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3D and 4D technology market size to increase by USD 371.19 billion: North America will account for 47% of market growth – Technavio

3D and 4D technology market size to increase by USD 371.19 billion: North America will account for 47% of market growth – Technavio
PR Newswire
NEW YORK, Jan. 25, 2023

NEW YORK, Jan. 25, 2023 /PRNewswire/ — The 3D and 4D Technology Market by Solut…

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3D and 4D technology market size to increase by USD 371.19 billion: North America will account for 47% of market growth - Technavio

PR Newswire

NEW YORK, Jan. 25, 2023 /PRNewswire/ -- The 3D and 4D Technology Market by Solution, End-user, and Geography - Forecast and Analysis 2023-2027 report has been published by Technavio. Market growth is estimated to accelerate at a CAGR of 19.64% and register an incremental growth of USD 371.19 billion during the forecast period. The report provides a comprehensive analysis of growth opportunities at regional levels, new product launches, the latest trends, and the post-pandemic recovery of the global market. Download a PDF sample report

Company profiles

The 3D and 4D technology market report includes information on the key products and recent developments of leading vendors, including:

  • 3D Systems Corp.: The company offers 3D and 4D technology products such as 3D printers.
  • American Paper Optics LLC: The company offers 3D and 4D technology products such as 3D Fireworks glasses.
  • Autodesk Inc: The company offers 3D and 4D technology products such as 3ds Max.
  • Barco NV: The company offers 3D and 4D technology products such as 3D walls, canvas, caves.
  • Desktop Metal Inc.: The company offers 3D and 4D technology products through its subsidiary ExOne Company.
  • Dolby Laboratories Inc.
  • FARO Technologies Inc.
  • General Electric Co.
  • Hexagon AB
  • To gain access to more vendor profiles available with Technavio, buy the report!

Regional analysis

Based on region, the global 3D and 4D technology market is segmented into North America, APAC, Europe, South America, and the Middle East and Africa. North America is estimated to account for 47% of the market's growth during the forecast period. An increase in government investments and the growing demand for 3D printers in the consumer electronics, education, and defense sectors are driving the growth of the market in the region. The expansion of facilities and the extensive use of 3D printing technology for different components and parts will also propel the growth of the regional market during the forecast period

Market dynamics

The market is driven by factors such as the use of 3D and 4D in security and surveillance systems, the increasing adoption of 3D displays in advertisement, and the growing prevalence of 3D printing technology. However, the high cost associated with 3D displays is hindering market growth.

Competitive analysis

The competitive scenario categorizes companies based on various performance indicators. Some of the factors considered include the financial performance of companies over the past few years, growth strategies, product innovations, new product launches, investments, growth in market share, among others. Request a sample

Market segmentation

  • Based on the solution, the market is segmented into 3D and 4D output device and 3D and 4D input device. The 3D and 4D output device segment accounted for the largest share of the market in 2022.
  • Based on geography, the market is segmented into North America, APAC, Europe, South America, and Middle East and Africa. North America held the largest share of the market in 2022.
  • Based on end-user, the market is segmented into entertainment, consumer electronics, and others.

Related Reports:

The 3D imaging market size is expected to increase by USD 29.17 billion from 2021 to 2026, and the market's growth momentum will accelerate at a CAGR of 17.5%. The increasing product launches is notably driving the 3D imaging market growth, although factors such as high initial costs of 3D imaging equipment may impede the market growth.

The 3D sensors market size is expected to increase by USD 10.84 billion from 2021 to 2026, and the market's growth momentum will accelerate at a CAGR of 23.19%. The use of 3D sensors in security and surveillance systems is notably driving the market growth, although factors such as accuracy and calibration issues during sensor fusion may impede the market growth.

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What are the key data covered in this 3D and 4D technology market report?

  • CAGR of the market during the forecast period
  • Detailed information on factors that will drive the growth of the 3D and 4D technology market between 2023 and 2027
  • Precise estimation of the 3D and 4D technology market size and its contribution to the parent market
  • Accurate predictions about upcoming trends and changes in consumer behavior
  • Growth of the industry across North America, Europe, APAC, Middle East and Africa, and South America
  • A thorough analysis of the market's competitive landscape and detailed information about vendors
  • Comprehensive analysis of factors that will challenge the growth of 3d and 4d technology market vendors

3D And 4D Technology Market Scope

Report Coverage

Details

Page number

162

Base year

2022

Historic period

2017-2021

Forecast period

2023-2027

Growth momentum & CAGR

Accelerate at a CAGR of 19.64%

Market growth 2023-2027

USD 371.19 billion

Market structure

Fragmented

YoY growth 2022-2023(%)

18.64

Regional analysis

North America, Europe, APAC, Middle East and Africa, and South America

Performing market contribution

North America at 47%

Key countries

US, China, Japan, Germany, and UK

Competitive landscape

Leading vendors, market positioning of vendors, competitive strategies, and industry risks

Key companies profiled

3D Systems Corp., American Paper Optics LLC, Barco NV, Desktop Metal Inc., Dolby Laboratories Inc., FARO Technologies Inc., General Electric Co., Hexagon AB, Koninklijke Philips NV, LG Electronics Inc., Nikon Corp., Optomec Inc., Panasonic Holdings Corp., Renishaw Plc, Samsung Electronics Co. Ltd., Sharp Corp., Sony Group Corp., Stratasys Ltd., Vicon Motion Systems Ltd., and Autodesk Inc.

Market dynamics

Parent market analysis, market growth inducers and obstacles, fast-growing and slow-growing segment analysis, COVID-19 impact and recovery analysis and future consumer dynamics, and market condition analysis for the forecast period.

Customization purview

If our report has not included the data that you are looking for, you can reach out to our analysts and get segments customized.

Browse for Technavio's information technology market reports

Table of contents:

1 Executive Summary

  • 1.1 Market overview 
    • Exhibit 01: Executive Summary – Chart on Market Overview
    • Exhibit 02: Executive Summary – Data Table on Market Overview
    • Exhibit 03: Executive Summary – Chart on Global Market Characteristics
    • Exhibit 04: Executive Summary – Chart on Market by Geography
    • Exhibit 05: Executive Summary – Chart on Market Segmentation by Solution
    • Exhibit 06: Executive Summary – Chart on Market Segmentation by End-user
    • Exhibit 07: Executive Summary – Chart on Incremental Growth
    • Exhibit 08: Executive Summary – Data Table on Incremental Growth
    • Exhibit 09: Executive Summary – Chart on Vendor Market Positioning

2 Market Landscape

  • 2.1 Market ecosystem 
    • Exhibit 10: Parent market
    • Exhibit 11: Market Characteristics

3 Market Sizing

  • 3.1 Market definition 
    • Exhibit 12: Offerings of vendors included in the market definition
  • 3.2 Market segment analysis 
    • Exhibit 13: Market segments
  • 3.3 Market size 2022
  • 3.4 Market outlook: Forecast for 2022-2027 
    • Exhibit 14: Chart on Global - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 15: Data Table on Global - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 16: Chart on Global Market: Year-over-year growth 2022-2027 (%)
    • Exhibit 17: Data Table on Global Market: Year-over-year growth 2022-2027 (%)

4 Historic Market Size

  • 4.1 Global 3D and 4D technology market 2017 - 2021
    • Exhibit 18: Historic Market Size – Data Table on Global 3D and 4D technology market 2017 - 2021 ($ billion)
  • 4.2 Solution Segment Analysis 2017 - 2021 
    • Exhibit 19: Historic Market Size – Solution Segment 2017 - 2021 ($ billion)
  • 4.3 End- user Segment Analysis 2017 - 2021 
    • Exhibit 20: Historic Market Size – End- user Segment 2017 - 2021 ($ billion)
  • 4.4 Geography Segment Analysis 2017 - 2021 
    • Exhibit 21: Historic Market Size – Geography Segment 2017 - 2021 ($ billion)
  • 4.5 Country Segment Analysis 2017 - 2021 
    • Exhibit 22: Historic Market Size – Country Segment 2017 - 2021 ($ billion)

5 Five Forces Analysis

  • 5.1 Five forces summary 
    • Exhibit 23: Five forces analysis - Comparison between 2022 and 2027
  • 5.2 Bargaining power of buyers 
    • Exhibit 24: Chart on Bargaining power of buyers – Impact of key factors 2022 and 2027
  • 5.3 Bargaining power of suppliers 
    • Exhibit 25: Bargaining power of suppliers – Impact of key factors in 2022 and 2027
  • 5.4 Threat of new entrants 
    • Exhibit 26: Threat of new entrants – Impact of key factors in 2022 and 2027
  • 5.5 Threat of substitutes 
    • Exhibit 27: Threat of substitutes – Impact of key factors in 2022 and 2027
  • 5.6 Threat of rivalry 
    • Exhibit 28: Threat of rivalry – Impact of key factors in 2022 and 2027
  • 5.7 Market condition 
    • Exhibit 29: Chart on Market condition - Five forces 2022 and 2027

6 Market Segmentation by Solution

  • 6.1 Market segments 
    • Exhibit 30: Chart on Solution - Market share 2022-2027 (%)
    • Exhibit 31: Data Table on Solution - Market share 2022-2027 (%)
  • 6.2 Comparison by Solution 
    • Exhibit 32: Chart on Comparison by Solution
    • Exhibit 33: Data Table on Comparison by Solution
  • 6.3 3D and 4D output device - Market size and forecast 2022-2027 
    • Exhibit 34: Chart on 3D and 4D output device - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 35: Data Table on 3D and 4D output device - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 36: Chart on 3D and 4D output device - Year-over-year growth 2022-2027 (%)
    • Exhibit 37: Data Table on 3D and 4D output device - Year-over-year growth 2022-2027 (%)
  • 6.4 3D and 4D input device - Market size and forecast 2022-2027 
    • Exhibit 38: Chart on 3D and 4D input device - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 39: Data Table on 3D and 4D input device - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 40: Chart on 3D and 4D input device - Year-over-year growth 2022-2027 (%)
    • Exhibit 41: Data Table on 3D and 4D input device - Year-over-year growth 2022-2027 (%)
  • 6.5 Market opportunity by Solution 
    • Exhibit 42: Market opportunity by Solution ($ billion)

7 Market Segmentation by End-user

  • 7.1 Market segments 
    • Exhibit 43: Chart on End-user - Market share 2022-2027 (%)
    • Exhibit 44: Data Table on End-user - Market share 2022-2027 (%)
  • 7.2 Comparison by End-user 
    • Exhibit 45: Chart on Comparison by End-user
    • Exhibit 46: Data Table on Comparison by End-user
  • 7.3 Entertainment - Market size and forecast 2022-2027
    • Exhibit 47: Chart on Entertainment - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 48: Data Table on Entertainment - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 49: Chart on Entertainment - Year-over-year growth 2022-2027 (%)
    • Exhibit 50: Data Table on Entertainment - Year-over-year growth 2022-2027 (%)
  • 7.4 Consumer electronics - Market size and forecast 2022-2027
    • Exhibit 51: Chart on Consumer electronics - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 52: Data Table on Consumer electronics - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 53: Chart on Consumer electronics - Year-over-year growth 2022-2027 (%)
    • Exhibit 54: Data Table on Consumer electronics - Year-over-year growth 2022-2027 (%)
  • 7.5 Others - Market size and forecast 2022-2027
    • Exhibit 55: Chart on Others - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 56: Data Table on Others - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 57: Chart on Others - Year-over-year growth 2022-2027 (%)
    • Exhibit 58: Data Table on Others - Year-over-year growth 2022-2027 (%)
  • 7.6 Market opportunity by End-user 
    • Exhibit 59: Market opportunity by End-user ($ billion)

8 Customer Landscape

  • 8.1 Customer landscape overview 
    • Exhibit 60: Analysis of price sensitivity, lifecycle, customer purchase basket, adoption rates, and purchase criteria

9 Geographic Landscape

  • 9.1 Geographic segmentation 
    • Exhibit 61: Chart on Market share by geography 2022-2027 (%)
    • Exhibit 62: Data Table on Market share by geography 2022-2027 (%)
  • 9.2 Geographic comparison 
    • Exhibit 63: Chart on Geographic comparison
    • Exhibit 64: Data Table on Geographic comparison
  • 9.3 North America - Market size and forecast 2022-2027
    • Exhibit 65: Chart on North America - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 66: Data Table on North America - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 67: Chart on North America - Year-over-year growth 2022-2027 (%)
    • Exhibit 68: Data Table on North America - Year-over-year growth 2022-2027 (%)
  • 9.4 Europe - Market size and forecast 2022-2027
    • Exhibit 69: Chart on Europe - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 70: Data Table on Europe - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 71: Chart on Europe - Year-over-year growth 2022-2027 (%)
    • Exhibit 72: Data Table on Europe - Year-over-year growth 2022-2027 (%)
  • 9.5 APAC - Market size and forecast 2022-2027
    • Exhibit 73: Chart on APAC - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 74: Data Table on APAC - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 75: Chart on APAC - Year-over-year growth 2022-2027 (%)
    • Exhibit 76: Data Table on APAC - Year-over-year growth 2022-2027 (%)
  • 9.6 Middle East and Africa - Market size and forecast 2022-2027 
    • Exhibit 77: Chart on Middle East and Africa - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 78: Data Table on Middle East and Africa - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 79: Chart on Middle East and Africa - Year-over-year growth 2022-2027 (%)
    • Exhibit 80: Data Table on Middle East and Africa - Year-over-year growth 2022-2027 (%)
  • 9.7 South America - Market size and forecast 2022-2027
    • Exhibit 81: Chart on South America - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 82: Data Table on South America - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 83: Chart on South America - Year-over-year growth 2022-2027 (%)
    • Exhibit 84: Data Table on South America - Year-over-year growth 2022-2027 (%)
  • 9.8 US - Market size and forecast 2022-2027
    • Exhibit 85: Chart on US - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 86: Data Table on US - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 87: Chart on US - Year-over-year growth 2022-2027 (%)
    • Exhibit 88: Data Table on US - Year-over-year growth 2022-2027 (%)
  • 9.9 China - Market size and forecast 2022-2027
    • Exhibit 89: Chart on China - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 90: Data Table on China - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 91: Chart on China - Year-over-year growth 2022-2027 (%)
    • Exhibit 92: Data Table on China - Year-over-year growth 2022-2027 (%)
  • 9.10 Germany - Market size and forecast 2022-2027
    • Exhibit 93: Chart on Germany - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 94: Data Table on Germany - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 95: Chart on Germany - Year-over-year growth 2022-2027 (%)
    • Exhibit 96: Data Table on Germany - Year-over-year growth 2022-2027 (%)
  • 9.11 Japan - Market size and forecast 2022-2027
    • Exhibit 97: Chart on Japan - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 98: Data Table on Japan - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 99: Chart on Japan - Year-over-year growth 2022-2027 (%)
    • Exhibit 100: Data Table on Japan - Year-over-year growth 2022-2027 (%)
  • 9.12 UK - Market size and forecast 2022-2027
    • Exhibit 101: Chart on UK - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 102: Data Table on UK - Market size and forecast 2022-2027 ($ billion)
    • Exhibit 103: Chart on UK - Year-over-year growth 2022-2027 (%)
    • Exhibit 104: Data Table on UK - Year-over-year growth 2022-2027 (%)
  • 9.13 Market opportunity by geography 
    • Exhibit 105: Market opportunity by geography ($ billion)

10 Drivers, Challenges, and Trends

  • 10.1 Market drivers
  • 10.2 Market challenges
  • 10.3 Impact of drivers and challenges 
    • Exhibit 106: Impact of drivers and challenges in 2022 and 2027
  • 10.4 Market trends

11 Vendor Landscape

  • 11.1 Overview
  • 11.2 Vendor landscape 
    • Exhibit 107: Overview on Criticality of inputs and Factors of differentiation
  • 11.3 Landscape disruption 
    • Exhibit 108: Overview on factors of disruption
  • 11.4 Industry risks 
    • Exhibit 109: Impact of key risks on business

12 Vendor Analysis

  • 12.1 Vendors covered 
    • Exhibit 110: Vendors covered
  • 12.2 Market positioning of vendors 
    • Exhibit 111: Matrix on vendor position and classification
  • 12.3 3D Systems Corp. 
    • Exhibit 112: 3D Systems Corp. - Overview
    • Exhibit 113: 3D Systems Corp. - Business segments
    • Exhibit 114: 3D Systems Corp. - Key news
    • Exhibit 115: 3D Systems Corp. - Key offerings
    • Exhibit 116: 3D Systems Corp. - Segment focus
  • 12.4 American Paper Optics LLC 
    • Exhibit 117: American Paper Optics LLC - Overview
    • Exhibit 118: American Paper Optics LLC - Product / Service
    • Exhibit 119: American Paper Optics LLC - Key offerings
  • 12.5 Autodesk Inc. 
    • Exhibit 120: Autodesk Inc. - Overview
    • Exhibit 121: Autodesk Inc. - Product / Service
    • Exhibit 122: Autodesk Inc. - Key news
    • Exhibit 123: Autodesk Inc. - Key offerings
  • 12.6 Barco NV 
    • Exhibit 124: Barco NV - Overview
    • Exhibit 125: Barco NV - Business segments
    • Exhibit 126: Barco NV - Key offerings
    • Exhibit 127: Barco NV - Segment focus
  • 12.7 Desktop Metal Inc. 
    • Exhibit 128: Desktop Metal Inc. - Overview
    • Exhibit 129: Desktop Metal Inc. - Business segments
    • Exhibit 130: Desktop Metal Inc. - Key news
    • Exhibit 131: Desktop Metal Inc. - Key offerings
    • Exhibit 132: Desktop Metal Inc. - Segment focus
  • 12.8 Dolby Laboratories Inc. 
    • Exhibit 133: Dolby Laboratories Inc. - Overview
    • Exhibit 134: Dolby Laboratories Inc. - Product / Service
    • Exhibit 135: Dolby Laboratories Inc. - Key news
    • Exhibit 136: Dolby Laboratories Inc. - Key offerings
  • 12.9 FARO Technologies Inc. 
    • Exhibit 137: FARO Technologies Inc. - Overview
    • Exhibit 138: FARO Technologies Inc. - Business segments
    • Exhibit 139: FARO Technologies Inc. - Key news
    • Exhibit 140: FARO Technologies Inc. - Key offerings
    • Exhibit 141: FARO Technologies Inc. - Segment focus
  • 12.10 Hexagon AB 
    • Exhibit 142: Hexagon AB - Overview
    • Exhibit 143: Hexagon AB - Business segments
    • Exhibit 144: Hexagon AB - Key offerings
    • Exhibit 145: Hexagon AB - Segment focus
  • 12.11 Koninklijke Philips NV 
    • Exhibit 146: Koninklijke Philips NV - Overview
    • Exhibit 147: Koninklijke Philips NV - Business segments
    • Exhibit 148: Koninklijke Philips NV - Key news
    • Exhibit 149: Koninklijke Philips NV - Key offerings
    • Exhibit 150: Koninklijke Philips NV - Segment focus
  • 12.12 LG Electronics Inc. 
    • Exhibit 151: LG Electronics Inc. - Overview
    • Exhibit 152: LG Electronics Inc. - Business segments
    • Exhibit 153: LG Electronics Inc. - Key news
    • Exhibit 154: LG Electronics Inc. - Key offerings
    • Exhibit 155: LG Electronics Inc. - Segment focus
  • 12.13 Panasonic Holdings Corp. 
    • Exhibit 156: Panasonic Holdings Corp. - Overview
    • Exhibit 157: Panasonic Holdings Corp. - Business segments
    • Exhibit 158: Panasonic Holdings Corp. - Key news
    • Exhibit 159: Panasonic Holdings Corp. - Key offerings
    • Exhibit 160: Panasonic Holdings Corp. - Segment focus
  • 12.14 Samsung Electronics Co. Ltd. 
    • Exhibit 161: Samsung Electronics Co. Ltd. - Overview
    • Exhibit 162: Samsung Electronics Co. Ltd. - Business segments
    • Exhibit 163: Samsung Electronics Co. Ltd. - Key news
    • Exhibit 164: Samsung Electronics Co. Ltd. - Key offerings
    • Exhibit 165: Samsung Electronics Co. Ltd. - Segment focus
  • 12.15 Sony Group Corp. 
    • Exhibit 166: Sony Group Corp. - Overview
    • Exhibit 167: Sony Group Corp. - Business segments
    • Exhibit 168: Sony Group Corp. - Key news
    • Exhibit 169: Sony Group Corp. - Key offerings
    • Exhibit 170: Sony Group Corp. - Segment focus
  • 12.16 Stratasys Ltd. 
    • Exhibit 171: Stratasys Ltd. - Overview
    • Exhibit 172: Stratasys Ltd. - Product / Service
    • Exhibit 173: Stratasys Ltd. - Key news
    • Exhibit 174: Stratasys Ltd. - Key offerings
  • 12.17 Vicon Motion Systems Ltd. 
    • Exhibit 175: Vicon Motion Systems Ltd. - Overview
    • Exhibit 176: Vicon Motion Systems Ltd. - Product / Service
    • Exhibit 177: Vicon Motion Systems Ltd. - Key offerings

13 Appendix

  • 13.1 Scope of the report
  • 13.2 Inclusions and exclusions checklist 
    • Exhibit 178: Inclusions checklist
    • Exhibit 179: Exclusions checklist
  • 13.3 Currency conversion rates for US$ 
    • Exhibit 180: Currency conversion rates for US$
  • 13.4 Research methodology 
    • Exhibit 181: Research methodology
    • Exhibit 182: Validation techniques employed for market sizing
    • Exhibit 183: Information sources
  • 13.5 List of abbreviations 
    • Exhibit 184: List of abbreviations

About Us

Technavio is a leading global technology research and advisory company. Their research and analysis focus on emerging market trends and provide actionable insights to help businesses identify market opportunities and develop effective strategies to optimize their market positions. With over 500 specialized analysts, Technavio's report library consists of more than 17,000 reports and counting, covering 800 technologies, spanning across 50 countries. Their client base consists of enterprises of all sizes, including more than 100 Fortune 500 companies. This growing client base relies on Technavio's comprehensive coverage, extensive research, and actionable market insights to identify opportunities in existing and potential markets and assess their competitive positions within changing market scenarios.

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Aging | Clearance of p16Ink4a+ cells: limited effects on β-cell mass and proliferation in mice

“[…] we set out to explore the effects of removing p16Ink4a+ senescent cells on the proliferative capacity and mass of β-cells […].” Credit: 2023…

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“[…] we set out to explore the effects of removing p16Ink4a+ senescent cells on the proliferative capacity and mass of β-cells […].”

Credit: 2023 Bahour et al.

“[…] we set out to explore the effects of removing p16Ink4a+ senescent cells on the proliferative capacity and mass of β-cells […].”

BUFFALO, NY- January 31, 2023 – A new research paper was published on the cover of Aging (listed as “Aging (Albany NY)” by Medline/PubMed and “Aging-US” by Web of Science) Volume 15, Issue 2, entitled, “Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity.”

Type 2 diabetes is partly characterized by decreased β-cell mass and function which have been linked to cellular senescence. Despite a low basal proliferative rate of adult β-cells, they can respond to growth stimuli, but this proliferative capacity decreases with age and correlates with increased expression of senescence effector, p16Ink4a

In a new study, researchers Nadine Bahour, Lucia Bleichmar, Cristian Abarca, Emeline Wilmann, Stephanie Sanjines, and Cristina Aguayo-Mazzucato from the Joslin Diabetes Center at Harvard Medical School hypothesized that selective deletion of p16Ink4a-positive cells would enhance the proliferative capacity of the remaining β-cells due to the elimination of the local senescence-associated secretory phenotype (SASP). 

“We aimed to investigate the effects of p16Ink4a-positive cell removal on the mass and proliferative capacity of remaining β-cells using INK-ATTAC mice as a transgenic model of senolysis.”

Clearance of p16Ink4a-positive subpopulation was tested in mice of different ages, males and females, and with two different insulin resistance models: high-fat diet (HFD) and insulin receptor antagonist (S961). Clearance of p16Ink4a-positive cells did not affect the overall β-cell mass. β-cell proliferative capacity negatively correlated with cellular senescence load and clearance of p16Ink4a positive cells in 1-year-old HFD mice improved β-cell function and increased proliferative capacity in a subset of animals. Single-cell sequencing revealed that the targeted p16Ink4a subpopulation of β-cells is non-proliferative and non-SASP producing whereas additional senescent subpopulations remained contributing to continued local SASP secretion. 

“In conclusion, deletion of p16Ink4a cells did not negatively impact beta-cell mass and blood glucose under basal and HFD conditions and proliferation was restored in a subset of HFD mice opening further therapeutic targets in the treatment of diabetes.”

 

DOI: https://doi.org/10.18632/aging.204483 

Corresponding Author: Cristina Aguayo-Mazzucato cristina.aguayo-mazzucato@joslin.harvard.edu 

Keywords: beta cells, mass, proliferation, senolysis, senescence

Sign up for free Altmetric alerts about this article:  https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204483

 

About Aging-US:

Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

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Las Vegas December 2022: Visitor Traffic Down 4.6% Compared to 2019; Convention Traffic Down 38.2%

Note: I like using Las Vegas as a measure of recovery for both leisure (visitors) and business (conventions).From the Las Vegas Visitor Authority: December 2022 Las Vegas Visitor StatisticsFrom the initial shadow of the omicron variant to record‐shatte…

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Note: I like using Las Vegas as a measure of recovery for both leisure (visitors) and business (conventions).

From the Las Vegas Visitor Authority: December 2022 Las Vegas Visitor Statistics
From the initial shadow of the omicron variant to record‐shattering room rates later in the year, Las Vegas enjoyed a robust recovery trajectory across core tourism indicators in 2022. With December 2022 visitation just 4.6% shy of December 2019, the year closed out with 38.8M annual visitors, 20.5% ahead of 2021 and ‐8.7% under 2019's tally.

Convention attendance for the year approached 5.0M attendees, dramatically ahead of pandemic‐suppressed volumes of 2021 and recovering to about three‐quarters of 2019's tally of 6.6M convention attendees.

Overall hotel occupancy reached 79.2% for the year , +12.4 pts YoY and down ‐9.7 pts vs. 2019. For the year, Weekend occupancy reached 89.3%, +8.0 pts over 2021 and ‐5.6 pts vs. 2019, while Midweek occupancy reached 74.7%, up 14.2 pts vs. 2021 but down ‐11.6 pts vs. 2019.

Strong room rates continued throughout 2022 as annual ADR reached $171, +24.5% higher than 2021 and +28.9% ahead of 2019 while RevPAR reached approx. $135 for the year, +47.6% YoY and +14.9% over 2019.
Click on graph for larger image.

The first graph shows visitor traffic for 2019 (dark blue), 2020 (light blue), 2021 (yellow) and 2022 (red)

Visitor traffic was down 4.6% compared to the same month in 2019.

Visitor traffic was up 10.1% compared to last December.

The second graph shows convention traffic.

Las Vegas Visitor Traffic
Convention traffic was down 38.2% compared to December 2019.

Note: There was almost no convention traffic from April 2020 through May 2021.

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US Job Opening Far Lower Than Reported By Department Of Labor, UBS Finds

US Job Opening Far Lower Than Reported By Department Of Labor, UBS Finds

When it comes to labor market data (or rather "data"), Biden’s labor…

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US Job Opening Far Lower Than Reported By Department Of Labor, UBS Finds

When it comes to labor market data (or rather "data"), Biden's labor department is a study in contrasts (and pats on shoulders). One day we get a contraction in PMI employment (both manufacturing and services), the other we get a major beat in employment. Then, one day the Household survey shows a plunge in employment (in fact, there has almost been no employment gain in the past 9 months) and a record in multiple jobholders and part-time workers, and the same day the Establishment Survey signals a spike in payrolls (mostly among waiters and bartenders). Or the day the JOLTS report shows an unexpected jump in job openings even as actual hiring slides to a two year low. Or the straw the breaks the latest trend in the labor market's back, is when the jobs report finally cracks and shows the fewest jobs added in over a year, and yet initial jobless claims tumble and reverse all recent increases despite daily news of mass layoffs across all tech companies, as the relentless barrage of conflicting data out of the Bureau of Labor Statistics (which is the principal "fact-finding" agency for the Biden Administration and a core pillar of the Dept of Labor) just won't stop, almost as if to make a very political point.

But while one can certainly appreciate Biden's desire to paint the glass of US jobs as always half full, reality is starting to make a mockery of the president's gaslighting ambitions, as one by one core pillars of the administration's "strong jobs" fabulation collapse. First it was the Philadelphia Fed shockingly stating that contrary to the BLS "goalseeking" of 1.1 million jobs in Q2 2022, the US actually only added a paltry 10,000 jobs (just as the Fed unleashed an unprecedented spree of 75bps rate hikes).

Then, it was Goldman's turn to make a mockery of the "curiously" low initial jobless claims, by comparing them to directly reported state-level WARN notices (mandatory under the Worker Adjustment and Retraining Notification (WARN) Act) which no low-level bureaucrat and Biden lackey can "seasonally adjust" because there they are: cold, hard, fact, immutable and truly representative of the underlying economic truth, and what they show is that - as the Goldman chart below confirms - layoffs are rising far faster than what the DOL's Initial Claims indicates.

More importantly, Goldman also found that WARN notices also track the JOLTS layoff rate: WARN notice counts remained elevated in late 2020 even as the layoff rate declined, but this likely reflects unusual reporting delays during the pandemic and the exclusion of layoffs at closing establishments in the JOLTS survey, which WARN notices capture provided firms remain in business. Not surprisingly, Goldman's tracking estimate based on December and January WARN notices for the large states covered not only shows that the recent drop in initial claims is unlikely, but that it is also consistent with a layoff rate of around 1.1%, higher than the 0.9% in the November JOLTS report.

And now, another core pillar of the US labor market is being dismantled, and it has to do with the Fed's favorite labor market indicator: the JOLTS report of job openings.

As UBS economist Pablo Villaneuva writes in a recent report by the bank's Evidence Lab group, Job openings in the JOLTS survey have not declined much since the March peak. Indeed, the BLS reports that openings were only 12% below the March 2022 peak in November and remain 48% above the pre-pandemic, 2019 average. This slight move downward has, as we noted recently, led to only a small decline in the vacancies-to-unemployment ratio, from 1.99 in March to 1.74 in November, still well above the 2019 average of 1.19.

Of course, such a high level of job openings is alarming to the Fed for the simple reason that it means Powell has failed at his mission at cooling off what appears to be a red hot jobs market; no wonder the Fed Chair has frequently flagged the high level of job openings as a sign of ongoing strength in the labor market. The bottom line, as UBS notes, is that "the BLS measure, although it has declined, remains historically high."

However, as in the abovementioned case of unexpectedly low jobless claims, there may be more here than meets the eye. According to Villanueva, "a range of other measures of job openings suggest normalization in the labor market—softening much more convincingly, often to pre-pandemic levels" - translation: whether on purpose or accidentally, the BLS is fabricating data. Also, the UBS economist flags, job openings are not a great indicator of current labor market conditions—they lagged the last two downturns in the labor market.

So what's the real story?

Well, as usual there is BLS "data" and everyone else... and as UBS cautions, other measures of openings tell a very different story: "Our UBS Evidence Lab data on job listings is weekly and more timely than the BLS series. The last datapoint is for the week of December 31. It shows openings down 30% from the March 2022 peak and only 25% higher than the 2019 average."

While BLS bureaucrats and Biden sycophants can argue UBS data is inaccurate, other longer dated series also indicate weaker openings. Take for example the NFIB Small Business Survey includes labor market measures that have correlated strongly with the JOLTS data over time but have weakened more sharply than the JOLTS measure in recent months. The percentage of small firms unable to fill open positions has a correlation of 0.95 with JOLTS openings since 2000. This series has declined 20% relative to the peak in May 2022 and is only 13% above the 2019 average. The NFIB series on percentage of firms with few or no qualified applicants tells a similar story.

Finally, the "Opportunity Insights" measure of openings (see here) is also below pre-pandemic levels.

So what's going on here?

As the UBS economist puts it, "in short, other surveys of job openings generally suggest that the BLS measure may be overstating labor market tightness. One reason to think the accuracy of the JOLTS data may have declined is that the sample shrank noticeably at the start of the pandemic. In 2019, the survey response rate was 60%. In December, it was 30%."

Or perhaps it's not gross BLS incompetence (or propaganda): maybe it's just a data quirk at key economic inflection points. As UBS observed in August, job openings tend to lag other labor market indicators. Ahead of the 2001 recession, the private sector job openings rate was still rising as private employment peaked and started printing negative. Again in 2007, as job openings were peaking, payroll employment in the revised data had slowed considerably, and job openings remained near their peak as employment was beginning to contract outright.

Whatever the reason for the discrepancy in this latest labor series, the bigger picture is getting troubling.

  1. We already knew that the employment as measured by the Household survey has been flat since March even as the Establishment survey signaled 2.7 million job gains since then. Shortly thereafter the Philadelphia Fed found that contrary to the BLS "goalseeking" of 1.1 million jobs in Q2 2022, the US actually only added a paltry 10,000 jobs in the second quarter of 2022. As such, the validity and credibility of the US nonfarm payrolls report is suspect at best.
  2. A few weeks ago, Goldman also put the credibility of DOL's weekly jobless claims report under question, when it found that initial claims as measured at the state level without seasonal adjustments or other "fudge factors" were running far higher than what the DOL reports every week.
  3. And now, we can also stick a fork in the JOLTS report, whose accuracy has just been steamrolled by UBS with its finding that job openings - a critical component of the US labor market and the Fed's preferred labor market indiator - are far lower than what the Dept of Labor suggests.

Bottom line: while it is obvious why the Biden admin would try hard to put as much lipstick as it can on US jobs data, the same data when measured with alternative measures shows a far uglier picture, one of a US labor market on the verge of cracking and hardly one meriting consistent rate hikes by the Fed.

Which, considering that in less than 24 hours the Fed will hike rates by another 25 bps, is extremely important, and we wish that we weren't the only media outlet to lay out the facts as the negative impact of continued policy error and tightening by the Fed will impact tens of millions Americans, not to mention the continued errors - whether premeditated or accidental - by the US Department of Labor. Alas, as so often happens, since nobody else in the "independent US press" is willing to touch the story of manipulated jobs data with a ten foot pole, it is again up to us to explain what is really going on.

The full UBS report available to pro subs.

Tyler Durden Tue, 01/31/2023 - 15:43

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