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Vaccibody rebrands as Nykode, and unveils big Regeneron partnership

Norwegian biotech Vaccibody has changed its name to Nykode Therapeutics, and celebrated its new identity with a sizeable
The post Vaccibody rebrands as Nykode, and unveils big Regeneron partnership appeared first on .



Norwegian biotech Vaccibody has changed its name to Nykode Therapeutics, and celebrated its new identity with a sizeable deal with Regeneron to develop vaccines for cancer and infectious diseases.

The Oslo-based company is getting $50 million upfront from Regeneron – split between cash and an equity investment – with another $875 million on the table if the partnered projects make headway through development and reach the market.

Nykode’s Vaccibody technology generates DNA plasmids directed against neoantigens, which are only found on tumours. They are an attractive target for cancer immunotherapies as they may be recognised as foreign and attacked by the immune system, while leaving healthy tissue unscathed.

The platform has already attracted other biopharma groups including Roche, which paid $200 million upfront last year for rights to an individualised cancer vaccine with another $515 million at the back end.

The deal with Regeneron covers up to five programmes, three in cancer and two in infectious diseases, which could each include multiple vaccine candidates. The US biotech will cover R&D costs as well as development, regulatory, manufacturing and sales for projects that progress.

For now, the specific targets or diseases are not being disclosed, but the partnership will be based on antigens selected by Regeneron as well as in vivo testing, with Nykode generating vaccine candidates and supplying them for initial clinical testing.

Regeneron’s head of oncology research, Gavin Thurston, said that the Vaccibody platform ” efficiently delivers vaccine payloads to antigen presenting cells and allows for vaccine candidates that can be easily manufactured.”

Vaccibody candidates have already shown robust CD8+ antigen-specific T cell responses in animal models and in patients with cancer, he added.

Along with the Roche and Regeneron deals, Nykode is also working with Nektar Therapeutic in oncology, and has teamed up with Adaptive Biotech on a second-generation COVID-19 vaccine targeting the beta variant of SARS-CoV-2 that started a phase 1/2 trial earlier this month.

Other companies working on neoantigen cancer vaccines include Cambridge, UK-based Neophore, Frame Therapeutics of the Netherlands and US biotech Gritstone.

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UK PM announces tougher measures amid more Covid cases

In total, the UK recorded 51,342 new COVID-19 cases in the last 24 hours…
The post UK PM announces tougher measures amid more Covid cases first appeared on Trading and Investment News.



In total, the UK recorded 51,342 new COVID-19 cases in the last 24 hours on Wednesday and a further 161 people have died within 28 days of testing positive for the novel coronavirus

UK Prime Minister Boris Johnson on Wednesday announced tougher measures such as work from home where possible, expanded face mask rules and use of COVID-19 vaccination certificates for entry to venues, as another 131 cases of the new Omicron variant were recorded, taking the total to 568.

The UK government’s Plan B winter strategy comes in force in stages starting this Friday, in an effort to slow the spread of the highly transmissible variant, which Johnson said shows a doubling time of two or three days.

Addressing a Downing Street media briefing, he said all signs indicate that Omicron transmits more rapidly than the previously dominant Delta variant of COVID-19.

From this Friday, we will further extend the legal requirement to wear face masks in public indoor venues, including theatres and cinemas. We will reintroduce guidance to work from home from Monday work from home if you can, go to work if you must but work from home if you can, said Johnson.

We’ll also make the NHS COVID pass mandatory for entry into nightclubs and venues where large crowds gather, including unseated indoor venues with more than 500 people, and seated outdoor venues with more than 4,000 people and any venue with more than 10,000 people, he said, adding that this will come into effect from next week.

Johnson once again called on everyone to come forward for their COVID vaccinations, including all adults now eligible for a third top-up booster dose.

We must be humbled in the face of this virus. As soon as it becomes clear that the boosters are capable of holding this Omicron variant and we have boosted enough people to do that job of keeping Omicron in equilibrium, we will be able to move forward as before. Please everybody play your part and get boosted, he said.

The government had so far stopped short of enforcing Plan B and issued guidelines for compulsory face masks on transport and some indoor settings, such as shops.

We now have, in the Omicron variant, a variant that is spreading much faster than any that we have seen before. That is why I ask everybody to go to get their booster jab as soon as they are called to come forward, said Johnson, when asked about Plan B in Parliament on Wednesday.

In total, the UK recorded 51,342 new COVID-19 cases in the last 24 hours on Wednesday and a further 161 people have died within 28 days of testing positive for the novel coronavirus.

Since the first jab was delivered one year ago today, our phenomenal vaccine rollout has saved hundreds of thousands of lives and given us the best possible protection against COVID-19, said Johnson.

Our fight against the virus is not over yet, but vaccines remain our first and best line of defence against the virus so the best way to continue to protect yourself and your loved ones is to get behind the vaccine programme and get boosted as soon as you’re eligible, he said.

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Canada’s Top Renewable & Clean Energy Stocks for December 2021

There’s no questioning the fact that as a population we’re moving towards cleaner, greener forms of energy. Fossil fuels will be a thing of the past, and the world will benefit immensely from it.How long will it take before Canadian renewable companies…



There's no questioning the fact that as a population we're moving towards cleaner, greener forms of energy. Fossil fuels will be a thing of the past, and the world will benefit immensely from it.

How long will it take before Canadian renewable companies dominate the energy scene? It's difficult to say. But if I were to guess, not long at all. That's why you need to have a look at these Canadian stocks before it's too late.

The renewable energy vs fossil fuel debate is a heated one

The effects of fossil fuels on the climate and climate change in general is an extremely touchy subject, and arguments from both sides tend to pack a sizable punch in terms of support. Plus, much like Canadian gold stocks, fossil fuel companies rely heavily on a commodity and can be quite cyclical.

But all while this is happening, green energy companies here in Canada are quietly amassing large asset bases and production capacities. It's an investment gold mine.

Your best bet as an investor is to funnel out the noise and instead take a position in a strong TSX listed renewable energy stock.

Because it's a matter of when, not if these companies take over as the primary method of energy generation

And while people sit on the sidelines, squabbling over if swapping to renewables is worth it, you can be making boatloads of money off of it.

Don't believe me? These clean energy companies have crushed the returns of the TSX Index.

So if you're new to buying stocks here in Canada, you may want to know what exactly these Canadian renewable energy companies do. Lets go over it.

What exactly do Canadian renewable energy companies do?

Renewable energy is defined as such:

"energy from natural resources that can be naturally replenished within a human lifespan." - Natural Resources Canada

Renewable energy companies provide sources of power that are often considered cleaner and more sustainable including but not limited to:

  • Hydroelectric
  • Wind
  • Solar
  • Biomass
  • Hydrogen

Renewable energy provides nearly 20% of Canada's energy supply, with hydroelectricity accounting for over half of that.

A common misconception with Canadian green energy companies? 

Renewable companies aren't the new kids on the block, despite many thinking so.

In fact, they have been around for quite some time now, and as a result clean energy stocks provide stable and reliable cash flows, much like regulated utility giants Fortis, Canadian Utilities and Emera.

The end result?

Clean energy companies are able to provide strong dividends to go along with upside potential in an ever growing industry.

Let’s take a closer look at four renewable energy companies we think are the cream of the crop here in Canada for 2021.

As requested by many readers, we've also added a solar energy company to the list in this most recent update. Solar stocks in Canada have been around for a while, but have remained relatively unknown due to high costs, and investors are starting to gain interest

What are the best Canadian renewable energy stocks?

4. Canadian Solar Inc (NASDAQ:CSIQ)

One of the primary reasons we've never included a Canadian solar company on this list of renewable energy stocks is the fact that the best of the best trades down south on the NASDAQ.

However, due to increasing demand we figure we'd start talking about Canadian Solar Inc (NASDAQ:CSIQ).

Solar stocks in general have surged as of late, but since its lows in March 2020 Canadian Solar has shot up over 81%.

The stock has dipped significantly from all time highs however as renewable energy companies have gone through a significant correction. But, there is still a bullish attitude.

We think investors, and analysts for that matter, are finally starting to see the potential in the once small cap Canadian (but U.S. traded) company.

Canadian Solar benefits from a fairly low cost of production and has a decent amount of projects planned for the future.

Initially, solar power faced a lot of criticism. Production costs were extremely high, and it wasn't looked at as a permanent solution to dirtier forms of power.

But the fact is, we wouldn't even need to capture one-hundredth of a percent of the energy hitting the earth in a year to be able to scrap every other form of energy generation. And as costs of production come down, it's becoming a more feasible clean energy generation method.

Canadian Solar has been a very frustrating stock for those buying it as a value investment.

But interestingly enough, even with a 81% run up, Canadian Solar is still fairly valued considering the future of solar energy.

Trading at only 0.38 times 2021 expected sales and 14.23 times 2021 expected earnings, valuations are not outrageous. The company has been fairly inconsistent with its growth, which is why the market isn't really willing to pay a high earnings multiple. But again, most of its inconsistencies have been as a result of what we've stated above.

Growth is expected to pick back up in 2022 and 2023, and 2023 expected revenue of $7B USD would mark a 100% increase from 2020 revenue of $3.47B. There is promise in the industry, and at current valuations the company is certainly worth a look.

Keep in mind however, this is the only renewable energy stock on this list that doesn't currently pay a dividend, and we would classify this stock as the highest risk of the bunch as well.

CSIQ 5 year performance vs the NASDAQ:


3. Northland Power (TSX:NPI)

Northland Power Logo

Northland Power (TSX:NPI) is a pure-play renewable energy company, and one that has been in business for a long period of time. The company was established in 1987, and operates nearly 2.8 GW of electricity, with potential future capacity in excess of 5 GW.

Northland has witnessed some incredible growth in terms of earnings over the last 3 years with a compound annual growth rate (CAGR) in excess of 30%. The company has also managed to more than double revenue since 2015.

The bulk of the company's renewable operations are located in Eastern Canada.

In fact, the farthest the company reaches out west are two facilities in Saskatchewan - its Spy Hill facility with 86 MW of production and its North Battleford facility, with 260 MW of production. Both of these facilities generate power by burning natural gas and full contracts are established until 2036 and 2033 respectively.

The company has a total of 27 assets, 2 of which we've already talked about. With 19 facilities in the province, Northland has a high percentage of its assets in Ontario. Quebec has 2 wind farms, while the Netherlands and Germany have one wind farm each, Netherlands being offshore.

The renewable company closed on its acquisition of EBSA back in September of 2019, a Colombian regulated utility company for around $1.05 billion. EBSA serves nearly half a million customers, and its revenue is highly regulated, thus highly reliable. It also provides Northland Power with strong revenue outside of North America.

In terms of performance, Northland Power, at least over the last year and a half, has not disappointed. Much like other Canadian renewable energy stocks, it was hit hard in the correction at the start of 2021. However, it held on better than most and didn't witness the volatility that many small/micro cap renewable companies did.

The company currently has a yield in the high 2% range and a payout ratio in terms of earnings of 104%. This payout ratio looks high, however the dividend is well covered by cash flow at 16.09%.

Northland Power's lack of dividend growth is one of the primary reasons it falls short on this list. Especially considering the company has ample room to grow it.

But, don't let that fool you, this is still a very strong renewable energy stock, one that has actually faced some recent weakness due to seasonal and temporary issues with its windfarms.

NPI.TO 5 year performance vs the TSX:

TSE:NPI vs TSX Index

2. Brookfield Renewable Energy Partners (TSX:BEP.UN)

Brookfield Renewable Partners

Brookfield Renewable Energy Partners (TSX:BEP.UN) is another pure-play renewable company and is one of the fastest growing by a landslide. The company is expected to grow earnings at a rate of nearly 40% over the next 5 years.

To add to this, the company is already the fastest growing pure-play renewable energy company in the country with a compound annual growth rate of 10.71%.

The company has over 20,000 MW of capacity and just shy of 6000 facilities in North America, Europe, Asia and South America.

The company's goal is to deliver shareholders annual returns in the 12-15% range. Thus far, it has more than accomplished its objective.

The company's portfolio consists of wind, solar, storage facilities and distributed generation and most importantly, hydroelectric, which makes up over 62% of its portfolio. An interesting note, this is down from the 75% that was noted last time we updated this article, a sign the company is diversifying its asset base.

Back in March of 2020, the company entered an agreement to buy Terraform Energy in an all stock deal. Why are we still mentioning this year later? Well, this purchase made Brookfield Renewable Partners the biggest pure-play renewable energy company in the world.

The company pays a generous dividend, north of 3%, and the dividend accounts for only 80%~ of funds from operations.

Management has stated they want its dividend to grow by 5-9% annually over the next 5 years. This would be an increase over its past results, so it will be interesting to see how the company performs.

Renewable companies faced a significant correction in 2021, which will be evident in the performance chart below. In our eyes, all this did was make Brookfield Renewables more attractive.

In our last update of this piece, we had stated that valuation was one of the main reasons it was number 3 on this list. Well, we've bumped it up to number 2 now due to its recent correction.

The company also set up a Canadian corporation, BEPC, to be the "equivalent" to the partnership BEP.UN. This is primarily a tax consideration, one that you'll need to figure out on your own which one is best for you.

Brookfield Renewables 5 year performance vs the TSX:


1. Algonquin Power (TSX:AQN)


Algonquin Power & Utilities (TSX:AQN) is a diversified generation, transmission and distribution utility company. The company provides rate regulated natural gas, water, and electricity generation, transmission, and distribution utility services to over 1 million customers in the United States and Canada.

The company is engaged in the generation of clean energy through its portfolio of long term contracted wind, solar and hydroelectric generating facilities representing more than 1,600 megawatts (MW) of installed capacity.

There are a few things we really like about the company, but there's one thing that stands out with Algonquin, and that is its growth rates.

Algonquin is one of the fastest growing utility companies on the TSX Index. In fact, the company grew earnings by 33% in 2020, and prior to a very unfortunate one-off event in Texas that ended up costing the company $55 million, analysts expected strong growth in 2021 as well.

They've changed their tune now, and overall it will be a flat or even shrinking year for Algonquin. But, it's important to understand that this is very temporary, and we'd expect the company to get back to growth in 2022. In fact, the company expects to inject $9.4B USD into capital projects through 2025, adding more than 1.6 GW of capacity.

2021 aside, you're not going to find many utility companies on the index that provide this kind of growth, especially one that offers a rock solid dividend to go along with it.

Algonquin, at the time of writing, yields north of 4%. In terms of earnings this works out to be a payout ratio of around 40%.

With a dividend growth streak of 10 years, the company has proven to be capable of consistently raising its dividend. In fact, Algonquin is one of the few Canadian Dividend Aristocrats that raised the dividend during the COVID-19 pandemic.

Algonquin is a top 5 holding in one of Canada's biggest utility ETFs, and pays its dividend in US dollars, providing an even more attractive proposition to Canadian investors.

AQN.TO 5 year performance vs the TSX

TSE:AQN vs TSX Index

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Best Canadian Tech Stocks to Look at in December 2021

Over the past five years, the S&P 500 and the TSX Technology Indexes have a CAGR of approximately 25%. Tech companies, especially in Canada, are booming right now. Which is exactly why we decided to come out with this list of the best performing…



Over the past five years, the S&P 500 and the TSX Technology Indexes have a CAGR of approximately 25%.

Tech companies, especially in Canada, are booming right now. Which is exactly why we decided to come out with this list of the best performing technology stocks in Canada.

When we saying booming, we're talking about the long term, as should be the mentality of most investors, especially those who are just learning how to buy stocks.

But even though it's booming, people usually head to the United States when looking for the best tech stocks to buy. So why is that? 

Tech stocks just aren't as prevalent on the TSX

The IT sector accounts for over a quarter of the S&P 500. 

Recently, the major indices underwent a sector reshuffle, however technology still accounts for 25.76% of the index. It is almost double that of the second largest sector. 

However, Canadian stocks in the technology sector accounts for only a single digit weighting of the TSX Index.  

As you can see, the lack of tech-listed companies on the TSX has hampered the overall performance of the Canadian markets. 

The good news? The lack of performance can lead to a lack of awareness. Thus, comes opportunity.

Even though the TSX’s IT sector is small, there are plenty of good investments.

The U.S. has its FAANG (Facebook, Amazon, Apple, Netflix, Google) stocks, but did you know Canada has its own acronym of tech all-stars?

Ryan Modesto, chief executive of 5i Research, coined the acronym “DOCKS” to reference Canada’s own FAANG stocks.

The five stocks include

  • Descartes Systems
  •  Open Text
  •  Constellation Software
  •  Kinaxis
  •  Shopify

A well-balanced portfolio should have exposure to the IT sector and you don’t have to go south of the border with US tech stocks to find it.

And I forgot to mention, we're continually identifying popular tech stocks for Premium members over at Stocktrades Premium. In fact, we had one tech option highlighted in 2021 that gained over 130% in just 5 months.

Interested in Stocktrades Premium? Just click here to unlock a huge discount. Otherwise, head down below to see some of Canada's top tech stocks.

What are the best tech stocks in Canada?

Nuvei (TSE:NVEI)

Going off the board with this pick, Nuvei (TSE:NVEI) is one of Canada’s newest IPOs.

The company went public in September of 2020 and its share price has performed quite well.

As of writing, Nuvei’s share price is up by ~238% since it went public. Not a bad return for those who got in early.

Is the jump in price justified? When compare to the valuations that peers commanded, we felt that the company’s IPO pricing did not do the company justice.

As we discussed with Premium members, there was a price disconnect which offered an attractive risk to reward opportunity.

Prior to listing, Nuvei was the largest privately held fin-tech company in the country. The company provides payment-processing technology for merchants.

Their suite of products serves both online and in-store transactions and counts Stripe, Paypal, Fiserv, Lightspeed POS, Global Payments, Shift4 Payments and WorldPay among its competitors.

Since going public, the company has attracted plenty of attention. There are 13 analysts covering the company – 5 rate it a “buy”, 6 an "outperform" and 2 a “hold”.

Although the company is not yet profitable, the expectation is for the company to turn a profit in 2021. And as of writing the company has turned out 3 straight profitable quarters, indicating that it is well on its way to consistent profitability. 

And, if we add this to the fact the company is expected to reach nearly $1.5B in revenue by 2023, and it looks like a very promising option.

It is important to note however, that newly listed companies carry additional risk.

Can it meet lofty estimates?

New listings are particularly vulnerable to performance as compared to expectations. Given this, IPOs such as Nuvei are most appropriate for investors with a higher risk profile.

Performance of Nuvei Vs TSX since its IPO


Kinaxis (TSE:KXS)


After several years in which it provided consistent and solid returns, Kinaxis’ (TSE:KXS) stock exploded in 2019 and continued its outperformance in 2020. 

In 2021 however, it's been a different story. In fact at the time of writing, Kinaxis is currently underperforming the TSX.

In 2019, the company’s stock price jumped by 42%. It then went on to gain 80.30% in 2020. A 2021 pullback is not surprising, considering its run up.

In September of 2020, it was named to the TSX30 – a ranking of the top performing TSX-listed stocks over the past three years.

Kinaxis’ crown jewel is RapidResponse, a cloud-based subscription software for supply chain operations. Not surprisingly, demand for reliable supply chain management software is at an all-time high.

Globalized companies are dealing with complex issues, more so as COVID-19 mitigation efforts are impacting the supply chain in a big way.

Economic and border shutdowns are causing havoc, and platforms such as RapidResponse are essential in minimizing supply chain disruptions. 

On the flip side, the pandemic has negatively impacted legacy customers. Some have been unable to renew contracts, or deferred projects. The good news is that the company is winning more business than it is losing, and the world is continuing to move forward from the pandemic.

One of the previous knocks on the company was the lack of diversification. But, the company is currently working hard to reduce this.

Although performance over the last few years has been impressive, the company has one of the lower expected growth rates on this list. Over the next couple of years, the company is expected to grow revenue and earnings by the high teens.

Given this, its not surprising it has pulled back. This is not a stock that should be trading at the same levels as hyper-growth stocks which are generating growth of 50% annually. But, the recent dip in price could provide an opportunity, as it is already starting to recover.

5 year performance of Kinaxis vs TSX

TSE:KXS 5 year returns vs TSX

Descartes (TSE:DSG)


Much like Kinaxis, Descartes (TSE:DSG) is benefiting from a complex and globalized supply chain. Descartes is a global provider of federated network and global logistics technology solutions.

It provides a full range of logistic and network solutions that connects trading partners. Descartes has more than 20K customers across 160+ countries.

Descartes operates the world’s largest multi-modal and neutral logistics network with high profile partners including UPS, Home Depot and Air Canada to name a few.

As governments worldwide face the prospects of additional shutdowns as the fourth wave persists, logistics are of the utmost importance. The company’s addressable market is estimated to be worth more than US$4 trillion.

In terms of reliability, Descartes has been one of the most consistent tech stocks on the TSX Index. Over the past five-years, the company has grown earnings at a double digit rate annually and over that time, the stock has returned more than 252%.

What can investors expect moving forward? Much of the same.

Analysts expect the company to grow earnings by approximately 19% annually over the next couple of years.

The company is laser focused on the higher-margin service revenues and on transitioning existing clients from its legacy license-based structure to its services-based structure.

Furthermore, the company is a serial acquirer. Since 2014, the company has closed on 24 acquisitions for total considerations of ~$US820 million.

Despite a challenging environment in 2020, in early November of 2020 it announced the acquisition of ShipTrack for $25 million, its third acquisition of the year.

5 year performance of Descartes vs TSX

Descartes TSE:DSG Vs TSX Index

Enghouse Systems (TSE:ENGH)

Enghouse dividend

Arguably the most underrated stock on this list, Enghouse Systems (TSE:ENGH) has ben among the top performing technology stocks for the past decade.

The company is one of the least-followed and known on this list, yet it has quietly outperformed some of the bigger names.

It develops enterprise software solutions for a range of vertical markets. It has benefited from the current pandemic in that it specializes on ERP solutions for remote work.

Given many companies have now made work from home a permanent option for staff, Enghouse is ideally situated to benefit.

The company’s stock price has grown by 136% over the last 5 years (including dividends) and one important thing to note is pandemic or not, Enghouse continuously delivers. 

The company has also been named to the TSX30, highlighting its strong performance over the last while.

Let’s put Enghouse’s long-term performance into further perspective.

A $10,000 investment in the company a decade ago would be worth more than $162K today. This is equal to a normalized return of 1,520%. The company has simply been a star.

Increasing Enghouse’s attractiveness, it is also one of the few tech-listed Canadian Dividend Aristocrats. After raising the dividend by 23% at the start of the pandemic, the company also issued a special dividend of $1.50 a share to end 2020.

It then went on to raise the dividend yet again in early 2021. This type of growth on the dividend end is a rarity when it comes to tech stocks.

Enghouse is uniquely positioned as a growth and income stock, a rarity in the tech industry.

Although the company trades at expensive valuations – it always has and given its strong performance, is deserving of a premium.

5 year performance of Enghouse vs TSX


Shopify (TSE:SHOP)

Shopify Logo

What more can be said about Shopify (TSE:SHOP) that hasn’t already been said.

It has been among our top tech stocks for years and is likely to go down as one of the (if not THE) most successful IPO’s this country has ever seen.

Since it went public in 2015, the company has returned 6,120%! A $10,000 investment in the company would be worth $621K today.

We’ve mentioned the TSX30 a couple of times already. Can you guess which stock has topped the list?

Of course you can – Shopify is #1 with returns of 923% over the past three years – more than double the second-best performing company.

The pandemic has accelerated the adoption of e-commerce which has benefited Shopify in a big way.

Earlier in the pandemic, Shopify announced that it was generating Black Friday level sales on its platform.

The company has more than doubled gross merchant volumes YOY and revenue has also grown at a torrid pace.

It has also allowed them to turn a profit, a notable achievement for a company that has not yet been able to generate positive earnings consistently.

Although recent price activity has been choppy, Shopify’s stock price is still up by 30% over the last year. Once again, this places the company among the best performing stocks on the TSX Index.

If you are worried you missed out, consider jumping into the stock when it consolidates or when it drops by 20% or more.

The stock does have a history of being quite volatile, and these types of moves happen at least a few times a year. Each time it has proven to be a buying opportunity. Interested in a little more stability rather than growth? Check out the top Canadian telecoms stocks.

5 year performance of Shopify vs TSX


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