International
AstraZeneca’s Asthma Drug Fasenra Meets Late-Stage Targets; Shares Rise
AstraZeneca’s Asthma Drug Fasenra Meets Late-Stage Targets; Shares Rise


AstraZeneca announced on Thursday that its Fasenra asthma therapy used in the treatment for a chronic inflammatory disease of the nasal passage linings, or sinuses met both co-primary endpoints in a late-stage trial.
Shares are gaining 2.2% in Thursday’s pre-market trading. AstraZeneca (AZN) said that high-level results from the Phase 3 trial showed that Fasenra (benralizumab) compared with placebo demonstrated a statistically “significant improvement” in the size of nasal polyps and in nasal blockage in patients with chronic rhinosinusitis with nasal polyps (CRSwNP).
CRSwNP is characterised by persistent inflammation of the mucous membrane lining the nasal passages and sinuses accompanied by benign growths, called nasal polyps.Nasal polyps can block nasal passages and lead to breathing problems, reduction in the sense of smell, nasal discharge, sleep disturbance and other adverse effects.
“Patients with chronic rhinosinusitis with nasal polyps suffer significantly with nasal congestion and a reduced quality of life. Current treatments, such as intranasal or oral corticosteroids and surgery to remove polyps, do not fully address patient needs,” said AstraZeneca’s Mene Pangalos. “The data indicate Fasenra can benefit patients with nasal polyps. We look forward to completing the full analysis and sharing these results at an upcoming medical meeting.”
More specifically, Fasenra showed a statistically significant improvement in the endoscopic total nasal polyp score (NPS) and the nasal blockage score (NBS) compared to placebo, in patients with severe bilateral nasal polyposis who were still symptomatic despite continued treatment with standard of care (SoC). SoC consists of intranasal corticosteroids (INCS) and prior surgery and/or use of systemic corticosteroids.
The safety profile and tolerability of Fasenra in this trial were consistent with the known profile of the medicine, AstraZeneca said. Fasenra is currently approved as an add-on maintenance treatment for severe eosinophilic asthma in the US, EU, Japan and other countries and is approved for self-administration in the US, EU and other countries.
AZN shares have gained 7.6% this year as the drugmaker joined the list of companies engaged in the development of a potential coronavirus vaccine. The Phase 2/3 study of the AstraZeneca/Oxford vaccine candidate was this week put on hold after an adverse event in a single participant from the UK. (See AstraZeneca stock analysis on TipRanks)
In reaction, SVB Leerink analyst Andrew Berens reiterated a Buy rating on the stock suggesting that the adverse event could have a broader impact and could cause near-term volatility in AstraZeneca's shares as well as in the stock of other companies with COVID vaccine programs until the exact nature of the event is clear.
As a result, Berens cautions that the overall speed of many of the programs could be affected as the investigation progresses and sponsors become more vigilant, as well as public sentiment regarding the safety of the vaccines once approved.
Overall, the stock scores a Strong Buy consensus from the analyst community with 4 unanimous Buy ratings. Looking ahead, the $81.17 average analyst price target puts the upside potential at a promising 51% in the coming 12 months.

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The post AstraZeneca’s Asthma Drug Fasenra Meets Late-Stage Targets; Shares Rise appeared first on TipRanks Financial Blog.
Government
Texas Reclaims Island From Mexican Cartels In Fight To Secure Border
Texas Reclaims Island From Mexican Cartels In Fight To Secure Border
Authored by J.M. Phelps via The Epoch Times (emphasis ours),
Hondurans…

Authored by J.M. Phelps via The Epoch Times (emphasis ours),
In the fight against Mexican cartels, Texas law enforcement recently took control of a dangerous island used by human traffickers.
The Epoch Times spoke to Texas Land Commissioner Dawn Buckingham, who identified Fronton Island as possibly “the most violent part” of the Texas–Mexico border. Belonging to Texas, Fronton Island is an island in the Rio Grande River. According to the General Land Office, “Fronton Island has been a hot spot for drug and human trafficking and dangerous cartel activity in the past couple of months.”
Ms. Buckingham further described the island as “a law enforcement-free refuge, one where cartels went for refuge when they needed it.” On Sept. 7, she issued a letter to the Texas Department of Public Safety, authorizing law enforcement access to the state-owned 170-acre island.
On an island where fully automatic weapons were once being fired regularly at night, as two violent cartels fought over its control, she said, “Law enforcement set foot on the island for the first time on Monday [Oct. 2].”
Ms. Buckingham cannot speak to the details of the operation, but said the island has been reclaimed by an elite force of Texas Rangers. “Clearing the island and taking away [the cartel’s] shelter, they are finding caches of weapons and more than I can’t speak fully about,” she added.
With a Texas flag planted on the island, Ms. Buckingham considers the operation a win against illegal immigration, drug trafficking, and human trafficking—but the scope of the problem exceeds this single region.
“Texas is still getting flooded with illegal immigrants,” she said. “We’re seeing millions and millions of folks coming across the border.”
To put this in perspective, she said, “The New York mayor is complaining about thousands of people coming [into his city], while Eagle Pass [in Texas] expects far more than that.” The numbers of migrants Eagle Pass has to brace for is “the equivalent of 2.7 million people illegally coming to New York every week.” In addition, she said, “these are not just family units, but a whole lot of young, military-aged males.”
“Recent surges of illegal immigrants are setting new records for crossing the border,” she said. “There are numerous videos circulating online showing thousands of people literally storming across the border,” she added. “This is literally an invasion.”
For those actually being processed by Border Patrol to enter the country, she said, their earliest court date to begin a legal process for their entry into the country would be the year 2027. “With a court date years in the future like this, many will just disappear,” she said.
Streaming Across the Border
According to Ms. Buckingham, “nearly everybody who comes who comes across the border has a wristband that indicates which cartel they belong to.”
“Everyone who comes across is owned by somebody, so you're basically seeing the largest increase in slavery that this world has ever seen,” she said. “Many are now obligated to the drug trade or the human trafficking trade because the cartels are controlling who crosses the border.”
“With enough fentanyl across our border to kill every man, woman, and child in the United States, this has to stop,” she said, adding that “Texas is doing everything we possibly can to get this stopped.”
One of the things Texas is doing is “creating a criminal record for the people who come across and break our laws so that they're easily identifiable,” she said. “Because of [President Joe] Biden’s policies, what we’re seeing right now is a lot of criminals who simply get turned back around to their country to turn around again and walk back across the border.”
“While Texas is fighting on every front and will continue to fight,” she said, “people need to seriously think about who they’re voting for in Congress and for president, because we need people who will enforce policies that stop illegal immigration, and the trafficking of drugs and people into our great country.”
In September alone, Border Patrol encountered a record 269,735 migrants at the border; 218,763 of whom were attempting to illegally enter the country. In fiscal year 2023, a record 169 people on the terror watch list were apprehended, and more than 25,500 pounds of fentanyl was seized at the border.
The White House and Department of Homeland Security did not return requests for comment.
Government
Texas Reclaims Island From Mexican Cartels In Fight To Secure Border
Texas Reclaims Island From Mexican Cartels In Fight To Secure Border
Authored by J.M. Phelps via The Epoch Times (emphasis ours),
Hondurans…

Authored by J.M. Phelps via The Epoch Times (emphasis ours),
In the fight against Mexican cartels, Texas law enforcement recently took control of a dangerous island used by human traffickers.
The Epoch Times spoke to Texas Land Commissioner Dawn Buckingham, who identified Fronton Island as possibly “the most violent part” of the Texas–Mexico border. Belonging to Texas, Fronton Island is an island in the Rio Grande River. According to the General Land Office, “Fronton Island has been a hot spot for drug and human trafficking and dangerous cartel activity in the past couple of months.”
Ms. Buckingham further described the island as “a law enforcement-free refuge, one where cartels went for refuge when they needed it.” On Sept. 7, she issued a letter to the Texas Department of Public Safety, authorizing law enforcement access to the state-owned 170-acre island.
On an island where fully automatic weapons were once being fired regularly at night, as two violent cartels fought over its control, she said, “Law enforcement set foot on the island for the first time on Monday [Oct. 2].”
Ms. Buckingham cannot speak to the details of the operation, but said the island has been reclaimed by an elite force of Texas Rangers. “Clearing the island and taking away [the cartel’s] shelter, they are finding caches of weapons and more than I can’t speak fully about,” she added.
With a Texas flag planted on the island, Ms. Buckingham considers the operation a win against illegal immigration, drug trafficking, and human trafficking—but the scope of the problem exceeds this single region.
“Texas is still getting flooded with illegal immigrants,” she said. “We’re seeing millions and millions of folks coming across the border.”
To put this in perspective, she said, “The New York mayor is complaining about thousands of people coming [into his city], while Eagle Pass [in Texas] expects far more than that.” The numbers of migrants Eagle Pass has to brace for is “the equivalent of 2.7 million people illegally coming to New York every week.” In addition, she said, “these are not just family units, but a whole lot of young, military-aged males.”
“Recent surges of illegal immigrants are setting new records for crossing the border,” she said. “There are numerous videos circulating online showing thousands of people literally storming across the border,” she added. “This is literally an invasion.”
For those actually being processed by Border Patrol to enter the country, she said, their earliest court date to begin a legal process for their entry into the country would be the year 2027. “With a court date years in the future like this, many will just disappear,” she said.
Streaming Across the Border
According to Ms. Buckingham, “nearly everybody who comes who comes across the border has a wristband that indicates which cartel they belong to.”
“Everyone who comes across is owned by somebody, so you're basically seeing the largest increase in slavery that this world has ever seen,” she said. “Many are now obligated to the drug trade or the human trafficking trade because the cartels are controlling who crosses the border.”
“With enough fentanyl across our border to kill every man, woman, and child in the United States, this has to stop,” she said, adding that “Texas is doing everything we possibly can to get this stopped.”
One of the things Texas is doing is “creating a criminal record for the people who come across and break our laws so that they're easily identifiable,” she said. “Because of [President Joe] Biden’s policies, what we’re seeing right now is a lot of criminals who simply get turned back around to their country to turn around again and walk back across the border.”
“While Texas is fighting on every front and will continue to fight,” she said, “people need to seriously think about who they’re voting for in Congress and for president, because we need people who will enforce policies that stop illegal immigration, and the trafficking of drugs and people into our great country.”
In September alone, Border Patrol encountered a record 269,735 migrants at the border; 218,763 of whom were attempting to illegally enter the country. In fiscal year 2023, a record 169 people on the terror watch list were apprehended, and more than 25,500 pounds of fentanyl was seized at the border.
The White House and Department of Homeland Security did not return requests for comment.
International
60 Million Americans Under Freeze Alerts As Powerful Arctic Blast Crashes Temps Nationwide
60 Million Americans Under Freeze Alerts As Powerful Arctic Blast Crashes Temps Nationwide
As highlighted in last week’s article (view here),…

As highlighted in last week's article (view here), temperatures across the Lower 48 are diving as a cold blast pours in from Canada. These bone-chilling temperatures come just in time for Halloween. About 250 million Americans are feeling below-average temperatures, while 60 million will be under frost or freeze alerts.
According to private weather forecaster BAMWX, the cold air invasion has already begun:
A lot of record cold lows on the table to start out November. 20s all the way down to Central Texas with temperatures 15 - 20F below normal.
We first called for a major Halloween cold front 2 weeks ago and it is here.
Fox Weather said the cold blast will affect more than "250 million Americans from coast to coast," while 60 million Americans, from Big Bend of Texas to the Great Lakes and Ohio Valley, will be under cold weather alerts.
Meteorologist Beau Dodson said the worst cold weather will be on Wednesday morning. He showed on a map where "new record low temperatures will be possible."
"Temperatures plunged across Texas now more than 30°F below normal for Oct 30th. Overall the Lower 48 is an astounding 13°F below normal," meteorologist Ryan Maue said.
This is wild!
... and this.
You won't hear it from our political leaders or the mainstream media, but 2023 has been a year where record cold weather temperatures have fallen on every continent, says David Craig. https://t.co/jsmVqLJTN3
— Toby Young (@toadmeister) October 29, 2023
Bloomberg data shows the cold shot will be short-lived. However, Lower 48 temps are expected to drop again by mid-month.
Recall it feels like just yesterday when corporate media was pushing climate misinformation by attempting to persuade the public that Earth was recklessly spiraling into a boiling crisis.
Also, remember, NOAA had to run far away from lying corporate media about the "hottest day ever." At the same time, 1,600 scientists around the world signed a declaration declaring there was no climate emergency.
We penned several notes that an El Nino winter could leave some parts of the Lower 48 with a cold and snowy winter:
- The 'Brrr' Is Coming Back
- What Does Strong El Niño Mean For Winter Activity Across US?
- US Meteorologist Warns: "Winter This Year Going To Be Very Different" As El Nino Ramps Up
New snow forecasts for the Mid-Alantic show a snowy winter from DC to NYC.
But-but-but corporate media said the Earth is boiling...
Time to buy a snowmobile?
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