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Bitcoin analysis predicts ‘spicy’ BTC price into FOMC as $27K holds

Bitcoin market gurus anticipate BTC price volatility to hit around the latest FOMC interest rates decision and Fed press conference.

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Bitcoin market gurus anticipate BTC price volatility to hit around the latest FOMC interest rates decision and Fed press conference.

Bitcoin (BTC) held $27,000 into Sept. 20 as the key macroeconomic date of the cryptocurrency trading week arrived.

BTC/USD 1-hour chart. Source: TradingView

Market “set to accommodate” BTC price volatility

Data from Cointelegraph Markets Pro and TradingView showed the BTC price focus shifting upward compared to the week prior.

Crypto markets showed conviction in the decision on interest rates by the United States Federal Reserve. The Federal Open Market Committee (FOMC) was due to announce its latest changes at 2 pm Eastern Time on the day.

As Cointelegraph reported, expectations almost unanimously favored rates staying at current levels, with the odds still at 99% at the time of writing, per data from CME Group’s FedWatch Tool.

“The market is pricing a 99% probability that the Fed are on hold at this meeting. And the data is conducive for that, core CPI inflation is now running at the Fed’s target on a 3-month annualized basis,” financial commentator Tedtalksmacro told X subscribers in part of his latest analysis.

“Potentially the first meeting where the Fed recognize that inflation is trending on the right path…”
Fed target rate probabilities chart. Source: CME Group

Despite this, the event was tipped to deliver short-term volatility.

Analyzing the state of the BTC/USD order book on the largest global exchange, Binance, monitoring resource Material Indicators said that liquidity around the spot price was noticeably thin.

“If one thing in particular stands out, it’s that liquidity is thinly distributed through the range,” part of its commentary stated.

“We could see some walls go up, but for now it appears the order book is set to accommodate more volatility.”

Material Indicators added that the subsequent speech and press conference from Fed Chair Jerome Powell should lead to further “spicy” BTC price action.

An accompanying chart showed some bid-side liquidity parked at $26,650, while substantial bids were still only at $25,000. To the upside, sellers lay in wait at $27,450 — the local BTC price high from September.

BTC/USD order book data for Binance. Source: Material Indicators/X

Bitcoin traders eye key levels

Continuing, others hoped for some range levels to be challenged as part of the FOMC reaction.

 Related: Bitcoin Bollinger Bands hit key zone as BTC price fights for $27K

“Good chance we take out some stops today during the volatility,” popular trader Daan Crypto Trades suggested.

BTC/USD annotated chart. Source: Daan Crypto Trades/X

Fellow trader Jelle said that he expected “choppy waters” on Bitcoin, and while scanning broader exchange activity, trader Skew predicted a lively FOMC trading environment.

Crypto Tony, meanwhile, flagged $26,800 as the line in the sand for Bitcoin bulls to protect.

“This is what I am looking for to remain in my long position. Must hold above $26,800 support zone, or we risk creating a deviation,” he commented alongside his own chart.

BTC/USD annotated chart. Source: Crypto Tony/X

Collect this article as an NFT to preserve this moment in history and show your support for independent journalism in the crypto space.

This article does not contain investment advice or recommendations. Every investment and trading move involves risk, and readers should conduct their own research when making a decision.

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David Baker’s lab shows generative AI can design antibodies. But are they good enough to become drugs?

The promise of using artificial intelligence to design biologic drugs from scratch is starting to look a lot less abstract.
This week, scientists led by…

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The promise of using artificial intelligence to design biologic drugs from scratch is starting to look a lot less abstract.

This week, scientists led by David Baker at the University of Washington revealed work showing that they have created therapeutically active proteins from scratch. Using the lab’s generative AI model they created an antibody that neutralizes a bacterial toxin and three that target the viruses responsible for Covid-19, RSV and the flu.

The study, which was posted Monday on bioRxiv and has not been peer-reviewed, showcases the potential power of using AI to make antibodies that target proteins just as their designers intended, rather than trawling through the blood of mice or humans in hopes of finding just the right one.

Yet it also suggests that AI-designed antibodies aren’t yet good enough to pass muster as drugs, at least not at the touch of a button. Scientists not involved in the study told Endpoints News that the work was a step in the right direction, but said the antibodies didn’t stick strongly enough to their targets to become real drug candidates, a point that Baker conceded.

“They’re just too weak for primetime,” Baker told Endpoints in an interview. “I think this is showing what the way of the future is going to be. But these things are not yet tight enough to be used as drugs.”

Making antibodies entirely on computers could become one of the most useful and lucrative applications of the growing de novo protein design field, in which scientists generate proteins never before seen in nature. While Baker’s Institute for Protein Design in Seattle has created other binding proteins before, they were simpler and more alien than the standard antibodies that pharma companies know and love.

Baker’s new preprint shows how his lab’s software, called RFdiffusion, can generate the structures of antibodies that mesh neatly with a specific surface on a bacterial or viral protein. It suggests that AI could help target the Achilles heel of such proteins. “Normally, you can’t really control that,” Baker said. “But in our approach, you specify where on the target you want to bind.”

When the lab tested its antibodies on the viral proteins and used high-powered microscopes to see the results, the structures and interactions were “basically identical” to what their computer program predicted, Baker said. “That was the wow moment.”

Big investments and blockbuster dreams

Many of biopharma’s best-selling drugs are antibodies, and the race is on to tap the AI technologies underpinning text and image generators like ChatGPT to create antibodies. Generate:Biomedicines, an AI startup just outside of Boston, has raised nearly $750 million to make therapeutic proteins, with an initial focus on antibodies. Absci, BigHat Biosciences, and Nabla Bio are also focused on making antibodies with AI.

Nicholas Polizzi

“Deep learning is making previously difficult design problems now tractable,” Nicholas Polizzi, a protein scientist at Dana-Farber Cancer Institute told Endpoints in an email. But like many problems in using AI for biology, “we are running up against a wall of not-enough-training-data,” he said.

The four targets chosen for Baker’s paper weren’t especially tough nuts to crack, since there are already many existing antibodies for those bacteria and viruses. Polizzi noted that the antibodies also targeted surfaces of those proteins for which strong binders already exist, a lower-hanging fruit than targeting a novel surface.

But Baker said that the structures of the antibodies were different enough from existing ones found in the Protein Data Bank — used as the training source for RFdiffusion — that he’s confident the model is coming up with new solutions and not just regurgitating what it’s been fed.

In addition to improving the AI model to make better antibodies, the lab is also working towards making antibodies against more difficult drug targets. Although RFdiffusion is open source, he also wants to make an easier-to-use text interface where scientists can ask the program to generate the amino acid sequence of an antibody that binds to specific sites of a protein.

“We’re not there yet,” Baker said. “But I don’t think we’re far away.”

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Visionary $15 million gift from Wayne & Wendy Holman to NYU Langone Health ensures continued excellence in newly named Holman Division of Endocrinology, Diabetes & Metabolism

NYU Langone Health has received a $15 million gift from innovators and philanthropists Wayne G. Holman, MD, and Wendy Holman to further elevate the world-class…

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NYU Langone Health has received a $15 million gift from innovators and philanthropists Wayne G. Holman, MD, and Wendy Holman to further elevate the world-class treatment and study of endocrine disorders in the newly named and endowed Holman Division of Endocrinology, Diabetes & Metabolism.

Credit: Mateo Salcedo / NYU Langone Health

NYU Langone Health has received a $15 million gift from innovators and philanthropists Wayne G. Holman, MD, and Wendy Holman to further elevate the world-class treatment and study of endocrine disorders in the newly named and endowed Holman Division of Endocrinology, Diabetes & Metabolism.

“Wayne and Wendy’s generosity in this important area of medicine will help NYU Langone further enhance our exceptional research, education and clinical care within the Holman Division of Endocrinology, Diabetes & Metabolism,” said Robert I. Grossman, MD, dean and CEO, NYU Langone. “NYU Langone has a rich history of developing novel treatment options to provide superior outcomes for the most complex cases, and thanks to this endowment, we can sustain these efforts over time.”

“This impactful gift will propel the division into its next phase of growth by establishing new translational research, clinical trials, academic forums, and advancing clinical care, among other initiatives,” said Steven Abramson, MD, Frederick H. King Professor of Internal Medicine and chair of the Department of Medicine at NYU Grossman School of Medicine. “I am excited for the medical advances that will undoubtedly come about because of the Holmans’ deep investment.”

The Holman Division of Endocrinology, Diabetes, & Metabolism, part of the Department of Medicine at NYU Grossman School of Medicine, is among the best in the country, ranked No. 2 U.S. News & World Report’s specialty rankings for 2023-24. The division’s robust research program has made major contributions to the studies of diabetes care, thyroid disease, obesity, neuroendocrinology, lipid disorders, and bone health.

Dr. Holman was recently elected to NYU Langone’s Board of Trustees. His gift is the largest ever given to the NYU Grossman School of Medicine by an alumnus.

“NYU Langone and its medical school gave me the gifts of knowledge, experience, and lifelong friendships. Wendy and I are happy to give back by supporting the dedicated and innovative researchers, physicians, and caregivers in the Holman Division of Endocrinology, Metabolism, and Diabetes who care for patients and advance work toward new treatments and cures,” said Dr. Holman. “We look forward to the achievements. Many thanks to those working so hard on these endeavors.”

For more than 18 years, Dr. Holman has served as founder and CEO of Ridgeback Capital, a private investment firm focusing on the life sciences. Dr. Holman’s work at Ridgeback Capital has provided funding to companies that have developed medicines for various cancers, infectious diseases, rare pediatric diseases, and more. In 2016, the Holmans founded Ridgeback Biotherapeutics, a biotech company focused on developing life-saving medications to treat diseases with limited or no treatment options. Ridgeback Biotherapeutics has brought two medicines—for Ebola and COVID-19—to regulatory approvals around the world. For decades, Dr. Holman and Mrs. Holman have leveraged their own success to help vulnerable populations, facilitating drug research and development at over a hundred biopharmaceutical companies.

“Wayne and I are happy to support advancements in collaboration with NYU Langone that will have a tangible positive effect on health and alleviate human suffering,” said Mrs. Holman. “We are confident the division will continue to make a significant impact on the field and benefit countless individuals, and we are proud to be part of that.”

“Wendy and Wayne are people who have dedicated every aspect of their lives to helping others. They see NYU Langone as an institution with the ability to magnify every dollar, and through which they can have exponential impact,” said Kenneth G. Langone, chair of the NYU Langone Board of Trustees. “And they’re right.”

Media Inquiries

Katie Ullman
Phone: 646-483-3984
Kathryn.ullman@nyulangone.org


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COVID-19 Infection Increases Risk Of Autoimmune Diseases By Up To 30 Percent: Study

COVID-19 Infection Increases Risk Of Autoimmune Diseases By Up To 30 Percent: Study

Authored by George Citroner via The Epoch Times (emphasis…

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COVID-19 Infection Increases Risk Of Autoimmune Diseases By Up To 30 Percent: Study

Authored by George Citroner via The Epoch Times (emphasis ours),

(Juan Gaertner/Shutterstock)

Surviving COVID-19 may leave you at heightened risk of developing debilitating autoimmune diseases like rheumatoid arthritis and lupus for up to a year after infection, according to new research.

However, the study also found that vaccinating against the virus could significantly lower your chances of developing these potentially life-altering inflammatory conditions.

COVID-19 Infection Severity Plays a Big Role

The study, published in Annals of Internal Medicine, analyzed national claims data from over 10 million Korean and 12 million Japanese patients aged 20 and above diagnosed with COVID-19 between January 2020 and December 2021. The dominant strains were the wild-type virus and the delta variant during this period. COVID-19 patients were compared with matched flu patients and uninfected controls.

A little less than 4 percent of Korean participants had a history of COVID-19, and about 1 percent had a history of flu. Among Japanese participants, about 8 percent had been infected with COVID-19, and slightly less than 1 percent had been infected with flu.

Researchers found that COVID-19 patients had a 25 percent to 30 percent increased risk of new-onset autoimmune rheumatic diseases (AIRDs) 30 days after infection compared to uninfected individuals.

More severe COVID-19 was linked to a greater risk of new-onset, untreated, and treated AIRD, with both wild-type and delta variants associated with AIRD risk. The risk of new-onset AIRD seemed to decline over time and trailed off after the first year.

COVID-19 infection is associated with numerous autoimmune disorders, Dr. Jacob Teitelbaum, a board-certified internist specializing in the treatment of chronic fatigue syndrome and fibromyalgia, told The Epoch Times. “For example, there is a marked increase in hyperthyroidism after COVID caused by autoimmune attack on the thyroid glands,” he said. With the immune system already on high alert from the virus and “having trouble shutting down,” it is not surprising that the body’s own tissues will often become collateral damage, he noted.

So this new study simply confirms what is already expected,” Dr. Teitelbaum added.

Vaccines Reduce Autoimmune Risk, but Only in Mild Cases

The findings also suggest that COVID-19 vaccination reduced the rate of AIRDs among patients who received one to two or more doses. This reduced risk was observed whether the vaccine used was mRNA-based or viral-vector type.

However, the reduced AIRD risk was only linked to patients with mild COVID-19 infection, not those with moderate or severe infection.

This is noteworthy, given growing evidence suggesting that COVID-19 vaccination could cause new-onset autoimmune diseases, including autoimmune glomerulonephritis, autoimmune hepatitis, and AIRDs.

AIRDs Increase Risk of Other Severe Conditions

AIRDs involve inflammation of the joints or connective tissue caused by attacks from the body’s immune system. These diseases can affect multiple organs and systems, leading to a wide range of symptoms and complications.

Some common AIRDs include:

  • Rheumatoid arthritis (RA): RA is a chronic autoimmune disorder that primarily affects joints, causing inflammation, pain, stiffness, and swelling. Untreated RA can lead to joint damage, deformities, disability, cardiovascular disease, osteoporosis, and lung problems over time.
  • Systemic lupus erythematosus (SLE): SLE is a systemic autoimmune disease affecting various organs and tissues like skin, joints, kidneys, heart, lungs, and brain. Symptoms may include fatigue, joint pain, skin rashes, fever, and organ inflammation. Complications involve kidney damage, cardiovascular disease, neurological disorders, and increased infection susceptibility.
  • Ankylosing spondylitis (AS): AS primarily affects the spine and sacroiliac joints, causing inflammation and eventual vertebrae fusion, leading to spinal stiffness and limited mobility. It can also impact other joints, eyes, and organs. Complications may include spinal deformities, eye inflammation, and cardiovascular problems.
  • Psoriatic arthritis (PsA): PsA is an autoimmune condition with joint inflammation and skin lesions (psoriasis). In addition to joint pain, swelling, and stiffness, PsA can cause nail changes, eye inflammation, and tendon inflammation (enthesitis). Complications could include diabetes and high blood pressure.
  • Sjögren’s syndrome: Sjögren’s syndrome primarily affects moisture-producing glands, leading to dry eyes and mouth. However, it can also cause systemic issues like joint pain, fatigue, and organ involvement of the kidneys, lungs, or nervous system. It increases the risk of lymphoma and other autoimmune diseases.
  • Systemic sclerosis (scleroderma): Scleroderma is characterized by excessive collagen production, causing thickening and hardening of skin and connective tissues. It can also affect internal organs like the lungs, heart, kidneys, and gastrointestinal tract. Complications may include gastrointestinal bleeding, lung and heart problems, and bowel obstruction.

Inexpensive Treatment Available but Ignored: Expert

AIRDs significantly impact quality of life and require long-term management with medications, physical therapy, and lifestyle modifications. Regular monitoring and comprehensive care from health care professionals are essential for managing these conditions and minimizing health risks.

However, effective yet inexpensive treatments for these conditions are largely ignored, Dr. Teitelbaum said.

Low-dose naltrexone, costing less than $1 a day, has been shown to help chronic pain or autoimmune conditions, he added. Additionally, highly absorbed curcumin and Boswellia serrata, found in curcumin, were proven as effective as Celebrex in treating rheumatic arthritis in a head-to-head study, he noted.

Tyler Durden Wed, 03/20/2024 - 02:45

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