On a dealmaking spree, Eli Lilly will buy another cancer biotech, this time swooping in for publicly traded radiopharma company Point Biopharma in a cash acquisition worth about $1.4 billion.
Lilly’s addition of a radiopharmaceutical company comes as the space heats up with new startups, a recent IPO from RayzeBio and high demand for Novartis’ Pluvicto. The Big Pharma is moving in on Point as it anticipates late-stage clinical data in the near term, with two radioligand cancer therapies in Phase III development.
The deal, disclosed Tuesday pre-market for $12.50 per share, marks at least the fifth acquisition for Lilly in as many months as it receives a financial and stock boost from the performance of its diabetes drug Mounjaro, which is also being prescribed off-label for weight loss, and its much-anticipated Alzheimer’s drug donanemab. In recent months, the Indianapolis Big Pharma has bought autoimmune biotech DICE Therapeutics, weight loss drugmaker Versanis, diabetes cell therapy company Sigilon and antibody-drug conjugate startup Emergence Therapeutics.
For Point, the tender offer marks a 68% premium to its 30-day volume-weighted average price. The deal is expected to close “near the end of 2023” and has already been greenlit by both boards, the companies said.
Point’s lead program is PNT2002, a PSMA-targeted radioligand therapy that will have topline data this quarter for patients with metastatic castration-resistant prostate cancer after progression on hormonal treatment. Point is also developing an SSTR-targeted radioligand therapy, PNT2003, for patients with gastroenteropancreatic neuroendocrine tumors. Novartis’ radioligand therapy Lutathera hit the mark in a Phase III in that population last month, and RayzeBio is currently enrolling for its Phase III.
“We are excited by the potential of this emerging modality and see the acquisition of Point as the beginning of our investment in developing multiple meaningful radioligand medicines for hard-to-treat cancers, as we have done in small molecule and biologic oncology drug discovery and development,” Jacob Van Naarden, president of Lilly’s oncology unit Loxo@Lilly, said in a statement.
Point is also based in Indianapolis. It went public in July 2021 via an RA Capital-sponsored SPAC known as Research Alliance Corp. I.
Notably, Lilly chief scientific officer Dan Skovronsky moved his way up the Big Pharma’s ladder after the drugmaker bought his radiopharma company, Avid Radiopharmaceuticals, in 2010.treatment therapy
Coinkite’s Newest Bitcoin Device Can Serve As A Lightning Wallet And Nostr Client
Satslink is a versatile and secure peer-to-peer device that empowers developers to explore a wide range of communications and mobile hardware applicat…
Coinkite has announced their latest product, Satslink. The under-production device sits at the intersection of many different areas of communications and mobile hardware, empowering developers to build a whole slew of different applications.
Rather than leaning on an opinionated framework, Satslink leverages open and flexible hardware enclosed by the Coldcard Q1’s exterior to bring variety and flexibility to developers. Those in possession of this device can choose what to do with it, and let their builder mentalities run wild on the many different possibilities the piece of hardware can offer.
At its core, Satslink is a peer-to-peer, hackable multi-purpose device. It features a secure element, as typical of Coinkite products, allowing the user to securely store private keys within the device. While it shares the external design with the Coldcard Q1, the internals are totally different from the company’s latest hardware wallet. Instead of focusing on air gapped security, the Satslink aims to bring secure communications to the day to day in ways that few would’ve considered possible.
“Being dissatisfied with the connected and DIY options, we felt the need to create a better hot platform,” NVK, founder at Coinkite, told Bitcoin Magazine. “Bitcoin is expanding scripting/mpc options and we now have Nostr. Someone had to make a good connected and portable device for developers and enthusiast to create the next generation of freedom functionality.”
Satslink leverages ESP32-S3, a low-power MCU-based system on a chip (SoC) with integrated 2.4 GHz Wi-Fi and Bluetooth Low Energy (Bluetooth LE). It consists of high-performance dual-core microprocessor (Xtensa® 32-bit LX7), a low power coprocessor, a Wi-Fi baseband, a Bluetooth LE baseband, RF module, and numerous peripherals. Satslink is programmed in micropython, with its source fully-available, and it is completely field upgradable with no locked-down ROM areas. Coinkite’s product also features a MicroSD slot for data transfer.
“The initial target is developers and enthusiasts,” NVK said. “But, because of the consumer friendly form factor, they will be able to start using anything the community creates. Like hot and sovereign lightning wallets and Nostr clients!”
Nostr, the open communications protocol that went viral after Block CEO and Twitter founder Jack Dorsey started endorsing and funding the project, is top of the list of possible use cases for Satslink. Given its peer-to-peer communication capabilities, Satslink can be used as a Nostr client, and since it can also work as a relay, one could send and receive messages as Nostr posts without those ever hitting the internet. Imagine a localized Nostr made up of many Satslink devices talking to each other through a sort of mesh network instead of the open web. That could be possible with this device.
Another interesting use case that many bitcoiners could relate to is having a sovereign controller for their home-based bitcoin stack. As some bitcoiners run bitcoin nodes and sometimes even self-hosted servers at home, one could program the Satslink to connect to their home stack on demand and perform desired actions remotely and securely given its networking capabilities. Satslink could be used to run a transaction coordinator, for instance, or be used as a whole wallet –– though Coinkite doesn’t recommend using the Satslink as your go-to cold storage solution for large bitcoin amounts.
Satslink’s communication features also boast NFC and a QR code reader, enabling even more use cases for its eventual users. Notably, this combination paired with Satslink’s versatility and programmability could even be used to turn it into a hardware wallet of another manufacturer. Whether that’s desirable or not, truth is it could be possible to turn a Satslink into Blockstream’s JADE wallet or other similar DIY hardware wallets.
While the possibilities are endless, what users actually build with this product remains to be seen. Coinkite’s device is currently available to preorder on the company’s website at a $189 price tag, and it is still unclear when the product will start shipping to buyers.bitcoin
Week Ahead: NIFTY Consolidates While Defending Key Levels; Vigilant Protection Of Profits Advised
In the previous technical note, it was mentioned that the volatility gauge INDIAVIX stays at its lowest levels and this setup keeps the markets vulnerable…
In the previous technical note, it was mentioned that the volatility gauge INDIAVIX stays at its lowest levels and this setup keeps the markets vulnerable to profit-taking bouts from the current levels. Over the past five days, the markets showed some signs of profit-taking, but at the same time, they largely consolidated and traded in a range. The trading range stayed modest at 362 points as the index oscillated within this range. The global equities remained largely stable, but some stress stayed visible. Overall, the markets continued to consolidate while defending important support levels; the headline index closed with a net gain of 97.55 points (+0.50%) on a weekly basis.
From a technical perspective, in the week before this one, the NIFTY had tested the 20-week MA and had taken support by rebounding from that point. The 20-week MA which currently stays at 19387 remains an important support for the markets on a closing basis. The markets will consolidate so long as they keep their head above this point; any violation of this level will make the markets incrementally weaker. The volatility gauge, INDIAVIX, showed a marginal increase of 3.08% to 10.62 on a weekly basis. It remains within a striking distance of 10.14, the lowest level seen on this indicator so far. This remains a point of concern as this keeps the markets exposed to profit-taking bouts as mentioned earlier.
Monday is likely to see a tepid start to the week; the levels of 19880 and 19950 are expected to act as potential resistance points. The supports come in at 19500 and 19380 levels.
The weekly RSI is 62.33; it stays neutral and does not show any divergence against the price. The weekly MACD is bearish and trades below its signal line. A bullish engulfing candle has emerged; however, it is of little significance as it has emerged with an overall uptrend after just a minor decline.
The pattern analysis of the weekly charts shows that the markets are unlikely to see any runaway up move; any extension of the move on the higher side will find resistance to the upward-rising trend line which begins from 18900 and joins subsequent higher tops. On the lower side, the NIFTY has important support at 20-week MA currently placed at 19387. So long as this is protected, the index will consolidate in a defined range and shall get incrementally weaker if this important support level is violated on a closing basis.
All and all, it is the time when we get cautious about the markets. Even if the move gets extended over the coming days, it would be prudent to use such moves on the upside to vigilantly protect profits at higher levels. Fresh purchases should be kept highly selective and within defensive and low-beta pockets. While keeping overall exposures at modest levels, a cautious outlook is advised over the coming week.
Sector Analysis for the coming week
In our look at Relative Rotation Graphs®, we compared various sectors against CNX500 (NIFTY 500 Index), which represents over 95% of the free float market cap of all the stocks listed.
Relative Rotation Graphs (RRG) show that the Nifty Pharma Index which was inside the leading quadrant until now has rolled inside the weakening quadrant. Besides this, the IT, Energy, Midcap100, Media, Metal, PSE, PSU Bank, and Infrastructure indices are also inside the leading quadrant. Out of these groups, except PSE, PSU Bank, and the Infrastructure index, all others are showing a slowdown and paring of their relative momentum against the broader markets.
Along with the Pharma index, the Realty, and the Auto Index are also inside the weakening quadrant. However, both of these indices are showing improvement in their relative momentum.
Nifty Bank and Financial Services index are seen languishing inside the lagging quadrant. The FMCG and the Consumption index are also inside the lagging quadrant, but they are seen improving their relative momentum against the broader Nifty 500 index.
The Nifty Commodities index and Services Sector index are inside the improving quadrant.
Important Note: RRG™ charts show the relative strength and momentum of a group of stocks. In the above Chart, they show relative performance against NIFTY500 Index (Broader Markets) and should not be used directly as buy or sell signals.
Milan Vaishnav, CMT, MSTA
Consulting Technical Analystequities stocks commodities
Ethereum losing streak vs. Bitcoin hits 15 months — Can ETH price reverse course?
Bitcoin ETF and halving buzz have boosted BTC’s demand compared to Ethereum in recent weeks.
The price of Ethereum’s native token,…
Bitcoin ETF and halving buzz have boosted BTC's demand compared to Ethereum in recent weeks.
Will it continue to weaken for the remainder of 2023? Let's take a closer look at the charts.
Ethereum price breaks below critical support vs. Bitcoin
The ETH/BTC pair dropped to as low as 0.056 BTC earlier this week. In doing so, the pair broke below its 200-week exponential moving average (200-week EMA; the blue wave) near 0.058 BTC, raising downside risks further into 2023.
The 200-week EMA has historically served as a reliable support level for ETH/BTC bulls. For instance, the pair rebounded 75% three months after testing the wave support in July 2022. Conversely, it dropped over 25% after losing the same support in October 2020.
ETH/BTC stares at similar selloff risks in 2023 after losing its 200-week EMA as support. In this case, the next downside target looks to be around its 0.5 Fib line near 0.051 BTC in 2023, down about 9.5% from current price levels.
Conversely, ETH price may rebound toward its 50-week EMA (the red wave) near 0.065 BTC if it reclaims the 200-week EMA as support.
Bitcoin bull case overshadows Ethereum
Ethereum's persistent weakness versus Bitcoin is reflected in institutional capital flow data.
For instance, as of Oct. 6, Bitcoin-specific investment funds had attracted $246 million year-to-date (YTD), according to CoinShares. On the other hand, Ethereum funds have lost capital, witnessing outflows worth $104 million in the same period.
The discrepancy is likely due to growing buzz about a potential spot Bitcoin exchange-traded product (ETF) approval in the U.S.
The halving will reduce the Bitcoin miners' block reward from 6.25 BTC to 3.125 BTC, a bullish case based on historical precedent that cuts new supply in half.
This article does not contain investment advice or recommendations. Every investment and trading move involves risk, and readers should conduct their own research when making a decision.bitcoin ethereum crypto btc etf crypto
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