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AstraZeneca closes busy week with $11B in revenue, new R&D site

AstraZeneca topped off a very busy week with the company’s first-quarter 2022 financial report, citing a total of $11.39 billion in revenue, a whopping…

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Penny Stocks To Watch: Why TOUR, JAN, ENDP, BRDS & WEJO Stock Are Moving

Penny stocks to watch with news
The post Penny Stocks To Watch: Why TOUR, JAN, ENDP, BRDS & WEJO Stock Are Moving appeared first on Penny Stocks to…

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Penny stocks are well-known for their high-risk and high-reward potential. When it comes to a choppy stock market, traders will flock to some of these names for quick gains instead of taking a chance at investing in a broader market that still has some downside left.

Needless to say, this week, in particular, could bring more speculation and uncertainty thanks to key economic data. The foremost is second-quarter GDP results set to report on Wednesday. The biggest question is, will GDP data signal signs or even confirm a recession?

According to the Bureau of Economic Analysis, the figures show some interesting trends:

“Real gross domestic product (GDP) decreased at an annual rate of 1.5 percent in the first quarter of 2022, following an increase of 6.9 percent in the fourth quarter of 2021. The decrease was revised down 0.1 percentage point from the “advance” estimate released in April. In the first quarter, there was a resurgence of COVID-19 cases from the Omicron variant and decreases in government pandemic assistance payments.”

But whether or not this read-out is bullish or bearish may not matter much to traders looking for penny stocks to buy. Let’s explain.

Penny Stocks To Watch

In general, broader market trends take a back seat to whatever individual catalysts are at play with penny stocks. If you’ve traded long enough, I’m sure you’ve seen the stock market crash lower, yet several penny stocks are exploding higher. This detached trend is unique and has become one of many reasons traders hunt for top trending penny stocks daily.

One of the most prominent reasons for cheap stocks to move iradically even with the stock market down tends to involve headlines. These can become significant catalysts for a bullish (or bearish) trend. Here’s a quick list of penny stocks with news that are moving during the week.

  • Wejo Group Limited (NASDAQ: WEJO)
  • Bird Global Inc. (NYSE: BRDS)
  • Tuniu Corp. (NASDAQ: TOUR)
  • JanOne Inc. (NASDAQ: JAN)
  • Endo International (NASDAQ: ENDP)

Best Penny Stocks To Buy Now

Are penny stocks with news the best to buy now? Much of that answer deals with specific trading styles. Sometimes, news catalysts can be short-lived, primarily suitable for day traders. In other instances, headlines include verbiage and further discussion that prompt a longer-term forecast for some. If a company posts news, diving deeper beyond the headline is a good idea.

Wejo Group Limited (NASDAQ: WEJO)

Who said penny stocks have no legitimate business with well-established companies? Wejo Group is a prime example of why that statement isn’t accurate. The smart-mobility could solutions company focuses on electric and autonomous vehicle data. This has become a point of interest for those looking at car companies aiming for self-driving and a more tech-focused model.

Why WEJO Stock Is Moving

This week, Wejo Group announced a collaboration with none other than Ford Motor Company (NYSE: F) in Europe. The two will leverage data and insights where Wejo can access personalized connected vehicle data from Ford vehicles.

“Providing actionable data insights to insurance providers is another example of how Wejo is expanding into additional markets and demonstrating new use cases for OEMs and insurance companies to monetize connected vehicle data for good,” said Richard Barlow, founder, and CEO, of Wejo.

Bird Global Inc. (NYSE: BRDS)

Another mobility company on the list of penny stocks to watch is one you might have seen “scooting” around your city. Bird Global offers eScooters and eBikes that anyone can rent using a Bird-connected app. Billing itself as a “micro electric vehicle company,” Bird’s suite of scooters and bikes is becoming popular among riders looking for urban travel without getting in an actual vehicle. Unfortunately, BRDS stock wasn’t such a high flyer after its IPO debut last year. Shares have gone from highs of $11.25 to lows of $0.4648 in a matter of 7 months.

Why BRDS Stock Is Moving

Earlier this month, Bird received a notice of non-compliance with the NYSE based on its low share price. The exchange requires companies to maintain a closing price of at least $1 for 30 consecutive trading days to keep the listing. Considering that the company plans to notify the NYSE by July 5th of its intention to “cure” the stock price deficiency, there could be some speculation building as the countdown begins.

Tuniu Corp. (NASDAQ: TOUR)

Travel is one of the industries taking a back seat over the last few years. Thanks to the rise of the pandemic and continued COVID restrictions, travel stocks haven’t faired as well as their market cohorts. However, the area of the industry that has remained beaten down involves companies with exposure to China’s market.

Tuniu Corp. is a prime example of the bearish sentiment for Chinese travel stocks. TOUR stock has slumped from over $2 to under $0.50 within the last year. The company offers an online leisure travel service focused on prepackaged and self-guided tours. This week, TOUR stock’s tides changed a bit, and shares have begun to rally.

[Read More] What to Know About Buying Penny Stocks on June 28th

Why TOUR Stock Is Moving

There isn’t any TOUR stock-specific news. However, broader industry information has come to light and acted as a catalyst. In particular, China has begun loosening its COVID quarantine rules. As a result, bullish sentiment has returned to the sector, prompting momentum in several travel names, including Tuniu.

JanOne Inc. (NASDAQ: JAN)

JanOne develops drugs with non-addictive and pain-relieving properties. One of its focuses is on curbing the opioid crisis. Its JAN101 platform is being developed for treating peripheral artery disease and is a catalyst behind the latest move in JAN stock today.

Why JAN Stock Is Moving

This week, JanOne announced that work was completed with Dr. Maureen Donovan at the University of Iowa. It will allow for an improved formulation of JAN101, which has been used successfully in trials for reducing pain and improving nerve function. Furthermore, JanOne expects to start manufacturing and validating processes “in the near future.”

One of the other attractive points of interest for traders is JAN stock’s float. Looking at multiple outlets, you’ll see that this figure is well below 10 million shares. In cases of low float penny stocks, volatility can play a leading role. Given the latest headline, this could be something to keep in mind heading into the rest of the week.

Endo International (NASDAQ: ENDP)

Shares of Endo International took flight this week. The specialty pharmaceutical company recently focused on developing an orthopedic product for treating osteoarthritis knee pain. It signed a deal with Taiwan Liposome to commercialize its TLC599 injectable compound, which is in Phase 3 development for osteoarthritis treatment.

[Read more] Penny Stocks To Buy Now? 4 Biotech Stocks To Watch Before July 2022

“TLC599 is fully aligned with our commitment to providing differentiated nonsurgical options to healthcare providers and their appropriate patients,” said Patrick Barry, Executive Vice President, and President, Global Commercial Operations at Endo, in a June 13th update.

Why ENDP Stock Is Moving

You won’t find anything in corporate newsfeeds if you’re looking for why ENDP stock is moving right now. However, if you dig deeper into the company’s filings, there may be something evident acting as a catalyst in the stock market today. Millennium Management LLC filed a 13G on June 27th, showing a 1.7% stake in the company. In our article Buy Penny Stocks Like Hedge Funds Do: A How-To Guide, we discussed specific forms and filings to pay attention to if you want to “follow” the money of investment firms.

A 13G pertains to “passive investors” owning less than 20% of a company’s outstanding shares. Once a “passive investor” reaches over 20% of the OS, they must start filing 13D statements.

Best Penny Stocks Today

News can be a way to find names for your penny stocks list. However, when it’s time to buy them, it’s best to dig a little deeper to determine if that news has lasting potential. Penny stocks with news experience volatility early. When it comes to follow-through, much of that comes down to the market itself. Today we looked at 5 penny stocks with news, industry-related speculation, or corporate developments. After seeing why they moved, are any on your watch list right now?

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The post Penny Stocks To Watch: Why TOUR, JAN, ENDP, BRDS & WEJO Stock Are Moving appeared first on Penny Stocks to Buy, Picks, News and Information | PennyStocks.com.

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COVID Falls From G7 Agenda – Focus Now On Russia, Russia, Russia

COVID Falls From G7 Agenda – Focus Now On Russia, Russia, Russia

Remember at the beginning of this year when you could not turn on the TV…

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COVID Falls From G7 Agenda - Focus Now On Russia, Russia, Russia

Remember at the beginning of this year when you could not turn on the TV or log on to the web without being bombarded by a non-stop wave of covid fear mongering? 

Remember when you couldn't even ask questions about the validity of the claims made by Anthony Fauci, the CDC and others without getting booted from social media? 

Remember the insanity and the zealotry of the devout covid cult sitting in their cars with masks on, walking around outside with their masks on, and then getting right in people's faces when they didn't have a mask on?

The covid pandemic event was a near perfect combination of induced fear in the minds of cowards, along with induced authoritarianism in the minds of people who, deep down, desperately want to control everyone else around them.

Where did all the hype go?  It disappeared in a matter of weeks once the corporate media gave up on the narrative.  There were a few reasons for this...

First, the Infection Fatality Rate of covid was far too small to warrant all the doom mongering.  With an average IFR of only 0.27% (recently adjusted to 0.23%), the vast majority of people have nothing to worry about from the virus.  Second, the lie of the “pandemic of the unvaccinated was exposed.  In fact, states and countries that actually tracked “breakthrough infections” showed that the vaccinated were far more likely to get infected than people who were not vaccinated and had natural immunity.  Third, the vaccine passport efforts failed in the US at the federal level and in red states, and thus, the rest of the world saw that half the country could function perfectly fine without medical tyranny.

Once there is a working example that defies the medical tyranny model, other countries are going to demand answers for why they have to remain in lockdown while some people can be free?  Only a few nations with the most extreme authoritarianism (like China) continue to enforce lockdowns and vax controls.  

All the excuses for lockdowns and forced vaccinations fell apart in the US, and any further push for vax passports was inspiring millions of Americans to potentially take up arms.  So, the establishment walked away from the plan.  It was as simple as that.

This abandonment of the precious covid program has been made evident in the latest G7 summit, which does not seem to have covid listed as a topic of discussion, and the pandemic has so far been completely overshadowed by other concerns.  World leaders have clearly moved on and are not even wearing masks for show anymore (If the vaccines actually work, what do you need a mask for?  If they don't work, then why take one?).  Instead, the subject of Russia and the war in Ukraine is dominating G7.  Secondary topics include climate change and “gender equality.”

The notion of covid as a nothing-burger issue seems to fall in line with shifts in public focus.  Inflation is currently on the top of the list of biggest problems facing the US (and most other countries), followed by violent crime.  Covid rates at the very bottom of the list in polling.  

The G7 summit will surely touch on inflation and other economic issues, but they appear intent on doing so only as a way to blame Russia for our economic decline.  To reiterate a fact that Joe Biden and many other world leader refuse to admit to:  The inflation crisis started WAY before Russia invaded Ukraine.  While sanctions against Russia will definitely expound on supply chain problems, the bigger issue is central bank fiat printing and too many dollars chasing too few goods.  

The Ukraine situation is also fading as a subject of widespread outrage among Americans.  Europe is more immediately affected because of their dependency on Russian oil and natural gas, but questions are rising about why we should be so focused on Ukraine when there are much bigger problems closer to home.  Overall, establishment politicians continue to ignore the one issue that the majority of the world wants answers and solutions for, which is economic decline.  But, in order to offer answers, they would first have to acknowledge the true gravity of the threat, and they're not going to do that until it's far too late to do anything about it. 

Tyler Durden Tue, 06/28/2022 - 08:47

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Epigenetics Links Severe Inflammatory Syndrome in Children to COVID Infection

Multisystem Inflammatory Syndrome in Children (MIS-C) is related with the epigenetic deregulation of a set of immune-controlling genes. A new study in…

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Scientists from the Josep Carreras Leukemia Research Institute and the Bellvitge Biomedical Research Institute (IDIBELL), say they have identified an epigenetic signature associated to the development of the Multisystem Inflammatory Syndrome in Children (MIS-C) after a SARS-CoV-2 virus infection. The signature has been named EPIMISC, in line with previous studies on the epigenetics of COVID-19 from the same team, which published this recent study, “Epigenetic profiling linked to multisystem inflammatory syndrome in children (MIS-C): A multicenter, retrospective study,” in eClinicalMedicine.

One of the puzzles of infection with the virus has been the remarkable resilience of children to exhibit severe COVID-19. However, a small percentage of the pediatric population affected by the virus experienced a serious health condition called MIS-C, also known as pediatric inflammatory multisystem syndrome (PIMS), that require admission to intensive care unit in around 60% of cases.

In MIS-C, different parts of the body can become inflamed, including the heart, lungs, kidneys, brain, skin, eyes, or gastrointestinal organs. The factors associated with the appearance of MIS-C beyond the presence of the virus are unknown.

“Most children and adolescents infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain asymptomatic or develop a mild coronavirus disease 2019 (COVID-19) that usually does not require medical intervention,” write the investigators.

“However, a small proportion of pediatric patients develop a severe clinical condition, multisystem inflammatory syndrome in children (MIS-C). The involvement of epigenetics in the control of the immune response and viral activity prompted us to carry out an epigenomic study to uncover target loci regulated by DNA methylation that could be altered upon the appearance of MIS-C.

Manel Esteller, MD, PhD, and Aurora Pujol, MD, PhD, served as the coordinators of the research about epigenetic alterations associated with Multisystem Inflammatory Syndrome in Children (MIS-C), a rare disorder that could appear in pediatric COVID-19. [Josep Carreras Leukemia Research Institute]
“Peripheral blood samples were recruited from 43 confirmed MIS-C patients. 69 non-COVID-19 pediatric samples and 15 COVID-19 pediatric samples without MIS-C were used as controls. The cases in the two groups were mixed and divided into discovery (MIS-C = 29 and non-MIS-C = 56) and validation (MIS-C = 14 and non-MIS-C = 28) cohorts, and balanced for age, gender, and ethnic background. We interrogated 850,000 CpG sites of the human genome for DNA methylation variants.

“The DNA methylation content of 33 CpG loci was linked with the presence of MIS-C. Of these sites, 18 (54.5%) were located in described genes. The top candidate gene was the immune T-cell mediator ZEB2; and others highly ranked candidates included the regulator of natural killer cell functional competence SH2D1B; VWA8, which contains a domain of the Von Willebrand factor A involved in the pediatric hemostasis disease; and human leukocyte antigen complex member HLA-DRB1; in addition to pro-inflammatory genes such as CUL2 and AIM2.

“The identified loci were used to construct a DNA methylation profile (EPIMISC) that was associated with MIS-C in both cohorts. The EPIMISC signature was also overrepresented in Kawasaki disease patients, a childhood pathology with a possible viral trigger, that shares many of the clinical features of MIS-C.

“We have characterized DNA methylation loci that are associated with MIS-C diagnosis. The identified genes are likely contributors to the characteristic exaggerated host inflammatory response observed in these patients. The described epigenetic signature could also provide new targets for more specific therapies for the disorder.”

“The COVID-19 disease in adults is characterized by difficulty breathing, while the studied rare syndrome associated with the same virus in children affects many more organs and can have severe consequences,” said Manel Esteller, MD, PhD, director of the Josep Carreras Leukemia Research Institute (IJC), ICREA Research Professor, and professor of genetics at the University of Barcelona. “As the bases for the disorder are unknown, we decided to compare the epigenome of healthy children, children with COVID-19 without MIS-C, and children with COVID-19 who experienced MIS-C.

“We found that MIS-C is characterized by a specific deregulation of epigenetic cellular programming that leads to a landscape of hyperinflammation that can damage tissues.”

The results of the study showed that specific genes were affected in patients, such as those associated with the activation of T lymphocytes, natural killer cells, the recognition of antigens and coagulation. This pattern of epigenetic deregulation was also observed in Kawasaki Syndrome, another inflammatory disease that peaked in 2009 and possibly linked to infection with the influenza virus A H1N1.

Interestingly, two of the 33 DNA methylation events that define the EPIMISC signature are also characteristic of adults without comorbidities who develop severe COVID-19 disease, as previously defined in the EPICOVID signature found by the same team last year.

This fact confirms that both processes, MIS-C in children and severe acute respiratory distress syndrome in adults, are inflammatory post-infectious complications and could be treated in a different way than the initial phase of the viral infection. On this regard, researchers hypothesize that pharmacological inhibition of the CUL2 gene, a mediator of inflammation, could be useful for MIS-C patients since it is known to protect against hyperinflammatory responses.

“It is interesting to see that two disorders that exhibit similar clinical manifestations, MIS-C and Kawasaki, also share a common epigenetic signature, which is different to the epigenetic signature caused by other viruses including HIV,” noted Aurora Pujol, MD, PhD, IDIBELL.

In the same line, Esteller concludes that “it seems that in both syndromes, MIS-C and Kawasaki, there is an exaggerated reaction of the children’s immune system against a viral attack. Knowing the mechanisms triggering both diseases will give us better tools to diagnose and treat them.”

The post Epigenetics Links Severe Inflammatory Syndrome in Children to COVID Infection appeared first on GEN - Genetic Engineering and Biotechnology News.

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