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Victor Davis Hanson: 10 Steps To Save America

Victor Davis Hanson: 10 Steps To Save America

Authored by Victor Davis Hanson via AmGreatness.com,

Yes, there is a way. But is there the…

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3 months ago

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Victor Davis Hanson: 10 Steps To Save America

Authored by Victor Davis Hanson via AmGreatness.com,

Yes, there is a way. But is there the will?

Most Americans know something has gone terribly wrong—and very abruptly—with the United States. They are certain that our wounds are almost all self-inflicted. The current pathologies are not a result of a natural disaster, an exhaustion of natural resources, plagues, or an existential war. 

Crushing national debt and annual deficits, spiraling food and fuel costs amid “normal” seven-percent-plus annual inflation, bread-and-circuses entitlements, a nonexistent border, a resurgence of racial tribalism, pandemic violent criminality, and humiliation abroad—all these pathologies are easily cited as symptoms of a sick patient. Our crises are not as the Left maintains—a nine-person Supreme Court, the Electoral College, or the filibuster—all distractions from existential problems the Left largely created. 

So, what are the therapies and prognoses for America?

In the spirit of constructive rather than blanket criticism, here is a partial, 10-point plan of national recovery.

1. Cut the Debt 

Americans’ national debt is now $31 trillion. That is about 123 percent of current GDP. The liabilities are unsustainable. We run annual deficits of $1.6 trillion. These financial obligations will eventually ensure that rising interest rates to service the debt crowd out essential spending for national defense and the general welfare. 

Or in extremis, in the not too distant future, the government will be forced to default on what it owes the “rich” bondholders and foreign debt holders. Or the government will be forced to confiscate private wealth, as for example occasional crazy suggestions to nationalize and absorb 401(k)k retirement plans into the soon-to-be-insolvent Social Security system. Or the state will simply print millions of dollars to pay off obligations, Weimar-style.

In addict style, the more we come to realize that our binging habit cannot go on, the less we can practice self-restraint. And the more it is the case that those who receive government redistributions outnumber those who pay the majority of federal income taxes, the less hope there remains to avoid insolvency.

In 2010 then-President Barack Obama appointed a bipartisan “National Commission on Fiscal Responsibility and Reform.” More commonly  remembered as the Simpson-Bowles commission, after chairmen Senators Alan Simpson (R-Wyo.) and Erskine Bowles (D-N.C.), it included private citizens and elected officials. 

The commission recommended radical tax simplifications and some cuts—along with reductions in tax deductions and credits, an increase in the gas tax, restraints on entitlement spending, and various spending caps. 

Obama and Congress ultimately rejected the recommendations and the commission’s blueprint died. But had it succeeded, the current debt would have long been frozen at the 2014 level of $17 trillion—with annual reductions ensuring that this coming year 2023 the debt would have plunged to $10 trillion and then disappeared in another decade. 

Something like Simpson-Bowles could still stop the madness and avoid the natural corrective on the horizon of financial collapse. Note that federal tax revenue has increased almost every year since 2010. Sometimes it grows by nearly a half-trillion dollars per annum, even as we sink deeper in debt. Our crisis, then, is one of spending what we do not have rather than one of declining revenue.

2. Secure the Border 

We no longer have a southern border. There have been 5 million illegal border crossings just since Joe Biden took office. He intentionally destroyed immigration law for cheap political advantage. Nearly 50 million current American residents were not born in the United States. Well over 20 million—and perhaps 30 million—are illegal aliens. Old melting-pot efforts at assimilation and integration eroded into the salad-bowl metaphor that has just become tribalism—even as intermarriage is at an all-time high. 

The Left brags that “demography is destiny” as it cheers the changes in the electorate aimed at ensuring its political dominance. And simultaneously, it smears conservatives who agree with its triumphalism as “great replacement theory” conspiracists. 

Yet we finally found a solution in 2019-2020. Had we continued replacing rickety border fencing with an effective wall and then completed it along the entire border, had we stopped catch-and-release, had we continued demanding that refugee status be obtained before entry, had we forced Mexico and Central American governments to stop exporting human capital and subjected them to taxes on more than $60 billion in annual remittances (along with trade penalties) for their complicity with the situation at the border, had we continued to deport those who entered illegally, had we returned to assimilation and integration on the theory any who entered America did so because they wanted to become Americans, then a desired legal, meritocratic, and diverse immigration policy might easily have assimilated and absorbed perhaps 200,000 skilled and legal immigrants per year. 

Again, we had the outlines of a solution and then simply destroyed it for liberal political agendas and cheap corporate labor. 

3. Tap Natural Resources 

Similarly, by 2020, the United States enjoyed inexpensive fuel. It was all but independent in gas and oil. It had become the world largest combined gas and oil producer. That status radically curtailed the need for optional military engagements in the Middle East. It gave America enormous clout against hostile oil exporters like Russia, Iran, and Venezuela. And such independence helped reduce vast trade deficits. 

Again, the Biden Administration simply exploded the idea of fossil-fuel independence as a gradual transition to sustainable energy. So simply doing the opposite of its policies would correct the pathology almost immediately: Issue more federal gas and oil leases, approve the Keystone and Constitution pipelines, reopen the Arctic National Wildlife Reserve, and build nuclear power plants. The present course of high-priced and scarce gasoline and oil is eroding the middle class, spiking inflation, widening class divisions, and reducing American autonomy abroad. 

4. Oppose Discrimination

Never has the United States seen more evidence of progress in racial relations, and never has such progress given way to more tribalism. If we do not return to a Martin Luther King, Jr. “content of our character” policy—one that views race as incidental rather than essential to who we are—then our future is a sectarian one with echoes of the former Yugoslavia, Rwanda, and Iraq. 

Affirmative action was never envisioned as permanent quotas and race-based reverse-discrimination. Yet after over a half-century it has ballooned under the idea of “diversity” to invent a victim class of nearly a third of the nation, absurdly and loosely defined—in an age of commonplace intermarriage—as “non-white.” 

Help for the underprivileged should be race-neutral and entirely based on class and income, given numerous ethnicities exceed the so-called white medium income. The labyrinth of racial categories grows unfathomable. The identity politics mess logically results, on the one hand, with rank iconic frauds like Elizabeth Warren, Ward Churchill, and Rachel Dolezal, and, the other hand, with well-off poseur victims in the manner of a Meghan Markle, Colin Kaepernick, or Jussie Smollett. 

Substitution of racial criteria for merit, rather than aiding the poor of all races, is creating a commissar-like drag on the economy, spiking racial and ethnic tensions, and ensuring that every group will eventually, for its survival, go tribal on the basis of the same logic that applies to nuclear proliferation. Again, the remedy? Just enforce civil rights statutes that prohibit racial discrimination and consider the Pavlovian shriek of “racism!” as the revealing projection of racists.

5. Disrupt and Reform Higher Education 

Our universities are failing to produce competent graduates essential to a meritocratic nation engaged in fierce global competition. Increasingly, students are politicized, largely ignorant, indebted, bitter, and unable to ensure American preeminence in basic science, technology, engineering, and math. 

Yet the solutions are again simple: get the government out of the student-loan business that ensures escalating tuition hikes greater than the rate of inflation. Eliminate faculty tenure and replace it with five-year contracts that require demonstrable achievement. Subject large endowments to taxation on their interest income to curb their wasted spending. Allow public schools to hire either those with school of education credentials or one-year master’s degrees that focused solely on academic study. Require standardized exit tests, in the fashion of erstwhile SAT and ACT entry tests, for the certification of the bachelor’s degree. Force universities to follow the Bill of Rights on campus, regarding due process and freedom of expression. 

These are not radical suggestions. Yet the likely fierce faculty opposition to them is proof that the Left envisions higher education as it views Silicon Valley—another private monopoly that helps to maintain political power in lieu of popular support.

6. Revive the Armed Forces 

Our military is in dire straits. It is overcommitted, under-resourced, and without any geo-political strategy other than ad hoc responses without defined objectives. It has become politically weaponized and, inevitably, unable to meet recruitment goals. The Pentagon remains obsessed with exorbitantly priced weapons that cannot be produced in sufficient numbers in an age of hostile swarms of cheap, mass-produced drones and thousands of batteries of ground-to-air and shore-to-ship missiles. 

Constant profiling, racial, and gender quotas and obsessions over proportional representation and disparate impact increasingly apply to training, education, and promotion—to everything except worries over the disproportionate profile of those killed in battle. The Pentagon has become adept in publishing racial data on every aspect of military service to emphasize disparity and bias—except concerning the combat dead. 

To address the changes, retiring high-ranking officers should refrain from board memberships on contracting corporations for at least five years upon leaving the military. The uniform code of military justice must be strictly enforced, including article 88 which prohibits retired officers from attacking in personal terms high-ranking elected officials, and in particular their commander-in-chief. 

Woke training is destroying morale and battlefield efficacy. The military must return to a race and gender neutral stance that does not erode meritocratic standards to fit political agendas. We should never again witness a chairman of the Joint Chiefs of Staff virtue signaling to Congress and the nation his intention to understand “white rage” in the ranks, without supplying any confirmatory evidence or data for his apparent allegation of systemic racism in the ranks—particularly not while the greatest U.S. defeat and humiliation in a half-century was unfolding on the horizon in Kabul. Any high-ranking military officer who informs his Chinese counterpart of his own psychiatric diagnosis that his commander-in-chief is unhinged and thus U.S. strategic intentions will first be relayed to Beijing should be summarily dismissed.

7. Fix Voting 

Elections are a mess. The greatest political revolution in our election history has been the change—accelerated under the cover of COVID and the George Floyd riots—in many key estates from a 20-30 percent “absentee ballot” vote to 70-80 percent early/mail-in balloting. In a mere four years we have all but destroyed Election Day voting and Election Night final tabulations as we had known them for decades. 

All discussions of voter IDs, fraud, and charges and countercharges of election denialism are irrelevant if there is no real mechanism to validate the authenticity of mail-in ballots that have incomplete or false addresses, names, and signatures, or do not match registration rolls. Third-party ballot harvesting and ballot curing should be outlawed at the federal level, and we should return to the requirement of requesting absentee ballots rather than automatically sending them out. Otherwise, no future election will again win the confidence of a majority of Americans. And without trust in balloting, consensual government becomes nonexistent.

8. Drain the Swamp 

Americans distrust the “swamp,” administrative state, or deep state. Call what you will, the Washington nexus of bureaucracies, media, and lobbyists has created a huge, unelected permanent army of auditors, regulators, investigators, and punishers, all mostly exempt from audit and accountability and without fear of their elected overseers. 

The easiest solution is to break up concentrations of power. Transfer out of Washington, in this age of zoom and telecommunications, major cabinet departments like Health and Human Services, Energy, or Agriculture into the hinterland. Restore the idea that lying to Congress, feigning amnesia, or pleading ignorance under oath to Congress or federal investigators or in depositions is a prosecutable felony with jail time. 

Had we restored equality under the law, then an Andrew McCabe, James Clapper, and John Brennan would not have dared lie under oath. And a Robert Mueller, James Comey, Anthony Fauci, or Jack Dorsey might have not so easily believed they simply could plead memory loss or mislead in a fashion that no American would dare to do with the IRS. 

Being forced to tell the truth would be a powerful deterrent against bureaucratic overreach. 

Finally, ossified centralized agencies like the FBI need to be broken up and their bureaus redistributed through the cabinet-level departments to avoid past pathologies resulting from a concentration of power.

9. Upend the Welfare State 

The number of those receiving federal and state subsidies is beginning to match the number of those who subsidize them. “No one wants to work anymore” is now a common public lament. Inflation and recession may come and go, but workers are now scarce whether we are in boom or bust times. Labor non-participation remains at an all-time high. Soon only 60 percent of the available labor force will be working. Trillion-dollar COVID subsidies have accelerated the idea that Americans need not work full-time to maintain a living. 

We can easily return to the “workfare” championed by a triangulating Bill Clinton in the 1990s that demanded healthy and able recipients to be gainfully employed upon receipt of state and federal cash. In the context of the homeless, we need to return to pre-Reagan norms of institutionalizing the mentally ill and creating hospitals and safe spaces away from American downtowns to house those who either cannot or will not take care of themselves. Defecating, urinating, injecting, and fornicating on city-streets are not victimless crimes, but assaults on civilized life as we once knew it.

10. Restore Norms 

Fact is, few public norms are left. Rather than the current therapeutic obsessions that seek to divide Americans into binaries of oppressors and the oppressed, we are in desperate need of civic education in K-12 that acquaints all children and teens with American institutions, key events like Gettysburg or D-Day, and familiarity with the Constitution and the duties of the citizen. We will get nowhere basing our understanding of the world on psychodramas and therapeutics. 

Neither journalists nor elites understand, much less appreciate, the First Amendment, and in ignorance despises the Second.

Like it or not, the nuclear family remains the bulwark of the American nation, which will not survive if current fertility rates of below 1.7 children per woman continue to diminish and age the population. The government must incentivize childbearing and child raising. 

Without clear punishment for violent crimes, deterrence is lost, and the innocent become victims of the exempt criminal class. Critical race theory, critical legal theory, and critical criminology theory are euphemisms for unleashing lawbreakers upon the vulnerable. We are in a strange cycle in which we deliberately do not enforce gun laws in our cities and then when murder reaches near historic proportions we blame unenforced guns laws rather than the criminals who are exempt in using deadly weapons as the cause. 

These are just a few of the many ways that the United States could stop the present madness—which, after all, was entirely self-created.

Tyler Durden Mon, 12/19/2022 - 16:20

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This course asks, ‘What is mindfulness?’ – but don’t expect a clear-cut answer

Mindfulness is everywhere in pop culture today, but that doesn’t mean people agree on what it means.

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March 23, 2023

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Practicing mindfulness doesn't have to mean being removed from the world. PeopleImages/iStock via Getty Images Plus
Text saying: Uncommon Courses, from The Conversation

Uncommon Courses is an occasional series from The Conversation U.S. highlighting unconventional approaches to teaching.

Title of course:

“What is Mindfulness?”

What prompted the idea for the course?

As a professor of religion and ethics, particularly Asian traditions, I had already been interested in teaching a course about mindfulness. Its popularity seems to be surging: I see “Mindful” on magazine racks, and almost everyone I’ve met at my university has used the word at some point.

But oftentimes people say to be “mindful” when they mean “pay attention” or “don’t forget”: being “mindful” of a slippery road, say, or telling students to be “mindful of the deadline.” I started wondering what other people meant each time they used the word. This made me realize my course shouldn’t be a lecture about mindfulness, but an opportunity to explore what it is in the first place.

What does the course explore?

The course explores the origins of mindfulness in yoga and Buddhism. Mindful meditation – being attentive to one’s body, feelings and thoughts – is part of one of the Buddha’s central teachings, the Noble Eightfold Path, and considered key to enlightenment.

But we explore the many meanings of “mindfulness” that have emerged in recent decades, too. American professor Jon Kabat-Zinn is credited with popularizing the kind of mindfulness that has caught on with non-Buddhists today, starting with his “mindfulness-based stress reduction” program in the 1970s.

Some people are upset that mindfulness has become too mainstream and fear that it has lost its intended meaning. Buddhism scholar Ronald Purser’s book “McMindfulness,” for example, argues that capitalist societies have embraced mindfulness as a way to put the burden of mental health back on the individual rather than address root problems.

Students in my class read a variety of these perspectives and discuss themes such as mindfulness and mental health, mindful eating and breathing, environmental mindfulness and even meditation apps. In the end, I want each student to decide for themselves what mindfulness is.

A woman in exercise clothes does a yoga pose inside a dark cathedral with stained glass windows.
Mia Michelson-Bartlett, yoga teacher and manager of visitors’ services, practices yoga and mindfulness meditation inside the Cathedral of St. John the Divine in New York City. Angela Weiss/AFP via Getty Images

Why is this course relevant now?

I first proposed this course right before the arrival of COVID-19, so when it launched for the first time, we met remotely over Zoom. I was tempted to drop the class after we went remote, but I quickly realized that it might help students who were wrestling with mental health issues at the beginning of the pandemic.

Each student kept a journal of our topics every week to practice mindfulness and to explore some of the therapeutic techniques. First, I asked them to find examples of the word in their everyday experiences – used on a poster at the student rec center, for example.

Later, I asked them to practice breathing and visualization techniques from the influential Vietnamese monk Thich Nhat Hanh, such as asking yourself every hour “What am I doing?” and reflecting on your mind, emotions and posture.

What’s a critical lesson from the course?

Buddhism changes dramatically depending on “whose” Buddhism you are talking about. The dalai lama’s form of Tibetan Buddhism, for example, is not the same as the Zen Buddhism of Thich Nhat Hanh.

A row of monks stand next to a small crowd of schoolchildren in uniform as one monk takes a child's hand.
Zen master Thich Nhat Hanh reaches for a student’s hand during a meditation walk on a ‘day of mindfulness’ in Hong Kong in 2007. Steve Cray/South China Morning Post via Getty Images

It’s the same with mindfulness. Thirteenth-century Zen master Dōgen taught pupils to seek mindfulness in seated meditation. Five hundred years later, on the other hand, Zen master Hakuin taught mindfulness in the midst of activity – practicing it not just on the meditation pillow, but amid the hustle and bustle of the streets.

All forms of Buddhism, though, focus on transforming suffering into lovingkindness. So teaching this course has persuaded me that if the way you teach mindfulness helps someone, it doesn’t matter if it’s “real” Buddhist mindfulness or not. If pop culture’s version of the concept relieves someone’s suffering, then I don’t want to be a gatekeeper and say, “This is not real mindfulness.”

What will the course prepare students to do?

All of the students in this course are first-semester freshmen. The class began as a way to get them to think critically about what mindfulness is but also offers tools to deal with the stress of college life.

Muscles grow after they heal and rest. The same is true when it comes to learning. Our minds need to take time to breathe, reflect on new information and absorb it.

I also hope students will understand that taking care of oneself can be an act of care for others. Just as on an airplane we are told to put on our own oxygen mask before helping the person next to us, we all need to take care of our own mental health in order to help those around us.

Kevin C. Taylor does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

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Post-bariatric surgery exercise modulates brain regions associated with regulation of food intake

Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety,…

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March 23, 2023

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Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety, for example. This was the result observed in a clinical trial conducted at Hospital das Clínicas (HC), the hospital complex run by the University of São Paulo’s Medical School (FM-USP) in Brazil. An article on the study, pointing to positive effects of exercise on obesity-related conditions in post-bariatric patients, is published in the International Journal of Obesity.

Credit: Carlos Merege Filho

Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety, for example. This was the result observed in a clinical trial conducted at Hospital das Clínicas (HC), the hospital complex run by the University of São Paulo’s Medical School (FM-USP) in Brazil. An article on the study, pointing to positive effects of exercise on obesity-related conditions in post-bariatric patients, is published in the International Journal of Obesity.

The study showed that an exercise training program starting three months after bariatric surgery produced functional alterations in brain networks associated with food intake and modified by obesity. The findings confirm the hypothesis that exercise and bariatric surgery act synergistically on the connectivity among brain regions associated with cognition, reward and emotional regulation, potentially moderating hunger and enhancing satiety.

According to the article, exercise increased the connectivity between the hypothalamus (the brain region that controls homeostasis, including regulation of appetite and energy expenditure) and the brain’s sensory areas. At the same time, it apparently decreased the link between the default mode network, which is more active during a resting state, and the salience network, the brain region involved in decision-making.

The researchers also found that exercise after bariatric surgery appeared to modulate the medial hypothalamic nucleus involved in appetite suppression and increased energy expenditure.

“The regulation of energy expenditure is governed by multiple internal and external signals. People with obesity display major dysregulation of brain regions associated with appetite and satiety. Our study showed that exercise by post-bariatric patients helped ‘normalize’ these complex networks so as to improve the central control of food intake. For example, some of these regions are activated and connect more intensely in people with obesity when they eat fatty or sugary food, increasing their desire to consume such food. We found that exercise counteracts this effect, at least in part,” Bruno Gualano, last author of the article, told Agência FAPESP. Gualano is a professor at FM-USP.

The study was supported by FAPESP via a research grant for the project “Effects of exercise training in patients undergoing bariatric surgery: a randomized clinical trial” and was part of the PhD research of Carlos Merege Filho, first author of the article, with a scholarship from FAPESP. The co-authors included Hamilton Roschel, Marco Aurélio Santo, Sônia Brucki, Claudia da Costa Leite, Maria Concepción García Otaduy and Mariana Nucci (all of whom are affiliated with HC-FM-USP); and John Kirwan of Pennington Biomedical Center (USA).

Considered one of the world’s main public health problems, obesity is a chronic disease characterized by excessive body fat accumulation and a major risk factor for cardiovascular and musculoskeletal disorders, as well as severe COVID-19. The parameter used for diagnosis in adults is body mass index (BMI), defined as weight in kilograms divided by height squared in meters. A BMI between 25 and 29.9 indicates overweight, while 30 or more signals obesity, according to the World Health Organization (WHO).

Brazil has one of the highest rates of overweight and obesity in the world. According to projections, almost 30% of the adult population will be obese in 2030. A billion people, or 17.5% of the world’s adult population, will be obese by then, according to the World Obesity Atlas 2022 published by the World Obesity Federation.

Importance

From the clinical standpoint, Gualano believes, the findings suggest that exercise should be considered an important complementary therapy to improve brain functions and enhance the known benefits of bariatric surgery, such as a reduction in cardiometabolic risk factors, as well as preservation of muscle mass and bone health.

He and his group have been conducting research in this field since 2018, as evidenced by other publications, one of which showed that exercise attenuated and reversed loss of muscle mass, improving muscle strength and function in post-bariatric patients. Genotypic and phenotypic analysis evidenced metabolic and structural remodeling of skeletal muscle.

In another study, exercise reduced risk factors for diseases associated with obesity, such as diabetes, high blood pressure and atherosclerosis (hardening of the arteries), by increasing sensitivity to insulin, combating inflammation and improving the health of blood vessels.

Methods

The randomized clinical trial reported in the International Journal of Obesity involved 30 women aged between 18 and 60 who had been submitted at HC-FM-USP’s bariatric surgery unit to a Roux-en-Y gastric bypass, which creates a small stomach pouch to restrict food intake and bypasses a large portion of the small intestine to limit calorie absorption. A majority of patients admitted to the unit are women. 

Half the study sample were randomly assigned to a six-month exercise program of resistance and aerobic training three times a week, starting three months after the operation and supervised by a team of physical education professionals.

Clinical, laboratory and brain functional connectivity parameters were assessed at the start of the trial, as a baseline, and again three and nine months after the operation. Functional magnetic resonance imaging (fMRI) was used to detect connectivity between anatomically distinct brain areas organized as networks, and to analyze the combined effects of the surgical procedure and exercise training. Data collection began in June 2018 and ended in August 2021.

“The literature has already shown that post-bariatric patients have many brain alterations compatible with improved control of appetite, satiety and hunger in neural circuits that govern food intake. Our study found that exercise training bolstered this response,” Gualano said, noting the importance of lifestyle changes to maintain the benefits of weight loss for people with obesity.

Bariatric surgery can currently be performed on patients with a BMI of between 30 and 35 and type 2 diabetes that has not been controlled for more than two years, and patients with a BMI over 35 who have other diseases associated with overweight, such as high blood pressure, sleep apnea or hepatic steatosis (fatty liver disease). For people with comorbidities, the recommended BMI is over 40.

In the past five years, 311,850 bariatric surgeries have been performed in Brazil; 14.1% were paid for by the SUS (Sistema Único de Saúde), the national health service. The rest were covered by insurance policies or paid for privately, according to the Brazilian Bariatric and Metabolic Surgery Society (SBCBM).

“Regular exercise is known to induce several physiological adaptations that translate into health benefits. These benefits are reversed if the patient stops exercising regularly. Our study didn’t measure the duration of the brain changes induced by exercise, however. They’re highly likely to diminish and possibly even go into reverse as the amount and intensity of exercise decrease. It’s crucial to adopt a healthy lifestyle in order for the responses to bariatric surgery to be long-lasting,” Gualano said.

Next steps for the research group will include studying the effects in people with obesity of exercise and diet combined with other weight loss strategies, including new drugs such as peptide analogs or incretin mimetics, a class of medications commonly used to treat type 2 diabetes. Incretins are gut hormones that aid digestion and blood sugar control by signaling to the brain to stop eating after a meal.

In early January, the National Health Surveillance Agency (ANVISA) approved semaglutide as an anti-obesity drug for long-term weight management. The drug had previously been approved only for patients with type 2 diabetes. It is the first injectable anti-obesity medication available in Brazil and is supposed to be administered once a week. It is said to enhance satiety, modulate appetite and control blood sugar. 

About São Paulo Research Foundation (FAPESP)

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe

Journal

International Journal of Obesity

DOI

10.1038/s41366-022-01251-8

Article Title

Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial

Article Publication Date

30-Dec-2022

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The CeMM & Angelini Ventures Healthy Lifespan Expansion Initiative

CeMM and Angelini Ventures are joining forces to support CeMM Principal Investigators Laura de Rooij and André Rendeiro in critical lifespan expansion…

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March 23, 2023

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CeMM and Angelini Ventures are joining forces to support CeMM Principal Investigators Laura de Rooij and André Rendeiro in critical lifespan expansion initiatives leveraging a novel academic/entrepreneurial dual-track program. De Rooij and Rendeiro, in collaboration with their teams, will lead an original research program on healthy lifespan expansion.  In parallel, they will collaborate on venture creation based on scientific and business insights developed by their work. Venture creation and related business development activities will take place along with scientific research.  The expectation is that this double-track initiative will allow for virtuous feedback cycles, propelling innovation through scientific research and bold venture creation goals.

Credit: CeMM

CeMM and Angelini Ventures are joining forces to support CeMM Principal Investigators Laura de Rooij and André Rendeiro in critical lifespan expansion initiatives leveraging a novel academic/entrepreneurial dual-track program. De Rooij and Rendeiro, in collaboration with their teams, will lead an original research program on healthy lifespan expansion.  In parallel, they will collaborate on venture creation based on scientific and business insights developed by their work. Venture creation and related business development activities will take place along with scientific research.  The expectation is that this double-track initiative will allow for virtuous feedback cycles, propelling innovation through scientific research and bold venture creation goals.

(Vienna, 22 March 2023) Some societal challenges are of such importance to assume the central stage in the public discourse on sustainability and the future of humanity. Such a challenge is aging. Aging is a multidimensional phenomenon, occurring at the individual and population levels of society and on the molecular, cellular, and organ level of the human body. The urgency of dealing with the consequences of aging is illustrated by the fact that in just over ten years from now, more than a third of the population of Italy, one of the world’s most rapidly aging countries, will be over 65 years of age. Expanding the lifespan in which individuals enjoy a healthy status, in which they can be independent and productive, is critical for economic, social, and cultural reasons.

The fundamental mechanisms of aging, at the molecular, cellular, and tissue level, are still unclear and most single theories fail to explain the phenomenon. Scientific leaders are increasingly interested in combining cutting-edge research with immediate value creation and effective societal impact. Laura de Rooij and André Rendeiro will be supported by a network of mentors and experts. At CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, the team will benefit from access to faculty peers, the center’s scientific leadership, a scientific advisory board, and the biotech ventures built in CeMM’s ecosystem of spinoffs. Through Angelini Ventures, the team will be supported to ideate and develop viable start-up companies emerging from their work and have access to an international network of investors, healthcare experts, and industry innovators.

 

“The Angelini Ventures team is delighted to partner with CeMM to collaborate on accelerating lifespan expansion research and venture creation. We believe this type of collaboration is the connective tissue between innovation and entrepreneurship. By combining our venture creation capabilities with the breakthrough research from CEMM, we can accelerate the pace of healthcare transformation,” says Paolo Di Giorgio, Chief Executive Officer of Angelini Ventures.

“CeMM is proud to pioneer a new training, research, and innovation method meant to foster a novel generation of professionals familiar with both the research and business worlds. In addition to expecting commercial success, the desired outcome is to create leaders able to inspire a new generation of scientists. Our goal is for the dual track of scientific research and business development to expand beyond the CeMM-Angelini network,” says CeMM Scientific Director Giulio Superti-Furga.

 

About the Principal Investigators

Laura de Rooij joined CeMM as principal investigator in September 2022. Her lab focuses on deciphering the transcriptomic landscape and role of circulating endothelial cells in health and aging. Laura de Rooij studied Biomedical Sciences at the University of Amsterdam (The Netherlands). She then joined the Stem Cell and Cancer Research Institute at McMaster University in Hamilton (Canada), where she studied the role of RNA binding proteins in leukemic stem cells via an in vivo two-step CRISPR-Cas9-mediated screening approach. For her post-doctoral studies, she returned to Europe to work under the mentorship of Prof. Carmeliet in the lab of Angiogenesis and Vascular Metabolism at VIB-KU Leuven (Belgium). Here she led and contributed to numerous single-cell transcriptome atlases of endothelial cells, generated from a diverse range of tissues, preclinical models, and clinical patient material in health and disease. Her studies have shed new light on the degree of vessel subtype heterogeneity in different tissues, as well as the altered composition and rewired molecular circuitries of endothelial cell subtypes in disease. Moreover, her efforts led to the discovery of previously unknown vascular subtypes and functions, including endothelial cells with a lipid-processing phenotype and potential prognostic relevance in breast cancer, and endothelial cells with a putative pro-fibrotic function in COVID-19. At CeMM, her lab focuses on deciphering the transcriptomic landscape and role of circulating endothelial cells in health and aging.
Read more about Laura de Rooij’s research

André Rendeiro is a Principal Investigator at CeMM since June 2022. He leads a group studying how cells interact to generate complex physiology in the human body, and how this changes over the lifespan of individuals and gives rise to disease. To do that, his group develops computational methods for the analysis of spatial data (spatial transcriptomics, highly multiplexed imaging, histopathological images), and its integration with various modalities of molecular, demographic, and clinical data of individuals along their lifespan. Prior to starting his group, André studied in Portugal, Austria, and Norway and earned his PhD in Molecular Medicine at CeMM in Vienna. During his PhD he developed methods for high-throughput cellular profiling and perturbation at single-cell resolution, applying them to leukemia, in the lab of Christoph Bock at CeMM. Between 2020 and 2022 he was a Postdoctoral Associate at the Institute for Precision Medicine and the Institute for Computational Biomedicine at Weill Cornell Medicine in New York. There he developed computational methods for the analysis of highly-multiplexed imaging that incorporate expression, morphology, micro-anatomy, and clinical covariates, in the lab of Olivier Elemento. He led the first tissue-level, single-cell resolution maps of lung pathology during COVID-19, and also contributed to the study of cancer, lung development, and disease, as well as COVID-19 immunology.
Read more about André Rendeiro’s research

The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences is an international, independent, and interdisciplinary research institution for molecular medicine under the scientific direction of Giulio Superti-Furga. CeMM is oriented toward medical needs and integrates basic research and clinical expertise to develop innovative diagnostic and therapeutic approaches for precision medicine. Research focuses on cancer, inflammation, metabolic and immune disorders, and rare diseases. The Institute’s research building is located on the campus of the Medical University and the Vienna General Hospital. www.cemm.at

Angelini Ventures, the venture capital arm of Angelini Industries, is an early-stage investment firm focused on accelerating disruptive innovations and trends in digital health and life sciences. The group will invest €300M across a global portfolio led by investment professionals and advisors in Europe, North America, and Asia. Angelini Ventures has deep domain expertise and leverages a global team, advisors, and strategic partners to help entrepreneurs scale their businesses into transformative category-leading companies. www.angeliniventures.com

Angelini Industries is a multinational industrial group originally founded in Ancona (Italy) in 1919 by Francesco Angelini. Today it is a solid, structured industrial business with around 5,800 employees operating in 21 countries.  Angelini Industries operates in the health, industrial technology, and consumer goods businesses. Its investment strategy aimed at growth, constant commitment to research and development, and deep knowledge of markets and business sectors make Angelini Industries an Italian leader in the industries in which it operates.  The group is committed to reducing its environmental impact and finding increasingly cutting-edge circular economy solutions. It adopts the most advanced health and safety standards for workers and the most rigorous processes to ensure the highest quality by verifying the entire supply chain: from supplier certification to the control of raw materials, the production process, the finished product, and packaging, to spot checks at the point of sale.  For over 100 years, the Angelini family has steered the development of Angelini Industries with an entrepreneurial style typical of Italian family businesses. www.angeliniindustries.com

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