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When Bitcoin Melts The System, Prosperity Steps In

When Bitcoin Melts The System, Prosperity Steps In

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“Overcome by the giddiness that flying lent him, Icarus soared into the sky, but in the process, he came too close to the sun, which due to the heat melted the wax.”

The Legend Of Icarus
Jacob Peter Gowy‘s “The Flight of Icarus” (1635 to 1637).

Central banking, along with fractional reserve banking — two inseparable evils of monetary policies — have been distorting market price signals for the last 50 years. 

In 1971, the Nixon Shock corrupted the global monetary system by fracturing the final linkage between gold and the U.S. dollar. Fiat currencies were unleashed, issued and managed by central banks. Over the years, delusional interventionism enabled by politicized narratives to serve a middle class convinced into believing central manipulation is in their best interest, has brought fiat currencies’ purchasing power to its knees. 

Today, savers are penalized, while speculators and spenders are rewarded. This tendency to be punished by lowering one’s time preference feels alienating to many. It just doesn’t feel right. Yet, few are capable of putting a finger on why that is, including banking professionals and money managers whose salaries depend on not understanding it. 

With a dysfunctional monetary system that doesn’t hold value over time, many artificial distortions arise in all markets. Like a cancer metastasizing in its host, fiat currencies are the initial viral load that contaminated all territories governed by the fiat dogma, spreading the pandemic of central and fractional reserve banking.

A Misunderstood Sister

It is a well understood yet underappreciated fact that money accounts for 50 percent of the value of all transactions globally, and therefore a broken money can have severe repercussions, as it tricks every user into misleading economic calculus, ultimately leading to a distorted, apathetic and broken society. The logical construct behind the dissection of today’s evils is actually very simple: money is broken; fix the money, fix the world. 

Time is an invariably forward passage common to all humans, agnostic of status, wealth, ethnicity or location. We only have so much of it. Money is an instrument to store time for later use, ready for trade with other specialized individuals. With money acting as a neutral good for trade, everyone is more productive with their special craft — the beauty of the specialization of labor! All voluntary and peaceful human action that emerges as part of a free society is enabled by money, a neutral good for exchange within a capitalistic society, a system built on the ability to accumulate capital for later productive use and to do good around oneself. 

What happens if money decays faster than time, melting away the time people have accrued? How is the common man affected psychologically by a devaluing currency? How do assets behave when people store their savings using them to preserve their wealth? How are industries and markets structurally influenced when being close to money production is highly profitable? How will narratives around inflationary, “growth at all cost” compare to peaceful deflationary realities where individuals earn more by waiting patiently? What happens when sound money is finally restored to the people using free and open tools such as Bitcoin? 

In this brief exploration, we will raise fundamental questions around national monetary manipulation with fiat currencies, their effects on life, business and psychology and how a global monetary melting led by Bitcoin will drastically shift the world toward sustained deflation — the ultimate step toward unrestrained prosperity and abundance. Hop on! 

Saving Is Freedom

People save to plan for future uncertainty and enjoyment. A dad may want to save to feed his family tomorrow in case of an unplanned job loss, or to organize a family trip for the next holiday. A young person may want to save to build a business. Saving is the essence of all human life. It allows one to construct a well-balanced life. Without savings, a man is bound to get stuck on a never-ending hamster wheel, chasing his shadow. 

Savings are the root of all capital accumulation, that serve as the base of life and investing, which leads to productivity improvements, if done well. Doing more with less is great, and that’s what life is all about, starting with biological evolution. A more productive dad can spend more time with his kids and wife. A more productive fungus has more room to grow and take over a larger territory. That’s all pretty basic, yet fundamental. 

When money decays over time and fails to hold value, something odd happens. 

People feel the need to spend it quickly,  because they can get more with it immediately, compared to holding it for later use. Holding a devaluing money presents a penalty to a responsible saver. Better spend it and buy other goods and services, or invest it in yield-generating assets to preserve wealth over time (or to at least offset the inflation rate). 

The root problem lies in the forceful decision of spending, instead of voluntary saving. With monetary inflation, people will tend to buy things they don’t need and invest in stuff they don’t understand. The resulting artificial demand for goods and services is unnatural and triggers many ills such as asset and consumer price inflation. Industries end up being built by producers responding to these artificially stimulated price signals, which cause systemic malinvestment, the scale of which we have yet to fathom. 

Industries Built On Fiat Vice

Governments today measure economic development with a national metric called the GDP, which necessarily relies on consumption of goods as one of its primary drivers. Consumption means spending, which lowers savings, and, because saving is the basis of investing via gradual capital accumulation, it is easy to see how flawed a focus on GDP is. 

Two great evils have emerged from fiat currencies and government-led measurements of economic progress: consumerism and short-sighted financial engineering. 

Entire industries have been built on a delusional vision for mankind corrupted by debt-fuelled consumerism. Overzealous application of financial engineering is the atrocity pushing the boundaries of exuberance when it comes to enslaving our lives: buy things we don’t need (consume) with money we don’t have (debt). 

If people were consuming less because money was holding value over time, would advertisers spend around $700 billion per year to promote goods and services? Would social media platforms be tracking their users and manipulating individual views as much as they are to serve advertising giants? Would the world’s best software engineers spend their precious time architecting machine-learning models to optimize online ad spend? Would the smartest pool of talent spend outrageous hours in financial services, losing the most precious hours of their youth with little societal benefit to show for it?

Global banking is estimated to be worth roughly $5.3 trillion. As one of the most well-paying industries, banking and financial services are attracting millions of workers, accounting for around 23 percent of the total global workforce, including talented software engineers and developers with the ability to horizontally move to other industries. Creating a massive industry, the growth of banking is a direct result of the corrupted fiat currency system, which incentivizes the construction of ever more complicated financial engineering schemes. All this to protect wealth from centrally induced inflation deemed necessary by those who benefit from its existence, which for everyone else ultimately only serves to increase systemic risk until an eventual rupture leads to socialized losses — bail outs. 

Facebook, Google, YouTube and Amazon are advertising companies — under the semblance of speech-enhancing global social networks — receiving close to 40 percent of the global ad spend. Roughly $618.7 billion was spent by advertisers on these platforms last year alone, which incentivizes these companies to track their users as much as they possibly can to serve their paying customers: advertisers. Talented engineers are attracted to these companies, not to support free speech at a massive scale as social media could allow, but because the pays are indeed quite generous, with a median pay of a quarter million dollars at Google

In a sense, banking and advertising are truly important industries, which most definitely can add value to the world but have been corrupted by the evil of fiat monetary inflation, to the point that benevolence is no longer possible. Advertising and banking are dominating global economic activity, while they ought to be supporting well-functioning free markets. 

A Dark And Invisible Beast

First and foremost, monetary inflation is an expansion of the money supply. Monetary inflation renders all previously existing circulating units less valuable by diluting their presence in the total supply. 

Currency holders lose purchasing power due to inflation, which encourages them to get rid of it, as we just discussed, affecting many aspects of life such as time preference. Instant gratification feels good, and intrinsically, all biological organisms enjoy pleasure in the short term, knowing that long-term pain may occur as a result. Take a night out with friends drinking: sipping that extra glass of bourbon is undeniably enjoyable in the moment, but the next morning may not be so pleasant. 

Rationally, if someone knows that saving money for later use will render this money more valuable, the incentive to not spend it right away is strikingly obvious. What happens then? Demand for unnecessary items may contract as people reduce their spending. People may start thinking twice about their willingness to spend the money they earned with hard work. “Do I really want to buy the latest pair of Nikes or the newest iPhone?” This simple shift of mindset seems inconsequential at first, but it leads to a rippling societal change — a complete reversal of current norms plagued by over-consumption of frivolities. 

Allowing someone to reflect before making a decision to deny future wealth appreciation is a fundamental restructuring of the individual psyche. Delayed consumption lends space to think rationally, preventing superficial consumption. Instead of consuming life in the short term, one invests in their life for the long term. How does reliable and scarce money affect the human psyche? How does an individual change when exposed to delicate scarcity as opposed to extravagant abundance? What happens to a society protected by incorruptible assurances of sound money? 

A Reversal Of The Human Psyche

“A rolling stone gathers no moss.” Living a carefree life that is not built on solid foundations is unstable. Like a stone in the forest under the trees, the moss that accumulates is synonymous with a fresh and healthy environment, where time passes. A stone that tumbles in the river at the mercy of currents will not accumulate any moss — a torrential existence of misery. 

Individuals are no different. Stability and prosperity come from a foundation built on a secure shelter, a decent nutrition, a healthy lifestyle, a loving family, caring friends, incorruptible values and generous savings for cold rainy days. Not having that unshakeable foundation can lead to a life of misery with no meaningful accomplishment. 

All valuable things are scarce, and money is no different. Something abundantly available has little value. Water in an ocean doesn’t have much value, but in a deserted area, it can mean life or death. As individuals are exposed to truly scarce money, over-consumption stops. 

Today, this phenomenon is observed in reverse, fuelled by massive consumer and corporate debt levels, the polar opposite of low time preference. People are spending their future in the present by neglecting the burden of debt, and borrowing large sums of money to pay for items they cannot afford. 

Education in the U.S. is an obscene illustration of that for young adults, with 44 million students collectively owing $1.6 trillion of debt for their university degrees. American mortgage debt is nearing $10 trillion, which is propping up the real estate market in an unsustainable fashion. In total for the U.S. alone, consumer debt reached $14 trillion, while the corporate debt market hit $10.5 trillion earlier this year. Prior to the massive wave of stimulus led by governments all around the world, the sovereign debt market already hit an all-time high of $66 trillion, more than approximately 80 percent of global GDP. Overall, global debt-fuelled growth is a symptom of an illness in the money that we use globally, no different to the effect felt by individuals.

As mentioned earlier, a man with sound money lowers his time preference, facing the irrefutable scarcity of his storehold of wealth. As his savings appreciate in value over time, he can wonder about what he should be spending his time and money on next. He is now allowed to think before acting, instead of running on life’s proverbial treadmill. Getting rid of superfluous possessions is the number one priority. Leaving behind a life of frivolous spending hidden by the vicious ornament of “carpe diem,” this newly born man discovers the timeless prosperity of stoicism. Patience, devotion and loyalty suddenly emerge from the dust as strong values upon which he can build his reasoning. 

Learning to appreciate the beauty of things around him, this man’s heart fills with love and empathy for others around him who are still on the treadmill. Few things truly matter, and chief among those that do are his family, his health and his life’s work to make things better around him. Sound money changed him. A fast life of abundance filled with comfort and certainty now feels shallow and miserable. Progress made through work, pain and love allows him to tackle uncertainty and find stability in the chaos of life. As he delays his own gratification to plan for his family or entrepreneurial venture, he reduces his consumption, accumulating liquid reserves. Savings allow him to be free, and because they are appreciating in purchasing power over time, the more patient he is, the more reward he inevitably reaps. 

What happens if this effect on the individual spreads to society? As people demand less of products and services under a bitcoin standard, but also reduce their speculation in asset classes to preserve their wealth, a global deflation flourishes, allowing individuals and families to attain increasing purchasing power, further driving society toward prosperity.  

A Global Delflationary Repricing 

When consumer behavior shifts, producers undoubtedly adapt their output to meet the new demand. If there is a demand shock, prices will plummet until buyers are found, such that producers can distribute their past production, and re-adjust their upcoming production cycle to meet lower demand levels. Producing less, entrepreneurs and organizations can focus on quality over volume, which should create more value for the buyers, perhaps willing to pay more for the products and services they are receiving, bringing prices back to an equilibrium. 

In a society with sound money, where monetary production is locked away from the greedy minds of faillible humans, such as is the case with bitcoin, consumption slows down. As mentioned, faced with inalterable scarcity, individuals understand the cost of instant gratification. Suddenly, frivolous spending seizes to be common, because it ends up being so costly in the future. When cash reserves appreciate over time, products and services become more affordable, and individuals along with businesses end up spending later to enjoy a higher purchasing power. 

Inflation may turn negative. Many investment strategies built on the mandate to preserve wealth and capital for the long term may turn obsolete as a result. Positive real returns today represent a key driver for long-term portfolio managers who are mandated to protect capital from inflation erosion over multiple decades. What happens when inflation turns negative? In such a scenario, cash doesn’t lose purchasing power. The well-known “cash is trash,” popularized by hedge fund superstar Ray Dalio, becomes a slogan of the past. Suddenly cash is restored with a fundamentally important property of sound money: a lasting storehold of wealth.

In a sound money society, cash is not only the most liquid saleable asset acting as a medium of exchange and measure of value, but it acts as a store of value. Anyone willing to solely preserve wealth over time and have access to liquidity to meet short- and medium-term obligations only has to hold cash. For trillions of dollars of capital parked in assets to preserve wealth over time, this represents a drastic shift. Bitcoin is the instrument which may turn the world upside down, reversing investment strategies for many asset managers across the world. 

As Bitcoin maintains a steady cadence in its process of monetization, it will continue to absorb a material amount of wealth from the fiat legacy paradigm, plagued with inflation and currency debasement, until total collapse. Some would argue that such a particular view is extreme, while others would maintain that it is absurd and ignorant not to hold it. As this process proceeds and bitcoin attains unfathomable levels of market value, asset classes such as real estate, gold and equities will be repriced. Fundamental valuation models for the classes of assets exist today, and are well understood. Undeniably, today, most of these asset classes are deemed to be overpriced by multiple investment managers looking to find value in underpriced assets. Truth be told, most of these assets have accrued a monetary premium, which emanates from their respective utility as decent storeholds of wealth. 

An asset that is understood by the market as a viable store of value is relatively scarce compared to the currency from which the saver is trying to find protection, while also being quite durable over time. Real estate is an asset class estimated to be worth $280 trillion and owes a material amount of this aggregate market valuation to the storehold of wealth use case. Indeed, many investors are parking capital in buildings of popular capital cities to preserve their wealth, often leaving their units vacant, as is the case in Vancouver. In other words, the utility of real estate, as a good for shelter, is not leveraged in this scenario, but only in the fact that urban properties are relatively scarce and durable in politically stable jurisdictions. 

Equities behave according to the same principles. As a market of roughly $90 trillion today, they are mostly well understood with valuation models such as price-to-earnings ratios. Generally speaking, over a certain threshold, based on the industry and other factors, a company will be deemed overpriced or undervalued. Most equities today are used in diversified, 60/40 portfolio allocation strategies to preserve wealth against the erosion of fiat. Fixed income markets are another massive segment used for wealth preservation, especially T-Bills which are deemed “risk free” by some market participants. 

What happens when investors withdraw from these asset classes to hold wealth-preserving cash? Most likely, a massive burst will follow. The monetary premium accrued over years of weak fiat currencies will be shifted back by a sound money standard, pushing investors outside of risk-on positions to preserve wealth. Investment will be made to derive a return on capital, not only to beat inflation from fiat currencies. 

In its early phase of monetization, Bitcoin as the global monetary base may capture significant portions of the aggregated monetary premium accrued by different asset classes over the last decades of fiat currency experimentation. As these asset classes are repriced by markets, free of artificial fiat monetary inflation, purchasing power will be restored to the people.   

One may wonder how long it may take for bitcoin to become the world’s dominant numeraire — the underlying unit of measurement of value that we collectively use to price assets and consumer goods. How much will markets such as real estate, stocks and gold shrink by, if Bitcoin absorbs their cumulative monetary premiums? How will consumption patterns change for individuals and businesses evolving under a deflationary Bitcoin standard? How will humans refocus their time and energy if massive industries such as advertising and financial services are reduced by 30 percent? What about 70 percent? Will humans get to Mars much quicker if the best talent can focus on rocket engineering instead of ads optimization? 

All these are fascinating questions that we may attempt to answer another time.

The post When Bitcoin Melts The System, Prosperity Steps In appeared first on Bitcoin Magazine.

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US Spent More Than Double What It Collected In February, As 2024 Deficit Is Second Highest Ever… And Debt Explodes

US Spent More Than Double What It Collected In February, As 2024 Deficit Is Second Highest Ever… And Debt Explodes

Earlier today, CNBC’s…

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US Spent More Than Double What It Collected In February, As 2024 Deficit Is Second Highest Ever... And Debt Explodes

Earlier today, CNBC's Brian Sullivan took a horse dose of Red Pills when, about six months after our readers, he learned that the US is issuing $1 trillion in debt every 100 days, which prompted him to rage tweet, (or rageX, not sure what the proper term is here) the following:

We’ve added 60% to national debt since 2018. Germany - a country with major economic woes - added ‘just’ 32%.   

Maybe it will never matter.   Maybe MMT is real.   Maybe we just cancel or inflate it out. Maybe career real estate borrowers or career politicians aren’t the answer.

I have no idea.  Only time will tell.   But it’s going to be fascinating to watch it play out.

He is right: it will be fascinating, and the latest budget deficit data simply confirmed that the day of reckoning will come very soon, certainly sooner than the two years that One River's Eric Peters predicted this weekend for the coming "US debt sustainability crisis."

According to the US Treasury, in February, the US collected $271 billion in various tax receipts, and spent $567 billion, more than double what it collected.

The two charts below show the divergence in US tax receipts which have flatlined (on a trailing 6M basis) since the covid pandemic in 2020 (with occasional stimmy-driven surges)...

... and spending which is about 50% higher compared to where it was in 2020.

The end result is that in February, the budget deficit rose to $296.3 billion, up 12.9% from a year prior, and the second highest February deficit on record.

And the punchline: on a cumulative basis, the budget deficit in fiscal 2024 which began on October 1, 2023 is now $828 billion, the second largest cumulative deficit through February on record, surpassed only by the peak covid year of 2021.

But wait there's more: because in a world where the US is spending more than twice what it is collecting, the endgame is clear: debt collapse, and while it won't be tomorrow, or the week after, it is coming... and it's also why the US is now selling $1 trillion in debt every 100 days just to keep operating (and absorbing all those millions of illegal immigrants who will keep voting democrat to preserve the socialist system of the US, so beloved by the Soros clan).

And it gets even worse, because we are now in the ponzi finance stage of the Minsky cycle, with total interest on the debt annualizing well above $1 trillion, and rising every day

... having already surpassed total US defense spending and soon to surpass total health spending and, finally all social security spending, the largest spending category of all, which means that US debt will now rise exponentially higher until the inevitable moment when the US dollar loses its reserve status and it all comes crashing down.

We conclude with another observation by CNBC's Brian Sullivan, who quotes an email by a DC strategist...

.. which lays out the proposed Biden budget as follows:

The budget deficit will growth another $16 TRILLION over next 10 years. Thats *with* the proposed massive tax hikes.

Without them the deficit will grow $19 trillion.

That's why you will hear the "deficit is being reduced by $3 trillion" over the decade.

No family budget or business could exist with this kind of math.

Of course, in the long run, neither can the US... and since neither party will ever cut the spending which everyone by now is so addicted to, the best anyone can do is start planning for the endgame.

Tyler Durden Tue, 03/12/2024 - 18:40

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Government

Buried Project Veritas Recording Shows Top Pfizer Scientists Suppressed Concerns Over COVID-19 Boosters, MRNA Tech

Buried Project Veritas Recording Shows Top Pfizer Scientists Suppressed Concerns Over COVID-19 Boosters, MRNA Tech

Submitted by Liam Cosgrove

Former…

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Buried Project Veritas Recording Shows Top Pfizer Scientists Suppressed Concerns Over COVID-19 Boosters, MRNA Tech

Submitted by Liam Cosgrove

Former Project Veritas & O’Keefe Media Group operative and Pfizer formulation analyst scientist Justin Leslie revealed previously unpublished recordings showing Pfizer’s top vaccine researchers discussing major concerns surrounding COVID-19 vaccines. Leslie delivered these recordings to Veritas in late 2021, but they were never published:

Featured in Leslie’s footage is Kanwal Gill, a principal scientist at Pfizer. Gill was weary of MRNA technology given its long research history yet lack of approved commercial products. She called the vaccines “sneaky,” suggesting latent side effects could emerge in time.

Gill goes on to illustrate how the vaccine formulation process was dramatically rushed under the FDA’s Emergency Use Authorization and adds that profit incentives likely played a role:

"It’s going to affect my heart, and I’m going to die. And nobody’s talking about that."

Leslie recorded another colleague, Pfizer’s pharmaceutical formulation scientist Ramin Darvari, who raised the since-validated concern that repeat booster intake could damage the cardiovascular system:

None of these claims will be shocking to hear in 2024, but it is telling that high-level Pfizer researchers were discussing these topics in private while the company assured the public of “no serious safety concerns” upon the jab’s release:

Vaccine for Children is a Different Formulation

Leslie sent me a little-known FDA-Pfizer conference — a 7-hour Zoom meeting published in tandem with the approval of the vaccine for 5 – 11 year-olds — during which Pfizer’s vice presidents of vaccine research and development, Nicholas Warne and William Gruber, discussed a last-minute change to the vaccine’s “buffer” — from “PBS” to “Tris” — to improve its shelf life. For about 30 seconds of these 7 hours, Gruber acknowledged that the new formula was NOT the one used in clinical trials (emphasis mine):


“The studies were done using the same volume… but contained the PBS buffer. We obviously had extensive consultations with the FDA and it was determined that the clinical studies were not required because, again, the LNP and the MRNA are the same and the behavior — in terms of reactogenicity and efficacy — are expected to be the same.

According to Leslie, the tweaked “buffer” dramatically changed the temperature needed for storage: “Before they changed this last step of the formulation, the formula was to be kept at -80 degrees Celsius. After they changed the last step, we kept them at 2 to 8 degrees celsius,” Leslie told me.

The claims are backed up in the referenced video presentation:

I’m no vaccinologist but an 80-degree temperature delta — and a 5x shelf-life in a warmer climate — seems like a significant change that might warrant clinical trials before commercial release.

Despite this information technically being public, there has been virtually no media scrutiny or even coverage — and in fact, most were told the vaccine for children was the same formula but just a smaller dose — which is perhaps due to a combination of the information being buried within a 7-hour jargon-filled presentation and our media being totally dysfunctional.

Bohemian Grove?

Leslie’s 2-hour long documentary on his experience at both Pfizer and O’Keefe’s companies concludes on an interesting note: James O’Keefe attended an outing at the Bohemian Grove.

Leslie offers this photo of James’ Bohemian Grove “GATE” slip as evidence, left on his work desk atop a copy of his book, “American Muckraker”:

My thoughts on the Bohemian Grove: my good friend’s dad was its general manager for several decades. From what I have gathered through that connection, the Bohemian Grove is not some version of the Illuminati, at least not in the institutional sense.

Do powerful elites hangout there? Absolutely. Do they discuss their plans for the world while hanging out there? I’m sure it has happened. Do they have a weird ritual with a giant owl? Yep, Alex Jones showed that to the world.

My perspective is based on conversations with my friend and my belief that his father is not lying to him. I could be wrong and am open to evidence — like if boxer Ryan Garcia decides to produce evidence regarding his rape claims — and I do find it a bit strange the club would invite O’Keefe who is notorious for covertly filming, but Occam’s razor would lead me to believe the club is — as it was under my friend’s dad — run by boomer conservatives the extent of whose politics include disliking wokeness, immigration, and Biden (common subjects of O’Keefe’s work).

Therefore, I don’t find O’Keefe’s visit to the club indicative that he is some sort of Operation Mockingbird asset as Leslie tries to depict (however Mockingbird is a 100% legitimate conspiracy). I have also met James several times and even came close to joining OMG. While I disagreed with James on the significance of many of his stories — finding some to be overhyped and showy — I never doubted his conviction in them.

As for why Leslie’s story was squashed… all my sources told me it was to avoid jail time for Veritas executives.

Feel free to watch Leslie’s full documentary here and decide for yourself.

Fun fact — Justin Leslie was also the operative behind this mega-viral Project Veritas story where Pfizer’s director of R&D claimed the company was privately mutating COVID-19 behind closed doors:

Tyler Durden Tue, 03/12/2024 - 13:40

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Association of prenatal vitamins and metals with epigenetic aging at birth and in childhood

“[…] our findings support the hypothesis that the intrauterine environment, particularly essential and non-essential metals, affect epigenetic aging…

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“[…] our findings support the hypothesis that the intrauterine environment, particularly essential and non-essential metals, affect epigenetic aging biomarkers across the life course.”

Credit: 2024 Bozack et al.

“[…] our findings support the hypothesis that the intrauterine environment, particularly essential and non-essential metals, affect epigenetic aging biomarkers across the life course.”

BUFFALO, NY- March 12, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 4, entitled, “Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort.”

Epigenetic gestational age acceleration (EGAA) at birth and epigenetic age acceleration (EAA) in childhood may be biomarkers of the intrauterine environment. In this new study, researchers Anne K. Bozack, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Robert O. Wright, Diane R. Gold, Emily Oken, Marie-France Hivert, and Andres Cardenas from Stanford University School of Medicine, Harvard Medical School, Harvard T.H. Chan School of Public Health, Columbia University, and Icahn School of Medicine at Mount Sinai investigated the extent to which first-trimester folate, B12, 5 essential and 7 non-essential metals in maternal circulation are associated with EGAA and EAA in early life. 

“[…] we hypothesized that OCM [one-carbon metabolism] nutrients and essential metals would be positively associated with EGAA and non-essential metals would be negatively associated with EGAA. We also investigated nonlinear associations and associations with mixtures of micronutrients and metals.”

Bohlin EGAA and Horvath pan-tissue and skin and blood EAA were calculated using DNA methylation measured in cord blood (N=351) and mid-childhood blood (N=326; median age = 7.7 years) in the Project Viva pre-birth cohort. A one standard deviation increase in individual essential metals (copper, manganese, and zinc) was associated with 0.94-1.2 weeks lower Horvath EAA at birth, and patterns of exposures identified by exploratory factor analysis suggested that a common source of essential metals was associated with Horvath EAA. The researchers also observed evidence of nonlinear associations of zinc with Bohlin EGAA, magnesium and lead with Horvath EAA, and cesium with skin and blood EAA at birth. Overall, associations at birth did not persist in mid-childhood; however, arsenic was associated with greater EAA at birth and in childhood. 

“Prenatal metals, including essential metals and arsenic, are associated with epigenetic aging in early life, which might be associated with future health.”

 

Read the full paper: DOI: https://doi.org/10.18632/aging.205602 

Corresponding Author: Andres Cardenas

Corresponding Email: andres.cardenas@stanford.edu 

Keywords: epigenetic age acceleration, metals, folate, B12, prenatal exposures

Click here to sign up for free Altmetric alerts about this article.

 

About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

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For media inquiries, please contact media@impactjournals.com.

 

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