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Futures Levitate Higher After China Vows To Accelerate Reopening

Futures Levitate Higher After China Vows To Accelerate Reopening

US futures were flat as the Fed minutes did not help resolve the uncertainty…

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Futures Levitate Higher After China Vows To Accelerate Reopening

US futures were flat as the Fed minutes did not help resolve the uncertainty about the path of Federal Reserve monetary tightening, while fresh prospects about China’s economic reopening sent oil higher. Nasdaq 100 and S&P 500 futures were up 0.2% at 745am ET having recovered from an earlier loss, as traders assessed minutes from the Fed’s last meeting which noted that officials saw risks from tightening more than necessary even as they planned on hiking until inflation was on a steady downward slope, while President Xi Jinping’s comments that China will persist with opening up its economy were also in focus and boosted commodities. The dollar gave up gains, and Treasury yields dipped, reversing some of this week's sharp gains. Bitcoin traded in a tight range around $23,500.

In US premarket trading, Cisco Systems advanced after issuing an upbeat forecast for quarterly sales as chip-supply shortages ease and the company is able to fill more orders. Keep an eye on US building products stocks as Deutsche Bank initiates coverage on 22 names, saying the US housing market is in the midst of a “mid-cycle crisis,” but that this is likely to be different from the downturn seen in the mid-2000s. Here are some other notable premarket movers:

  • Bluebird Bio’s (BLUE) shares rise as much as 10% as analysts digest yesterday’s FDA clearance of its Zynteglo therapy, ahead of its launch call due later today.
  • BJ’s Wholesale (BJ) shares gain 6% after the warehouse club operator reported adjusted earnings per share for the second quarter that beat the average analyst estimate.
  • Cisco Systems (CSCO) rose 6% after issuing an upbeat forecast for quarterly sales as chip-supply shortages ease and the company is able to fill more orders.
  • Elanco Animal Health (ELAN) cut to equal-weight from overweight at Morgan Stanley as visibility on the firm’s outlook remains weak. Elanco shares fall 1.7% in US premarket trading.
  • Estee Lauder (EL) falls 1.3% after the beauty company’s forecasts for first quarter and the full year trailed consensus estimates. In Europe, shares of L’Oreal declined after EL’s release.
  • Five months after disclosing a stake in Bed Bath & Beyond Inc., (BBBY) activist shareholder Ryan Cohen wants out, sparking a selloff in the shares of the home goods retailer. Shares fall 13%.
  • Kohl’s (KSS) drops 7% after slashing its guidance for the year, including adjusted earnings per share, operating margin and net sales growth. Peer Macy’s (M), which reports Aug. 23, falls 3%.
  • Mattel (MAT) rises 0.8% after it was initiated with a buy rating at BofA, which said that the company has “successfully” completed its turnaround and is now in growth mode.
  • MoffettNathanson cut the recommendation on Verizon Communications Inc. (VZ) to underperform from market perform, as T-Mobile widens its competitive advantage in 5G and AT&T undercuts it with aggressive promotions. Verizon shares fall 0.8%.
  • NetEase (NTES) shares rise as much as 3% after the Chinese video-game giant’s 2Q revenue came in slightly above the consensus analyst estimate.
  • NuScale Power (SMR) was initiated with a recommendation of buy at Guggenheim Securities, as analyst Shahriar Pourreza says its “shares represent one of the only opportunities for public exposure to the next generation of nuclear.” Shares gain 4%.

While policy makers warned against over-tightening and signaled the potential for slower rate increases at some point, they also flagged the risk of inflation pressures becoming entrenched. The nuanced messaging wasn’t dovish enough for markets to sustain a risk-on stance into Thursday. Caution was the byword of the moment with further clues awaited at the Fed’s annual symposium in Jackson Hole, Wyoming next week.

“People are a little overly optimistic about how likely it is that we can solve the inflation problem quickly and in a way where we don’t have to include more policy and more rising rates,” Kathryn Kaminski, AlphaSimplex Group chief research strategist and portfolio manager, said on Bloomberg Television.

While most saw the FOMC minutes as dovish, others disagreed. According to Ipek Ozkardeskaya, a senior analyst at Swissquote, the Fed meeting minutes were more hawkish than what was needed to give another boost to US equities. “Investors quickly realized that there was no mention of cutting the rates in the foreseeable future. If anything, the Fed would continue lifting the rates, and keep them steady for a while.”

Equities had rallied in recent weeks as investors bet July’s softer inflation print would allow the Fed to rethink its aggressive pace of hiking rates. The Nasdaq 100 had led the advance amid relief at the prospect of easier policy, boosted by raging CTA buying, stock buybacks, a return of retail investors and hedge funds forced to FOMO-chase higher.

"This rally is over-extended in the technology sector,” said Freddie Lait, chief investment officer at Latitude Investment Management. “The relative valuation of most of those Nasdaq stocks compared to other stocks around the world has become extreme again, and positioning has become quite extreme again, and so I wouldn’t be surprised to see that rolling over into the end of the summer.” The Nasdaq 100 is now trading at 23.2 times forward earnings, above the average level of 20.2 times over the past decade.

In Europe, the Stoxx 600 index was 0.2% higher as the latest report of euro-area inflation met expectations, sparing traders of any ugly surprise. FTSE MIB outperforms, adding 0.4%, IBEX lags, dropping 0.2%. Autos, energy and chemicals are the strongest-performing sectors. Concerns of tightening monetary conditions increased after the European Central Bank’s Governing Council member Martins Kazaks said rate hikes will continue in the region. Thin trading exaggerated moves across markets. The Stoxx 600 witnessed a 33% drop in volumes relative to the 30-day average. Here are the biggest European movers:

  • Siegfried shares jump as much as 13%, the most since October 1998, after 1H results analysts say were a significant beat, also noting effective management of macro risks.
  • GN Store Nord shares rise as much as 10% after the Danish audio firm presented its latest earnings, which included a guidance cut that was less pessimistic than analysts expected.
  • Zur Rose shares rise as much as 14%, the most since May, after its latest earnings report, which includes a goal to be profitable in 2023, a plan Jefferies call “very positive.”
  • Nibe rise as much as 8.6% after the Swedish heat pump manufacturer published earnings. Analysts note solid results, which beat expectations, as well as a positive outlook.
  • Global Fashion Group shares rise as much as 31%, the most intraday on record, after reporting better-than-expected earnings for the second quarter, also offering some FY clarity.
  • Balfour Beatty shares rise as much as 3.8% after Peel Hunt further raised FY22 profit forecasts for the UK construction and engineering firm and saw scope for material share price upside.
  • Adyen shares tumble the most since 2018 as 1H Ebitda and net revenue missed consensus analyst forecasts. Analysts point out that accelerated hiring is also a cause of Ebitda miss.
  • AutoStore shares wipe out an earlier jump of 13% to fall as much as 6.8%. Analysts say results look strong, albeit they note a small miss on orders and guidance for more margin pressure in 2H.
  • Made.com shares drop as much as 12%, biggest decliner in the FTSE All-Share Index, after the online furniture seller said it’s considering “all options” to strengthen its balance sheet.

Earlier in the session, Asian stocks fell as disappointing results from some key Chinese firms and worries about the outlook for the region’s biggest economy weighed on investor sentiment. The MSCI Asia Pacific Index slipped as much as 0.7%, with benchmarks in the biggest markets of Japan and China down close to 1%. Risk appetite improved a smidge after President Xi Jinping said China will persist with opening up its economy, the comments coming in after the nation’s markets closed. China’s largest developer Country Garden Holdings, saw its stock slump after it warned that first-half earnings probably tumbled by as much as 70% amid an escalating property crisis. Tencent, the nation’s most-valuable company, logged its first-ever revenue drop though its shares -- which have fallen for three straight months -- advanced.

Thursday’s losses in Asia tracked declines in US shares overnight. Minutes of the Fed’s latest meeting showed that officials agreed on the need to eventually dial back the pace of interest-rate hikes but also wanted to gauge how their monetary tightening was working toward curbing US inflation.  The minutes “lacked fresh impetus needed to bring up the pricing of Fed’s rate hikes,” Saxo Capital Markets’ Asia-Pacific strategy team wrote in a note. “Chairman Powell’s speech at the Jackson Hole Symposium next week will be keenly watched for further inputs.” Meanwhile, consumer discretionary and technology were among the worst-performing sectors on the Asian benchmark. Goldman Sachs and Nomura further cut their forecasts for China’s economic growth, with a power supply crunch adding more uncertainty to the outlook.

Japanese stocks fell, following US peers lower after minutes from the Federal Reserve’s last meeting showed officials see risks from tightening more than necessary. The Topix fell 0.8% to close at 1,990.50, while the Nikkei declined 1% to 28,942.14. Toyota Motor Corp. contributed the most to the Topix decline, decreasing 1.8%. Out of 2,170 shares in the index, 565 rose and 1,503 fell, while 102 were unchanged.

Australia's S&P/ASX 200 index fell 0.2% to close at 7,112.80 as investors assessed a slew of corporate results and jobs data. Australian employment unexpectedly dropped in July, giving the Reserve Bank scope for more flexibility in its tightening cycle. Telix Pharma slumped after reporting a net loss for the first half. IPH was the top performer after saying it’s buying Canadian firm Smart & Biggar. In New Zealand, the S&P/NZX 50 index fell 0.3% to 11,814.34.

In FX, the Bloomberg Dollar Spot Index advanced a second day and the greenback rose versus most of its Group-of-10 peers, with Norway’s krone as the best performer. The euro traded in a narrow range against the dollar for a third consecutive day. Norway’s krone extended an advance versus the euro after Norges Bank raised the key interest rate to 1.75% from 1.25%, in line with what most economists in a Bloomberg survey had expected. The central bank also said the policy rate “will most likely be raised further in September.” The pound extended losses against the dollar, hitting the lowest since July 26, amid broad-based greenback strength.
The yen fell in a volatile session as traders mulled rising US yields and their negative impact on stocks. Japan’s government bond yields rose

In rates, Treasuries were slightly richer across the curve with gains led by long-end, having outperformed bunds and gilts during European morning. US yields richer by ~2bp across long-end of the curve with 5s30s spread flatter by ~1bp on the day; 10-year yields around 2.87% within narrow overnight range, outperforming bunds by 4bp in the sector. Front-end German yields lag after ECB’s Isabel Schnabel says the euro area’s inflation outlook has not changed fundamentally.  Bunds bear-flattened out to the 10-year sector as money markets added to ECB tightening bets after the ECB’s Schnabel said the euro area’s inflation outlook has not changed fundamentally, in an interview cited by Reuters, suggesting that another hike of similar magnitude may be coming next month.  Australia’s bond yields trimmed opening gains and the nation’s currency eased after employment contracted for the first time since October 2021.

In commodities, oil jumps to session high after Xi says China will persist with opening up its economy. WTI rises 1.5% to trade around $89. Spot gold rises roughly $4 to trade near $1,766/oz. Most base metals trade in the red; LME nickel falls 0.5%, underperforming peers. LME copper outperforms, adding 1%, after Xi’s comments

Looking at the day ahead, the FOMC minutes from July will be the main highlight, and the other central bank speaker will be Fed Governor Bowman. Otherwise, earnings releases include Target, Lowe’s and Cisco Systems, and data releases include US retail sales and UK CPI for July.

Market Snapshot

  • S&P 500 futures down 0.3% to 4,265.50
  • STOXX Europe 600 down 0.1% to 438.54
  • MXAP down 0.6% to 161.98
  • MXAPJ down 0.5% to 526.40
  • Nikkei down 1.0% to 28,942.14
  • Topix down 0.8% to 1,990.50
  • Hang Seng Index down 0.8% to 19,763.91
  • Shanghai Composite down 0.5% to 3,277.54
  • Sensex down 0.3% to 60,079.59
  • Australia S&P/ASX 200 down 0.2% to 7,112.78
  • Kospi down 0.3% to 2,508.05
  • German 10Y yield little changed at 1.11%
  • Euro down 0.1% to $1.0165
  • Gold spot up 0.1% to $1,763.18
  • U.S. Dollar Index up 0.20% to 106.79

Top Overnight News from Bloomberg

  • The US says it has commenced bilateral trade negotiations w/Taiwan, something Washington signaled was going to happen back in June. WSJ
  • A United Nations expert on slavery has found it “reasonable to conclude” that forced labour is taking place in the China’s far-western region of Xinjiang. SCMP
  • China’s state media said local governments could sell more than $229 billion of bonds to fund infrastructure investment and plug budget gaps, a further move by Beijing to shore up an economy hit by worsening coronavirus outbreaks and a property slump. BBG
  • More AMTD intrigue. The investment firm that stunned investors when its post-IPO stock soared 32,000% was probed by Hong Kong's watchdog even before its US listing, people familiar said. AMTD Group's office and the home of ex-UBS banker Calvin Choi were searched in February 2021. The regulator investigated its underwriting arrangements as recently as November, one person said. BBG
  • Norway hiked by 50 bps to 1.75% and flagged the potential for another increase of that magnitude next month. ECB official Martins Kazaks said euro-area rates will continue to go up, while his colleague Isabel Schnabel suggested another big hike may come in September. The Philippines raised by 50 bps as expected. Sri Lanka held. Turkey is expected to follow suit later. BBG
  • Tighter links between crypto and US stock prices are forcing digital asset hedge funds to consider buying expensive data from other markets. The influx of traditional trading firms into crypto, which already have the inputs needed to track what's up in stocks, is also adding pressure. Hedge fund bosses said crypto firms may see market data costs rise to $500,000 a month from near zero. BBG
  • Allen Weisselberg, a long-time executive for Donald Trump’s company, will plead guilty on Thurs and while he won’t implicate the former president or Trump’s family, his testimony could be used against the Trump Organization. NYT
  • The decision of 10 members of the House of Representatives to vote to impeach former President Trump has cost some of them their seats, including the most vocal critic, Rep. Liz Cheney, R-Wyo., who lost the state's primary Tuesday to Trump-backed candidate Harriet Hageman.  Trump has spent most of his post-presidency backing candidates who are running against the lawmakers he considers disloyal to him. Four of these 10 Republicans have lost the primaries, four have chosen not to seek reelection, and two made it through their primaries and are running in November’s general election to keep their seats. USA Today
  • AMZN is searching for a senior movie-studio executive to help lead its growing entertainment division, turning to rivals for a chance to poach an experienced Hollywood player. Amazon Studios has held conversations with several Hollywood leaders about the role, including NFLX's film head, Scott Stuber, one of the streamer’s most powerful and visible executives, according to people familiar with the matter. WSJ
  • The probability of a 75 bps rate hike in September, which was climbing on Wednesday morning, dropped below 50% after the FOMC minutes....

A more detailed look at global markets courtesy of Newsquawk

APAC stocks mostly declined following the weak handover from global counterparts which were pressured as yields climbed on the back of the red-hot UK inflation data and with only a brief reprieve seen after the FOMC Minutes noted many officials saw a risk the Fed could tighten more than necessary. ASX 200 was subdued as participants digested the latest influx of earnings releases and disappointing jobs data which showed a surprise contraction in headline Employment Change. Nikkei 225 slipped back beneath the 29,000 level in tandem with the overall downbeat sentiment. Hang Seng and Shanghai Comp conformed to the glum mood after both Goldman Sachs and Nomura cut their China GDP growth forecasts and with focus also on earnings releases including Tencent after it posted its first-ever decline in quarterly revenue although its shares were lifted and it had vowed a return to growth, while Country Garden led the declines after the developer issued a profit warning of as much as an 87% drop in H1 net.

Top Asian News

  • China may issue CNY 1.5tln in additional debt as part of an investment push, according to China Securities News.
  • China's COVID-19 cases rose to a 3-month high of 3,424 on Wednesday from 2,888 the day before.
  • Nomura cut its China 2022 GDP growth forecast to 2.8% from 3.3%.
  • China's MOFCOM says, re. US CHIPS act, some provisions restrict normal economic, trade and investment activities of relevant enterprises in China. Will, when necessary, take forceful measures to safeguard interests.
  • China's President Xi says they will persist with opening up the economy, via CCTV.
  • China's banking regulator is reportedly looking into the property sector loan portfolios of some local/foreign lenders to assess systemic risk, via Reuters citing sources.

European bourses began the session mixed/flat and are yet to gain any real traction in relatively limited newsflow, Euro Stoxx 50 +0.5%.  Though, it is worth pointing out DAX 40 +1.0% outperformance, after lagging on Wednesday, amid strength in their heavyweight industry names. Stateside, performance is similar ahead of a few corporate updates, data and Fed speak, ES +0.1%

Top European News

  • The FTSE 100’s Weirdly Good Run of Form Hits a Wall of Problems
  • Norway Raises Rates to Highest in Decade to Stem Inflation
  • Embracer CEO Eyes IP Windfall After Buying ‘Lord of the Rings’
  • PwC Raises UK Partner Pay to £1 Million for First Time
  • ‘Enough Is Enough’ Rally Pulls UK Crowds as Rail Strike Begins
  • Truss Planning Review of Regulators in City of London Shakeup

FX

  • Buck bounces after brief post-FOMC minutes dip on dovish elements, DXY touches Fib at 106.960 from 106.500 low.
  • Euro derives more support from rising EGB yields amidst hawkish ECB commentary, EUR/USD holds around 1.0150 amidst raft of option expiries extending beyond 1.0200.
  • Norwegian Krona underpinned by another half point hike from Norges Bank and signal for further tightening in September, EUR/NOK towards base of 9.8550-9.9150 range.
  • Aussie finds support at psychological level against Greenback after mixed jobs data, but Kiwi cautious ahead of NZ trade, AUD/USD nearer 0.6950 than 0.6900, NZD/USD closer to 0.6250 than 0.6300.
  • Sterling still stunned by double digit UK CPI and economic ramifications, Cable ducks under 1.2000, albeit fractionally and briefly.
  • Loonie gleans some traction from firmer oil prices pre-Canadian PPI, USD/CAD closer to 1.2900 than 1.2950.
  • Yuan retreats amidst reports of property loan portfolio probes and PBoC LPR cuts, USD/CNY 6.7900+ and USD/CNH 6.8000+.

Fixed Income

  • EGBs and Gilts regain some poise after extended and heavy declines on hawkish ECB rhetoric.
  • Bunds back up near 154.00 within 154.47-153.24 range, UK benchmark 114.00+ between 114.41-113.63 parameters.
  • US Treasuries idling post-FOMC minutes and pre-busy agenda - 10 year T-note flat at 118.24+ vs 119-01+ high and 118-18 low.

Commodities

  • WTI and Brent were bolstered by rhetoric from the Russian Defence Ministry re. Zaporizhia and as China's President Xi spoke
  • Currently, the benchmarks are in proximity to their respective highs of USD 89.56/bbl and USD 95.44/bbl.
  • Spot gold experienced a marginal haven bid bringing the yellow metal to an incremental new session peak of USD 1767/oz and eclipsing the 21-DMA at USD 1764/oz.
  • Broader metal space is mixed and features essentially unchanged action for Aluminium, after Wednesday’s noted rally, while LME Copper has climbed back towards a test of the USD 8k handle

Central Banks

  • ECB's Schnabel says a recession alone would not be enough to control inflation, growth is going to slow and a technical EZ recession is possible. Inflation concerns from before the July hike have not alleviated, outlook is unchanged. Number of indicators point to a de-anchoring of inflation expectations. Short-term inflation could still accelerate. Re. fragmentation: markets are more stable now, but volatility is elevated and liquidity is low.
  • Norwegian Key Policy Rate 1.75% vs. Exp. 1.75% (Prev. 1.25%) via a unanimous decision; policy rate will most likely be raised further in September. Click here for reaction & newsquawk analysis.
  • BoE will aim to unwind the full stock of Corporate Bond Purchase Scheme (CBPS) holdings at end-2023/early-2024, subject to market conditions.
  • Turkey's central bank shocked markets when it unexpectedly cut rates by 100bps to 13% from 14%. All 21 economists polled by Bloomberg had expected an unchanged print.

DB's Tim Wessel concludes the overnight wrap

Starting in Europe, where the looming energy crisis remains at the forefront. An update from our team, who just published the fourth edition of their indispensable gas monitor (link here), where they note the surprisingly fast rebuild of German gas storage, driven by reductions in industrial activity, reduces the risk that rationing may become reality this winter. Many more insights within, so do read the full piece for analysis spanning scenarios. Keep in mind, that while gas may be available, it is set to come at a higher clearing price, which manifest itself in markets yesterday where European natural gas futures rose a further +2.64% to €226 per megawatt-hour, just shy of their closing record at €227 in March. But, that’s still well beneath their intraday high from March, where at one point they traded at €345. Further, one-year German power futures increased +6.30%, breaching €500 for the first time, closing at €507. Germany is weighing consumer relief measures in light of climbing consumer prices and also announced that planned nuclear facility closures would be “temporarily” postponed.

The upward energy price pressure and attenuated (albeit, not eliminated) risk of rationing pushed European sovereign yields higher. 10yr German bunds climbed +7.1bps to 0.97%, while 10yr OATs kept the pace, increasing +7.4bps. 10yr BTPs increased +15.9bps, widening sovereign spreads, while high yield crossover spreads widened +10.2bps in the credit space.

Equities were resilient, however, with the STOXX 600 posting a +0.16% gain after flitting around a narrow range all day. Regional indices were also robust to climbing energy prices, with the DAX up +0.68% and the CAC +0.34% higher. In the States the S&P 500 registered a modest +0.19% gain, with the NASDAQ mirroring the index, falling -0.19%. Retail shares drove the S&P on the day, with the two consumer sectors both gaining more than +1%, following strong earnings reports from Wal Mart and Home Depot.

Treasury yields also climbed, but the story was the further flattening in the curve. 2yr yields were +7.5bps higher while 10yr yields managed to increase just +1.6bps, leaving 2s10s at its second most negative close of the cycle at -46bps. 10yr yields are another basis point higher this morning. A hodgepodge of data painted a mixed picture. Housing permits beat expectations (+1674k vs. +1640k) while starts (+1446k vs. +1527k) fell to their slowest pace since February 2021. However, under the hood, even permits weren’t necessarily as strong as first glance, as single family permits fell -4.3% with gains in multifamily pushing the aggregate higher. Indeed, year-over-year, single family permits have now fallen -11.7% while multifamily permits are +23.5% higher. So the single family housing market continues to feel the impact of Fed tightening. Meanwhile, industrial production climbed +0.6% month-over-month (vs. +0.3%), with capacity utilization hitting its highest level since 2008 at 80.3%.

Drifting north of the border, Canadian inflation slowed to 7.6% YoY in July in line with estimates, while the average of core measures climbed to a record 5.3%. Bank of Canada Governor Macklem penned an opinion piece saying that while it looks like inflation may have peaked, “the bad news is that inflation will likely remain too high for some time.” In turn, Canadian OIS rates by December climbed +16.2bps.

In other data, the expectations component of the German ZEW survey fell to -55.3, its lowest level since October 2008 at the depths of the GFC. In the UK, regular pay (excluding bonuses) fell by -3.0% in real terms over the year to April-June 2022, its fastest decline on record.

On the Iranian nuclear deal, EU negotiators reportedly found Iran’s response constructive, though Iran still had some concerns. Notably, Iran is looking for guarantees that if a future US administration withdraws from the JCPOA the US will "have to pay a price”, seeking insulation from the vagaries of representative democracy.

Asian equity markets are trading higher after Wall Street’s solid performance overnight. The Nikkei (+0.76%) is leading gains across the region with the Hang Seng (+0.57%), the Shanghai Composite (+0.23%) and the CSI (+0.51%) all rebounding from its opening losses this morning. US futures are struggling to gain traction this morning with the S&P 500 (-0.02%) and NASDAQ 100 (-0.09%) trading just below flat.

The Reserve Bank of New Zealand lifted its official cash rate (OCR) for the fourth consecutive time by an expected +50bps to 3%, a seven-year high, while bringing forward the estimate of future rate increases. The central bank expects the OCR will reach 3.69% at the end of this year and expects it to peak at 4.1% in March 2023, higher and sooner than previously forecast.

Early morning data coming out from Japan showed that exports rose +19.0% y/y in July (v/s +17.6% expected) posting 17 straight months of gains while imports advanced +47.2% (v/s +45.5% expected) driven by global fuel inflation and a weakening yen. With the imports outweighing exports, the nation reported trade deficit for the 14th consecutive month, swelling to -2.13 trillion yen in July (v/s -1.91 trillion yen expected) compared to a revised deficit of -1.95 trillion yen in June.

In terms of the day ahead, the FOMC minutes from July will be the main highlight, and the other central bank speaker will be Fed Governor Bowman. Otherwise, earnings releases include Target, Lowe’s and Cisco Systems, and data releases include US retail sales and UK CPI for July.

Tyler Durden Thu, 08/18/2022 - 08:18

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Simple blood test could predict risk of long-term COVID-19 lung problems

UVA Health researchers have discovered a potential way to predict which patients with severe COVID-19 are likely to recover well and which are likely to…

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UVA Health researchers have discovered a potential way to predict which patients with severe COVID-19 are likely to recover well and which are likely to suffer “long-haul” lung problems. That finding could help doctors better personalize treatments for individual patients.

Credit: UVA Health

UVA Health researchers have discovered a potential way to predict which patients with severe COVID-19 are likely to recover well and which are likely to suffer “long-haul” lung problems. That finding could help doctors better personalize treatments for individual patients.

UVA’s new research also alleviates concerns that severe COVID-19 could trigger relentless, ongoing lung scarring akin to the chronic lung disease known as idiopathic pulmonary fibrosis, the researchers report. That type of continuing lung damage would mean that patients’ ability to breathe would continue to worsen over time.

“We are excited to find that people with long-haul COVID have an immune system that is totally different from people who have lung scarring that doesn’t stop,” said researcher Catherine A. Bonham, MD, a pulmonary and critical care expert who serves as scientific director of UVA Health’s Interstitial Lung Disease Program. “This offers hope that even patients with the worst COVID do not have progressive scarring of the lung that leads to death.”

Long-Haul COVID-19

Up to 30% of patients hospitalized with severe COVID-19 continue to suffer persistent symptoms months after recovering from the virus. Many of these patients develop lung scarring – some early on in their hospitalization, and others within six months of their initial illness, prior research has found. Bonham and her collaborators wanted to better understand why this scarring occurs, to determine if it is similar to progressive pulmonary fibrosis and to see if there is a way to identify patients at risk.

To do this, the researchers followed 16 UVA Health patients who had survived severe COVID-19. Fourteen had been hospitalized and placed on a ventilator. All continued to have trouble breathing and suffered fatigue and abnormal lung function at their first outpatient checkup.

After six months, the researchers found that the patients could be divided into two groups: One group’s lung health improved, prompting the researchers to label them “early resolvers,” while the other group, dubbed “late resolvers,” continued to suffer lung problems and pulmonary fibrosis. 

Looking at blood samples taken before the patients’ recovery began to diverge, the UVA team found that the late resolvers had significantly fewer immune cells known as monocytes circulating in their blood. These white blood cells play a critical role in our ability to fend off disease, and the cells were abnormally depleted in patients who continued to suffer lung problems compared both to those who recovered and healthy control subjects. 

Further, the decrease in monocytes correlated with the severity of the patients’ ongoing symptoms. That suggests that doctors may be able to use a simple blood test to identify patients likely to become long-haulers — and to improve their care.

“About half of the patients we examined still had lingering, bothersome symptoms and abnormal tests after six months,” Bonham said. “We were able to detect differences in their blood from the first visit, with fewer blood monocytes mapping to lower lung function.”

The researchers also wanted to determine if severe COVID-19 could cause progressive lung scarring as in idiopathic pulmonary fibrosis. They found that the two conditions had very different effects on immune cells, suggesting that even when the symptoms were similar, the underlying causes were very different. This held true even in patients with the most persistent long-haul COVID-19 symptoms. “Idiopathic pulmonary fibrosis is progressive and kills patients within three to five years,” Bonham said. “It was a relief to see that all our COVID patients, even those with long-haul symptoms, were not similar.”

Because of the small numbers of participants in UVA’s study, and because they were mostly male (for easier comparison with IPF, a disease that strikes mostly men), the researchers say larger, multi-center studies are needed to bear out the findings. But they are hopeful that their new discovery will provide doctors a useful tool to identify COVID-19 patients at risk for long-haul lung problems and help guide them to recovery.

“We are only beginning to understand the biology of how the immune system impacts pulmonary fibrosis,” Bonham said. “My team and I were humbled and grateful to work with the outstanding patients who made this study possible.” 

Findings Published

The researchers have published their findings in the scientific journal Frontiers in Immunology. The research team consisted of Grace C. Bingham, Lyndsey M. Muehling, Chaofan Li, Yong Huang, Shwu-Fan Ma, Daniel Abebayehu, Imre Noth, Jie Sun, Judith A. Woodfolk, Thomas H. Barker and Bonham. Noth disclosed that he has received personal fees from Boehringer Ingelheim, Genentech and Confo unrelated to the research project. In addition, he has a patent pending related to idiopathic pulmonary fibrosis. Bonham and all other members of the research team had no financial conflicts to disclose.

The UVA research was supported by the National Institutes of Health, grants R21 AI160334 and U01 AI125056; NIH’s National Heart, Lung and Blood Institute, grants 5K23HL143135-04 and UG3HL145266; UVA’s Engineering in Medicine Seed Fund; the UVA Global Infectious Diseases Institute’s COVID-19 Rapid Response; a UVA Robert R. Wagner Fellowship; and a Sture G. Olsson Fellowship in Engineering.

  

To keep up with the latest medical research news from UVA, subscribe to the Making of Medicine blog at http://makingofmedicine.virginia.edu.


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Looking Back At COVID’s Authoritarian Regimes

After having moved from Canada to the United States, partly to be wealthier and partly to be freer (those two are connected, by the way), I was shocked,…

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After having moved from Canada to the United States, partly to be wealthier and partly to be freer (those two are connected, by the way), I was shocked, in March 2020, when President Trump and most US governors imposed heavy restrictions on people’s freedom. The purpose, said Trump and his COVID-19 advisers, was to “flatten the curve”: shut down people’s mobility for two weeks so that hospitals could catch up with the expected demand from COVID patients. In her book Silent Invasion, Dr. Deborah Birx, the coordinator of the White House Coronavirus Task Force, admitted that she was scrambling during those two weeks to come up with a reason to extend the lockdowns for much longer. As she put it, “I didn’t have the numbers in front of me yet to make the case for extending it longer, but I had two weeks to get them.” In short, she chose the goal and then tried to find the data to justify the goal. This, by the way, was from someone who, along with her task force colleague Dr. Anthony Fauci, kept talking about the importance of the scientific method. By the end of April 2020, the term “flatten the curve” had all but disappeared from public discussion.

Now that we are four years past that awful time, it makes sense to look back and see whether those heavy restrictions on the lives of people of all ages made sense. I’ll save you the suspense. They didn’t. The damage to the economy was huge. Remember that “the economy” is not a term used to describe a big machine; it’s a shorthand for the trillions of interactions among hundreds of millions of people. The lockdowns and the subsequent federal spending ballooned the budget deficit and consequent federal debt. The effect on children’s learning, not just in school but outside of school, was huge. These effects will be with us for a long time. It’s not as if there wasn’t another way to go. The people who came up with the idea of lockdowns did so on the basis of abstract models that had not been tested. They ignored a model of human behavior, which I’ll call Hayekian, that is tested every day.

These are the opening two paragraphs of my latest Defining Ideas article, “Looking Back at COVID’s Authoritarian Regimes,” Defining Ideas, March 14, 2024.

Another excerpt:

That wasn’t the only uncertainty. My daughter Karen lived in San Francisco and made her living teaching Pilates. San Francisco mayor London Breed shut down all the gyms, and so there went my daughter’s business. (The good news was that she quickly got online and shifted many of her clients to virtual Pilates. But that’s another story.) We tried to see her every six weeks or so, whether that meant our driving up to San Fran or her driving down to Monterey. But were we allowed to drive to see her? In that first month and a half, we simply didn’t know.

Read the whole thing, which is longer than usual.

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The hostility Black women face in higher education carries dire consequences

9 Black women who were working on or recently earned their PhDs told a researcher they felt isolated and shut out.

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Isolation can make opportunities elusive. fotostorm via Getty Images

Isolated. Abused. Overworked.

These are the themes that emerged when I invited nine Black women to chronicle their professional experiences and relationships with colleagues as they earned their Ph.D.s at a public university in the Midwest. I featured their writings in the dissertation I wrote to get my Ph.D. in curriculum and instruction.

The women spoke of being silenced.

“It’s not just the beating me down that is hard,” one participant told me about constantly having her intelligence questioned. “It is the fact that it feels like I’m villainized and made out to be the problem for trying to advocate for myself.”

The women told me they did not feel like they belonged. They spoke of routinely being isolated by peers and potential mentors.

One participant told me she felt that peer community, faculty mentorship and cultural affinity spaces were lacking.

Because of the isolation, participants often felt that they were missing out on various opportunities, such as funding and opportunities to get their work published.

Participants also discussed the ways they felt they were duped into taking on more than their fair share of work.

“I realized I had been tricked into handling a two- to four-person job entirely by myself,” one participant said of her paid graduate position. “This happened just about a month before the pandemic occurred so it very quickly got swept under the rug.”

Why it matters

The hostility that Black women face in higher education can be hazardous to their health. The women in my study told me they were struggling with depression, had thought about suicide and felt physically ill when they had to go to campus.

Other studies have found similar outcomes. For instance, a 2020 study of 220 U.S. Black college women ages 18-48 found that even though being seen as a strong Black woman came with its benefits – such as being thought of as resilient, hardworking, independent and nurturing – it also came at a cost to their mental and physical health.

These kinds of experiences can take a toll on women’s bodies and can result in poor maternal health, cancer, shorter life expectancy and other symptoms that impair their ability to be well.

I believe my research takes on greater urgency in light of the recent death of Antoinette “Bonnie” Candia-Bailey, who was vice president of student affairs at Lincoln University. Before she died by suicide, she reportedly wrote that she felt she was suffering abuse and that the university wasn’t taking her mental health concerns seriously.

What other research is being done

Several anthologies examine the negative experiences that Black women experience in academia. They include education scholars Venus Evans-Winters and Bettina Love’s edited volume, “Black Feminism in Education,” which examines how Black women navigate what it means to be a scholar in a “white supremacist patriarchal society.” Gender and sexuality studies scholar Stephanie Evans analyzes the barriers that Black women faced in accessing higher education from 1850 to 1954. In “Black Women, Ivory Tower,” African American studies professor Jasmine Harris recounts her own traumatic experiences in the world of higher education.

What’s next

In addition to publishing the findings of my research study, I plan to continue exploring the depths of Black women’s experiences in academia, expanding my research to include undergraduate students, as well as faculty and staff.

I believe this research will strengthen this field of study and enable people who work in higher education to develop and implement more comprehensive solutions.

The Research Brief is a short take on interesting academic work.

Ebony Aya received funding from the Black Collective Foundation in 2022 to support the work of the Aya Collective.

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