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Less Than 1 In 100 Million Chance That COVID-19 Has Natural Origin: New Study

Less Than 1 In 100 Million Chance That COVID-19 Has Natural Origin: New Study

Authored by Hans Mahncke via The Epoch Times (emphasis ours),

A…

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Less Than 1 In 100 Million Chance That COVID-19 Has Natural Origin: New Study

Authored by Hans Mahncke via The Epoch Times (emphasis ours),

A new study on the origins of the pandemic, “Endonuclease fingerprint indicates a synthetic origin of SARS-CoV2,” published on the preprint server bioRxiv, concludes that it is highly likely that the SARS-CoV-2 virus that causes COVID-19 originated in a laboratory. The odds of a natural origin, according to the study, are placed at less than 1 in 100 million.

Travelers walk through Ronald Reagan Washington National Airport in Arlington, Va., on April 19, 2022. (Stefani Reynolds/AFP via Getty Images)

Unlike previous studies that analyzed qualitative aspects such as virus features, the new study for the first time assesses the likelihood of a laboratory origin on a quantitative basis. This breakthrough methodology allowed the authors to present objective findings that appear to exceed any previous studies. 

Significantly, the new study does not rely on any of the known evidence pointing toward a lab origin of the SARS-CoV-2 virus. For instance, it does not take into consideration the highly unusual Furin Cleavage Site that makes the virus particularly virulent and which it is widely thought to have been inserted into the virus at the Wuhan Institute of Virology. Nor does it factor in the huge coincidence that the pandemic started on the door steps of the world’s premier coronavirus laboratory

The P4 laboratory on the campus of the Wuhan Institute of Virology in Wuhan, Hubei Province, China, on May 13, 2020. (Hector Retamal/AFP via Getty Images)

Instead, the authors—Valentin Bruttel, a molecular immunologist at the University of Würzburg in Germany; Alex Washburne, a mathematical biologist at Selva Science; and Antonius VanDongen, a pharmacologist at Duke University—took a novel approach that assesses the genesis of the SARS-CoV-2 virus from an entirely new angle. The authors examined tiny fingerprints left behind in the process in which viruses are assembled in laboratories. While use of seamless genetic engineering techniques in creating viruses in laboratories typically conceals evidence of manipulation, the new study developed a statistical process for uncovering such hidden evidence by comparing the distribution of certain strands of genetic code in wild viruses and lab-made viruses. 

When viruses are constructed in a lab, they are typically assembled by piecing together various virus parts. According to a blog post from Washburne that accompanied the release of the study, it is like taking Mr. Potato Head from the movie Toy Story and replacing his arms with the arms of GI Joe to help “us study things like whether GI Joe arms provide any clear benefit for an important task in the virus life cycle like lifting weights.”

In other words, one of the main purposes of manipulating viruses is to better understand which parts of viruses make them particularly infectious, lethal, or transmissible. A related purpose is to develop bioweapons but the authors of the new study reject the idea that that is why SARS-CoV-2 was made. They believe that the virus “was assembled in a lab via common methods used to assemble infectious clones pre-COVID.”

A recent experiment at Boston University is an example of piecing together virus parts. Researchers created a COVID-19 variant that killed 80 percent of exposed mice using the backbone of the ancestral SARS-CoV-2 virus and replacing its spike gene with that from the Omicron variant. Put another way, the Boston lab created a COVID-19 version of Frankenstein’s monster by piecing together different parts from different variants of the SARS-CoV-2 virus.  

Piecing together viruses in labs is subject to limitations. The genetic information for SARS-CoV-2 is contained in 30,000 base pairs of RNA nucleotides. However, the 30,000 base pairs are not pieced together all at once. Instead, laboratory viruses are assembled from a collection of smaller strands of base pairs that are later “glued” back together as chimeras, or compounds. Enzymes are used to cut viruses apart at certain points along the DNA strand (laboratories use DNA instead of RNA as it is more stable; the assembled DNA is then added to bacteria that create RNA viruses). 

Enzymes are proteins that cut through DNA strands at specific recognition sites. These recognition sites, or cutting sites, are the genetic sequences within DNA strands that are sought out by the enzymes. Enzymes are like biological scissors that cut only at particular cutting sites marked by sequences that are recognized by particular enzymes. 

Since cutting sites look like normal sequences of nucleotides, they can be found on RNA strands of naturally occurring viruses as well as on lab-made viruses. This is why this form of genetic engineering leaves no seams or obvious fingerprints. However, there is an important difference between cutting sites on wild-type and lab-made viruses that the authors exploited. Naturally occurring cutting sites are not necessarily located where scientists want them to be. Laboratories therefore routinely insert cutting sites in favorable locations and remove them from unfavorable locations.

While naturally occurring cutting sites and cutting sites added in a lab are biologically indistinguishable, Bruttel, Washburne and VanDongen hypothesized that they could detect a “very subtle but identifiable fingerprint” by plotting the distribution of the cutting sites on the SARS-CoV-2 virus. They would then compare this to the distribution of such sites on wild-type SARS viruses, as well as on other, pre-pandemic lab-made SARS viruses. They carried out their analyses for the most commonly used enzymes (biological “scissors”) which, according to a series of pre-pandemic publications from the Wuhan Institute of Virology, were also used for experiments in the Wuhan lab.

A researcher at the Wuhan Institute of Virology in Wuhan in China’s central Hubei Province feeds a bat with a worm in a 2017 video. (Screenshot)

The results of the new study are stark. While cutting sites on wild-type SARS viruses are randomly distributed, they tend to be regularly spaced on pre-pandemic lab-made viruses, as well as on SARS-CoV-2. So the authors found that regular spacing suggests that the location of the cutting sites was manipulated in a lab.

The new study also compared the length of the longest segments seen in wild-type viruses and lab-made viruses. The longest segments in wild-type viruses are far longer than any found in lab-made viruses, including in SARS-CoV-2. The findings again pointed to a lab origin for COVID-19.

The longest segments in lab-made viruses were found to be unusually short. As previously noted, the process of genetically engineering viruses requires scientists to use several shorter segments, which are then pieced together. Natural viruses are not pieced together and thus the length of segments is randomly determined and includes very short and very long segments. 

Bruttel, Washburne, and VanDongen estimate that the odds that the SARS-CoV-2 virus arose naturally lie between 1 in 100 and 1 in 1,400. However, this estimate only factors in the distribution of cutting sites. The authors also observed a concentration of mutations within the cutting sites that was “extremely unlikely in wild coronaviruses and nearly universal in synthetic viruses.” The estimate drops to a 1 in 100 million chance that SARS-CoV-2 was a naturally-occurring virus if these mutations are factored in. When considering additional criteria, such as the fact that the “sticky ends” where the viruses are “glued” back together all happen to fit perfectly, the authors estimate the odds of a natural origin to be even lower. 

The authors conclude that SARS-CoV-2 was assembled in a lab using common methods for assembling viruses. The authors do not speculate on which lab the virus escaped from.

In response to the new study, Kristian Andersen, the leading author of the Proximal Origin paper—the Dr. Anthony Fauci-led effort to dispel the lab leak theory—went on Twitter to slam the new study as “kindergarten molecular biology.” Andersen’s criticism is that cutting sites are common in naturally occurring SARS viruses. However, this criticism does not explain the very unusual placement of cutting sites in SARS-CoV-2.

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Tyler Durden Tue, 10/25/2022 - 05:00

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Are Voters Recoiling Against Disorder?

Are Voters Recoiling Against Disorder?

Authored by Michael Barone via The Epoch Times (emphasis ours),

The headlines coming out of the Super…

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Are Voters Recoiling Against Disorder?

Authored by Michael Barone via The Epoch Times (emphasis ours),

The headlines coming out of the Super Tuesday primaries have got it right. Barring cataclysmic changes, Donald Trump and Joe Biden will be the Republican and Democratic nominees for president in 2024.

(Left) President Joe Biden delivers remarks on canceling student debt at Culver City Julian Dixon Library in Culver City, Calif., on Feb. 21, 2024. (Right) Republican presidential candidate and former U.S. President Donald Trump stands on stage during a campaign event at Big League Dreams Las Vegas in Las Vegas, Nev., on Jan. 27, 2024. (Mario Tama/Getty Images; David Becker/Getty Images)

With Nikki Haley’s withdrawal, there will be no more significantly contested primaries or caucuses—the earliest both parties’ races have been over since something like the current primary-dominated system was put in place in 1972.

The primary results have spotlighted some of both nominees’ weaknesses.

Donald Trump lost high-income, high-educated constituencies, including the entire metro area—aka the Swamp. Many but by no means all Haley votes there were cast by Biden Democrats. Mr. Trump can’t afford to lose too many of the others in target states like Pennsylvania and Michigan.

Majorities and large minorities of voters in overwhelmingly Latino counties in Texas’s Rio Grande Valley and some in Houston voted against Joe Biden, and even more against Senate nominee Rep. Colin Allred (D-Texas).

Returns from Hispanic precincts in New Hampshire and Massachusetts show the same thing. Mr. Biden can’t afford to lose too many Latino votes in target states like Arizona and Georgia.

When Mr. Trump rode down that escalator in 2015, commentators assumed he’d repel Latinos. Instead, Latino voters nationally, and especially the closest eyewitnesses of Biden’s open-border policy, have been trending heavily Republican.

High-income liberal Democrats may sport lawn signs proclaiming, “In this house, we believe ... no human is illegal.” The logical consequence of that belief is an open border. But modest-income folks in border counties know that flows of illegal immigrants result in disorder, disease, and crime.

There is plenty of impatience with increased disorder in election returns below the presidential level. Consider Los Angeles County, America’s largest county, with nearly 10 million people, more people than 40 of the 50 states. It voted 71 percent for Mr. Biden in 2020.

Current returns show county District Attorney George Gascon winning only 21 percent of the vote in the nonpartisan primary. He’ll apparently face Republican Nathan Hochman, a critic of his liberal policies, in November.

Gascon, elected after the May 2020 death of counterfeit-passing suspect George Floyd in Minneapolis, is one of many county prosecutors supported by billionaire George Soros. His policies include not charging juveniles as adults, not seeking higher penalties for gang membership or use of firearms, and bringing fewer misdemeanor cases.

The predictable result has been increased car thefts, burglaries, and personal robberies. Some 120 assistant district attorneys have left the office, and there’s a backlog of 10,000 unprosecuted cases.

More than a dozen other Soros-backed and similarly liberal prosecutors have faced strong opposition or have left office.

St. Louis prosecutor Kim Gardner resigned last May amid lawsuits seeking her removal, Milwaukee’s John Chisholm retired in January, and Baltimore’s Marilyn Mosby was defeated in July 2022 and convicted of perjury in September 2023. Last November, Loudoun County, Virginia, voters (62 percent Biden) ousted liberal Buta Biberaj, who declined to prosecute a transgender student for assault, and in June 2022 voters in San Francisco (85 percent Biden) recalled famed radical Chesa Boudin.

Similarly, this Tuesday, voters in San Francisco passed ballot measures strengthening police powers and requiring treatment of drug-addicted welfare recipients.

In retrospect, it appears the Floyd video, appearing after three months of COVID-19 confinement, sparked a frenzied, even crazed reaction, especially among the highly educated and articulate. One fatal incident was seen as proof that America’s “systemic racism” was worse than ever and that police forces should be defunded and perhaps abolished.

2020 was “the year America went crazy,” I wrote in January 2021, a year in which police funding was actually cut by Democrats in New York, Los Angeles, San Francisco, Seattle, and Denver. A year in which young New York Times (NYT) staffers claimed they were endangered by the publication of Sen. Tom Cotton’s (R-Ark.) opinion article advocating calling in military forces if necessary to stop rioting, as had been done in Detroit in 1967 and Los Angeles in 1992. A craven NYT publisher even fired the editorial page editor for running the article.

Evidence of visible and tangible discontent with increasing violence and its consequences—barren and locked shelves in Manhattan chain drugstores, skyrocketing carjackings in Washington, D.C.—is as unmistakable in polls and election results as it is in daily life in large metropolitan areas. Maybe 2024 will turn out to be the year even liberal America stopped acting crazy.

Chaos and disorder work against incumbents, as they did in 1968 when Democrats saw their party’s popular vote fall from 61 percent to 43 percent.

Views expressed in this article are opinions of the author and do not necessarily reflect the views of The Epoch Times or ZeroHedge.

Tyler Durden Sat, 03/09/2024 - 23:20

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Veterans Affairs Kept COVID-19 Vaccine Mandate In Place Without Evidence

Veterans Affairs Kept COVID-19 Vaccine Mandate In Place Without Evidence

Authored by Zachary Stieber via The Epoch Times (emphasis ours),

The…

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Veterans Affairs Kept COVID-19 Vaccine Mandate In Place Without Evidence

Authored by Zachary Stieber via The Epoch Times (emphasis ours),

The U.S. Department of Veterans Affairs (VA) reviewed no data when deciding in 2023 to keep its COVID-19 vaccine mandate in place.

Doses of a COVID-19 vaccine in Washington in a file image. (Jacquelyn Martin/Pool/AFP via Getty Images)

VA Secretary Denis McDonough said on May 1, 2023, that the end of many other federal mandates “will not impact current policies at the Department of Veterans Affairs.”

He said the mandate was remaining for VA health care personnel “to ensure the safety of veterans and our colleagues.”

Mr. McDonough did not cite any studies or other data. A VA spokesperson declined to provide any data that was reviewed when deciding not to rescind the mandate. The Epoch Times submitted a Freedom of Information Act for “all documents outlining which data was relied upon when establishing the mandate when deciding to keep the mandate in place.”

The agency searched for such data and did not find any.

The VA does not even attempt to justify its policies with science, because it can’t,” Leslie Manookian, president and founder of the Health Freedom Defense Fund, told The Epoch Times.

“The VA just trusts that the process and cost of challenging its unfounded policies is so onerous, most people are dissuaded from even trying,” she added.

The VA’s mandate remains in place to this day.

The VA’s website claims that vaccines “help protect you from getting severe illness” and “offer good protection against most COVID-19 variants,” pointing in part to observational data from the U.S. Centers for Disease Control and Prevention (CDC) that estimate the vaccines provide poor protection against symptomatic infection and transient shielding against hospitalization.

There have also been increasing concerns among outside scientists about confirmed side effects like heart inflammation—the VA hid a safety signal it detected for the inflammation—and possible side effects such as tinnitus, which shift the benefit-risk calculus.

President Joe Biden imposed a slate of COVID-19 vaccine mandates in 2021. The VA was the first federal agency to implement a mandate.

President Biden rescinded the mandates in May 2023, citing a drop in COVID-19 cases and hospitalizations. His administration maintains the choice to require vaccines was the right one and saved lives.

“Our administration’s vaccination requirements helped ensure the safety of workers in critical workforces including those in the healthcare and education sectors, protecting themselves and the populations they serve, and strengthening their ability to provide services without disruptions to operations,” the White House said.

Some experts said requiring vaccination meant many younger people were forced to get a vaccine despite the risks potentially outweighing the benefits, leaving fewer doses for older adults.

By mandating the vaccines to younger people and those with natural immunity from having had COVID, older people in the U.S. and other countries did not have access to them, and many people might have died because of that,” Martin Kulldorff, a professor of medicine on leave from Harvard Medical School, told The Epoch Times previously.

The VA was one of just a handful of agencies to keep its mandate in place following the removal of many federal mandates.

“At this time, the vaccine requirement will remain in effect for VA health care personnel, including VA psychologists, pharmacists, social workers, nursing assistants, physical therapists, respiratory therapists, peer specialists, medical support assistants, engineers, housekeepers, and other clinical, administrative, and infrastructure support employees,” Mr. McDonough wrote to VA employees at the time.

This also includes VA volunteers and contractors. Effectively, this means that any Veterans Health Administration (VHA) employee, volunteer, or contractor who works in VHA facilities, visits VHA facilities, or provides direct care to those we serve will still be subject to the vaccine requirement at this time,” he said. “We continue to monitor and discuss this requirement, and we will provide more information about the vaccination requirements for VA health care employees soon. As always, we will process requests for vaccination exceptions in accordance with applicable laws, regulations, and policies.”

The version of the shots cleared in the fall of 2022, and available through the fall of 2023, did not have any clinical trial data supporting them.

A new version was approved in the fall of 2023 because there were indications that the shots not only offered temporary protection but also that the level of protection was lower than what was observed during earlier stages of the pandemic.

Ms. Manookian, whose group has challenged several of the federal mandates, said that the mandate “illustrates the dangers of the administrative state and how these federal agencies have become a law unto themselves.”

Tyler Durden Sat, 03/09/2024 - 22:10

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Low Iron Levels In Blood Could Trigger Long COVID: Study

Low Iron Levels In Blood Could Trigger Long COVID: Study

Authored by Amie Dahnke via The Epoch Times (emphasis ours),

People with inadequate…

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Low Iron Levels In Blood Could Trigger Long COVID: Study

Authored by Amie Dahnke via The Epoch Times (emphasis ours),

People with inadequate iron levels in their blood due to a COVID-19 infection could be at greater risk of long COVID.

(Shutterstock)

A new study indicates that problems with iron levels in the bloodstream likely trigger chronic inflammation and other conditions associated with the post-COVID phenomenon. The findings, published on March 1 in Nature Immunology, could offer new ways to treat or prevent the condition.

Long COVID Patients Have Low Iron Levels

Researchers at the University of Cambridge pinpointed low iron as a potential link to long-COVID symptoms thanks to a study they initiated shortly after the start of the pandemic. They recruited people who tested positive for the virus to provide blood samples for analysis over a year, which allowed the researchers to look for post-infection changes in the blood. The researchers looked at 214 samples and found that 45 percent of patients reported symptoms of long COVID that lasted between three and 10 months.

In analyzing the blood samples, the research team noticed that people experiencing long COVID had low iron levels, contributing to anemia and low red blood cell production, just two weeks after they were diagnosed with COVID-19. This was true for patients regardless of age, sex, or the initial severity of their infection.

According to one of the study co-authors, the removal of iron from the bloodstream is a natural process and defense mechanism of the body.

But it can jeopardize a person’s recovery.

When the body has an infection, it responds by removing iron from the bloodstream. This protects us from potentially lethal bacteria that capture the iron in the bloodstream and grow rapidly. It’s an evolutionary response that redistributes iron in the body, and the blood plasma becomes an iron desert,” University of Oxford professor Hal Drakesmith said in a press release. “However, if this goes on for a long time, there is less iron for red blood cells, so oxygen is transported less efficiently affecting metabolism and energy production, and for white blood cells, which need iron to work properly. The protective mechanism ends up becoming a problem.”

The research team believes that consistently low iron levels could explain why individuals with long COVID continue to experience fatigue and difficulty exercising. As such, the researchers suggested iron supplementation to help regulate and prevent the often debilitating symptoms associated with long COVID.

It isn’t necessarily the case that individuals don’t have enough iron in their body, it’s just that it’s trapped in the wrong place,” Aimee Hanson, a postdoctoral researcher at the University of Cambridge who worked on the study, said in the press release. “What we need is a way to remobilize the iron and pull it back into the bloodstream, where it becomes more useful to the red blood cells.”

The research team pointed out that iron supplementation isn’t always straightforward. Achieving the right level of iron varies from person to person. Too much iron can cause stomach issues, ranging from constipation, nausea, and abdominal pain to gastritis and gastric lesions.

1 in 5 Still Affected by Long COVID

COVID-19 has affected nearly 40 percent of Americans, with one in five of those still suffering from symptoms of long COVID, according to the U.S. Centers for Disease Control and Prevention (CDC). Long COVID is marked by health issues that continue at least four weeks after an individual was initially diagnosed with COVID-19. Symptoms can last for days, weeks, months, or years and may include fatigue, cough or chest pain, headache, brain fog, depression or anxiety, digestive issues, and joint or muscle pain.

Tyler Durden Sat, 03/09/2024 - 12:50

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