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The coupling between healthspan and lifespan in Caenorhabditis depends on…

“The ultimate goal of exploiting model organisms to screen for anti-aging interventions is to identify treatments that might translate to healthy lifespan…

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“The ultimate goal of exploiting model organisms to screen for anti-aging interventions is to identify treatments that might translate to healthy lifespan extension in humans.”

Credit: 2024 Banse et al.

“The ultimate goal of exploiting model organisms to screen for anti-aging interventions is to identify treatments that might translate to healthy lifespan extension in humans.”

BUFFALO, NY- April 23, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 7, entitled, “The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background.”

Aging is characterized by declining health that results in decreased cellular resilience and neuromuscular function. The relationship between lifespan and health, and the influence of genetic background on that relationship, has important implications in the development of pharmacological anti-aging interventions. 

In this new study, researchers Stephen A. Banse, E. Grace Jackson, Christine A. Sedore, Brian Onken, David Hall, Anna Coleman-Hulbert, Phu Huynh, Theo Garrett, Erik Johnson, Girish Harinath, Delaney Inman, Suzhen Guo, Mackenzie Morshead, Jian Xue, Ron Falkowski, Esteban Chen, Christopher Herrera, Allie J. Kirsch, Viviana I. Perez, Max Guo, Gordon J. Lithgow, Monica Driscoll, and Patrick C. Phillips from the University of Oregon, The State University of New Jersey (Rutgers), The Buck Institute for Research on Aging, and National Institute on Aging assessed swimming performance as well as survival under thermal and oxidative stress across a nematode genetic diversity test panel to evaluate health effects for three compounds previously studied in the Caenorhabditis Intervention Testing Program and thought to promote longevity in different ways – NP1 (nitrophenyl piperazine-containing compound 1), propyl gallate, and resveratrol. 

“Overall, we find the relationships among median lifespan, oxidative stress resistance, thermotolerance, and mobility vigor to be complex.” 

The researchers showed that oxidative stress resistance and thermotolerance vary with compound intervention, genetic background, and age. The effects of tested compounds on swimming locomotion, in contrast, are largely species-specific. In this study, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Notably, some compounds exert strong impact on some health measures without an equally strong impact on lifespan. 

“Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible anti-aging interventions, with data underscoring how personalized treatments might be required to optimize health benefits.”

 

Read the full paper: DOI: https://doi.org/10.18632/aging.205743 

Corresponding Authors: Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips

Corresponding Emails: glithgow@buckinstitute.org, driscoll@dls.rutgers.edu, pphil@uoregon.edu 

Keywords: aging, healthspan, genetic diversity, compound intervention

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About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at www.Aging-US.com​​ and connect with us:

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Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

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US PMIs Scream Stagflation As Manufacturing ‘Contracts’, Prices Rise, Heaviest Job Cuts Since GFC

US PMIs Scream Stagflation As Manufacturing ‘Contracts’, Prices Rise, Heaviest Job Cuts Since GFC

After a mixed bag from preliminary April…

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US PMIs Scream Stagflation As Manufacturing 'Contracts', Prices Rise, Heaviest Job Cuts Since GFC

After a mixed bag from preliminary April European PMIs (Services strong-er, Manufacturing weaker-er, surging prices)...

Accelerated increases in input costs, likely driven not only by higher oil prices but also, more concerningly, by higher wages, are a cause for scrutiny Concurrently service-sector companies have raised their prices at a faster rate than in March, fueling expectations that services inflation will persist. ”

and after March US PMIs exposed the end of the disinflation narrative...

"Most notable was an especially steep rise in prices charged for consumer goods, which rose at a pace not seen for 16 months, underscoring the likely bumpy path in bringing inflation down to the Fed's 2% target. ”

...S&P Global's preliminary US f°r April just dropped and they were ugly with both Manufacturing and Services disappointingly dropping further as the former    dropped back into contraction:

  • •    Flash US Services Business Activity Index at 50.9 (Exp: 52.0; March: 51.7) - 5-month low.

  • •    Flash US Manufacturing PMI at 49.9 (Exp 52.0; March: 51.9) - 4-month low.

Source: Bloomberg

Commenting on the data, Chris Williamson, Chief Business Economist at S&P Global Market Intelligence said:

The US economic upturn lost momentum at the start of the second quarter, with the flash PMI survey respondents reporting below-trend business activity growth in April. Further pace may be lost in the coming months, as April saw inflows of new business fall for the first time in six months and firms’ future output expectations slipped to a five-month low amid heightened concern about the outlook.

The more challenging business environment prompted companies to cut payroll numbers at a rate not seen since the global financial crisis if the early pandemic lockdown months are excluded.

After March showed accelerating prices, flash April data confirmed the trend

Notably, the drivers of inflation have changed.

"Manufacturing has now registered the steeper rate of price increases in three of the past four months, with factory cost pressures intensifying in April amid higher raw material and fuel prices, contrasting with the wagerelated services-led price pressures seen throughout much of 2023.”

So slower growth and much faster inflation - that does not sound like a recipe for rate-cuts... in fact quite the opposite.

Tyler Durden Tue, 04/23/2024 - 10:08

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Supreme Court Denies Bid To Expand No-Excuse Mail-In Ballots In Texas

Supreme Court Denies Bid To Expand No-Excuse Mail-In Ballots In Texas

Authored by Tom Ozimek via The Epoch Times (emphasis ours),

The U.S….

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Supreme Court Denies Bid To Expand No-Excuse Mail-In Ballots In Texas

Authored by Tom Ozimek via The Epoch Times (emphasis ours),

The U.S. Supreme Court has declined to hear a legal challenge to a Texas law that requires voters under the age of 65 to provide justification to vote by mail, meaning that the Democrat-aligned attempt to sharply expand “no-excuse” mail-in ballots in the Lone Star state has failed, with implications for other states.

Empty envelopes of opened vote-by-mail ballots for the presidential primary are stacked on a table at King County Elections in Renton, Washington, on March 10, 2020. (Jason Redmond/AFP)

According to an April 22 order list, the high court denied petition for a writ of cetriorari in a case that stems from a federal lawsuit filed in 2020 on behalf of the Texas Democratic Party and several voters who requested that Texas lift its age-based limitations on no-excuse mail-in voting.

Texas law only allows individuals to vote by mail without a qualifying excuse, like sickness, if they are 65 years or older. In their original complaint, which made its way through a number of lower courts before ending up before the Supreme Court, the petitioners alleged that the Texas voting law violates the 26th Amendment of the U.S. Constitution, which prohibits denying the right to vote due to age.

The Supreme Court’s refusal to hear the appeal means that the Texas law stays in place, delivering a win to election integrity advocates who argue that no-excuse mail-in voting is prone to fraud and makes elections less secure.

At the same time, the high court’s decision to deny certiorari is a setback for groups who see laws like Texas’s age-based limits on no-excuse mail-in ballots as “voter suppression” or an unfair attempt to impose barriers to voting for certain groups, in this case younger voters.

The high court’s decision not to hear the appeal has broader implications, however, since six other states–Indiana, Kentucky, Louisiana, Mississippi, South Carolina, and Tennessee–have similar laws on the books that let older voters to request absentee ballot without having to provide any justification.

Public opinion in Texas over the issue of no-excuse mail-in voting is split, according to some polls.

More Details

In their initial petition filed in 2020 on behalf of the Texas Democratic Party and a group of voters amids the COVID-19 pandemic, the plaintiffs requested that Texas lift its age-based restrictions to no-excuse mail-in voting, citing public health risks related to the outbreak.

A district court judge sided with the plaintiffs in May 2020, temporarily blocking the Texas law.

Led by Texas Attorney General Ken Paxton, Texas officials then filed an appeal with the 5th U.S. Circuit Court of Appeals, which paused the district court’s ruling while the appeal played out.

The plaintiffs then asked the U.S. Supreme Court to reimpose the district court’s decision to freeze enforcement of the age-based limits to no-excuse mail-in voting, or to take the case up for review, but the high court rejected both requests.

Ultimately, the 5th Circuit voided the lower court’s May 2020 order in full. This led the plaintiffs to file an amended complaint in the district court, this time asserting other claims, including ones of racial discrimination under Section 2 of the Voting Rights Act and arguing that the age limitations on mail-in ballots violated the Equal Protection Clause of the 14th and 26th Amendments.

In a July 2022 order, the district court judge dismissed all of the plaintiffs’ claims, leading to another appeal before the 5th Circuit, which ultimately affirmed the district court’s decision to dismiss.

The plaintiffs filed a petition for a writ of certiorari in the U.S. Supreme Court in December 2023, asking the high court to declare Texas’s age-based voting law unconstitutional.

The court declined to review the plaintiffs’ appeal, leaving Texas’s age restrictions in place and denying a bid to expand no-excuse mail-in voting in the Lone Star state.

The Epoch Times has reached out to counsel for both petitioners and respondents with a request for comment on the high court’s decision.

Election Integrity or Voter Suppression?

The Supreme Court ruling comes amid a broader fight between those who see election integrity efforts as “voter suppression” and those who believe that the security of U.S. elections is too lax and should be tightened.

According to a running tally by the left-leaning Brennan Center for Justice, expansive voting laws far outpaced restrictive ones in 2023.

At least 53 expansive voting laws were introduced last year in at least 23 states, compared to 17 restrictive laws being passed in 14 states, suggesting that the election integrity movement is falling behind.

Amid concerns over voter fraud, former House Speaker Newt Gingrich recently suggested that to win the presidential election in November, Republicans need to outvote Democrats by a significant margin.

Everybody who wants an honest election should know that in the long run, we need the French model: Everybody votes on the same day, everybody has a photo ID, everybody’s accounted as a person,” Mr. Gingrich said in a February interview on Fox News.

“But until we get to that, if Republicans want to win this year, under the rules that exist this year, they need to outvote the Democrats by about 5 percent, which is a margin big enough that it can’t be stolen,” he said.

Elsewhere, an election integrity monitor laid out over a dozen “critical” reforms that it believes are necessary in order to secure voter integrity in the 2024 election, including outlawing ranked choice voting and non-citizen voting, consolidating election dates, requiring voter ID, and safeguarding vulnerable mail ballots.

Tyler Durden Mon, 04/22/2024 - 23:00

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Royal Caribbean shares huge onboard health and safety news

The cruise line has taken steps to make cruises safer and those efforts have been working.

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When you go to a hotel or a theme park and get infected with a virus, you don't know exactly what happened. Maybe you caught the virus at the airport, in a rest stop, on an airplane, or even at your hotel or in a restaurant.

That's generally because by the time you get sick, you're no longer at the place where you got infected. Cruise ships, however, lack the same plausible deniability, and historically viruses spread quickly on ships.

Related: Royal Caribbean bets big on new ships, private destinations

On a seven-day cruise, you might actually have picked up an illness at the supermarket or at work, but when you get sick on the ship, people blame the cruise line. When someone falls ill, cruise lines don't actually care where they got infected. They simply want to slow down the spread of the disease.

That has always been the case, but the Covid pandemic and the Centers for Disease Control (CDC) shutting down the cruise industry from the U.S. for over a year put shipboard illness under a bigger microscope. For months, the federal agency reported on onboard Covid levels and did little to share all of the steps the major cruise lines had taken to mitigate outbreaks.

Now, with Covid becoming less of a concern, Royal Caribbean has shared some big news about its efforts to control another virus, norovirus, which spreads quickly on ships. 

Cruise ships put thousands of people in relatively close quarters.

Image source: Dukas/Universal Images Group via Getty Images

Royal Caribbean has made ships safer

"Norovirus is a very contagious virus that causes vomiting and diarrhea. Anyone can get infected and sick with norovirus. Norovirus is sometimes called the 'stomach flu' or 'stomach bug.' However, norovirus illness is not related to the flu, which is caused by influenza virus," according to the CDC.

The virus can cause problems on cruise ships, but it's actually a pretty rare occurrence.

"Norovirus is the most frequent (over 90%) cause of outbreaks of diarrheal disease on cruise ships and these outbreaks often get media attention, which is why some people call norovirus the 'cruise ship virus.' However, norovirus outbreaks on cruise ships account for only a small percentage (1%) of all reported norovirus outbreaks," the federal agency reported.

You are much more likely to get norovirus in a land-based restaurant or healthcare facility than on a cruise ship, but cruise outbreaks make for good stories and get widespread media attention.

Royal Caribbean began its Norovirus Eradication Campaign in 2023. It's a six-step program that has worked to stop outbreaks on its ships, the Royal Caribbean Blog reported.

Royal Caribbean's plan has worked

Royal Caribbean has enacted a comprehensive plan designed to contain norovirus and prevent its spread.

  1. Enhanced acute GI training for onboard medical teams and traveling doctors
  2. Increased doctor oversight of its Outbreak Prevention Plan, which covers requirements like hand washing, buffet oversight, and disinfectant mandates for all public areas aboard its ships.
  3. Switching to PDI SaniCloth Prime hospital-grade disinfectant wipes, wipes certified to kill norovirus by the EPA.

  4. New contactless tap technology, eliminating the need for crew to handle guest cards

  5. Enhanced crew training on what to do when experiencing acute GI symptoms and how to avoid cross-contamination in food and beverage service areas

  6. An update to Royal Caribbean's Safety & Quality Management system to stop self-service in buffets if the onboard norovirus rate exceeds 1.5%

"After the eradication campaign was implemented in June 2023, there was not a single norovirus outbreak onboard any Royal Caribbean International or Celebrity Cruise ship for the remainder of 2023," the report shared.

Celebrity Constellation, however, did have an outbreak in January 2024 that was listed on a CDC website, according to Royal Caribbean Blog.

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