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Week Ahead – Doves are back in control

US stocks rallied to record highs and dollar weakness returned as investors shrug off the hawkish tilt given at last week’s FOMC policy decision.  A wrath of Fed speak showed that more policymakers are in the camp that inflation will be transitory. …

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US stocks rallied to record highs and dollar weakness returned as investors shrug off the hawkish tilt given at last week’s FOMC policy decision.  A wrath of Fed speak showed that more policymakers are in the camp that inflation will be transitory.  The trading week ended with a mixed inflation report that contained a downside surprise with the monthly reading.  The key inflation indicator for the Fed rose to 3.4%, the highest levels since the early 1990s as the reopening of the economy was combined with the base effects of when everything shutdown last year.  The month-over-month decline however supports the argument that inflation might be peaking.  It will take a couple more monthly reports to provide deeper clarity on whether the surge in prices might actually be persistent, but for now the doves are in control.

If the Treasury curve continues to steepen, Wall Street might not have such a quiet summer.  Currently, the 10-year Treasury yield is stuck in the middle of the trading range that has been in place since March (1.40% to 1.75%).  With high-yield spreads at the tightest levels since June 2007, this market is ready for a major breakout at some point this year.  Easy monetary policy is accompanied with robust growth and that should continue to drive the rise in Treasury yields.

The upcoming week is filled with economic releases and a wrath of central bank speak.  Monday will have speeches by Fed’s Williams, ECB’s de Guindos, and lots of commentary from the G-20.  Tuesday’s spotlight will shine on ECB’s Lagarde and the Fed’s Barkin. Wednesday will provide a key update from the OECD on global minimum tax. Thursday is a busy day filled with global manufacturing PMI readings, an OPEC+ ministerial meeting, and weekly initial jobless claims.  Friday is all about the nonfarm payroll report which should show further momentum in the labor market. The prior two reports disappointed, so many traders may look for a sharp bounce back here. Expectations are for 695,000 jobs created in June, but with the expiration of some federal unemployment benefits, a big upside surprise could happen.

Payrolls to bounce back after disappointing reports in April and May

BOE aftermath to confirm tightening is in the distant future

OPEC+ to cautiously increase output

 

Country

US

Wall Street has digested a wrath of Fed speak and is clearly in wait-and-see mode over both how hot inflation will run and how much will the labor market recovery accelerate.  The US economic recovery was close to peaking, but with a bipartisan infrastructure spending plan, it just might run a little hotter.  Investors will closely monitor whether the bill will get enough lawmaker support.

The main economic release of the week will be the June nonfarm payroll report.  The US jobs report will most likely show further progress in the labor market recovery with the median estimate of 695,000.  The economy has a shortfall of roughly ten million jobs to fill before the Fed can deem substantial progress has been achieved.  If some of the hawkish members of the Fed want to stand by their expectations of a late rate hike at the end of 2022, this labor market better start to see a strong acceleration higher.  The second most important release will be the June ISM manufacturing report which should show factory activity remains robust.  Deepening supply woes could lead to further fears of persistent pricing pressures.

EU

Inflation remains a buzzword for most of the major central banks, as economies reopen. The markets are unclear where ECB policymakers stand on inflation and tapering stimulus.

On Saturday (June 26), Germany’s Minister of Finance Olaf Scholz will meet with the European Commission’s  Paolo Gentiloni and Frans Timmermans and Swedish Prime Minister Stefan Lofvenspeak at the Party of European Socialists conference in Berlin.

The MSC will host a debate on foreign and security policy, attended by the three German Chancellor candidates – Annalena Baerbock, Armin Laschet and Olaf Scholz.

The second round of the French regional elections will be held on Sunday (June 27). These elections are critical ahead of the presidential vote in 2022 and could determine the fate of President Emmanuel Macron’s reform agenda. Macron and far-right leader Marine Le Pen did poorly in the first round.

There are a host of meetings on Monday:

Foreign ministers from across the globe will meet in Rome at the Global Coalition to Defeat ISIS conference. The meeting is co-hosted by Italian Foreign Minister Luigi Di Maio and Secretary of State Anthony Blinken.

G-20 foreign ministers, including Blinken, will meet in Matera, Italy. Topics on the agenda include building back better with global partners, with a focus on Africa.

ECB Vice President Luis de Guindos, Bundesbank President Jens Weidmann and Deutsche Bank CEO Christian Sewing will address the Frankfurt Euro Finance Summit.

The EU Agriculture and Fisheries Council meets in Luxembourg, with a focus on reform of the EU’s Common Agricultural Policy.

On Tuesday, the Brussels Economic Forum will host online speeches from German Chancellor Angela Merkel, ECB President Christine Lagarde, EU Economy Commissioner Paolo Gentiloni and WTO Director-General Ngozi Okonjo-Iweala.

ECB Governing Council member Francois Villeroy de Galhau speaks at the Paris Europlace conference. French Finance Minister Bruno Le Maire is also scheduled to deliver remarks.

On the data front, there are a host of releases on Tuesday:

The Eurozone will publish June data for Economic Confidence and Consumer Confidence.

Germany will release CPI for June, with a consensus of 0.4% m/m and 2.3% y/y.

France releases ILO Unemployment for Q1 and Consumer Confidence for June.

On Wednesday, French President Emmanuel Macron will host Presidents Alberto Fernandez of Argentina and Andres Manuel Lopez Obrador of Mexico at a UN gender equality meeting in Paris.

Germany releases unemployment for June. The consensus is -15 thousand, unchanged from the prior release.

On Thursday, we’ll get a look at the June Manufacturing PMIs for the Eurozone, Germany and France, Spain and Italy.

The week wraps up with ECB President Christine Lagarde, who will speak at the Rencontres Economiques d’Aix-en-Provence economic forum on Friday.

Sweden

Sweden’s central bank, the Riksbank, is expected to maintain the benchmark rate unchanged at zero at its policy meeting on Thursday. Investors will be focused on any hints as to policy changes which could affect the Swedish krona, which has been rising.

UK

The British pound could remain heavy if the BOE continues to drive home the point that the tightening of monetary policy is far away as the economy still warrants much support.  Investors will closely follow BOE speak this week over any data points.

On Monday, BoE Chief Economist Andy Haldane, who is leaving the central bank later this month, will address the Policy Exchange think tank on the topic of “making a success of leveling up.”

On Tuesday, Andrew Hauser, Executive Director for Markets at the BoE, will speak on a panel at the 8th Asset Pricing Workshop, hosted by the Center for Applied Macro Finance at the University of York. Hauser will speak on “liquidity in government bond and repo markets.”

The UK will release the Nationwide House Price Index, Mortgage Approvals and Money Supply.

Haldane will deliver remarks at the Institute for Government on Wednesday. Haldane will discuss “changes in monetary policy and central bank communications over the past 30 years.”

In economic news, the UK releases Final GDP for the first quarter. No change is expected from the preliminary readings of -1.5% q/q and -6.1% y/y.

On Thursday, BoE Governor Andrew Bailey delivers remarks at the “Plain Numbers Launch.” He will also speak at the Mansion House at a Financial and Professional Services event.

Emerging Markets

Czech Republic

On Tuesday, no revisions are expected with the Czech Republic’s final GDP reading for the first quarter.  On Thursday, manufacturing PMI for June is expected to show a modest improvement from 61.8 to 62.1.

Poland

Poland inflation will closely be watched on Wednesday.  Poland’s central bank has been resistant to raising interest rates as pricing pressures continue to rise. The June inflation report is expected to see prices tick higher on a monthly basis to 0.4%, and ease from 4.7% to 4.6% on an annual basis.

China

Note: China releases May Industrial Profits on Sunday. Despite high base effects, a print well below 100% could see regional sentiment hit in early Monday trading. AUD and NZD selling could occur.

China releases heavyweight official and Caixin PMIs Wednesday and Friday which are usually market moving in the short-term. China equities have rallied this week and could fall if the PMIs disappoint as there is a vast amount of money invested in the China recovery story.

Elsewhere China has widened its attempts to force down commodity prices with some success. However the US infrastructure Bill looks closer to reality and that may undo China’s efforts in this area. Having rallied the past week, if commodities start rising again, China growth companies may suffer. Evergrande secured more funding this week, relieving the default worries circulating on the Mainland.

China’s clampdown on tech continues with anti-trust launched against Didi Chuxing which is coincidentally nearing a US IPO. China’s interventions in recent times continue to weigh on equity sentiment.

The PBOC has set a series of weaker CNY fixes in the past week and also added net liquidity vis the repos for the first time in months. It appears to be signalling that it has seen enough Yuan strength. USD/CNY and by default, USD/Asia have remained bid and if US-derived strength occurs, Asian FX could correct sharply.

India

India’s COVID-19 cases appear to be on the right track as cases fall.  That has led to increased buying of oil by importers which has put a floor under USD/INR over the last week as parts of the country reopen. The INR has remained under pressure due to this and post-FOMC US Dollar strength. Notably it has retraced no losses versus the greenback as opposed to DM currencies. USD/INR is in danger of breaking higher through 74.400 which could trigger foreign investor flight from local equities and the bond market.

IIndia releases its Current Account, Foreign Debt, Manufacturing PMI, Balance of Trade in the coming week. The pandemic will have wreaked havoc with all of them which could add to the clouds over India equities in the week ahead as they have remained unchanged for the week, even as markets globally post gains.

Australia & New Zealand

The AUD/USD and NZD/USD have performed poorly this week, even as other DMs have posted gains after the post-FOMC selloff. Both remain vulnerable to deeper selloffs as barometers of global risk sentiment, especially if Friday’s US Non-Farm Payrolls outperforms. The failure of Asian FX to retrace any of its post-FOMC losses suggests sentiment remains nervously weak with regards to the potential for faster US tightening.

NZ releases ANZ Jobs which should provide some support to NZD and local equities. Australia releases Private Credit, Balance of Trade and Markit Manufacturing PMI. The former are likely to be more market-moving if they post weak results.

ALthough not reflected in their equity or currencies, both Australia and New Zealand go into the weekend on Covid-19 tenderhooks, with parts of inner Sydney being locked down and the NZ to NSW part of the air bubble being suspended. If cases appear in Wellington this weekend, or escalate sharply in NSW, both their equity markets and currencies will start the week under pressure.

Japan

Japan has a heavy data week with Thursday’s Tankan Survey the week’s highlight. The data will only be good for short-term volatility. Japan equities are slavishly following the day-to-day direction of Wall Street at the moment.

USD/JPY has risen to 111.00 as the US/Japan yield differential firmed up after the BoJ was unmoved. Unless that continues, USD/JPY will struggle to maintain gains above 111.00. For now, USD/JPY remains an entirely yield differential play, so look to US markets for direction.

Political risk is increasing in Japan. PM Suga has been dragged into the Toshiba Board governance scandal with accusations of direct interference. This is an evolving situation which won’t unseat him, but threatens to make the rumoured post-Olympics snap election a much more closely run affair.

Markets

Oil

Energy traders will pay close attention to the OPEC+ meeting that will likely show a modest production increase in August.  The need for more supply is growing and the oil market will likely support an increase around a half million barrels per day.  What will complicate the meeting is the uncertainty over Iranian output.  The seventh round of Iran nuclear talks may resume and the urgency is growing to get a deal done before the August 3rd inauguration day.  A deal still seems likely and depending on how much sanction relief Iran gets coud drive the next major move in crude.

Gold

Gold has started to stabilize as investors await further clarity over pricing pressures.  Inflation is still looking transitory and that could provide support for bullion. Precious metal traders will pay close attention to how much support is behind the bipartisan $579 billion infrastructure deal.  Democrats will continue to work on a separate bill that will cover child and elder care, education, health care and climate change.

Gold is not in the clear just yet and could quickly fall back into the danger zone if the dollar and Treasury yields start to surge.  If gold does not recapture the $1,800 level over the next week or two, momentum technical selling could settle in.

Bitcoin

Bitcoin remains stuck in a trading range, awaiting any developments over progress into transitioning into cleaner energy and how quickly mining can get transitioned out of China.  If Wall Street is still behind Bitcoin, fresh endorsements should follow Andreessen Horowitz’s $2.2 billion crypto-focused venture fund.  Bitcoin remains trapped in the $30,000 to $41,000 trading range and that should last a little longer.

Key Economic Events

Saturday, June 26

– Germany’s Minister of Finance Scholz, the European Commission’s Gentiloni and Timmermans, and Swedish Prime Minister Lofven speak on the final day of the Party of European Socialists conference

– German chancellor debates

Sunday, June 27

-Second round of French regional elections.

Economic Data/Events:

  • China industrial profits

Monday, June 28

– Global Coalition to defeat ISIS meet in Rome

-G-20 foreign ministers meet in the southern Italian city of Matera.

– ECB Vice President de Guindos and Bundesbank President Weidmann speak at the Frankfurt Euro Finance Summit.

– New York Fed President Williams takes part in a virtual BIS panel discussion.

– Outgoing BOE Chief Economist Haldane speaks

– The Russell Reconstitution takes effect for both the 1000 and 2000 indexes.

– US Sixth Fleet cohosts Sea Breeze 2021 with Ukraine

– The European Commission publishes its summer economic forecasts.

Economic Data/Events:

  • Mexico Trade Balance
  • South Africa BER consumer confidence

Tuesday, June 29

– German Chancellor Merkel, ECB President Lagarde, EU Economy Commissioner Gentiloni and WTO Director-General Okonjo-Iweala speak at Brussels Economic Forum

– BOE policy maker Hauser speaks on a panel

– Richmond Fed President Barkin speaks at a Market News International (MNI) event.

– Reserve Bank of Australia Governor Lowe addresses a banking summit in Sydney.

– ECB Governing Council member Francois Villeroy and France Finance Minister Le Maire speak at the Paris Europlace conference

– India’s Oil Minister Pradhan speaks at Bloomberg’s virtual BNEF Summit, in New Delhi.

Economic Data/Events:

  • China June Manufacturing PMI: 50.8e v 51.0 prior, non-Manufacturing PMI: 55.5e v 55.2 prior
  • US S&P CoreLogic house prices, FHFA house price index, Conference Board consumer confidence
  • Czech Republic GDP
  • Eurozone economic confidence, consumer confidence
  • France ILO unemployment, consumer confidence
  • Germany CPI
  • Japan jobless rate, retail sales, supermarket sales
  • Mexico international reserves
  • UK Nationwide house price index, mortgage approvals, money supply
  • Turkey economic confidence

Wednesday, June 30

– OECD attempts to finalize a proposal to overhaul global minimum corporate taxation, which will be presented at the G-20 meeting in July

– BOE’s Haldane speaks at the Institute for Government on the changes in monetary policy and central bank communications

– French President Macron meets Argentinian President Fernandez and Mexican President Lopez Obrador

– US House Financial Services holds a hearing titled “America on FIRE: Will the Crypto Frenzy Lead to Financial Independence and Early Retirement or Financial Ruin?”

Economic Data/Events:

  • US ADP employment change, Chicago PMI, pending home sales
  • UK GDP, current account balance, total business investment
  • Canada GDP
  • Turkey Trade Balance
  • Germany Unemployment
  • Russia Unemployment
  • Japan Industrial production
  • Eurozone CPI
  • Poland CPI
  • Russia CPI
  • Hong Kong retail sales, money supply, budget balance
  • New Zealand ANZ business confidence
  • Australia private sector credit
  • Singapore money supply, bank loans
  • Japan vehicle production, housing starts, consumer confidence index
  • Thailand BoP current account balance, trade
  • South Africa Trade Balance, money supply, private sector credit, monthly budget balance
  • Russia current account balance, retail sales, real wages
  • EIA Crude Oil Inventory Report

Thursday, July 1

– China’s President Xi Jinping addresses the nation on the 100th anniversary of the founding of the Chinese Communist Party

– OPEC+ ministerial meeting held

– BOE Governor Bailey speaks at both the “Plain Numbers Launch” and the Mansion House for a Financial and Professional Services event.

– Canadian markets are close to observe Canada Day.

Economic Data/Events:

  • US construction spending, initial jobless claims, June ISM manufacturing: 61.0e v 61.2 prior, Markit Manufacturing PMI
  • Sweden central bank (Riksbank) rate decision: Expected to keep benchmark interest rate at zero
  • Eurozone Unemployment rate
  • European Manufacturing PMIs: Eurozone, UK, Germany, France, Germany, Spain, Italy, Turkey, Hungary, Czech Republic, Poland
  • India Manufacturing PMI
  • Thailand Manufacturing PMI
  • South Africa Manufacturing PMI
  • Russia Manufacturing PMI
  • New Zealand building permits
  • Japan vehicle sales, Jibun Bank PMI
  • Australia commodity index, trade balance
  • China Caixin manufacturing PMI
  • Russia gold and forex reserves

EARNINGS: For a list of the day’s biggest releases, click here.

Friday, July 2

– ECB President Lagarde speaks at the Rencontres Economiques d’Aix-en-Provence.

– SIFMA advises fixed income markets close early at 2:00pm EST to observe Independence Day

Economic Data/Events:

  • US June Change in Nonfarm Payrolls: 695Ke v 559K prior, factory orders, unemployment rate, trade balance, durable goods
  • Eurozone PPI
  • New Zealand ANZ consumer confidence
  • Japan monetary base
  • Thailand foreign reserves, forward contracts
  • Singapore PMI, electronics sector index
  • Russia GDP
  • Spain unemployment change
  • Canada international merchandise trade, Markit manufacturing PMI, building permits

Sovereign Rating Updates:

No sovereigns rating updates on the calendar

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Chronic stress and inflammation linked to societal and environmental impacts in new study

From anxiety about the state of the world to ongoing waves of Covid-19, the stresses we face can seem relentless and even overwhelming. Worse, these stressors…

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From anxiety about the state of the world to ongoing waves of Covid-19, the stresses we face can seem relentless and even overwhelming. Worse, these stressors can cause chronic inflammation in our bodies. Chronic inflammation is linked to serious conditions such as cardiovascular disease and cancer – and may also affect our thinking and behavior.   

Credit: Image: Vodovotz et al/Frontiers

From anxiety about the state of the world to ongoing waves of Covid-19, the stresses we face can seem relentless and even overwhelming. Worse, these stressors can cause chronic inflammation in our bodies. Chronic inflammation is linked to serious conditions such as cardiovascular disease and cancer – and may also affect our thinking and behavior.   

A new hypothesis published in Frontiers in Science suggests the negative impacts may extend far further.   

“We propose that stress, inflammation, and consequently impaired cognition in individuals can scale up to communities and populations,” explained lead author Prof Yoram Vodovotz of the University of Pittsburgh, USA.

“This could affect the decision-making and behavior of entire societies, impair our cognitive ability to address complex issues like climate change, social unrest, and infectious disease – and ultimately lead to a self-sustaining cycle of societal dysfunction and environmental degradation,” he added.

Bodily inflammation ‘mapped’ in the brain  

One central premise to the hypothesis is an association between chronic inflammation and cognitive dysfunction.  

“The cause of this well-known phenomenon is not currently known,” said Vodovotz. “We propose a mechanism, which we call the ‘central inflammation map’.”    

The authors’ novel idea is that the brain creates its own copy of bodily inflammation. Normally, this inflammation map allows the brain to manage the inflammatory response and promote healing.   

When inflammation is high or chronic, however, the response goes awry and can damage healthy tissues and organs. The authors suggest the inflammation map could similarly harm the brain and impair cognition, emotion, and behavior.   

Accelerated spread of stress and inflammation online   

A second premise is the spread of chronic inflammation from individuals to populations.  

“While inflammation is not contagious per se, it could still spread via the transmission of stress among people,” explained Vodovotz.   

The authors further suggest that stress is being transmitted faster than ever before, through social media and other digital communications.  

“People are constantly bombarded with high levels of distressing information, be it the news, negative online comments, or a feeling of inadequacy when viewing social media feeds,” said Vodovotz. “We hypothesize that this new dimension of human experience, from which it is difficult to escape, is driving stress, chronic inflammation, and cognitive impairment across global societies.”   

Inflammation as a driver of social and planetary disruption  

These ideas shift our view of inflammation as a biological process restricted to an individual. Instead, the authors see it as a multiscale process linking molecular, cellular, and physiological interactions in each of us to altered decision-making and behavior in populations – and ultimately to large-scale societal and environmental impacts.  

“Stress-impaired judgment could explain the chaotic and counter-intuitive responses of large parts of the global population to stressful events such as climate change and the Covid-19 pandemic,” explained Vodovotz.  

“An inability to address these and other stressors may propagate a self-fulfilling sense of pervasive danger, causing further stress, inflammation, and impaired cognition in a runaway, positive feedback loop,” he added.  

The fact that current levels of global stress have not led to widespread societal disorder could indicate an equally strong stabilizing effect from “controllers” such as trust in laws, science, and multinational organizations like the United Nations.   

“However, societal norms and institutions are increasingly being questioned, at times rightly so as relics of a foregone era,” said Prof Paul Verschure of Radboud University, the Netherlands, and a co-author of the article. “The challenge today is how we can ward off a new adversarial era of instability due to global stress caused by a multi-scale combination of geopolitical fragmentation, conflicts, and ecological collapse amplified by existential angst, cognitive overload, and runaway disinformation.”    

Reducing social media exposure as part of the solution  

The authors developed a mathematical model to test their ideas and explore ways to reduce stress and build resilience.  

“Preliminary results highlight the need for interventions at multiple levels and scales,” commented co-author Prof Julia Arciero of Indiana University, USA.  

“While anti-inflammatory drugs are sometimes used to treat medical conditions associated with inflammation, we do not believe these are the whole answer for individuals,” said Dr David Katz, co-author and a specialist in preventive and lifestyle medicine based in the US. “Lifestyle changes such as healthy nutrition, exercise, and reducing exposure to stressful online content could also be important.”  

“The dawning new era of precision and personalized therapeutics could also offer enormous potential,” he added.  

At the societal level, the authors suggest creating calm public spaces and providing education on the norms and institutions that keep our societies stable and functioning.  

“While our ‘inflammation map’ hypothesis and corresponding mathematical model are a start, a coordinated and interdisciplinary research effort is needed to define interventions that would improve the lives of individuals and the resilience of communities to stress. We hope our article stimulates scientists around the world to take up this challenge,” Vodovotz concluded.  

The article is part of the Frontiers in Science multimedia article hub ‘A multiscale map of inflammatory stress’. The hub features a video, an explainer, a version of the article written for kids, and an editorial, viewpoints, and policy outlook from other eminent experts: Prof David Almeida (Penn State University, USA), Prof Pietro Ghezzi (University of Urbino Carlo Bo, Italy), and Dr Ioannis P Androulakis (Rutgers, The State University of New Jersey, USA). 


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Acadia’s Nuplazid fails PhIII study due to higher-than-expected placebo effect

After years of trying to expand the market territory for Nuplazid, Acadia Pharmaceuticals might have hit a dead end, with a Phase III fail in schizophrenia…

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After years of trying to expand the market territory for Nuplazid, Acadia Pharmaceuticals might have hit a dead end, with a Phase III fail in schizophrenia due to the placebo arm performing better than expected.

Steve Davis

“We will continue to analyze these data with our scientific advisors, but we do not intend to conduct any further clinical trials with pimavanserin,” CEO Steve Davis said in a Monday press release. Acadia’s stock $ACAD dropped by 17.41% before the market opened Tuesday.

Pimavanserin, a serotonin inverse agonist and also a 5-HT2A receptor antagonist, is already in the market with the brand name Nuplazid for Parkinson’s disease psychosis. Efforts to expand into other indications such as Alzheimer’s-related psychosis and major depression have been unsuccessful, and previous trials in schizophrenia have yielded mixed data at best. Its February presentation does not list other pimavanserin studies in progress.

The Phase III ADVANCE-2 trial investigated 34 mg pimavanserin versus placebo in 454 patients who have negative symptoms of schizophrenia. The study used the negative symptom assessment-16 (NSA-16) total score as a primary endpoint and followed participants up to week 26. Study participants have control of positive symptoms due to antipsychotic therapies.

The company said that the change from baseline in this measure for the treatment arm was similar between the Phase II ADVANCE-1 study and ADVANCE-2 at -11.6 and -11.8, respectively. However, the placebo was higher in ADVANCE-2 at -11.1, when this was -8.5 in ADVANCE-1. The p-value in ADVANCE-2 was 0.4825.

In July last year, another Phase III schizophrenia trial — by Sumitomo and Otsuka — also reported negative results due to what the company noted as Covid-19 induced placebo effect.

According to Mizuho Securities analysts, ADVANCE-2 data were disappointing considering the company applied what it learned from ADVANCE-1, such as recruiting patients outside the US to alleviate a high placebo effect. The Phase III recruited participants in Argentina and Europe.

Analysts at Cowen added that the placebo effect has been a “notorious headwind” in US-based trials, which appears to “now extend” to ex-US studies. But they also noted ADVANCE-1 reported a “modest effect” from the drug anyway.

Nonetheless, pimavanserin’s safety profile in the late-stage study “was consistent with previous clinical trials,” with the drug having an adverse event rate of 30.4% versus 40.3% with placebo, the company said. Back in 2018, even with the FDA approval for Parkinson’s psychosis, there was an intense spotlight on Nuplazid’s safety profile.

Acadia previously aimed to get Nuplazid approved for Alzheimer’s-related psychosis but had many hurdles. The drug faced an adcomm in June 2022 that voted 9-3 noting that the drug is unlikely to be effective in this setting, culminating in a CRL a few months later.

As for the company’s next R&D milestones, Mizuho analysts said it won’t be anytime soon: There is the Phase III study for ACP-101 in Prader-Willi syndrome with data expected late next year and a Phase II trial for ACP-204 in Alzheimer’s disease psychosis with results anticipated in 2026.

Acadia collected $549.2 million in full-year 2023 revenues for Nuplazid, with $143.9 million in the fourth quarter.

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Digital Currency And Gold As Speculative Warnings

Over the last few years, digital currencies and gold have become decent barometers of speculative investor appetite. Such isn’t surprising given the evolution…

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Over the last few years, digital currencies and gold have become decent barometers of speculative investor appetite. Such isn’t surprising given the evolution of the market into a “casino” following the pandemic, where retail traders have increased their speculative appetites.

“Such is unsurprising, given that retail investors often fall victim to the psychological behavior of the “fear of missing out.” The chart below shows the “dumb money index” versus the S&P 500. Once again, retail investors are very long equities relative to the institutional players ascribed to being the “smart money.””

“The difference between “smart” and “dumb money” investors shows that, more often than not, the “dumb money” invests near market tops and sells near market bottoms.”

Net Smart Dumb Money vs Market

That enthusiasm has increased sharply since last November as stocks surged in hopes that the Federal Reserve would cut interest rates. As noted by Sentiment Trader:

“Over the past 18 weeks, the straight-up rally has moved us to an interesting juncture in the Sentiment Cycle. For the past few weeks, the S&P 500 has demonstrated a high positive correlation to the ‘Enthusiasm’ part of the cycle and a highly negative correlation to the ‘Panic’ phase.”

Investor Enthusiasm

That frenzy to chase the markets, driven by the psychological bias of the “fear of missing out,” has permeated the entirety of the market. As noted in This Is Nuts:”

“Since then, the entire market has surged higher following last week’s earnings report from Nvidia (NVDA). The reason I say “this is nuts” is the assumption that all companies were going to grow earnings and revenue at Nvidia’s rate. There is little doubt about Nvidia’s earnings and revenue growth rates. However, to maintain that growth pace indefinitely, particularly at 32x price-to-sales, means others like AMD and Intel must lose market share.”

Nvidia Price To Sales

Of course, it is not just a speculative frenzy in the markets for stocks, specifically anything related to “artificial intelligence,” but that exuberance has spilled over into gold and cryptocurrencies.

Birds Of A Feather

There are a couple of ways to measure exuberance in the assets. While sentiment measures examine the broad market, technical indicators can reflect exuberance on individual asset levels. However, before we get to our charts, we need a brief explanation of statistics, specifically, standard deviation.

As I discussed in “Revisiting Bob Farrell’s 10 Investing Rules”:

“Like a rubber band that has been stretched too far – it must be relaxed in order to be stretched again. This is exactly the same for stock prices that are anchored to their moving averages. Trends that get overextended in one direction, or another, always return to their long-term average. Even during a strong uptrend or strong downtrend, prices often move back (revert) to a long-term moving average.”

The idea of “stretching the rubber band” can be measured in several ways, but I will limit our discussion this week to Standard Deviation and measuring deviation with “Bollinger Bands.”

“Standard Deviation” is defined as:

“A measure of the dispersion of a set of data from its mean. The more spread apart the data, the higher the deviation. Standard deviation is calculated as the square root of the variance.”

In plain English, this means that the further away from the average that an event occurs, the more unlikely it becomes. As shown below, out of 1000 occurrences, only three will fall outside the area of 3 standard deviations. 95.4% of the time, events will occur within two standard deviations.

Standard Deviation Chart

A second measure of “exuberance” is “relative strength.”

“In technical analysis, the relative strength index (RSI) is a momentum indicator that measures the magnitude of recent price changes to evaluate overbought or oversold conditions in the price of a stock or other asset. The RSI is displayed as an oscillator (a line graph that moves between two extremes) and can read from 0 to 100.

Traditional interpretation and usage of the RSI are that values of 70 or above indicate that a security is becoming overbought or overvalued and may be primed for a trend reversal or corrective pullback in price. An RSI reading of 30 or below indicates an oversold or undervalued condition.” – Investopedia

With those two measures, let’s look at Nvidia (NVDA), the poster child of speculative momentum trading in the markets. Nvidia trades more than 3 standard deviations above its moving average, and its RSI is 81. The last time this occurred was in July of 2023 when Nvidia consolidated and corrected prices through November.

NVDA chart vs Bollinger Bands

Interestingly, gold also trades well into 3 standard deviation territory with an RSI reading of 75. Given that gold is supposed to be a “safe haven” or “risk off” asset, it is instead getting swept up in the current market exuberance.

Gold vs Bollinger Bands

The same is seen with digital currencies. Given the recent approval of spot, Bitcoin exchange-traded funds (ETFs), the panic bid to buy Bitcoin has pushed the price well into 3 standard deviation territory with an RSI of 73.

Bitcoin vs Bollinger Bands

In other words, the stock market frenzy to “buy anything that is going up” has spread from just a handful of stocks related to artificial intelligence to gold and digital currencies.

It’s All Relative

We can see the correlation between stock market exuberance and gold and digital currency, which has risen since 2015 but accelerated following the post-pandemic, stimulus-fueled market frenzy. Since the market, gold and cryptocurrencies, or Bitcoin for our purposes, have disparate prices, we have rebased the performance to 100 in 2015.

Gold was supposed to be an inflation hedge. Yet, in 2022, gold prices fell as the market declined and inflation surged to 9%. However, as inflation has fallen and the stock market surged, so has gold. Notably, since 2015, gold and the market have moved in a more correlated pattern, which has reduced the hedging effect of gold in portfolios. In other words, during the subsequent market decline, gold will likely track stocks lower, failing to provide its “wealth preservation” status for investors.

SP500 vs Gold

The same goes for cryptocurrencies. Bitcoin is substantially more volatile than gold and tends to ebb and flow with the overall market. As sentiment surges in the S&P 500, Bitcoin and other cryptocurrencies follow suit as speculative appetites increase. Unfortunately, for individuals once again piling into Bitcoin to chase rising prices, if, or when, the market corrects, the decline in cryptocurrencies will likely substantially outpace the decline in market-based equities. This is particularly the case as Wall Street can now short the spot-Bitcoin ETFs, creating additional selling pressure on Bitcoin.

SP500 vs Bitcoin

Just for added measure, here is Bitcoin versus gold.

Gold vs Bitcoin

Not A Recommendation

There are many narratives surrounding the markets, digital currency, and gold. However, in today’s market, more than in previous years, all assets are getting swept up into the investor-feeding frenzy.

Sure, this time could be different. I am only making an observation and not an investment recommendation.

However, from a portfolio management perspective, it will likely pay to remain attentive to the correlated risk between asset classes. If some event causes a reversal in bullish exuberance, cash and bonds may be the only place to hide.

The post Digital Currency And Gold As Speculative Warnings appeared first on RIA.

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