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Soy expansion in Brazil linked to increase in childhood leukemia deaths

URBANA, Ill. – Over the past decades, Brazil has become the world’s leading soybean producer, as well as the leading consumer of pesticides. Despite…

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URBANA, Ill. – Over the past decades, Brazil has become the world’s leading soybean producer, as well as the leading consumer of pesticides. Despite concerns about potential public health consequences, little is known about the effects of pesticide exposure in the general population. A new study from the University of Illinois Urbana-Champaign in collaboration with the University of Denver and University of Wisconsin-Madison looks at how soy expansion and increased pesticide use in Brazil’s Cerrado and Amazon biomes correlate with increased childhood cancer mortality.

Credit: Lisa Rausch, University of Wisconsin

URBANA, Ill. – Over the past decades, Brazil has become the world’s leading soybean producer, as well as the leading consumer of pesticides. Despite concerns about potential public health consequences, little is known about the effects of pesticide exposure in the general population. A new study from the University of Illinois Urbana-Champaign in collaboration with the University of Denver and University of Wisconsin-Madison looks at how soy expansion and increased pesticide use in Brazil’s Cerrado and Amazon biomes correlate with increased childhood cancer mortality.

“The Brazilian Amazon region is undergoing a transition from low-input cattle production to intensified soy culture with high use of pesticides and herbicides. The expansion has happened really quickly, and it appears educational efforts and training for pesticide applicators didn’t match the growth in pesticide use. When not used properly, there are health implications,” said Marin Skidmore, assistant professor in the Department of Agricultural and Consumer Economics, part of the College of Agricultural, Consumer and Environmental Sciences (ACES) at U. of I. Skidmore is lead author on the paper, published in Proceedings of the National Academy of Sciences (PNAS).

“As this transition was happening, there were documented cases of pesticide poisoning of agricultural workers and evidence of chemicals in the blood and urine samples of non-agricultural workers in the surrounding communities,” Skidmore said. “This indicates that this rollout had happened in a potentially dangerous way that was leaving people exposed.”

The researchers investigated public health consequences of exposure to pesticides, focusing on children as the most vulnerable population. They specifically looked at deaths from acute lymphoblastic leukemia (ALL), the most common childhood bloodborne cancer.

Their study drew from data on health outcomes, land use, surface water, and demographics in the Amazon and Cerrado biomes. The sample primarily consisted of areas that are classified as “rural” and have at least 25% of land cover in agriculture.

Soy production in the Cerrado area tripled from 2000 to 2019, and in the Amazon region there was a 20-fold increase, from 0.25 to 5 million hectares. Pesticide use in the study region increased between three- and ten-fold during the period as well. Brazilian soy farmers apply pesticides at a rate 2.3 times higher per hectare than the United States.

“Our results show a significant relationship between Brazil’s soy expansion and childhood deaths from ALL in the region,” Skidmore said. “Results suggest that about half of pediatric leukemia deaths over a ten-year period may be linked to agricultural intensification and exposure to pesticides.”

Skidmore and her colleagues show that a 10-percentage point increase in soy production is associated with an additional 0.40 deaths from ALL of children under 5 and an additional 0.21 deaths under 10 per 10,000 population. In total, they estimate that 123 children under 10 died from ALL associated with pesticide exposure between 2008 and 2019, out of a total of 226 reported deaths from ALL in the same period.

Skidmore emphasized that the study doesn’t provide a direct, causal link between pesticide exposure and cancer deaths, but the researchers take a number of steps to rule out other potential explanations. They found no correlations between ALL deaths and soy consumption, changes in socioeconomic status, or prevalence of crops with lower rates of pesticide applications.

The researchers also investigated contamination of water sources as a primary method of pesticide exposure.

“We looked for evidence of pesticide application upstream, in the watershed that flows into a region, and we found it is related to leukemia outcomes in the downstream region. This indicates that pesticide runoff into surface water is a likely method of exposure,” Skidmore explained.

“About 50% of the rural households in this region had a well or cistern at the time of the 2006 agricultural census, which left the other 50% reliant on surface water as a source of drinking water. If the surface water is contaminated, pesticides used in soy production upstream can reach children living downstream through waterways.” 

“Our concern is that our results are only the tip of the iceberg. We measured one small, very precise outcome. Pesticide exposure may also result in non-fatal cases of leukemia, and there is a risk of impacts on the adult and teenage community,” she said.

ALL is a highly treatable disease, but it requires access to quality medical care. In the entire Amazon region, the researchers identified only two high-complexity pediatric oncology centers, although other facilities can also provide treatment. They found that the increase in observed pediatric ALL deaths following soy expansion was limited to municipalities that were more than 100 kilometers from a treatment center. 

“Our results indicate that there are several ways to mitigate the relationship between pesticide exposure and ALL deaths,” Skidmore said. “This includes training and education for agricultural workers, smart regulations for pesticide use, and access to health care. We certainly are not advocating for a wholesale stop of using these inputs. They are important and valuable technologies, but they need to be handled safely and with some checks in place.”

Brazil is currently developing a certification program that requires pesticide applicators to undergo safety training and education. Such programs exist in many countries, including the United States, where pesticide applicators are required to be licensed and participate in an annual pesticide safety education and testing program.

“I think there is a strong awareness that safe use of pesticides is what’s best both for agricultural productivity and for the communities. This soy expansion and boom are in many ways a huge win for Brazil’s economy,” Skidmore stated.

“We want to highlight that when changes happen fast, there are risks associated with that, and this is not isolated to Brazil. There is a lot of focus on agricultural intensification for global food security around the world. We need to find a balance where we get the productive benefits while mitigating any potential risks. When there is rapid rollout of these technologies in a new region, often an underdeveloped or poor region, how do we ensure there are guardrails in place to prevent another case like this?”


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There will soon be one million seats on this popular Amtrak route

“More people are taking the train than ever before,” says Amtrak’s Executive Vice President.

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While the size of the United States makes it hard for it to compete with the inter-city train access available in places like Japan and many European countries, Amtrak trains are a very popular transportation option in certain pockets of the country — so much so that the country’s national railway company is expanding its Northeast Corridor by more than one million seats.

Related: This is what it's like to take a 19-hour train from New York to Chicago

Running from Boston all the way south to Washington, D.C., the route is one of the most popular as it passes through the most densely populated part of the country and serves as a commuter train for those who need to go between East Coast cities such as New York and Philadelphia for business.

Veronika Bondarenko captured this photo of New York’s Moynihan Train Hall. 

Veronika Bondarenko

Amtrak launches new routes, promises travelers ‘additional travel options’

Earlier this month, Amtrak announced that it was adding four additional Northeastern routes to its schedule — two more routes between New York’s Penn Station and Union Station in Washington, D.C. on the weekend, a new early-morning weekday route between New York and Philadelphia’s William H. Gray III 30th Street Station and a weekend route between Philadelphia and Boston’s South Station.

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According to Amtrak, these additions will increase Northeast Corridor’s service by 20% on the weekdays and 10% on the weekends for a total of one million additional seats when counted by how many will ride the corridor over the year.

“More people are taking the train than ever before and we’re proud to offer our customers additional travel options when they ride with us on the Northeast Regional,” Amtrak Executive Vice President and Chief Commercial Officer Eliot Hamlisch said in a statement on the new routes. “The Northeast Regional gets you where you want to go comfortably, conveniently and sustainably as you breeze past traffic on I-95 for a more enjoyable travel experience.”

Here are some of the other Amtrak changes you can expect to see

Amtrak also said that, in the 2023 financial year, the Northeast Corridor had nearly 9.2 million riders — 8% more than it had pre-pandemic and a 29% increase from 2022. The higher demand, particularly during both off-peak hours and the time when many business travelers use to get to work, is pushing Amtrak to invest into this corridor in particular.

To reach more customers, Amtrak has also made several changes to both its routes and pricing system. In the fall of 2023, it introduced a type of new “Night Owl Fare” — if traveling during very late or very early hours, one can go between cities like New York and Philadelphia or Philadelphia and Washington. D.C. for $5 to $15.

As travel on the same routes during peak hours can reach as much as $300, this was a deliberate move to reach those who have the flexibility of time and might have otherwise preferred more affordable methods of transportation such as the bus. After seeing strong uptake, Amtrak added this type of fare to more Boston routes.

The largest distances, such as the ones between Boston and New York or New York and Washington, are available at the lowest rate for $20.

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The next pandemic? It’s already here for Earth’s wildlife

Bird flu is decimating species already threatened by climate change and habitat loss.

I am a conservation biologist who studies emerging infectious diseases. When people ask me what I think the next pandemic will be I often say that we are in the midst of one – it’s just afflicting a great many species more than ours.

I am referring to the highly pathogenic strain of avian influenza H5N1 (HPAI H5N1), otherwise known as bird flu, which has killed millions of birds and unknown numbers of mammals, particularly during the past three years.

This is the strain that emerged in domestic geese in China in 1997 and quickly jumped to humans in south-east Asia with a mortality rate of around 40-50%. My research group encountered the virus when it killed a mammal, an endangered Owston’s palm civet, in a captive breeding programme in Cuc Phuong National Park Vietnam in 2005.

How these animals caught bird flu was never confirmed. Their diet is mainly earthworms, so they had not been infected by eating diseased poultry like many captive tigers in the region.

This discovery prompted us to collate all confirmed reports of fatal infection with bird flu to assess just how broad a threat to wildlife this virus might pose.

This is how a newly discovered virus in Chinese poultry came to threaten so much of the world’s biodiversity.

H5N1 originated on a Chinese poultry farm in 1997. ChameleonsEye/Shutterstock

The first signs

Until December 2005, most confirmed infections had been found in a few zoos and rescue centres in Thailand and Cambodia. Our analysis in 2006 showed that nearly half (48%) of all the different groups of birds (known to taxonomists as “orders”) contained a species in which a fatal infection of bird flu had been reported. These 13 orders comprised 84% of all bird species.

We reasoned 20 years ago that the strains of H5N1 circulating were probably highly pathogenic to all bird orders. We also showed that the list of confirmed infected species included those that were globally threatened and that important habitats, such as Vietnam’s Mekong delta, lay close to reported poultry outbreaks.

Mammals known to be susceptible to bird flu during the early 2000s included primates, rodents, pigs and rabbits. Large carnivores such as Bengal tigers and clouded leopards were reported to have been killed, as well as domestic cats.

Our 2006 paper showed the ease with which this virus crossed species barriers and suggested it might one day produce a pandemic-scale threat to global biodiversity.

Unfortunately, our warnings were correct.

A roving sickness

Two decades on, bird flu is killing species from the high Arctic to mainland Antarctica.

In the past couple of years, bird flu has spread rapidly across Europe and infiltrated North and South America, killing millions of poultry and a variety of bird and mammal species. A recent paper found that 26 countries have reported at least 48 mammal species that have died from the virus since 2020, when the latest increase in reported infections started.

Not even the ocean is safe. Since 2020, 13 species of aquatic mammal have succumbed, including American sea lions, porpoises and dolphins, often dying in their thousands in South America. A wide range of scavenging and predatory mammals that live on land are now also confirmed to be susceptible, including mountain lions, lynx, brown, black and polar bears.

The UK alone has lost over 75% of its great skuas and seen a 25% decline in northern gannets. Recent declines in sandwich terns (35%) and common terns (42%) were also largely driven by the virus.

Scientists haven’t managed to completely sequence the virus in all affected species. Research and continuous surveillance could tell us how adaptable it ultimately becomes, and whether it can jump to even more species. We know it can already infect humans – one or more genetic mutations may make it more infectious.

At the crossroads

Between January 1 2003 and December 21 2023, 882 cases of human infection with the H5N1 virus were reported from 23 countries, of which 461 (52%) were fatal.

Of these fatal cases, more than half were in Vietnam, China, Cambodia and Laos. Poultry-to-human infections were first recorded in Cambodia in December 2003. Intermittent cases were reported until 2014, followed by a gap until 2023, yielding 41 deaths from 64 cases. The subtype of H5N1 virus responsible has been detected in poultry in Cambodia since 2014. In the early 2000s, the H5N1 virus circulating had a high human mortality rate, so it is worrying that we are now starting to see people dying after contact with poultry again.

It’s not just H5 subtypes of bird flu that concern humans. The H10N1 virus was originally isolated from wild birds in South Korea, but has also been reported in samples from China and Mongolia.

Recent research found that these particular virus subtypes may be able to jump to humans after they were found to be pathogenic in laboratory mice and ferrets. The first person who was confirmed to be infected with H10N5 died in China on January 27 2024, but this patient was also suffering from seasonal flu (H3N2). They had been exposed to live poultry which also tested positive for H10N5.

Species already threatened with extinction are among those which have died due to bird flu in the past three years. The first deaths from the virus in mainland Antarctica have just been confirmed in skuas, highlighting a looming threat to penguin colonies whose eggs and chicks skuas prey on. Humboldt penguins have already been killed by the virus in Chile.

A colony of king penguins.
Remote penguin colonies are already threatened by climate change. AndreAnita/Shutterstock

How can we stem this tsunami of H5N1 and other avian influenzas? Completely overhaul poultry production on a global scale. Make farms self-sufficient in rearing eggs and chicks instead of exporting them internationally. The trend towards megafarms containing over a million birds must be stopped in its tracks.

To prevent the worst outcomes for this virus, we must revisit its primary source: the incubator of intensive poultry farms.

Diana Bell does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

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This is the biggest money mistake you’re making during travel

A retail expert talks of some common money mistakes travelers make on their trips.

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Travel is expensive. Despite the explosion of travel demand in the two years since the world opened up from the pandemic, survey after survey shows that financial reasons are the biggest factor keeping some from taking their desired trips.

Airfare, accommodation as well as food and entertainment during the trip have all outpaced inflation over the last four years.

Related: This is why we're still spending an insane amount of money on travel

But while there are multiple tricks and “travel hacks” for finding cheaper plane tickets and accommodation, the biggest financial mistake that leads to blown travel budgets is much smaller and more insidious.

A traveler watches a plane takeoff at an airport gate.

Jeshoots on Unsplash

This is what you should (and shouldn’t) spend your money on while abroad

“When it comes to traveling, it's hard to resist buying items so you can have a piece of that memory at home,” Kristen Gall, a retail expert who heads the financial planning section at points-back platform Rakuten, told Travel + Leisure in an interview. “However, it's important to remember that you don't need every souvenir that catches your eye.”

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According to Gall, souvenirs not only have a tendency to add up in price but also weight which can in turn require one to pay for extra weight or even another suitcase at the airport — over the last two months, airlines like Delta  (DAL) , American Airlines  (AAL)  and JetBlue Airways  (JBLU)  have all followed each other in increasing baggage prices to in some cases as much as $60 for a first bag and $100 for a second one.

While such extras may not seem like a lot compared to the thousands one might have spent on the hotel and ticket, they all have what is sometimes known as a “coffee” or “takeout effect” in which small expenses can lead one to overspend by a large amount.

‘Save up for one special thing rather than a bunch of trinkets…’

“When traveling abroad, I recommend only purchasing items that you can't get back at home, or that are small enough to not impact your luggage weight,” Gall said. “If you’re set on bringing home a souvenir, save up for one special thing, rather than wasting your money on a bunch of trinkets you may not think twice about once you return home.”

Along with the immediate costs, there is also the risk of purchasing things that go to waste when returning home from an international vacation. Alcohol is subject to airlines’ liquid rules while certain types of foods, particularly meat and other animal products, can be confiscated by customs. 

While one incident of losing an expensive bottle of liquor or cheese brought back from a country like France will often make travelers forever careful, those who travel internationally less frequently will often be unaware of specific rules and be forced to part with something they spent money on at the airport.

“It's important to keep in mind that you're going to have to travel back with everything you purchased,” Gall continued. “[…] Be careful when buying food or wine, as it may not make it through customs. Foods like chocolate are typically fine, but items like meat and produce are likely prohibited to come back into the country.

Related: Veteran fund manager picks favorite stocks for 2024

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