably the best line on Biden:

"he doesn't care... he lives in an alternative reality."

*  *  *

Watch SOTU Live here...

*   *   *

Mises' Connor O'Keeffe, warns: "Be on the Lookout for These Lies in Biden's State of the Union Address." 

On Thursday evening, President Joe Biden is set to give his third State of the Union address. The political press has been buzzing with speculation over what the president will say. That speculation, however, is focused more on how Biden will perform, and which issues he will prioritize. Much of the speech is expected to be familiar.

The story Biden will tell about what he has done as president and where the country finds itself as a result will be the same dishonest story he's been telling since at least the summer.

He'll cite government statistics to say the economy is growing, unemployment is low, and inflation is down.

Something that has been frustrating Biden, his team, and his allies in the media is that the American people do not feel as economically well off as the official data says they are. Despite what the White House and establishment-friendly journalists say, the problem lies with the data, not the American people's ability to perceive their own well-being.

As I wrote back in January, the reason for the discrepancy is the lack of distinction made between private economic activity and government spending in the most frequently cited economic indicators. There is an important difference between the two:

  • Government, unlike any other entity in the economy, can simply take money and resources from others to spend on things and hire people. Whether or not the spending brings people value is irrelevant

  • It's the private sector that's responsible for producing goods and services that actually meet people's needs and wants. So, the private components of the economy have the most significant effect on people's economic well-being.

Recently, government spending and hiring has accounted for a larger than normal share of both economic activity and employment. This means the government is propping up these traditional measures, making the economy appear better than it actually is. Also, many of the jobs Biden and his allies take credit for creating will quickly go away once it becomes clear that consumers don't actually want whatever the government encouraged these companies to produce.

On top of all that, the administration is dealing with the consequences of their chosen inflation rhetoric.

Since its peak in the summer of 2022, the president's team has talked about inflation "coming back down," which can easily give the impression that it's prices that will eventually come back down.

But that's not what that phrase means. It would be more honest to say that price increases are slowing down.

Americans are finally waking up to the fact that the cost of living will not return to prepandemic levels, and they're not happy about it.

The president has made some clumsy attempts at damage control, such as a Super Bowl Sunday video attacking food companies for "shrinkflation"—selling smaller portions at the same price instead of simply raising prices.

In his speech Thursday, Biden is expected to play up his desire to crack down on the "corporate greed" he's blaming for high prices.

In the name of "bringing down costs for Americans," the administration wants to implement targeted price ceilings - something anyone who has taken even a single economics class could tell you does more harm than good. Biden would never place the blame for the dramatic price increases we've experienced during his term where it actually belongs—on all the government spending that he and President Donald Trump oversaw during the pandemic, funded by the creation of $6 trillion out of thin air - because that kind of spending is precisely what he hopes to kick back up in a second term.

If reelected, the president wants to "revive" parts of his so-called Build Back Better agenda, which he tried and failed to pass in his first year. That would bring a significant expansion of domestic spending. And Biden remains committed to the idea that Americans must be forced to continue funding the war in Ukraine. That's another topic Biden is expected to highlight in the State of the Union, likely accompanied by the lie that Ukraine spending is good for the American economy. It isn't.

It's not possible to predict all the ways President Biden will exaggerate, mislead, and outright lie in his speech on Thursday. But we can be sure of two things. The "state of the Union" is not as strong as Biden will say it is. And his policy ambitions risk making it much worse.

*  *  *

The American people will be tuning in on their smartphones, laptops, and televisions on Thursday evening to see if 'sloppy joe' 81-year-old President Joe Biden can coherently put together more than two sentences (even with a teleprompter) as he gives his third State of the Union in front of a divided Congress. 

President Biden will speak on various topics to convince voters why he shouldn't be sent to a retirement home.

According to CNN sources, here are some of the topics Biden will discuss tonight:

  • Economic issues: Biden and his team have been drafting a speech heavy on economic populism, aides said, with calls for higher taxes on corporations and the wealthy – an attempt to draw a sharp contrast with Republicans and their likely presidential nominee, Donald Trump.

  • Health care expenses: Biden will also push for lowering health care costs and discuss his efforts to go after drug manufacturers to lower the cost of prescription medications — all issues his advisers believe can help buoy what have been sagging economic approval ratings.

  • Israel's war with Hamas: Also looming large over Biden's primetime address is the ongoing Israel-Hamas war, which has consumed much of the president's time and attention over the past few months. The president's top national security advisers have been working around the clock to try to finalize a ceasefire-hostages release deal by Ramadan, the Muslim holy month that begins next week.

  • An argument for reelection: Aides view Thursday's speech as a critical opportunity for the president to tout his accomplishments in office and lay out his plans for another four years in the nation's top job. Even though viewership has declined over the years, the yearly speech reliably draws tens of millions of households.

Sources provided more color on Biden's SOTU address: 

The speech is expected to be heavy on economic populism. The president will talk about raising taxes on corporations and the wealthy. He'll highlight efforts to cut costs for the American people, including pushing Congress to help make prescription drugs more affordable.

Biden will talk about the need to preserve democracy and freedom, a cornerstone of his re-election bid. That includes protecting and bolstering reproductive rights, an issue Democrats believe will energize voters in November. Biden is also expected to promote his unity agenda, a key feature of each of his addresses to Congress while in office.

Biden is also expected to give remarks on border security while the invasion of illegals has become one of the most heated topics among American voters. A majority of voters are frustrated with radical progressives in the White House facilitating the illegal migrant invasion. 

It is probable that the president will attribute the failure of the Senate border bill to the Republicans, a claim many voters view as unfounded. This is because the White House has the option to issue an executive order to restore border security, yet opts not to do so

Maybe this is why? 

While Biden addresses the nation, the Biden administration will be armed with a social media team to pump propaganda to at least 100 million Americans. 

"The White House hosted about 70 creators, digital publishers, and influencers across three separate events" on Wednesday and Thursday, a White House official told CNN. 

Not a very capable social media team... 

The administration's move to ramp up social media operations comes as users on X are mostly free from government censorship with Elon Musk at the helm. This infuriates Democrats, who can no longer censor their political enemies on X. 

Meanwhile, Democratic lawmakers tell Axios that the president's SOTU performance will be critical as he tries to dispel voter concerns about his elderly age. The address reached as many as 27 million people in 2023. 

"We are all nervous," said one House Democrat, citing concerns about the president's "ability to speak without blowing things."

The SOTU address comes as Biden's polling data is in the dumps. 

BetOnline has created several money-making opportunities for gamblers tonight, such as betting on what word Biden mentions the most. 

As well as...

We will update you when Tucker Carlson's live feed of SOTU is published. 

Tyler Durden Fri, 03/08/2024 - 07:44

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