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Probiotics regulate our immune system and could help fight off COVID – new research

A recent clinical trial shows that taking probiotics can lead to a quicker recovery from a coronavirus infection.

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You’ve probably heard of probiotics – the “good bacteria” that can benefit our health. We consume them in an expanding variety of ways, often in foods marketed as being healthy. These bacteria can be contained in supplement capsules, yogurts, drinks or even snack bars.

They work by helping prevent other, disease-causing bacteria from infecting our gut. They may also interact with our gut’s immune cells, helping regulate the cells’ activity in the complex gut environment, which is important for preventing unwanted inflammation that can trigger inflammatory bowel disease. Research has also shown that the effects of probiotics may go beyond the gut, regulating immune responses in the lungs as well.

Right now, our immune systems face the constant threat of having to fight off the coronavirus, with it circulating at record levels around the world since the emergence of the highly infectious omicron variant. There are limited treatments available for people that get seriously ill, and current vaccines aren’t highly effective at preventing infection in people that haven’t recently taken a booster.

But if probiotics positively affect our immune system, and their effects are not limited to the gut, could they offer a cheap and accessible way of helping our bodies fight off COVID?

Bacteria lead to quicker recovery

A recent trial conducted in Mexico showed that people with the coronavirus who took a specific combination of four probiotic bacterial strains recovered quicker compared to those who took a placebo. Those given probiotics also had increased antibody responses to the virus that peaked earlier than the placebo group’s.

Probiotic bacteria in the gut
Though they are delivered to the gut, probiotic bacteria can exert an influence across the body. nobeastsofierce/Shutterstock

Importantly, those taking the probiotics had lesser symptoms and lower amounts of the virus in their bodies 15 days after their initial infection compared to people taking the placebo.

These encouraging results are some of the first to show that probiotics could help our immune system fight off COVID. The authors suggest that probiotic supplementation could help people recover quicker. This could reduce the self-isolation periods currently imposed on infected people in numerous countries throughout the world.

That said, we need to be careful interpreting these results. Despite being a double-blind, placebo-controlled clinical trial (generally regarded as the gold standard for testing medical treatments), it had some limitations. It excluded those over the age of 60 and didn’t account for vaccination status of the trial participants. This means we don’t yet know if probiotics provide any benefit to those who are most at risk of developing severe COVID.

In addition, taking probiotics may be inappropriate for those with a weakened immune system. This is due to a potential increased risk of infection resulting from consuming large quantities of live bacteria.

An axis of immunity

Research has uncovered a potential positive effect – but can we explain why this happens? How is it that bacteria that arrive in our gut end up helping the immune response against COVID up in the lungs?

Immunologists think they have an answer. They’ve proposed the idea of a gut-lung immune axis. The theory is that immune cells exposed to probiotics in the gut could be activated by these bacteria and then travel to the lung upon infection. In COVID, these would be B cells – the white blood cells that produce antibodies. They could be “primed” in the gut to go on to produce more antibodies when they encounter the virus in the lung or nose.

However, before probiotics can be properly considered for treating COVID, more studies are needed to validate these results. Clinical trials using probiotics to treat disease often produce varying results, as the effects of probiotic bacteria on immune cells may be highly specific to the bacteria used. Trials must also be performed in different groups of people to see what effect the bacteria have, as we know that COVID is more severe in some than others. Ethnicity has been associated with COVID mortality, for example.

Kimchee, sour cream and other probiotic foods on a table
It’s not time yet to start loading up on probiotic foods to protect against COVID. Nina Firsova/Shutterstock

Certainly, there’s no direct evidence currently that the probiotic bacterial strains contained in a store-bought probiotic yogurt would have the same effect as the probiotics tested in the Mexican study. It’s also important to remember that not all the probiotic bacteria contained in foods may be live by the time they are consumed, which could affect their potency.

What to eat now

While the evidence on probiotics is being gathered, in the meantime another way to look after your gut bacteria is to eat a healthy fibre-rich diet. The latest research shows that those who consume a healthy diet high in fruits and vegetables are less likely to develop severe COVID. A high-fibre diet that stimulates the gut bacteria may even help your immune system to generate a stronger response to COVID vaccination.

As COVID will likely remain highly prevalent in the world for the foreseeable future, probiotics have the potential to become a useful tool in our fight against the disease. However, before we all run out to our local health food store to stock up, we need to wait for research to confirm what types of probiotic bacteria could help our immune system and who would most benefit from consuming them.

Andrew Smith receives funding from the UK Medical Research Council, Medimmune (AstraZeneca), Ferring Pharmaceuticals and Imhotex Ltd. He acts as a consultant for Imhotex Ltd and sits on the Medical Research Awards Panel for Crohn's & Colitis UK.

Paul Gill does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

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You can now enter this country without a passport

Singapore has been on a larger push to speed up the flow of tourists with digital immigration clearance.

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In the fall of 2023, the city-state of Singapore announced that it was working on end-to-end biometrics that would allow travelers passing through its Changi Airport to check into flights, drop off bags and even leave and exit the country without a passport.

The latter is the most technologically advanced step of them all because not all countries issue passports with the same biometrics while immigration laws leave fewer room for mistakes about who enters the country.

Related: A country just went visa-free for visitors with any passport

That said, Singapore is one step closer to instituting passport-free travel by testing it at its land border with Malaysia. The two countries have two border checkpoints, Woodlands and Tuas, and as of March 20 those entering in Singapore by car are able to show a QR code that they generate through the government’s MyICA app instead of the passport.

A photograph captures Singapore's Tuas land border with Malaysia.

Here is who is now able to enter Singapore passport-free

The latter will be available to citizens of Singapore, permanent residents and tourists who have already entered the country once with their current passport. The government app pulls data from one's passport and shows the border officer the conditions of one's entry clearance already recorded in the system.

More Travel:

While not truly passport-free since tourists still need to link a valid passport to an online system, the move is the first step in Singapore's larger push to get rid of physical passports.

"The QR code initiative allows travellers to enjoy a faster and more convenient experience, with estimated time savings of around 20 seconds for cars with four travellers, to approximately one minute for cars with 10 travellers," Singapore's Immigration and Checkpoints Authority wrote in a press release announcing the new feature. "Overall waiting time can be reduced by more than 30% if most car travellers use QR code for clearance."

More countries are looking at passport-free travel but it will take years to implement

The land crossings between Singapore and Malaysia can get very busy — government numbers show that a new post-pandemic record of 495,000 people crossed Woodlands and Tuas on the weekend of March 8 (the day before Singapore's holiday weekend.)

Even once Singapore implements fully digital clearance at all of its crossings, the change will in no way affect immigration rules since it's only a way of transferring the status afforded by one's nationality into a digital system (those who need a visa to enter Singapore will still need to apply for one at a consulate before the trip.) More countries are in the process of moving toward similar systems but due to the varying availability of necessary technology and the types of passports issued by different countries, the prospect of agent-free crossings is still many years away.

In the U.S., Chicago's O'Hare International Airport was chosen to take part in a pilot program in which low-risk travelers with TSA PreCheck can check into their flight and pass security on domestic flights without showing ID. The UK has also been testing similar digital crossings for British and EU citizens but no similar push for international travelers is currently being planned in the U.S.

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This country became first in the world to let in tourists passport-free

Singapore has been on a larger push to speed up the flow of tourists with digital immigration clearance.

Published

on

In the fall of 2023, the city-state of Singapore announced that it was working on end-to-end biometrics that would allow travelers passing through its Changi Airport to check into flights, drop off bags and even leave and exit the country without a passport.

The latter is the most technologically advanced step of them all because not all countries issue passports with the same biometrics while immigration laws leave fewer room for mistakes about who enters the country.

Related: A country just went visa-free for visitors with any passport

That said, Singapore is one step closer to instituting passport-free travel by testing it at its land border with Malaysia. The two countries have two border checkpoints, Woodlands and Tuas, and as of March 20 those entering in Singapore by car are able to show a QR code that they generate through the government’s MyICA app instead of the passport.

A photograph captures Singapore's Tuas land border with Malaysia.

Here is who is now able to enter Singapore passport-free

The latter will be available to citizens of Singapore, permanent residents and tourists who have already entered the country once with their current passport. The government app pulls data from one's passport and shows the border officer the conditions of one's entry clearance already recorded in the system.

More Travel:

While not truly passport-free since tourists still need to link a valid passport to an online system, the move is the first step in Singapore's larger push to get rid of physical passports.

"The QR code initiative allows travellers to enjoy a faster and more convenient experience, with estimated time savings of around 20 seconds for cars with four travellers, to approximately one minute for cars with 10 travellers," Singapore's Immigration and Checkpoints Authority wrote in a press release announcing the new feature. "Overall waiting time can be reduced by more than 30% if most car travellers use QR code for clearance."

More countries are looking at passport-free travel but it will take years to implement

The land crossings between Singapore and Malaysia can get very busy — government numbers show that a new post-pandemic record of 495,000 people crossed Woodlands and Tuas on the weekend of March 8 (the day before Singapore's holiday weekend.)

Even once Singapore implements fully digital clearance at all of its crossings, the change will in no way affect immigration rules since it's only a way of transferring the status afforded by one's nationality into a digital system (those who need a visa to enter Singapore will still need to apply for one at a consulate before the trip.) More countries are in the process of moving toward similar systems but due to the varying availability of necessary technology and the types of passports issued by different countries, the prospect of agent-free crossings is still many years away.

In the U.S., Chicago's O'Hare International Airport was chosen to take part in a pilot program in which low-risk travelers with TSA PreCheck can check into their flight and pass security on domestic flights without showing ID. The UK has also been testing similar digital crossings for British and EU citizens but no similar push for international travelers is currently being planned in the U.S.

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Analysts issue unexpected crude oil price forecast after surge

Here’s what a key investment firm says about the commodity.

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Oil is an asset defined by volatility.

U.S. crude prices stood above $60 a barrel in January 2020, just as the covid pandemic began. Three months later, prices briefly went negative, as the pandemic crushed demand.

By June 2022 the price rebounded all the way to $120, as fiscal and monetary stimulus boosted the economy. The price fell back to $80 in September 2022. Since then, it has bounced between about $65 and $90.

Over the past two months, the price has climbed 15% to $82 as of March 20.

Oil prices often trade in a roller-coaster fashion.

Bullish factors for oil prices

The move stems partly from indications that economic growth this year will be stronger than analysts expected.

Related: The Fed rate decision won't surprise markets. What happens next might

Vanguard has just raised its estimate for 2024 U.S. GDP growth to 2% from 0.5%.

Meanwhile, China’s factory output and retail sales exceeded forecasts in January and February. That could boost oil demand in the country, the world's No. 1 oil importer.

Also, drone strokes from Ukraine have knocked out some of Russia’s oil refinery capacity. Ukraine has hit at least nine major refineries this year, erasing an estimated 11% of Russia’s production capacity, according to Bloomberg.

“Russia is a gas station with an army, and we intend on destroying that gas station,” Francisco Serra-Martins, chief executive of drone manufacturer Terminal Autonomy, told the news service. Gasoline, of course, is one of the products made at refineries.

Speaking of gas, the recent surge of oil prices has sent it higher as well. The average national price for regular gas totaled $3.52 per gallon Wednesday, up 7% from a month ago, according to the American Automobile Association. And we’re nearing the peak driving season.

Another bullish factor for oil: Iraq said Monday that it’s cutting oil exports by 130,000 barrels per day in coming months. Iraq produced much more oil in January and February than its OPEC (Organization of Petroleum Exporting Countries) target.

Citigroup’s oil-price forecast

Yet, not everyone is bullish on oil going forward. Citigroup analysts see prices falling through next year, Dow Jones’s Oil Price Information Service (OPIS) reports.

More Economic Analysis:

The analysts note that supply is at risk in Israel, Iran, Iraq, Libya, and Venezuela. But Saudi Arabia, the UAE, Kuwait, and Russia could easily make up any shortfall.

Moreover, output should also rise this year and next in the U.S., Canada, Brazil, and Guyana, the analysts said. Meanwhile, global demand growth will decelerate, amid increased electric vehicle use and economic weakness.

Regarding refineries, the analysts see strong gains in capacity and capacity upgrades this year.

What if Donald Trump is elected president again? That “would likely be bearish for oil and gas," as Trump's policies could boost trade tension, crimping demand, they said.

The analysts made predictions for European oil prices, the world’s benchmark, which sat Wednesday at $86.

They forecast a 9% slide in the second quarter to $78, then a decline to $74 in the third quarter and $70 in the fourth quarter.

Next year should see a descent to $65 in the first quarter, $60 in the second and third, and finally $55 in the fourth, Citi said. That would leave the price 36% below current levels.

U.S. crude prices will trade $4 below European prices from the second quarter this year until the end of 2025, the analysts maintain.

Related: Veteran fund manager picks favorite stocks for 2024

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