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Golden Goose Award announces 2023 awardees for discoveries in DNA sequencing technique, a bacteria-inspired method that saves crops and chicken pedigree lines

WASHINGTON, D.C. – The Golden Goose Award, which celebrates federally funded research that sounds silly, but ultimately benefits society, has selected…

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WASHINGTON, D.C. – The Golden Goose Award, which celebrates federally funded research that sounds silly, but ultimately benefits society, has selected five researchers across the fields of biology, agriculture and genomics for their unexpected breakthroughs as 2023 awardees. On September 27, 2023, the American Association for the Advancement of Science (AAAS), the world’s largest multidisciplinary scientific society, will co-host the 12th annual Golden Goose Award ceremony with the Association of American Universities, a founding member of the Golden Goose Award, at the Library of Congress to celebrate the awardees’ achievements.

Credit: AAAS

WASHINGTON, D.C. – The Golden Goose Award, which celebrates federally funded research that sounds silly, but ultimately benefits society, has selected five researchers across the fields of biology, agriculture and genomics for their unexpected breakthroughs as 2023 awardees. On September 27, 2023, the American Association for the Advancement of Science (AAAS), the world’s largest multidisciplinary scientific society, will co-host the 12th annual Golden Goose Award ceremony with the Association of American Universities, a founding member of the Golden Goose Award, at the Library of Congress to celebrate the awardees’ achievements.

Thanks to funding from federal agencies, these five scientists were able to take research risks or pursue wonky research, yielding unexpected discoveries that benefit humanity. As Congress is considering cutting research and development funding in the 2024 budget, these scientific achievements serve as a reminder that this funding is a cornerstone for how discoveries are made, while keeping the nation competitive, broadening the U.S. research portfolio and fostering collaboration across sectors.

For this year’s awardees, their scientific quests unfolded in unique ways:

  • Reviving a dormant idea that has dramatically advanced DNA sequencing.
    Awardees: Mark Akeson (UC Santa Cruz), Daniel Branton (Harvard University), and David Deamer (UC Santa Cruz)

A scientist conceived of an approach to DNA sequencing that later catalyzed the technology industry to create a commercialized and cost-effective pocket-sized device, enabling analyses in any setting with several potentially life-saving applications. The original idea for nanopore sequencing struck David Deamer while he was driving along a forested road in Oregon in 1989. He immediately pulled to the side of the road and scribbled down a concept, which quickly became just another set of notes stored in a dusty desk drawer. As genomics research expanded, Deamer dug up those field notes after a conversation with Daniel Branton and later teamed up with Mark Akeson to successfully pull a single strand of DNA through a channel to read its genetic sequence, a technique known as nanopore sequencing, which served as the foundation for the widely used device.

Despite the rejection from top-tier journals and the scientific community’s skepticism, the road to success took 30 years of research, persistence and a bit of serendipitous fortune to prove many wrong. In 2014, nanopore sequencing was commercialized into a $1,000 pocket-sized device and is widely used for pathogen analysis in outbreak surveillance of infectious diseases such as tuberculosis, Ebola, Zika and COVID-19. It has been used virtually anywhere, including the top of an arctic iceberg, a remote settlement in Africa where electrical power is unreliable, and on board the International Space Station.

  • Using millions of years-old bacteria to genetically modify plants resistant to pests.
    Awardee: Mary-Dell Chilton (Syngenta)

In the 1970s, scientists were trying to uncover whether bacteria’s ability to repair their own DNA could also hijack plant growth — a survival strategy which, while savvy, threatened agricultural crops. Determined to find the answer, Mary-Dell Chilton analyzed data at her kitchen table after her kids had gone to bed. To her surprise, she discovered that bacteria could transfer their DNA into plants. The technique she eventually developed based on the bacteria’s natural abilities, known as Agrobacterium-mediated transformation (AMT), is now widely adopted by U.S. corn, soybean and cotton farmers.

Cotton with pest-resistant traits has contributed to a massive decrease in insecticides applied (66% between 1994-2019), which decreases costs and environmental impacts while increasing crop yields and profits. Today, AMT is still used to deliver CRISPR/Cas9 components into plants and is ubiquitous in biotechnology research.

  • A 65-year-old experiment helped inform what we know about chickens today.
    Awardee: Paul Siegel (Virginia Tech)

Imagine a single science experiment – run by a single scientist – for 65 years and counting. Paul Siegel’s curiosity about how to best breed and raise chickens ignited from his time raising chickens from the age of three on a 35-acre farm. Nearly daily, Siegel, now 90, still visits the Virginia Tech lab where he began his seminal work in 1957. That’s when Siegel began breeding two pedigree lines of chickens, one high-weight and one low-weight. Those lines continue today, along with another longtime set of lines related to immunity, yielding discoveries about immune function, reproductive biology, genomic evolution and more.

This work is well known to poultry scientists throughout the world and serves as a foundation for modern methods of raising and breeding chickens, a major global food source. The impact of Siegel’s work on humans, rather than chickens, is perhaps his most profound contribution: He has trained and mentored hundreds of students throughout his distinguished career.

“The Golden Goose Award reinforces the importance of investing in basic research across disciplines to propel innovation and improve lives,” said Sudip S. Parikh, chief executive officer at AAAS and executive publisher of the Science family of journals. “We can trace thousands of patents, like the DNA sequencing device, which stemmed from federal investments in research and development.”

Former U.S. Representative Jim Cooper (D-TN) conceived of the award as a counterpoint to criticisms that basic research is a waste of federal spending, leading to a coalition of business, university and scientific organizations establishing the award in 2012. Thanks to his legacy, the award will continue to elevate the importance of recognizing basic science that ultimately improves people’s quality of life.

The Golden Goose Award is grateful for the support of sponsors, including Wiley, a global knowledge company and a leader in research, publishing, and knowledge solutions.

# # #
 

The American Association for the Advancement of Science (AAAS) is the world’s largest general scientific society and publisher of the journal Science, as well as Science Translational Medicine; Science Signaling; a digital, open-access journal, Science Advances; Science Immunology; and Science Robotics. AAAS was founded in 1848 and includes more than 250 affiliated societies and academies of science, serving 10 million individuals. The nonprofit AAAS is open to all and fulfills its mission to “advance science and serve society” through initiatives in science policy, international programs, science education, public engagement, and more. For additional information about AAAS, visit www.aaas.org.

 


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Are Voters Recoiling Against Disorder?

Are Voters Recoiling Against Disorder?

Authored by Michael Barone via The Epoch Times (emphasis ours),

The headlines coming out of the Super…

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Are Voters Recoiling Against Disorder?

Authored by Michael Barone via The Epoch Times (emphasis ours),

The headlines coming out of the Super Tuesday primaries have got it right. Barring cataclysmic changes, Donald Trump and Joe Biden will be the Republican and Democratic nominees for president in 2024.

(Left) President Joe Biden delivers remarks on canceling student debt at Culver City Julian Dixon Library in Culver City, Calif., on Feb. 21, 2024. (Right) Republican presidential candidate and former U.S. President Donald Trump stands on stage during a campaign event at Big League Dreams Las Vegas in Las Vegas, Nev., on Jan. 27, 2024. (Mario Tama/Getty Images; David Becker/Getty Images)

With Nikki Haley’s withdrawal, there will be no more significantly contested primaries or caucuses—the earliest both parties’ races have been over since something like the current primary-dominated system was put in place in 1972.

The primary results have spotlighted some of both nominees’ weaknesses.

Donald Trump lost high-income, high-educated constituencies, including the entire metro area—aka the Swamp. Many but by no means all Haley votes there were cast by Biden Democrats. Mr. Trump can’t afford to lose too many of the others in target states like Pennsylvania and Michigan.

Majorities and large minorities of voters in overwhelmingly Latino counties in Texas’s Rio Grande Valley and some in Houston voted against Joe Biden, and even more against Senate nominee Rep. Colin Allred (D-Texas).

Returns from Hispanic precincts in New Hampshire and Massachusetts show the same thing. Mr. Biden can’t afford to lose too many Latino votes in target states like Arizona and Georgia.

When Mr. Trump rode down that escalator in 2015, commentators assumed he’d repel Latinos. Instead, Latino voters nationally, and especially the closest eyewitnesses of Biden’s open-border policy, have been trending heavily Republican.

High-income liberal Democrats may sport lawn signs proclaiming, “In this house, we believe ... no human is illegal.” The logical consequence of that belief is an open border. But modest-income folks in border counties know that flows of illegal immigrants result in disorder, disease, and crime.

There is plenty of impatience with increased disorder in election returns below the presidential level. Consider Los Angeles County, America’s largest county, with nearly 10 million people, more people than 40 of the 50 states. It voted 71 percent for Mr. Biden in 2020.

Current returns show county District Attorney George Gascon winning only 21 percent of the vote in the nonpartisan primary. He’ll apparently face Republican Nathan Hochman, a critic of his liberal policies, in November.

Gascon, elected after the May 2020 death of counterfeit-passing suspect George Floyd in Minneapolis, is one of many county prosecutors supported by billionaire George Soros. His policies include not charging juveniles as adults, not seeking higher penalties for gang membership or use of firearms, and bringing fewer misdemeanor cases.

The predictable result has been increased car thefts, burglaries, and personal robberies. Some 120 assistant district attorneys have left the office, and there’s a backlog of 10,000 unprosecuted cases.

More than a dozen other Soros-backed and similarly liberal prosecutors have faced strong opposition or have left office.

St. Louis prosecutor Kim Gardner resigned last May amid lawsuits seeking her removal, Milwaukee’s John Chisholm retired in January, and Baltimore’s Marilyn Mosby was defeated in July 2022 and convicted of perjury in September 2023. Last November, Loudoun County, Virginia, voters (62 percent Biden) ousted liberal Buta Biberaj, who declined to prosecute a transgender student for assault, and in June 2022 voters in San Francisco (85 percent Biden) recalled famed radical Chesa Boudin.

Similarly, this Tuesday, voters in San Francisco passed ballot measures strengthening police powers and requiring treatment of drug-addicted welfare recipients.

In retrospect, it appears the Floyd video, appearing after three months of COVID-19 confinement, sparked a frenzied, even crazed reaction, especially among the highly educated and articulate. One fatal incident was seen as proof that America’s “systemic racism” was worse than ever and that police forces should be defunded and perhaps abolished.

2020 was “the year America went crazy,” I wrote in January 2021, a year in which police funding was actually cut by Democrats in New York, Los Angeles, San Francisco, Seattle, and Denver. A year in which young New York Times (NYT) staffers claimed they were endangered by the publication of Sen. Tom Cotton’s (R-Ark.) opinion article advocating calling in military forces if necessary to stop rioting, as had been done in Detroit in 1967 and Los Angeles in 1992. A craven NYT publisher even fired the editorial page editor for running the article.

Evidence of visible and tangible discontent with increasing violence and its consequences—barren and locked shelves in Manhattan chain drugstores, skyrocketing carjackings in Washington, D.C.—is as unmistakable in polls and election results as it is in daily life in large metropolitan areas. Maybe 2024 will turn out to be the year even liberal America stopped acting crazy.

Chaos and disorder work against incumbents, as they did in 1968 when Democrats saw their party’s popular vote fall from 61 percent to 43 percent.

Views expressed in this article are opinions of the author and do not necessarily reflect the views of The Epoch Times or ZeroHedge.

Tyler Durden Sat, 03/09/2024 - 23:20

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Veterans Affairs Kept COVID-19 Vaccine Mandate In Place Without Evidence

Veterans Affairs Kept COVID-19 Vaccine Mandate In Place Without Evidence

Authored by Zachary Stieber via The Epoch Times (emphasis ours),

The…

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Veterans Affairs Kept COVID-19 Vaccine Mandate In Place Without Evidence

Authored by Zachary Stieber via The Epoch Times (emphasis ours),

The U.S. Department of Veterans Affairs (VA) reviewed no data when deciding in 2023 to keep its COVID-19 vaccine mandate in place.

Doses of a COVID-19 vaccine in Washington in a file image. (Jacquelyn Martin/Pool/AFP via Getty Images)

VA Secretary Denis McDonough said on May 1, 2023, that the end of many other federal mandates “will not impact current policies at the Department of Veterans Affairs.”

He said the mandate was remaining for VA health care personnel “to ensure the safety of veterans and our colleagues.”

Mr. McDonough did not cite any studies or other data. A VA spokesperson declined to provide any data that was reviewed when deciding not to rescind the mandate. The Epoch Times submitted a Freedom of Information Act for “all documents outlining which data was relied upon when establishing the mandate when deciding to keep the mandate in place.”

The agency searched for such data and did not find any.

The VA does not even attempt to justify its policies with science, because it can’t,” Leslie Manookian, president and founder of the Health Freedom Defense Fund, told The Epoch Times.

“The VA just trusts that the process and cost of challenging its unfounded policies is so onerous, most people are dissuaded from even trying,” she added.

The VA’s mandate remains in place to this day.

The VA’s website claims that vaccines “help protect you from getting severe illness” and “offer good protection against most COVID-19 variants,” pointing in part to observational data from the U.S. Centers for Disease Control and Prevention (CDC) that estimate the vaccines provide poor protection against symptomatic infection and transient shielding against hospitalization.

There have also been increasing concerns among outside scientists about confirmed side effects like heart inflammation—the VA hid a safety signal it detected for the inflammation—and possible side effects such as tinnitus, which shift the benefit-risk calculus.

President Joe Biden imposed a slate of COVID-19 vaccine mandates in 2021. The VA was the first federal agency to implement a mandate.

President Biden rescinded the mandates in May 2023, citing a drop in COVID-19 cases and hospitalizations. His administration maintains the choice to require vaccines was the right one and saved lives.

“Our administration’s vaccination requirements helped ensure the safety of workers in critical workforces including those in the healthcare and education sectors, protecting themselves and the populations they serve, and strengthening their ability to provide services without disruptions to operations,” the White House said.

Some experts said requiring vaccination meant many younger people were forced to get a vaccine despite the risks potentially outweighing the benefits, leaving fewer doses for older adults.

By mandating the vaccines to younger people and those with natural immunity from having had COVID, older people in the U.S. and other countries did not have access to them, and many people might have died because of that,” Martin Kulldorff, a professor of medicine on leave from Harvard Medical School, told The Epoch Times previously.

The VA was one of just a handful of agencies to keep its mandate in place following the removal of many federal mandates.

“At this time, the vaccine requirement will remain in effect for VA health care personnel, including VA psychologists, pharmacists, social workers, nursing assistants, physical therapists, respiratory therapists, peer specialists, medical support assistants, engineers, housekeepers, and other clinical, administrative, and infrastructure support employees,” Mr. McDonough wrote to VA employees at the time.

This also includes VA volunteers and contractors. Effectively, this means that any Veterans Health Administration (VHA) employee, volunteer, or contractor who works in VHA facilities, visits VHA facilities, or provides direct care to those we serve will still be subject to the vaccine requirement at this time,” he said. “We continue to monitor and discuss this requirement, and we will provide more information about the vaccination requirements for VA health care employees soon. As always, we will process requests for vaccination exceptions in accordance with applicable laws, regulations, and policies.”

The version of the shots cleared in the fall of 2022, and available through the fall of 2023, did not have any clinical trial data supporting them.

A new version was approved in the fall of 2023 because there were indications that the shots not only offered temporary protection but also that the level of protection was lower than what was observed during earlier stages of the pandemic.

Ms. Manookian, whose group has challenged several of the federal mandates, said that the mandate “illustrates the dangers of the administrative state and how these federal agencies have become a law unto themselves.”

Tyler Durden Sat, 03/09/2024 - 22:10

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Low Iron Levels In Blood Could Trigger Long COVID: Study

Low Iron Levels In Blood Could Trigger Long COVID: Study

Authored by Amie Dahnke via The Epoch Times (emphasis ours),

People with inadequate…

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Low Iron Levels In Blood Could Trigger Long COVID: Study

Authored by Amie Dahnke via The Epoch Times (emphasis ours),

People with inadequate iron levels in their blood due to a COVID-19 infection could be at greater risk of long COVID.

(Shutterstock)

A new study indicates that problems with iron levels in the bloodstream likely trigger chronic inflammation and other conditions associated with the post-COVID phenomenon. The findings, published on March 1 in Nature Immunology, could offer new ways to treat or prevent the condition.

Long COVID Patients Have Low Iron Levels

Researchers at the University of Cambridge pinpointed low iron as a potential link to long-COVID symptoms thanks to a study they initiated shortly after the start of the pandemic. They recruited people who tested positive for the virus to provide blood samples for analysis over a year, which allowed the researchers to look for post-infection changes in the blood. The researchers looked at 214 samples and found that 45 percent of patients reported symptoms of long COVID that lasted between three and 10 months.

In analyzing the blood samples, the research team noticed that people experiencing long COVID had low iron levels, contributing to anemia and low red blood cell production, just two weeks after they were diagnosed with COVID-19. This was true for patients regardless of age, sex, or the initial severity of their infection.

According to one of the study co-authors, the removal of iron from the bloodstream is a natural process and defense mechanism of the body.

But it can jeopardize a person’s recovery.

When the body has an infection, it responds by removing iron from the bloodstream. This protects us from potentially lethal bacteria that capture the iron in the bloodstream and grow rapidly. It’s an evolutionary response that redistributes iron in the body, and the blood plasma becomes an iron desert,” University of Oxford professor Hal Drakesmith said in a press release. “However, if this goes on for a long time, there is less iron for red blood cells, so oxygen is transported less efficiently affecting metabolism and energy production, and for white blood cells, which need iron to work properly. The protective mechanism ends up becoming a problem.”

The research team believes that consistently low iron levels could explain why individuals with long COVID continue to experience fatigue and difficulty exercising. As such, the researchers suggested iron supplementation to help regulate and prevent the often debilitating symptoms associated with long COVID.

It isn’t necessarily the case that individuals don’t have enough iron in their body, it’s just that it’s trapped in the wrong place,” Aimee Hanson, a postdoctoral researcher at the University of Cambridge who worked on the study, said in the press release. “What we need is a way to remobilize the iron and pull it back into the bloodstream, where it becomes more useful to the red blood cells.”

The research team pointed out that iron supplementation isn’t always straightforward. Achieving the right level of iron varies from person to person. Too much iron can cause stomach issues, ranging from constipation, nausea, and abdominal pain to gastritis and gastric lesions.

1 in 5 Still Affected by Long COVID

COVID-19 has affected nearly 40 percent of Americans, with one in five of those still suffering from symptoms of long COVID, according to the U.S. Centers for Disease Control and Prevention (CDC). Long COVID is marked by health issues that continue at least four weeks after an individual was initially diagnosed with COVID-19. Symptoms can last for days, weeks, months, or years and may include fatigue, cough or chest pain, headache, brain fog, depression or anxiety, digestive issues, and joint or muscle pain.

Tyler Durden Sat, 03/09/2024 - 12:50

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