Gold nanoparticle loaded with CRISPR used to edit genes

Oct 08 15:10 2019 Print This Article

CRISPR (clustered regularly interspaced short palindromic repeats) gene editing is usually paired with a virus (9, 12a, etc.) but this time scientists are using a gold nanoparticle. From a May 27, 2019 news item on Nanowerk (Note: Links have been removed),

Scientists at Fred Hutchinson Cancer Research Center took a step toward making gene therapy more practical by simplifying the way gene-editing instructions are delivered to cells. Using a gold nanoparticle instead of an inactivated virus, they safely delivered gene-editing tools in lab models of HIV and inherited blood disorders, as reported in Nature Materials (“Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations”).

A May 27, 2019 Fred Hutchinson Cancer Research Center news release (also on EurekAlert) by Jake Siegel, which originated the news item, expands on the theme, provides more detail,

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About Article Author

Frogheart

FrogHeart provides commentary about nanotech, science policy and communication, society, and the arts. Run by Maryse de la Giroday, a science communications consultant and writer, FrogHeart is one of the largest independent scince blogs in Canada. Since the websites launch in 1994, Giroday's list of clients includes Océ NV, Telgate Systems, Nortel Networks, Redback Systems, Forintek, Gretag AG, Inetco Systems, and Creo Products (which later became part of Kodak). She has also taught in SFU’s Writing and Communications Program. Giroday earned a Bachelor's degree in Communications from Simon Fraser University in 1992 and a Masters in Creative Writing and New Media from De Montford University in Leicester, UK.

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