Industrial and manufacturing production surprise on the upside (0.3% m/m vs. 0.1% consensus, 0.4% vs. 0.1% respectively), with August growth revised up. Here is a picture of key indicators followed by the NBER BCDC as well as monthly GDP (SPGMI) and GDPNow (at 5.4% q/q SAAR as of today).

Figure 1: Nonfarm Payroll employment incorporating preliminary benchmark (dark blue), civilian employment (orange), industrial production (red), personal income excluding transfers in Ch.2017$ (green), manufacturing and trade sales in Ch.2017$ (black), consumption in Ch.2017$ (light blue), and monthly GDP in Ch.2017$ (pink), GDP (blue bars), all log normalized to 2021M11=0. Source: BLS via FRED, BLS preliminary benchmark, Federal Reserve, BEA 2023Q2 third release incorporating comprehensive revisions, S&P Global/IHS Markit (nee Macroeconomic Advisers, IHS Markit) (10/2/2023 release), Atlanta Fed (10/17/2023 release), and author’s calculations.

Hard to see the recession as being here in September (not speaking of October onward). Though the usual caveat applies – all series will be revised, and GDP very much.

Here are more nowcasts as of today.

Figure 1: GDP as reported (bold black), GDPNow of 10/17 (blue square), NY Fed nowcast of 10/13 (green triangles), Goldman Sachs tracking as of 10/17 (pink inverted triangle), IMF October WEO (sky blue square), all in billions Ch.2017$, SAAR. Source: BEA comprehensive revision, Atlanta Fed, NY Fed, Goldman Sachs, IMF WEO, and author’s calculations.

No slowdown in Q3 according to these nowcasts.

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VANCOUVER – American Eagle Gold Corp. [TSXV-AE; OTCQB-AMEGF] reported Hole NAK23-12 has intersected 900 metres of 0.50% CiEq (copper equivalent) from surface in the North zone of Nak copper-gold porphyry project, northern British Columbia.

Highlights: NAK23-12 returned 900 metres of 0.50% CuEq from surface in the North Copper Zone, including 540 metres of 0.61% CuEq from 344 metres.

Copper contributed over 70% of the CuEq calculation, averaging 0.35% copper throughout the 900-metre intercept.

NAK23-12 affirms that the North zone, like the South Copper-Gold Zone (South Zone) hosts broad and continuous mineralization. Drill hole ended in strong mineralization, measuring 3 metres of 1% copper equivalent six metres from the end of hole. Assays from five additional drill holes are pending.

“NAK23-12 represents our most consistently mineralized interval over such a wide length. This hole’s high copper content also stands out, accounting for over 70% of the reported Copper Equivalent grade within the hole. NAK23-12 continues validating NAK’s scale and grade in the North and South Zones. Notably, this hole also ended in high-grade mineralization of 1% CuEq, highlighting that this system remains open in all directions and at depth.”

NAK23-12 was collared 190 metres west of hole NAK22-04 and drilled on a 080 azimuth, testing the east-west extent of the bornite-rich copper mineralization encountered in NAK22-04. From 80 metres to 119.80 metres, a densely bornite and chalcopyrite-mineralized fine-grained dyke was encountered in contact with variably mineralized host sedimentary rocks.

The dyke returned 39.8 metres of 0.95% CuEq, including 0.86% copper, and was associated with a broader 50 metres interval, including disseminated mineralization in the bounding sedimentary rocks, returning 0.88% CuEq.

At 344 metres depth, NAK23-12 encountered a strongly mineralized conglomerate that hosts abundant disseminated chalcopyrite and bornite within both clasts and matrix of the conglomerate, along with common shallow dipping veins and veinlets of bornite and chalcopyrite. Bornite increases in abundance relative to chalcopyrite with depth, as it did in NAK22-04, and chalcocite mineralization appears in narrow veinlets below 600 metres. At a depth of 840 metres, the first instance of Babine stock granodiorite was encountered.

It hosts a similar abundance of bornite-chalcocite-chalcopyrite veins as the conglomerate but lacks the densely disseminated sulphide. Assays from 351 metres to the beginning of the consistent granodiorite at 884 metres returned 540 metres grading 0.61% CuEq, with 0.41% Cu and 0.16g/t Au.

Alteration below 344 metres is consistent with the potassic alteration observed with South Zone mineralization, with magnetite-biotite rich replacements and seams, along with common pink potassium feldspar alteration selvages to sulphide veins.

Assays for drill holes NAK23-13 and -14 will be received in the coming weeks. These holes were drilled to the south and north of the east-west section containing holes NAK23-12 and NAK22-04, testing the east-west extent of the North zone mineralization in those areas. Both holes encountered encouraging bornite-chalcopyrite mineralization within conglomeratic rocks over broad intervals. These observations, along with those from the Company’s drilling at the South Zone this season, strongly suggest that good exploration potential exists between the two zones to the west of the 2022 drill fence, which is west of the only deep hole drilled between the zones (hole NAK22-03, which returned 906 metres of 0.21% CuEq).

The NAK Project is in the Babine copper-gold porphyry district of British Columbia, near past-producing mines and with excellent infrastructure. Previous drilling at NAK revealed a large near-surface copper-gold system measuring over 1.5 km x 1.5 km.

Historical exploration was limited to shallow depths, averaging 170 metres. In 2022, American Eagle’s 2022 drilling program explored deeper and discovered significant copper-gold mineralization along a northerly trend. The objective for 2023 is to expand the known mineralized footprint at NAK and to identify higher-grade zones of copper and gold. The property is accessible by road and can be drilled year-round. The promising initial results make NAK a candidate for further exploration.

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Broadcast Date: November 3, 2023
Time: 8:00 am PT, 11:00 am ET, 17:00 CET

Hydrogen/deuterium exchange coupled to mass spectrometry (HX-MS) is a valuable technique for analyzing the structural features and dynamic properties of individual proteins and large protein complexes. HX-MS can be used to study a wide range of structural properties including protein folding, ligand binding and allostery, and epitope mapping in the development of therapeutic antibodies. However, HX-MS is not routinely used in protein structure analysis because of data analysis challenges that limit its throughput and scope.  

In this GEN webinar, Dr. David Schriemer, University of Calgary, will present an innovative approach for applying HX-MS to protein analysis in biotherapeutics development. He will demonstrate a data independent acquisition-based HX-MS workflow that significantly reduces analysis times, enables the study of larger datasets, and paves the way for a standardized strategy for protein structure analysis. Dr. Schriemer will show how HX-MS can rapidly characterize drug-binding interactions using a 500-kDa mammalian kinase using affinity pulldowns.  

Key takeaways from the webinar include:

• Discovering the latest MS advances that benefit HX-MS technology.
• Learning about the implementation of data-independent acquisition for HX-MS.
• Learning how to use HX-MS to study drug binding interactions and higher-order protein structure dynamics.
• Understanding the data mining approach used to confirm peptide ID and authenticate, or even correct, MS1-based deuteration calculations.

A live Q&A session will follow the presentations, offering you a chance to pose questions to our expert panelist.

Produced with support from:

David Schriemer, PhD
Professor
University of Calgary

The post Automated Protein Structure Analysis Using DIA Based Hydrogen Deuterium Exchange Mass Spectrometry appeared first on GEN - Genetic Engineering and Biotechnology News.

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