Connect with us

Uncategorized

Web3 Gamer: PUBG devs’ Web3 project, Animoca’s $20M raise, Shardbound review

The company behind PUBG announces a new Web3 platform, monetization in Web3 and more.
PUBG meets CosmosKrafton, the company behind…

Published

on

The company behind PUBG announces a new Web3 platform, monetization in Web3 and more.

PUBG meets Cosmos

Krafton, the company behind PlayerUnknowns Battlegrounds (PUBG), is venturing into Web3 with Settlus, a Cosmos-based blockchain project specifically designed for the creator economy. Settlus aims to provide content creators with a payment platform that streamlines transparent settlement processes.

The South Korean gaming giants project was announced at the Korea Blockchain Weeks Circle Hacker House event, co-presented by Circle and AngelHack. Circle CEO Jeremy Allaire highlighted PUBGs large user base of 30 million monthly active users.

Cosmos software development kit will serve as the framework, and network gas fees will be payable using stablecoins.

A metaverse project by the name of Migaloo is also in the works. The project will center around user-generated content, allowing creators to automatically create nonfungible tokens of their digital content and earn royalties from platform sales.

Krafton previously announced a collaboration with Solana Labs in March 2022 to support the design and marketing of blockchain-based games and services, but no Web3 products have been released since. Settlus testnet is scheduled to launch in early 2024.

Whos after players wallets: Web3 games or big publishers?

Web3 games may be marketed toward the allure of monetary gain, as most of the demographic is made of investors and financiers who wish to get something in return. Traditional gaming is doing the same. The only difference is that, in Web2 gaming, its the company and its shareholders getting all the revenue instead of the ecosystem. Free-to-play multiplayer online game League of Legends generated $1.75 billion in revenue for Riot Games in 2020 mostly from cosmetic skin sales.

For a free-to-play game, earning money through cosmetics can be understandable. But what about games that charge players the full premium?

Soccer franchise FIFAs Ultimate Team mode, which allows users to buy card packs that contain footballers they can use on their team, brought its publisher, Electronic Arts (EA), $1.62 billion in content revenue in 2021. As one Web3 gaming put it:

Gamers recall the backlash Star Wars Battlefront II received when EA Studios locked the most prominent characters of the franchise, including Darth Vader and Luke Skywalker, behind loot boxes.

A comment from Electronic Arts community team regarding the complaints about the situation received more than 680,000 downvotes on Reddit, setting a Guinness World Record for the most downvoted comment of all time.

Most downvoted Reddit comment of all time. (Reddit)

Web3 gaming is nowhere near traditional gaming in terms of the user base. For example, Axie Infinity, one of the most popular Web3 games, reached a daily average of 11,072 users, while Roblox averaged 23,864,489 daily users during April 2023.

There were 2,155 Roblox players for each Axie Infinity player in April 2023. (CoinGecko)

Web3 game developers search for a solution in alternative business models, like play-to-earn, to draw in the masses and bridge the gap with traditional gaming, promising users monetary gains in exchange for their time.

Traditional gaming and Web3 gaming are not that different. But Web3 gaming receives more hate than it deserves on monetization, primarily due to preconceptions around the cryptocurrency ecosystem.

Traditional games can get away with money-grab decisions because there are a lot of great games balancing the sheets. For Web3 games, the solution to breaking the general prejudice lies in creating better games, not turning the space into a cash counter.

Is $20 million enough to develop an ID system for Web3 gaming?

Animoca Brands raised $20 million in a funding round to accelerate the development of its Mocaverse project. The company was valued at $5 billion last year and has numerous investments in its portfolio, such as NFT marketplace OpenSea and Web3 games such as The Sandbox and Axie Infinity.

The funding round was led by CMCC Global and featured familiar names, including Sky Mavis founder Aleksander Larsen and Guild Games founder Gabby Dizon. Animoca Brands co-founder and executive chairman Yat Siu, who also participated in the round, commented on their goal:

The ongoing evolution of the internet involves a shift from hierarchical power structures to autonomous ones, and the DAO-based approach of Mocaverse ensures that its community will be focused on driving innovation and collaboration across the broader Animoca Brands ecosystem.

Mocaverse is preparing to launch its non-transferrable NFT collection called Moca ID as part of the funding round. The collection will enable owners to create their on-chain identities and participate in the Mocaverse.

Holders of Moca ID will have exclusive access to experiences within the project and earn loyalty points with their engagement. These loyalty points will be utilized in a permissionless and interoperable loyalty system that will be progressively decentralized. Will $20 million be enough to develop this ambitious system? With backing from a brand as solid as Animoca, the skys the limit.

Hot take: Shardbound

I was a hardcore League of Legends player back in the day. My only issue with the game back then was the mouse clicks. LoL was only available for PC during the early 2010s, and as a rookie copywriter at my agency, I was not able to play it silently during the office hours.

This is why the announcement of Vainglory, an iOS game sharing the same DNA with established titles like LoL and DOTA, was a big deal for me. I got an iPhone 6, then an iPad, just to be able to play that game silently like an office anarchist. 

Read also
Features

Cleaning up crypto: How much enforcement is too much?

Features

Insiders guide to real-life crypto OGs: Part 1

I played Vainglory for years and sold my iPad only after they finally pulled the plug on the game by shutting down its servers. So, imagine my surprise when I heard the guys behind Vainglory were making a Web3 game.

With experience from Grand Theft Auto developer Rockstar Studios, League of Legends maker Riot Games and award-winning Vainglory in their pockets, Bazooka Tango co-founders Bo Daly and Stephan Sherman took on the Shardbound project and were kind enough to walk me through the game and answer my questions. 

In a nutshell, Shardbound is a turn-based tactical collectible card game that puts players against each other on a tile-based isometric map. After being given the chance to play the alpha version, I can fairly say Shardbound is a promising game not just in the Web3 sense that brings a new approach to an age-old genre. The general look of the game feels similar to auto chess battlers, such as Dota Underlords and Teamfight Tactics, with an art style resembling Blizzard games like Heroes of the Storm. 

The free-to-play game bears all the usual tactical card game elements weve seen in the likes of Hearthstone, such as heroes who have skills and cards with mana, health, attack damage numbers and different abilities. Except all this happens on a 3D hex map that introduces fresh movement mechanics. Players get to move and position their minions and heroes as they like to get the maximum strategic advantage.

Blue mana crystals, which randomly spawn on the map, award players with extra mana when attacked. Players can win the match by either collecting 10 victory points or by zeroing out their rival heros health. Victory points are earned by hitting randomly spawned orange crystals, which grant the hero or minion that hits them an orange shard. If the hero or entity is killed by the end of the next round, the shard goes to the opponent. If they stay alive, the shard disappears and the holder gains a victory point.

Shardbound is a PvP tactical card game played on a tile-based isometric map.

Shardbound has six different factions, each offering a unique hero and a different playstyle. For example, Landshapers, represented by the color green, offer a more control-oriented gameplay, while purple color-coded Bloodbinders take a more vampire-like approach and allow the player to damage their own hero to strengthen their minions.

Shardbound features six different factions.

Cards can be upgraded by combining copies up to five levels. The fifth level is called the tournament grade, with the end goal being to have a deck of 30 tournament cards. 

Shardbound has two sides: one in Web2 and one in Web3. It is possible to reach tournament grade on the Web2 side, but it is much harder, as cards are dropped from mystery boxes, which means the player is mostly dependent on their luck. The Web3 side allows tradeable and purchasable cards, making the upgrade process much easier. 

Competitive players will eventually have to get into the Web3 side of Shardbound to keep their competitive edge.

Even in the alpha stage, Sharbound bears immense potential and is a candidate to be an all-time classic with its innovative features. The game gives Web3 gaming an actual product that focuses on gameplay instead of monetization. If they dont stray from their current path and gain some mainstream adoption, it is safe to say that Shardbound is set for success. 

More from Web3 gaming space:

Polkastarter Gaming rebranded to GAM3S.GG after securing $2 million in seed funding.

Crypto entertainment experience Tokyo Beast was announced at Korea Blockchain Week.

Planetarium unveiled Verse8 and Immortal Rising 2.

Zynga released the mint details for its Web3 IP, Sugartown.

Blockchain-based MMO Heroes of Mavia introduced the mass ownership model.

The Captain Tsubasa avatar collection is coming to The Sandbox.

Creator of the Deadfellaz NFT collection, DFZ Labs, is creating a trading card game codenamed RIP TCG.

Read More

Continue Reading

Uncategorized

Analyst revamps MicroStrategy stock price target after Bitcoin buy

Here’s what could happen to MicroStrategy shares next.

Published

on

How does Michael Saylor feel about bitcoin? We'll let him tell you in his own words.

"Bitcoin is a swarm of cyberhornets serving the goddess of wisdom, feeding on the fire of truth, exponentially growing ever smarter, faster, and stronger behind a wall of encrypted energy," the executive chairman and co-founder of MicroStrategy  (MSTR)  once said.

Too subtle? Still not sure how the former CEO of the software intelligence company feels about the world's largest cryptocurrency? 

Maybe this will help.

"Bitcoin is a bank in cyberspace, run by incorruptible software, offering a global, affordable, simple and secure savings account to billions of people that don't have the option or desire to run their own hedge fund," Saylor said.

Okay, so the guy really likes bitcoin. And on March 19, the first day of spring, MicroStrategy took a bigger bite out of bitcoin when the company said it had bought 9,245 bitcoins for $623 million between March 11 and March 18.

MicroStrategy said it a completed a $603.75 million convertible debt offering — its second in a week — to raise money to buy bitcoin.

The company now holds about $13.5 billion of bitcoin, which adds up to more than 1% of the 21 million bitcoin that will ever exist, according to CoinDesk.

An analyst adjusts his price target for MicroStrategy

shutterstock

Committed to developing bitcoin network

MicroStrategy said in a regulatory filing that it had paid roughly $7.53 billion for its bitcoin stash, an average of $35,160 per coin.

The company's stock fell on Tuesday, while bitcoin posted its biggest single-day loss since November 2022. MicroStrategy was off slightly to $1,416 at last check on Wednesday and bitcoin was up 2.3% to $63.607.

Related: Analyst unveils Nvidia stock price 'line in the sand'

Phong Le, MicroStrategy’s president and CEO, told analysts during the company’s Feb. 6 fourth-quarter-earnings call that "we remain highly committed to our bitcoin strategy with a long-term focus.."

"We consider MicroStrategy to be the world's first bitcoin development company," he said. "We are a publicly traded operating company committed to the continued development of the bitcoin network through activities in the financial markets, advocacy, and technology innovation."

MicroStrategy earned $4.96 a share in the quarter, beating the FactSet consensus of a loss of 64 cents, and light years beyond the year-ago loss of $21.93 a share.

Revenue totaled $124.5 million, compared with FactSet's call for $133 million and the year-earlier tally of $132.6 million.

During the call, Saylor told analysts that "2024 is the year of birth of bitcoin as an institutional-grade asset class."

MicroStrategy, he said, completed the first 15 years of the bitcoin life cycle, back when it was largely unregulated and misunderstood. 

"The next 15 years, I would expect, will be a regulated, institutional, high-growth period of bitcoin, very, very different in many ways from the last 15 years," Saylor said.

Crypto's dark days

"Bitcoin itself is performing well for a number of reasons, but one reason is because it represents the digital transformation of capital," he added.

Of course, life with bitcoin wasn't always sunshine and roses. 

More Wall Street Analysts:

We take you back now to those less-than-thrilling days yesteryear, when covid-19 was on the rampage and the price of bitcoin fell 30% from March 8 to March 12 2020.

By the end of 2021, bitcoin had fallen nearly 30%. And 2023 saw the cryptocurrency sector wracked with bankruptcy and scandal, with the likes of FTX CEO Sam Bankman-Fried being convicted of fraud, conspiracy, and money laundering. 

SBF, as he has been known, is scheduled to be sentenced in Manhattan federal court on March 28. He faces a long stretch.

But bitcoin rose about 160% in 2023 and hit a record $73,750 on March 14.

Saylor recently said that his high hopes for bitcoin this year stemmed largely from the U.S. Securities and Exchange Commission approving spot bitcoin ETFs and the upcoming bitcoin halving, where when bitcoin's mining reward is split in half.

MicroStrategy is the first bitcoin development company, Saylor told analysts, but perhaps not for long. 

"We've published our playbook, and we're showing other companies how to do it," he said.

TD Cowen analyst Lance Vitanza cited MicroStrategy's latest bitcoin acquisition when he adjusted his price target for the company's shares on March 20.

The analyst cut the investment firm's price target on MicroStrategy to $1,450 from $1,560 and affirmed an outperform rating on the shares. 

He says the shares remain an attractive vehicle for investors looking to gain bitcoin exposure.

Related: Veteran fund manager picks favorite stocks for 2024

Read More

Continue Reading

Uncategorized

FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet

“This discovery unveils a potential novel molecular target for therapeutic strategies against hepatic steatosis during the aging process […]” Credit:…

Published

on

“This discovery unveils a potential novel molecular target for therapeutic strategies against hepatic steatosis during the aging process […]”

Credit: 2024 Kim et al.

“This discovery unveils a potential novel molecular target for therapeutic strategies against hepatic steatosis during the aging process […]”

BUFFALO, NY- March 20, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 5, entitled, “FoxO6-mediated ApoC3 upregulation promotes hepatic steatosis and hyperlipidemia in aged rats fed a high-fat diet.”

FoxO6, an identified factor, induces hyperlipidemia and hepatic steatosis during aging by activating hepatic lipoprotein secretion and lipogenesis leading to increased ApoC3 concentrations in the bloodstream. However, the intricate mechanisms underlying hepatic steatosis induced by elevated FoxO6 under hyperglycemic conditions remain intricate and require further elucidation.

In this new study, researchers Dae Hyun Kim, Seulah Lee, Sang Gyun Noh, Jaewon Lee, and Hae Young Chung from Pusan National University aimed to delineate the regulatory pathway involving ApoC3 controlled by FoxO6 and its resultant functional impacts.

“[…] we employed a spectrum of models including liver cell cultures, aged rats subjected to HFD, transgenic mice overexpressing FoxO6 (FoxO6-Tg), and FoxO6 knockout mice (FoxO6-KO).”

Their findings indicate that FoxO6 triggered ApoC3-driven lipid accumulation in the livers of aged rats on an HFD and in FoxO6-Tg, consequently leading to hepatic steatosis and hyperglycemia. Conversely, the absence of FoxO6 attenuated the expression of genes involved in lipogenesis, resulting in diminished hepatic lipid accumulation and mitigated hyperlipidemia in murine models. Additionally, the upregulation of FoxO6 due to elevated glucose levels led to increased ApoC3 expression, consequently instigating cellular triglyceride mediated lipid accumulation. The transcriptional activation of FoxO6 induced by both the HFD and high glucose levels resulted in hepatic steatosis by upregulating ApoC3 and genes associated with gluconeogenesis in aged rats and liver cell cultures.

“Our conclusions indicate that the upregulation of ApoC3 by FoxO6 promotes the development of hyperlipidemia, hyperglycemia, and hepatic steatosis in vivo, and in vitro. Taken together, our findings underscore the significance of FoxO6 in driving hyperlipidemia and hepatic steatosis specifically under hyperglycemic states by enhancing the expression of ApoC3 in aged rats.”
 

Read the full paper: DOI: https://doi.org/10.18632/aging.205610 

Corresponding Author: Hae Young Chung

Corresponding Email: hyjung@pusan.ac.kr 

Keywords: HFD-feeding, aging, forkhead transcription factor O6, ApoC3, lipid accumulation, hepatic steatosis

Click here to sign up for free Altmetric alerts about this article.

 

About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at www.Aging-US.com​​ and connect with us:

  • Facebook
  • X, formerly Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Reddit
  • Pinterest
  • Spotify, and available wherever you listen to podcasts

 

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###


Read More

Continue Reading

Uncategorized

ARPA-H appoints Etta Pisano to lead its Advancing Clinical Trials Readiness Initiative

The Advanced Research Projects Agency for Health (ARPA-H) has appointed Etta D. Pisano, MD, FACR, senior portfolio lead, to build the agency’s clinical…

Published

on

The Advanced Research Projects Agency for Health (ARPA-H) has appointed Etta D. Pisano, MD, FACR, senior portfolio lead, to build the agency’s clinical trial portfolio and lead the ARPA-H Advancing Clinical Trials Readiness Initiative under ARPA-H Resilient Systems Mission Office Director Jennifer Roberts.

Credit: N/A

The Advanced Research Projects Agency for Health (ARPA-H) has appointed Etta D. Pisano, MD, FACR, senior portfolio lead, to build the agency’s clinical trial portfolio and lead the ARPA-H Advancing Clinical Trials Readiness Initiative under ARPA-H Resilient Systems Mission Office Director Jennifer Roberts.

The first radiologist to be appointed to such a role, Dr. Pisano is an internationally recognized expert in women’s health, breast cancer research, and the use of artificial intelligence in medical imaging applications.

“I am honored to be working for ARPA-H to identify and promote research that can improve healthcare quality, efficacy and delivery, and to improve patient care and access to clinical trials for all Americans, including women, rural residents, and the underserved,” said Dr. Pisano.

Dr. Pisano will continue to serve as study chair of the large-scale Tomosynthesis Mammographic Imaging Screening Trial (TMIST) for the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN). TMIST is led by ECOG-ACRIN with funding from the National Cancer Institute, part of the National Institutes of Health. She will also continue to serve as the American College of Radiology® (ACR®) Chief Research Officer (CRO). Dr. Pisano previously served as the principal investigator of the landmark Digital Mammographic Imaging Screening Trial (DMIST).

The TMIST breast cancer screening study is among the fastest growing National Cancer Institute (NCI) trials of the COVID-19 era. Under Dr. Pisano’s leadership, TMIST is assembling one of the most diverse cancer screening trial populations ever. Approximately 21% of TMIST U.S. participants are Black—more than double the average rate for Black participation in NCI-funded clinical trials (9%).

With ARPA-H, Dr. Pisano will work to build underserved and minority participation in clinical trials—including identifying and onboarding rural facilities and those outside of large academic medical centers—such as emerging retail healthcare sites. 

These duties are also very consistent with the missions of ECOG-ACRIN and ACR, which include promoting the exploration and identification of next-generation technologies that can benefit patients and providers.

“This is a great opportunity for Etta, and I’m excited about the impact she will make on our approach to clinical trials,” said Mitchell D. Schnall, MD, PhD, group co-chair of ECOG-ACRIN.

About ECOG-ACRIN

The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) is an expansive membership-based scientific organization that designs and conducts cancer research involving adults who have or are at risk of developing cancer. The Group comprises nearly 1400 member institutions and 21,000 research professionals in the United States and around the world. ECOG-ACRIN is known for advancing precision medicine and biomarker research through its leadership of major national clinical trials integrating cutting-edge genomic approaches. Member researchers and advocates collaborate across more than 40 scientific committees to design studies spanning the cancer care spectrum, from early detection to management of advanced disease. ECOG-ACRIN is funded primarily by the National Cancer Institute, part of the National Institutes of Health. Visit ecog-acrin.org, and follow us on X @eaonc, Facebook, LinkedIn, and Instagram.

Media Contact: Diane Dragaud, Director of Communications, communications@ecog-acrin.org.


Read More

Continue Reading

Trending