Connect with us

Tom Brady Confirms Retirement, Snubs Patriots In Emotional Statement

Tom Brady Confirms Retirement, Snubs Patriots In Emotional Statement

Update (1050ET): NFL Commissioner Roger Goodell has released the following statement about Tom Brady’s retirement, saying Brady inspired "fans around the world with one…

Published

on

Tom Brady Confirms Retirement, Snubs Patriots In Emotional Statement

Update (1050ET): NFL Commissioner Roger Goodell has released the following statement about Tom Brady's retirement, saying Brady inspired "fans around the world with one of the greatest careers in NFL history."

Tom Brady will be remembered as one of the greatest to ever play in the NFL. An incredible competitor and leader, his stellar career is remarkable for its longevity but also for the sustained excellence he displayed year after year. Tom made everyone around him better and always seemed to rise to the occasion in the biggest moments.

His record five Super Bowl MVP awards and seven Super Bowl championships set a standard that players will chase for years. He inspired fans in New England, Tampa and around the world with one of the greatest careers in NFL history. It has been a privilege to watch him compete and have him in the NFL. We thank him for his many contributions to our game and wish Tom and his family all the best in the future.

* * *

In a statement that made no mention of the Patriots, any Patriots staff or fans, or even the city of Boston/state of Massachusetts, Tom Brady confirmed his plans to retire on Tuesday morning after 22 seasons in the NFL. He shared the news a lengthy statement posted to Twitter.

Brady had earlier denied reports about his impending retirement, only to turn around and confirm it on his own terms days later.

Despite not knowing "what to expect" when he moved to the Bucs, Brady thanked the team's fans: "your support and embrace have enriched my life," he said. But the sport of football requires a "100% commitment", and Brady feels it's now time for him to focus on other things, like his family, and his businesses - including a blockchain company called Autograph.io. But while he thanks everyone from his agents and managers, to the Buccaneers staff, coaches and players, Brady didn't thank Patriots coach Bill Belichick, with whom he reportedly shared a frosty relationship, especially toward the end of his time with the team.

Read the full thread below:

I have always believed the sport of football is an "all-in" proposition - if a 100% competitive commitment isn't there, you won't succeed, and success is what I love so much about our game. There is a physical, mental, and emotional challenge EVERY single day that has allowed me to maximize my highest potential. And I have tried my very best these past 22 years. There are no shortcuts to success on the field or in life.

This is difficult for me to write, but here it goes: I am not going to make that competitive commitment anymore. I have loved my NFL career, and now it is time to focus my time and energy on other things that require my attention.

I've done a lot of reflecting the past week and have asked myself difficult questions. And I am so proud of what we have achieved. My teammates, coaches, fellow competitors, and fans deserve 100% of me, but right now, it's best I leave the field of play to the next generation of dedicated and committed athletes.

To my Bucs teammates the past two years, I love you guys, and I have loved going to battle with you. You have dug so deep to challenge yourself, and it inspired me to wake up every day and give you my best. I am always here for you guys and want to see you continue to push yourselves to be your best. I couldn't be happier with what we accomplished together.

To all the Bucs fans, thank you. I didn't know what to expect when I arrived here, but your support and embrace have enriched my life and that of my family. I have been honored to play for such a passionate and fun fan base. What a Krewe!!!

To the city of Tampa and the entire Tampa-St. Petersburg region, thank you. It has been wonderful to be a resident of such a fun place to live. I want to be invited to our next boat parade!

To the Glazer family, thank you for taking a chance on me and supporting me. I know I was demanding at times, but you provided everything we needed to win, and your ownership was everything a player could ask for.

To Jason Licht, thank you for your daily support and friendship -1 will never forget it. I had never been through free agency, and I had some trepidation about how we could achieve success. Your leadership gave me confidence, and I will always be grateful.

To my head coach Bruce Arians, thanks for putting up with me! Your firm leadership and guidance were ideal. There is no way we could have had success without your experience, intuition, and wisdom. I am very grateful.

To all the Bucs coaches, my sincere thanks for all the hard work, dedication, and discipline that goes into creating a winning team. I have learned so much from all of you and will value the relationships we have.

To every single Bucs staffer and employee, thank you. Each of you is critically important, and I was greeted with a smile every day. That means so much to me. Your work is made up of long hours and hard tasks, but please know I see each and every one of you. Thank you so much.

To Alex Guerrero, thank you. I could never have made every Sunday without you; it's that simple. Your dedication to your craft and our friendship and brotherhood are immeasurable. We have an unbreakable bond, and I love you.

To Don Yee and Steve Dubin, thank you. You've been with me every step of the way since I left the University of Michigan and before I entered the league. What a journey it's been, and I couldn't do it without you.

To my parents and entire family (and extended family of countless friends), I love you and thank you for your never-ending support and love. I could never have imagined the time and energy you have given for me the past 30 years in football. I can never repay you. And just know I love you so much.

And lastly to my wife, Gisele, and my children Jack, Benny and Vivi. You are my inspiration. Our family is my greatest achievement. I always came off the field and home to the most loving and supportive wife who has done EVERYTHING for our family to allow me to focus on my career. Her selflessness allowed me to reach new heights professionally, and I am beyond words what you mean to me and our family. Te amo amor da minha vida.

My playing career has been such a thrilling ride, and far beyond my imagination, and full of ups and downs. When you're in it every day, you really don't think about any kind of ending. As I sit here now, however, I think of all the great players and coaches I was privileged to play with and against - the competition was fierce and deep, JUST HOW WE LIKE IT. But the friendships and relationships are just as fierce and deep. I will remember and cherish these memories and re-visit them often. I feel like the luckiest person in the world.

The future is exciting. I'm fortunate to have cofounded incredible companies like @autograph.io @bradybrand @tb12sports that I am excited to continue to help build and grow, but exactly what my days will look like will be a work-in-progress. As I said earlier, I am going to take it day by day. I know for sure I want to spend a lot of time giving to others and trying to enrich other people's lives, just as so many have done for me.

With much love, appreciation, and gratitude,

Tom

Twitter responded with an outpouring of affection for Brady.

Brady led the NFL in yards passing (5,316), touchdowns (43), completions (485) and attempts (719), but the Buccaneers lost at home to the Los Angeles Rams last Sunday in the divisional round. As the AP notes, Brady had cited a desire to spend more time with his wife and children despite still playing at the top of his game.

Patriots fans might be miffed given the two decades of winning and half a dozen Superbowl victories they had with Brady.

But Buccaneers fans are equally ecstatic to see him retire "as a Buc".

And the NYT, clearly miffed by Brady's decision to deny reports about his retirement, only to confirm it "on his terms" later, had this to say: "The hours that elapsed before Brady confirmed the decision on his terms reinforced the maniacal control that has governed his professional life and career."

Still, nobody can knock Brady's personal accomplishments on field: as a reuslt, he's retiring with three league Most Valuable Player Awards and as the NFL career leader in touchdown passes, passing yardage and victories.

After playing 20 seasons with the Patriots, Brady joined the Bucs in 2020 amid the Covid-19 pandemic, instilling a winning culture to a franchise that hadn’t won a playoff game in 18 years. With his old friend Rob Gronkowski joining him in Tampa, Brady helped the Buccaneers become the first team to play in a Super Bowl in its stadium.

The big question now: Brady's Republican politics have been an open secret for most of his career. Now that he's made a home in famously conservative Florida, will we see a Senator Brady, or a governor Brady? He wouldn't be the first professional athlete to make the transition to politics.

Tyler Durden Tue, 02/01/2022 - 10:24

Read More

Continue Reading

Uncategorized

PR55α-controlled PP2A Inhibits p16 Expression and Blocks Cellular Senescence Induction

“Our results show that PR55α specifically reduces p16 expression […]” Credit: 2024 Palanivel et al. “Our results show that PR55α specifically…

Published

on

“Our results show that PR55α specifically reduces p16 expression […]”

Credit: 2024 Palanivel et al.

“Our results show that PR55α specifically reduces p16 expression […]”

BUFFALO, NY- March 19, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 5, entitled, “PR55α-controlled protein phosphatase 2A inhibits p16 expression and blocks cellular senescence induction by γ-irradiation.”

Cellular senescence is a permanent cell cycle arrest that can be triggered by both internal and external genotoxic stressors, such as telomere dysfunction and DNA damage. The execution of senescence is mainly by two pathways, p16/RB and p53/p21, which lead to CDK4/6 inhibition and RB activation to block cell cycle progression. While the regulation of p53/p21 signaling in response to DNA damage and other insults is well-defined, the regulation of the p16/RB pathway in response to various stressors remains poorly understood. 

In this new study, researchers Chitra Palanivel, Lepakshe S. V. Madduri, Ashley L. Hein, Christopher B. Jenkins, Brendan T. Graff, Alison L. Camero, Sumin Zhou, Charles A. Enke, Michel M. Ouellette, and Ying Yan from the University of Nebraska Medical Center report a novel function of PR55α, a regulatory subunit of PP2A Ser/Thr phosphatase, as a potent inhibitor of p16 expression and senescence induction by ionizing radiation (IR), such as γ-rays. 

“During natural aging, there is a gradual accumulation of p16-expressing senescent cells in tissues [76]. To investigate the significance of PR55α in this up-regulation of p16, we compared levels of the p16 and PR55α proteins in a panel of normal tissue specimens derived from young (≤43 y/o) and old (≥68 y/o) donors.”

The results show that ectopic PR55α expression in normal pancreatic cells inhibits p16 transcription, increases RB phosphorylation, and blocks IR-induced senescence. Conversely, PR55α-knockdown by shRNA in pancreatic cancer cells elevates p16 transcription, reduces RB phosphorylation, and triggers senescence induction after IR. Furthermore, this PR55α function in the regulation of p16 and senescence is p53-independent because it was unaffected by the mutational status of p53. Moreover, PR55α only affects p16 expression but not p14 (ARF) expression, which is also transcribed from the same CDKN2A locus but from an alternative promoter. In normal human tissues, levels of p16 and PR55α proteins were inversely correlated and mutually exclusive. 

“Collectively, these results describe a novel function of PR55α/PP2A in blocking p16/RB signaling and IR-induced cellular senescence.”
 

Read the full paper: DOI: https://doi.org/10.18632/aging.205619 

Corresponding Authors: Michel M. Ouellette, Ying Yan

Corresponding Emails: mouellet@unmc.edu, yyan@unmc.edu

Keywords: p16, p14, CDKN2A locus, p53, RB, PR55α, PP2A, γ-irradiation

Click here to sign up for free Altmetric alerts about this article.

 

About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at www.Aging-US.com​​ and connect with us:

  • Facebook
  • X, formerly Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Reddit
  • Pinterest
  • Spotify, and available wherever you listen to podcasts

 

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###


Read More

Continue Reading

Government

Bolsonaro Indicted By Brazilian Police For Falsifying Covid-19 Vaccine Records

Bolsonaro Indicted By Brazilian Police For Falsifying Covid-19 Vaccine Records

Federal police in Brazil have indicted former President Jair…

Published

on

Bolsonaro Indicted By Brazilian Police For Falsifying Covid-19 Vaccine Records

Federal police in Brazil have indicted former President Jair Bolsonaro for falsifying his Covid-19 vaccine card in order to travel to the United States and elsewhere during the pandemic.

Federal prosecutors will review the indictment and decide whether to pursue the case - which would be the first time the former president has faced criminal charges.

According to the indictment, Bolsonaro ordered a top deputy to obtain falsified Covid-19 vaccine records of himself and his 13-year-old daughter in late 2022, right before he flew to Florida for a three-month stay following his election loss.

Brazilian police are also waiting to hear back from the US DOJ on whether Bolsonaro used said cards to enter the United States, which would open him up to further criminal charges, the NY Times reports.

Bolsonaro has repeatedly claimed not to have received the Covid-19 vaccine, but denies any involvement in a plan to falsify his vaccination records. A previous investigation by Brazil's comptroller general concluded that Bolsonaro's vaccination records were false.

The records show that Bolsonaro, a COVID-19 skeptic who publicly opposed the vaccine, received a dose of the immunizer in a public healthcare center in Sao Paulo in July 2021. [ZH: hilarious, Reuters calling the vaccine an 'immunizer.']

The investigation concluded, however, that the former president had left the city the previous day and didn't leave Brasilia until three days later, according to a statement.

The nurse listed in the records as having applied the vaccine on Bolsonaro denied doing so and was no longer working at the center. The listed vaccine lot was also not available on that date, the comptroller general's office said. -Reuters

"It's a selective investigation. I'm calm, I don't owe anything," Bolsonaro told Reuters. "The world knows that I didn't take the vaccine."

During the pandemic, Bolsonaro panned the vaccine - and instead insisted on alternative treatments such as Ivermectin, which has antiviral properties against Covid-19. For this, he was investigated by Brazil's congress, which recommended that the former president be charged with "crimes against humanity," among other things, for his actions during the pandemic.

In May, Brazilian police raided Bolsonaro's home, confiscating his cell phone and arresting one of his closest aides and two of his security cards in connection to the vaccine record investigation.

Brazil's electoral court ruled that Bolsonaro can't run for public office until 2030 after he suggested that the country's voting system was rigged. For that, he has to sit out the 2026 election.

Tyler Durden Tue, 03/19/2024 - 11:00

Read More

Continue Reading

Spread & Containment

TJ Maxx and Marshalls follow Costco and Target on upcoming closures

Many of these stores have information customers need to know.

Published

on

U.S. consumers have come to increasingly rely on the near ubiquity of convenience stores and big-box retailers. 

Many of us depend on these stores being open practically all day, every day, even during some of the biggest holidays. After all, Black Friday beckons retail stores to open just hours after a Thanksgiving Day dinner in hopes of attracting huge crowds of shoppers in search of early holiday sales. 

Related: Walmart announces more store closures for 2024

And it's largely true that before the covid pandemic most of our favorite stores were open all the time. Practically nothing — from inclement weather to bad news to holidays — could shut down a major operation like Walmart  (WMT)  or Target  (TGT)

Then the pandemic hit, and it turned everything we thought we knew about retail operations upside down. 

Everything from grocery stores to shopping malls shut down in an effort to contain potential spread. And when they finally reopened to the public, different stores took different precautionary measures. Some monitored how many shoppers were inside at once, while others implemented foot-traffic rules dictating where one could enter and exit an aisle. And almost every one of them mandated wearing masks at one point or another. 

Though these safety measures seem like a distant memory, one relic from the early 2020s remains firmly a part of our new American retail life. 

A woman in a face mask shopping in the HomeGoods kitchen aisle.

Jeff Greenberg/Getty Images

Store closures announced for spring 2024

Many retailers have learned to adapt after a volatile start to this third decade, and in many ways this requires serving customers better and treating employees better to retain a workforce. 

In some cases, the changes also reflect a change in shopping behavior, as more customers order online and leave more breathing room for brick-and-mortar operations. This also means more time for employees. 

Thanks to this, big retailers have recently changed how they operate, especially during holiday hours, with Walmart recently saying it would close during Thanksgiving to give employees more time to spend with loved ones.

"I am delighted to share that once again, we'll be closing our doors for Thanksgiving this year," Walmart U.S. CEO John Furner told associates in a video posted to Twitter in November. "Thanksgiving is such a special day during a very busy season. We want you to spend that day at home with family and loved ones." 

Other retailers have now followed suit, with Costco  (COST) , Aldi, and Target all saying they would close their doors for 24 hours on Easter Sunday, March 31. 

Now, the stores that operate under TJX Cos.  (TJX)  will also shut down during the holiday, including HomeGoods, TJ Maxx and Marshalls

Though it closed on Thanksgiving, Walmart says it will remain open for shoppers on Easter. 

Here's a list of stores that are closing for Easter 2024: 

  • Target
  • Costco
  • Aldi
  • TJ Maxx
  • Marshalls
  • HomeGoods
  • Publix
  • Macy's
  • Best Buy
  • Apple
  • ACE Hardware

Others are expected to remain open, including:

  • Walmart
  • Ikea
  • Petco
  • Home Depot

Most of the stores closing on Sunday will reopen for regular business hours on Monday. 

Read More

Continue Reading

Trending