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AAV Gene Therapy Discovery and Optimization
In this GEN webinar, our expert speakers Weiheng Su, PhD, and Qiong Zhou, PhD, will discuss strategies and tools for designing optimal viral vectors…
Broadcast Date: October 31, 2023
Time: 8:00 am PT, 11:00 am ET, 17:00 CET
Gene therapies are maturing rapidly with an increasing number of these treatments gaining regulatory approval in recent years. Viral vectors, such as adeno-associated viruses (AAVs), have emerged as one of the most used gene delivery vehicles in many disease contexts. Their unique features make them suitable vectors for in vivo gene therapies for various conditions including ophthalmological, metabolic, hematological, and neurological diseases.
In this GEN webinar, our expert speakers will discuss strategies and tools for designing optimal viral vectors for gene therapy delivery. They will present an integrated platform designed to support the discovery stages of a viral gene therapy program. During the webinar, you’ll learn:
• How WuXi AppTec can help to engineer and optimize viral vectors, including rationalized promoter design and transcription unit optimization.
• Fast, scalable, cost-effective viral vector production methods using industry standard transient transfection, packaging cell lines, and the novel TESSA technology.
• How to utilize a range of in vitro and in vivo assays for efficacy and safety evaluation.
A live Q&A session will follow the presentation, offering you a chance to pose questions to our expert panelists.
Webinar produced with support from:
The post AAV Gene Therapy Discovery and Optimization appeared first on GEN - Genetic Engineering and Biotechnology News.
genetic therapyUncategorized
Walmart and Target make key self-checkout changes to fight theft
Both chains are making changes customers may not like, but self-checkout isn’t going anywhere, according to one industry expert.
In parts of the world, public bathrooms come with a charge, but people pay on the honor system. The money charged allows for better upkeep of the facilities and most people don't mind dropping a small bill or some coins into a lockbox and many of the people who don't are likely dealing with larger problems.
The honor system, however, requires honor. It's based on the idea that most people are trustworthy and that they will pay their fair share.
Related: Beloved mall retailer files Chapter 7 bankruptcy, will liquidate
In the case of a bathroom, people cheating the system are only stealing a low-value service. In the case of self-checkout, a variation on the honor system, people looking to steal by "forgetting" to scan an item can be a very expensive problem.
That has led retailers including Target, Walmart, and Dollar General to make changes. Target has limited the amount of items you can scan at self-checkout at some stores while Dollar General has literally eliminated it in some locations.
Walmart, like Target, has experimented with item limits and limiting the hours of operation for self-checkout. Now, in some stores, the chain has decided to designate some of its self-checkout stations for Walmart+ members and delivery drivers using the Spark app.
Advantage Solutions General Manager Andy Keenan answered some questions about Walmart, self-checkout, and theft from TheStreet via email.
What Walmart's self-checkout changes mean
TheStreet: What are the benefits of reserving self-checkout registers for Spark drivers and Walmart+ customers?
Keenan: The benefits include exclusivity and perks of membership, speed, and convenience when shopping.
TheStreet: If this rolls out more broadly, what do you anticipate being the impact on non-Walmart+ customers?
Keenan: There is the potential for non-Walmart+ customers to become agitated, they are losing convenience because they are not enrolled. Customers who are looking for convenience will have fewer options for speed to check out.
TheStreet: Do lane restrictions like limiting lanes to 10 items or fewer help reduce time spent waiting in lines?
Keenan: Yes, but retailers must have a diverse amount of check lane options including 10 items or fewer to ensure that the speed of checkout actually transpires.
TheStreet: Do you believe self-checkout is leading to partial shrink? If so, do you think that this move to shut off self-checkout lanes will help prevent theft in the future?
Keenan: Yes, self-checkout is leading to partial shrink. We believe this tends to be more due to errors in scanning and intentional theft.
There are already front-end transformation tests going on in stores, reducing the number of self-checkouts and shifting back to cashier checkouts in order to measure the reduction in shrink. Early indicators show that a move back to cashier checkouts combined with other shrink initiatives will help prevent theft.
Self-checkout is not going away
While changes are ongoing, Keenan believes self-checkout is here to stay.
“Self-checkout is not, as one recent article called it, a failed experiment. It’s actually part of the next evolution of the retail customer experience, and evolutions take time,” Keenan said in a web post about the findings of the 2024 Advantage Shopper Outlook survey.
He makes it clear that rising labor costs and struggles to find workers make some for of self-checkout inevitable.
“Since the pandemic, there’s been a revolution on hourly labor,” Keenan said. “Labor in certain markets that would cost you $16 an hour now costs you $19 or $20 an hour, and it’s a gig economy. The people who once stood at a checkout stand in the front of a store are now driving for Instacart or DoorDash because the hours are more flexible. They want to make their own schedule, and it’s varied work. Today, most retailers can’t offer that.”
Basically, while there are kinks to work out, self-checkout simply makes sense for retailers.
“The notion that we’re going to pivot away from technology that helps offset labor needs and will ultimately continue to improve customer experience because of some challenges is far-fetched. We need to continue to embrace the technology and realize that it may always be imperfect, but it will always be evolving. The noise that, ‘Oh, self-checkout might not be working,’ that’s just a moment in time,” he added.
bankruptcy pandemicUncategorized
Hitting Home: Housing Affordability in the U.S.
The Issue:
Housing is becoming unaffordable to a widening swathe of the American population. This deteriorating affordability directly impacts American…
The Issue:
Housing is becoming unaffordable to a widening swathe of the American population. This deteriorating affordability directly impacts American lives, including where people choose to live and work. It has also been cited as a major contributor to key social problems like rising homelessness and worsening child wellbeing.
The Facts:
- Median house prices are now 6 times the median income, up from a range of between 4 and 5 two decades ago. In cities along the coasts, the numbers are higher, exceeding 10 in San Francisco.
- The ratio of median rents to median income has also crept from 25 percent to 30 percent in two decades.
- Households — renters in particular — are increasingly cost-burdened, having to spend more than 30% of their income on rent, mortgage and other housing needs. Among homeowners, about 40 percent of those in the $35-49 income range are cost-burdened. The share of cost-burdened renters in that income range has risen sharply from under 40 percent of households in 2010 to over 60 percent today (see chart).
- Historically, rural and interior areas of the country have been more affordable. But, even prior to the pandemic, migration toward these locations has helped drive faster house price appreciation than in more expensive regions.
- Demographic developments have contributed to the demand-supply imbalance. Supply is crimped by more older Americans opting to age in place. On the demand side, the biggest driver is new household formation. Americans formed about a million new households a year between 2015-2017, but the pace has almost doubled according to the most recent data, largely reflecting a pickup in household formation rates among millennials.
- A long-standing lack of homebuilding, which partly reflects tight regulatory restrictions in many parts of the country, has also contributed to rising home prices.
- More recently, higher interest rates since 2022 have exacerbated these secular trends to make housing even more unaffordable. The mortgage rate on a 30-year home loan soared from 3 ½ percent in early 2022 to nearly 8% in October 2023 as the Fed raised policy interest rates; the mortgage rate had only eased to about 7% in March 2024 as the tightening cycle had peaked. The problem is compounded by mortgage lock-in: higher interest rates have left many homeowners — many of whom bought homes or refinanced at the lows of 2020-21 — with cheaper-than-market mortgages, reluctant to sell their house and reset their mortgage at current, higher rates.
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Good news and bad news Thursday: the bad news is real retail sales
– by New Deal democratThe bad economic news this morning was that after taking into account inflation, retail sales, which rose 0.6% nominally, were…
- by New Deal democrat
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