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US dollar weakness should reinforce the blossoming rally in cyclical stocks

US dollar weakness should reinforce the blossoming rally in cyclical stocks

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3 years ago

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We were recently joined by clients for a discussion about global investment opportunities, in the context of technically overbought conditions in US stocks. In this blog, we share our views regarding where we see risks and opportunities in international markets.

From a valuation perspective, in which regions and countries do you see the most risk and opportunity? Where do the US and Canada fit into that valuation spectrum?

Following a high-velocity selloff and subsequent v-shaped rebound, US stocks have surprisingly clung to their status as one of, if not the most overvalued market segments of the developed world. Indeed, US and developed market price-to-sales (P/S) ratios are trading at notable premia relative to the global benchmark and history. In our view, unprecedented policy support has encouraged extreme risk taking by investors, a consequence of which has been frothy valuations in US stocks.

At the other end of the valuation spectrum, structural underperformance from Chinese and emerging market (EM) stocks – until recently – has compressed their P/S ratios to deep discounts compared to the world-wide stock market and history. Clearly, Europe and Canada are developed economic regions. However, European and Canadian stocks currently trade at discounts like those of Chinese and EM stocks.

While valuation is a good starting point for an investment thesis, it isn’t enough on its own. Indeed, cheap valuations require catalysts to unleash the potential opportunities embedded in share prices. On that score, leading indicators of business activity across the emerging world – China and South Korea in particular – have been proving more resilient than those of the developed world, including the US, Europe, Japan and Canada.

We believe compelling opportunities exist for investors in EM stocks at a time when many emerging economies – especially Asia excluding Japan – are recovering from the virus-related “sudden stop” in activity. Attractive valuations and improving economic growth may be the right combination for unlocking the potential rewards presented by EM stocks. So far, so good.

Figures 1 & 2. Not all regions and countries are made equal. For selectivity, we prefer targeting low valuations and faster growth over high valuations and slower growth both across and within regions.

Source: Bloomberg L.P., Haver, Invesco, 07/01/20. Notes: Circled indices represent low valuations and faster growth. P/S = Price-to-sales ratio. Ranked from left to right—from highest premium to lowest discount. ACWI = All Country World Index. EU = European Union. EU Excluding UK Composite PMI = France, Germany, Ireland, Italy and Spain. Diffusion indices have the properties of leading indicators, and are convenient summary measures showing the prevailing direction and scope of change*. An investment cannot be made in an index. Past performance does not guarantee future results.

US companies are highly exposed to international markets. Don’t US stocks provide investors with enough international diversification?

Contrary to popular belief, US companies aren’t the most globally exposed. In fact, they have the lowest international exposure – capturing 39% of total revenues – of all the major developed markets that we follow. Some may be surprised to learn that French companies’ international revenues represent a whopping 82% of their total revenues!1

Admittedly, it’s difficult to determine how much international exposure an investor should have without knowing several things about them, including their risk tolerance, goals, life stage, and planned retirement date.

That said, there’s a simple way of assessing whether investors own enough international stocks. In our view, the weight of the MSCI USA Index in the MSCI All Country World Index (ACWI) is a good starting point for benchmarking your international diversification. US stocks capture 58% of the global equity benchmark, which means that non-US stocks capture 42% of the worldwide stock market.2

Many investors are surprised to learn that non-US equities represent almost half of a passively indexed global equity portfolio, represented by the MSCI ACWI. Moreover, what they thought was a generous allocation to international stocks – typically 25% – is far below the entire universe of stocks.

As aggressive as it may seem, in our view, setting international equity allocations equal to their weight in the global benchmark would express a neutral stance on the asset class.

Figures 3 & 4. US companies have the lowest international exposure of all the major developed markets

Source: FactSet, Invesco, 07/17/20. Notes: An investment cannot be made in an index. Past performance does not guarantee future results.

Looking back, what was the cost of the shutdown, and how might it have impacted second-quarter S&P 500 earnings?

While it may seem like a daunting task to quantify the earnings impact of COVID-19 and the related cost of the shutdown, we think it’s possible.

First, we need a baseline for second-quarter 2020 S&P 500 trailing 12-month operating earnings per share (EPS), which we assume to be $121. Next, we require a weekly earnings number ($121/52 = $2.32).

Then, we must guess how many companies were shut down. Obviously, all companies weren’t idle during the virus-related shutdown. In fact, some firms benefitted tremendously in the health care, consumer staples, technology, and communications sectors. We naively assume half of firms were idle ($2.32/2 = $1.16).

For the final step, we erode the baseline by the lost earnings of those companies over a 12-week shutdown ($1.16*12 = $14). In other words, we suspect second-quarter 2020 S&P 500 earnings may have been $14 lower than analysts believe, which would equate to $107 or a 31% decline from year-ago levels.

Figure 5. We suspect 2Q20 S&P 500 earnings may have been $14 lower than analysts believe

Source: Standard & Poor’s, Invesco, 07/17/20. Notes: Operating earnings per share = Income from product (goods and services), excluding corporate (M&A, financing and layoffs) and unusual items, divided by total shares outstanding. Earnings are priced in US dollars. An investment cannot be made in an index.

While this approach is simplistic, it’s worth noting second-quarter 2020 S&P 500 operating EPS settled at $139 or -9% year-over-year, just $3 below our simulation of $142 or -7% year-over-over. As we anticipated, it seems a broad market earnings recession began in 1Q20, which we expect to be followed by much deeper decreases in coming quarters.3

Despite the popularity of earnings, we underscore that they’re quarterly, lagging variables whereas stocks are real-time financial market variables and leading economic indicators that get ahead of fundamentals by a good 3-6 months. Said differently, scrutinizing second quarter earnings – when we’re already in the third quarter – is akin to driving a car forward while looking in the rearview mirror.

Where do you see materials and commodities going during these COVID-19 times?

We expect materials stocks to outperform the broader market, given synchronized central bank support. For example, the Federal Reserve (Fed) has embarked on a seemingly open-ended commitment to continue buying securities until the economic and labor market outlooks improve substantially.

An important consequence of the Fed’s unprecedented balance sheet expansion is the weakness of the US dollar, which should reinforce the blossoming rally in cyclical stocks through foreign exposure/sales, Rest of the World (RoW) profits, positive translation effects and increased competitiveness. In other words, US goods and services become cheaper when the currency depreciates.

If quantitative easing (QE) represents a choice between interest rates and the US dollar, the Fed has opted to save growth and jobs by loosening the monetary screws and inflating the money supply at the expense of the currency. From that perspective, it’s reasonable to expect the US dollar to weaken further if the Fed keeps such an abundant supply of currency in circulation.

In turn, the US dollar is inversely related to the relative performance of the materials sector, the fundamental link being foreign exposure. According to Standard & Poor’s, materials companies relied on foreigners for 57% of their total sales in 2018, second only to information technology at 58%.

US dollar weakness helps US-based materials companies be more competitive on the world economic stage. Dollar depreciation augments the value of foreign sales (denominated in strengthening currencies) when they’re translated to the home currency.

The flipside of US dollar weakness is commodity price strength. Indeed, early-stage commodities have been on an upward track, supporting a positive view of the materials sector. Commodity prices – barometers of materials companies’ input and/or output prices – are key drivers of materials stocks. The CRB BLS Raw Industrials Sub-Index is a good gauge of basic commodities close to the early stages of the production process. As such, they’re among the first to respond to changes in global economic activity.

Our positive view of materials stocks depends on whether the global economic recovery gathers pace. Should the economy suffer a relapse, it would likely be difficult for materials stocks to continue outperforming. If the US dollar keeps weakening alongside forceful blasts of QE from the major central banks, materials stocks should continue to benefit. Indeed, standing in the way of size buyers like the Fed has been an unprofitable strategy in the past.

Figures 6 & 7. The flipside of policy-induced currency weakness is commodities and materials strength.

Source: Bloomberg L.P., Invesco, 07/17/20. Notes: USD = US dollar. The broad currency index is a weighted average of the foreign exchange value of the US dollar against the currencies of a broad group of major US trading partners. CRB = Commodity Research Bureau. BLS = Bureau of Labor Statistics. The CRB BLS Raw Industrials Sub-Index measures the prices of burlap, copper scrap, cotton, hides, lead scrap, print cloth, rosin, rubber, steel scrap, tallow, tin, wool tops and zinc. Commodities and stocks are priced in USD. An investment cannot be made in an index. Past performance does not guarantee future results.

Footnotes

1. FactSet, 07/17/20

2. MSCI, 07/17/20.

3. Standard & Poor’s, 07/17/20.

Definitions

A P/S ratio is the market capitalization of a given country or region divided by its total revenues.

The MSCI USA Index is designed to measure large and mid market capitalization stocks in the United States.

The MSCI ACWI is designed to measure large and mid market capitalization stocks in the developed and emerging markets.

QE is a form of unconventional monetary policy where a central bank makes large scale asset purchases in order to increase the money supply and encourage lending and investment.

The CRB BLS Raw Industrials Sub-Index measures the prices of burlap, copper scrap, cotton, hides, lead scrap, print cloth, rosin, rubber, steel scrap, tallow, tin, wool tops and zinc.

Important Information

Blog Header Image: Javier Garcia / Unsplash

The risks of investing in securities of foreign issuers, including emerging market issuers, can include fluctuations in foreign currencies, political and economic instability, and foreign taxation issues.

To the extent the fund invests a greater amount in any one sector or industry, there is increased risk to the fund if conditions adversely affect that sector or industry.

Commodities may subject an investor to greater volatility than traditional securities such as stocks and bonds and can fluctuate significantly based on weather, political, tax, and other regulatory and market developments. 

All investing involves risk, including risk of loss.

A decision as to whether, when and how to use options involves the exercise of skill and judgment and even a well conceived option transaction may be unsuccessful because of market behavior or unexpected events. The prices of options can be highly volatile and the use of options can lower total returns.

In general, stock values fluctuate, sometimes widely, in response to activities specific to the company as well as general market, economic and political conditions.

The opinions referenced above are those of the authors as of August 3, 2020. These comments should not be construed as recommendations, but as an illustration of broader themes. Forward-looking statements are not guarantees of future results. They involve risks, uncertainties and assumptions; there can be no assurance that actual results will not differ materially from expectations. This does not constitute a recommendation of any investment strategy or product for a particular investor. The opinions expressed are those of the authors, are based on current market conditions and are subject to change without notice. These opinions may differ from those of other Invesco investment professionals.

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This course asks, ‘What is mindfulness?’ – but don’t expect a clear-cut answer

Mindfulness is everywhere in pop culture today, but that doesn’t mean people agree on what it means.

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60 mins ago

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March 23, 2023

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Practicing mindfulness doesn't have to mean being removed from the world. PeopleImages/iStock via Getty Images Plus
Text saying: Uncommon Courses, from The Conversation

Uncommon Courses is an occasional series from The Conversation U.S. highlighting unconventional approaches to teaching.

Title of course:

“What is Mindfulness?”

What prompted the idea for the course?

As a professor of religion and ethics, particularly Asian traditions, I had already been interested in teaching a course about mindfulness. Its popularity seems to be surging: I see “Mindful” on magazine racks, and almost everyone I’ve met at my university has used the word at some point.

But oftentimes people say to be “mindful” when they mean “pay attention” or “don’t forget”: being “mindful” of a slippery road, say, or telling students to be “mindful of the deadline.” I started wondering what other people meant each time they used the word. This made me realize my course shouldn’t be a lecture about mindfulness, but an opportunity to explore what it is in the first place.

What does the course explore?

The course explores the origins of mindfulness in yoga and Buddhism. Mindful meditation – being attentive to one’s body, feelings and thoughts – is part of one of the Buddha’s central teachings, the Noble Eightfold Path, and considered key to enlightenment.

But we explore the many meanings of “mindfulness” that have emerged in recent decades, too. American professor Jon Kabat-Zinn is credited with popularizing the kind of mindfulness that has caught on with non-Buddhists today, starting with his “mindfulness-based stress reduction” program in the 1970s.

Some people are upset that mindfulness has become too mainstream and fear that it has lost its intended meaning. Buddhism scholar Ronald Purser’s book “McMindfulness,” for example, argues that capitalist societies have embraced mindfulness as a way to put the burden of mental health back on the individual rather than address root problems.

Students in my class read a variety of these perspectives and discuss themes such as mindfulness and mental health, mindful eating and breathing, environmental mindfulness and even meditation apps. In the end, I want each student to decide for themselves what mindfulness is.

A woman in exercise clothes does a yoga pose inside a dark cathedral with stained glass windows.
Mia Michelson-Bartlett, yoga teacher and manager of visitors’ services, practices yoga and mindfulness meditation inside the Cathedral of St. John the Divine in New York City. Angela Weiss/AFP via Getty Images

Why is this course relevant now?

I first proposed this course right before the arrival of COVID-19, so when it launched for the first time, we met remotely over Zoom. I was tempted to drop the class after we went remote, but I quickly realized that it might help students who were wrestling with mental health issues at the beginning of the pandemic.

Each student kept a journal of our topics every week to practice mindfulness and to explore some of the therapeutic techniques. First, I asked them to find examples of the word in their everyday experiences – used on a poster at the student rec center, for example.

Later, I asked them to practice breathing and visualization techniques from the influential Vietnamese monk Thich Nhat Hanh, such as asking yourself every hour “What am I doing?” and reflecting on your mind, emotions and posture.

What’s a critical lesson from the course?

Buddhism changes dramatically depending on “whose” Buddhism you are talking about. The dalai lama’s form of Tibetan Buddhism, for example, is not the same as the Zen Buddhism of Thich Nhat Hanh.

A row of monks stand next to a small crowd of schoolchildren in uniform as one monk takes a child's hand.
Zen master Thich Nhat Hanh reaches for a student’s hand during a meditation walk on a ‘day of mindfulness’ in Hong Kong in 2007. Steve Cray/South China Morning Post via Getty Images

It’s the same with mindfulness. Thirteenth-century Zen master Dōgen taught pupils to seek mindfulness in seated meditation. Five hundred years later, on the other hand, Zen master Hakuin taught mindfulness in the midst of activity – practicing it not just on the meditation pillow, but amid the hustle and bustle of the streets.

All forms of Buddhism, though, focus on transforming suffering into lovingkindness. So teaching this course has persuaded me that if the way you teach mindfulness helps someone, it doesn’t matter if it’s “real” Buddhist mindfulness or not. If pop culture’s version of the concept relieves someone’s suffering, then I don’t want to be a gatekeeper and say, “This is not real mindfulness.”

What will the course prepare students to do?

All of the students in this course are first-semester freshmen. The class began as a way to get them to think critically about what mindfulness is but also offers tools to deal with the stress of college life.

Muscles grow after they heal and rest. The same is true when it comes to learning. Our minds need to take time to breathe, reflect on new information and absorb it.

I also hope students will understand that taking care of oneself can be an act of care for others. Just as on an airplane we are told to put on our own oxygen mask before helping the person next to us, we all need to take care of our own mental health in order to help those around us.

Kevin C. Taylor does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

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Post-bariatric surgery exercise modulates brain regions associated with regulation of food intake

Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety,…

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1 hour ago

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March 23, 2023

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Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety, for example. This was the result observed in a clinical trial conducted at Hospital das Clínicas (HC), the hospital complex run by the University of São Paulo’s Medical School (FM-USP) in Brazil. An article on the study, pointing to positive effects of exercise on obesity-related conditions in post-bariatric patients, is published in the International Journal of Obesity.

Credit: Carlos Merege Filho

Physical exercise practiced by patients submitted to bariatric surgery acts on brain regions involved in food intake, reducing hunger or accelerating satiety, for example. This was the result observed in a clinical trial conducted at Hospital das Clínicas (HC), the hospital complex run by the University of São Paulo’s Medical School (FM-USP) in Brazil. An article on the study, pointing to positive effects of exercise on obesity-related conditions in post-bariatric patients, is published in the International Journal of Obesity.

The study showed that an exercise training program starting three months after bariatric surgery produced functional alterations in brain networks associated with food intake and modified by obesity. The findings confirm the hypothesis that exercise and bariatric surgery act synergistically on the connectivity among brain regions associated with cognition, reward and emotional regulation, potentially moderating hunger and enhancing satiety.

According to the article, exercise increased the connectivity between the hypothalamus (the brain region that controls homeostasis, including regulation of appetite and energy expenditure) and the brain’s sensory areas. At the same time, it apparently decreased the link between the default mode network, which is more active during a resting state, and the salience network, the brain region involved in decision-making.

The researchers also found that exercise after bariatric surgery appeared to modulate the medial hypothalamic nucleus involved in appetite suppression and increased energy expenditure.

“The regulation of energy expenditure is governed by multiple internal and external signals. People with obesity display major dysregulation of brain regions associated with appetite and satiety. Our study showed that exercise by post-bariatric patients helped ‘normalize’ these complex networks so as to improve the central control of food intake. For example, some of these regions are activated and connect more intensely in people with obesity when they eat fatty or sugary food, increasing their desire to consume such food. We found that exercise counteracts this effect, at least in part,” Bruno Gualano, last author of the article, told Agência FAPESP. Gualano is a professor at FM-USP.

The study was supported by FAPESP via a research grant for the project “Effects of exercise training in patients undergoing bariatric surgery: a randomized clinical trial” and was part of the PhD research of Carlos Merege Filho, first author of the article, with a scholarship from FAPESP. The co-authors included Hamilton Roschel, Marco Aurélio Santo, Sônia Brucki, Claudia da Costa Leite, Maria Concepción García Otaduy and Mariana Nucci (all of whom are affiliated with HC-FM-USP); and John Kirwan of Pennington Biomedical Center (USA).

Considered one of the world’s main public health problems, obesity is a chronic disease characterized by excessive body fat accumulation and a major risk factor for cardiovascular and musculoskeletal disorders, as well as severe COVID-19. The parameter used for diagnosis in adults is body mass index (BMI), defined as weight in kilograms divided by height squared in meters. A BMI between 25 and 29.9 indicates overweight, while 30 or more signals obesity, according to the World Health Organization (WHO).

Brazil has one of the highest rates of overweight and obesity in the world. According to projections, almost 30% of the adult population will be obese in 2030. A billion people, or 17.5% of the world’s adult population, will be obese by then, according to the World Obesity Atlas 2022 published by the World Obesity Federation.

Importance

From the clinical standpoint, Gualano believes, the findings suggest that exercise should be considered an important complementary therapy to improve brain functions and enhance the known benefits of bariatric surgery, such as a reduction in cardiometabolic risk factors, as well as preservation of muscle mass and bone health.

He and his group have been conducting research in this field since 2018, as evidenced by other publications, one of which showed that exercise attenuated and reversed loss of muscle mass, improving muscle strength and function in post-bariatric patients. Genotypic and phenotypic analysis evidenced metabolic and structural remodeling of skeletal muscle.

In another study, exercise reduced risk factors for diseases associated with obesity, such as diabetes, high blood pressure and atherosclerosis (hardening of the arteries), by increasing sensitivity to insulin, combating inflammation and improving the health of blood vessels.

Methods

The randomized clinical trial reported in the International Journal of Obesity involved 30 women aged between 18 and 60 who had been submitted at HC-FM-USP’s bariatric surgery unit to a Roux-en-Y gastric bypass, which creates a small stomach pouch to restrict food intake and bypasses a large portion of the small intestine to limit calorie absorption. A majority of patients admitted to the unit are women. 

Half the study sample were randomly assigned to a six-month exercise program of resistance and aerobic training three times a week, starting three months after the operation and supervised by a team of physical education professionals.

Clinical, laboratory and brain functional connectivity parameters were assessed at the start of the trial, as a baseline, and again three and nine months after the operation. Functional magnetic resonance imaging (fMRI) was used to detect connectivity between anatomically distinct brain areas organized as networks, and to analyze the combined effects of the surgical procedure and exercise training. Data collection began in June 2018 and ended in August 2021.

“The literature has already shown that post-bariatric patients have many brain alterations compatible with improved control of appetite, satiety and hunger in neural circuits that govern food intake. Our study found that exercise training bolstered this response,” Gualano said, noting the importance of lifestyle changes to maintain the benefits of weight loss for people with obesity.

Bariatric surgery can currently be performed on patients with a BMI of between 30 and 35 and type 2 diabetes that has not been controlled for more than two years, and patients with a BMI over 35 who have other diseases associated with overweight, such as high blood pressure, sleep apnea or hepatic steatosis (fatty liver disease). For people with comorbidities, the recommended BMI is over 40.

In the past five years, 311,850 bariatric surgeries have been performed in Brazil; 14.1% were paid for by the SUS (Sistema Único de Saúde), the national health service. The rest were covered by insurance policies or paid for privately, according to the Brazilian Bariatric and Metabolic Surgery Society (SBCBM).

“Regular exercise is known to induce several physiological adaptations that translate into health benefits. These benefits are reversed if the patient stops exercising regularly. Our study didn’t measure the duration of the brain changes induced by exercise, however. They’re highly likely to diminish and possibly even go into reverse as the amount and intensity of exercise decrease. It’s crucial to adopt a healthy lifestyle in order for the responses to bariatric surgery to be long-lasting,” Gualano said.

Next steps for the research group will include studying the effects in people with obesity of exercise and diet combined with other weight loss strategies, including new drugs such as peptide analogs or incretin mimetics, a class of medications commonly used to treat type 2 diabetes. Incretins are gut hormones that aid digestion and blood sugar control by signaling to the brain to stop eating after a meal.

In early January, the National Health Surveillance Agency (ANVISA) approved semaglutide as an anti-obesity drug for long-term weight management. The drug had previously been approved only for patients with type 2 diabetes. It is the first injectable anti-obesity medication available in Brazil and is supposed to be administered once a week. It is said to enhance satiety, modulate appetite and control blood sugar. 

About São Paulo Research Foundation (FAPESP)

The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at www.fapesp.br/en and visit FAPESP news agency at www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe

Journal

International Journal of Obesity

DOI

10.1038/s41366-022-01251-8

Article Title

Exercise modifies hypothalamic connectivity and brain functional networks in women after bariatric surgery: a randomized clinical trial

Article Publication Date

30-Dec-2022

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The CeMM & Angelini Ventures Healthy Lifespan Expansion Initiative

CeMM and Angelini Ventures are joining forces to support CeMM Principal Investigators Laura de Rooij and André Rendeiro in critical lifespan expansion…

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March 23, 2023

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CeMM and Angelini Ventures are joining forces to support CeMM Principal Investigators Laura de Rooij and André Rendeiro in critical lifespan expansion initiatives leveraging a novel academic/entrepreneurial dual-track program. De Rooij and Rendeiro, in collaboration with their teams, will lead an original research program on healthy lifespan expansion.  In parallel, they will collaborate on venture creation based on scientific and business insights developed by their work. Venture creation and related business development activities will take place along with scientific research.  The expectation is that this double-track initiative will allow for virtuous feedback cycles, propelling innovation through scientific research and bold venture creation goals.

Credit: CeMM

CeMM and Angelini Ventures are joining forces to support CeMM Principal Investigators Laura de Rooij and André Rendeiro in critical lifespan expansion initiatives leveraging a novel academic/entrepreneurial dual-track program. De Rooij and Rendeiro, in collaboration with their teams, will lead an original research program on healthy lifespan expansion.  In parallel, they will collaborate on venture creation based on scientific and business insights developed by their work. Venture creation and related business development activities will take place along with scientific research.  The expectation is that this double-track initiative will allow for virtuous feedback cycles, propelling innovation through scientific research and bold venture creation goals.

(Vienna, 22 March 2023) Some societal challenges are of such importance to assume the central stage in the public discourse on sustainability and the future of humanity. Such a challenge is aging. Aging is a multidimensional phenomenon, occurring at the individual and population levels of society and on the molecular, cellular, and organ level of the human body. The urgency of dealing with the consequences of aging is illustrated by the fact that in just over ten years from now, more than a third of the population of Italy, one of the world’s most rapidly aging countries, will be over 65 years of age. Expanding the lifespan in which individuals enjoy a healthy status, in which they can be independent and productive, is critical for economic, social, and cultural reasons.

The fundamental mechanisms of aging, at the molecular, cellular, and tissue level, are still unclear and most single theories fail to explain the phenomenon. Scientific leaders are increasingly interested in combining cutting-edge research with immediate value creation and effective societal impact. Laura de Rooij and André Rendeiro will be supported by a network of mentors and experts. At CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences, the team will benefit from access to faculty peers, the center’s scientific leadership, a scientific advisory board, and the biotech ventures built in CeMM’s ecosystem of spinoffs. Through Angelini Ventures, the team will be supported to ideate and develop viable start-up companies emerging from their work and have access to an international network of investors, healthcare experts, and industry innovators.

 

“The Angelini Ventures team is delighted to partner with CeMM to collaborate on accelerating lifespan expansion research and venture creation. We believe this type of collaboration is the connective tissue between innovation and entrepreneurship. By combining our venture creation capabilities with the breakthrough research from CEMM, we can accelerate the pace of healthcare transformation,” says Paolo Di Giorgio, Chief Executive Officer of Angelini Ventures.

“CeMM is proud to pioneer a new training, research, and innovation method meant to foster a novel generation of professionals familiar with both the research and business worlds. In addition to expecting commercial success, the desired outcome is to create leaders able to inspire a new generation of scientists. Our goal is for the dual track of scientific research and business development to expand beyond the CeMM-Angelini network,” says CeMM Scientific Director Giulio Superti-Furga.

 

About the Principal Investigators

Laura de Rooij joined CeMM as principal investigator in September 2022. Her lab focuses on deciphering the transcriptomic landscape and role of circulating endothelial cells in health and aging. Laura de Rooij studied Biomedical Sciences at the University of Amsterdam (The Netherlands). She then joined the Stem Cell and Cancer Research Institute at McMaster University in Hamilton (Canada), where she studied the role of RNA binding proteins in leukemic stem cells via an in vivo two-step CRISPR-Cas9-mediated screening approach. For her post-doctoral studies, she returned to Europe to work under the mentorship of Prof. Carmeliet in the lab of Angiogenesis and Vascular Metabolism at VIB-KU Leuven (Belgium). Here she led and contributed to numerous single-cell transcriptome atlases of endothelial cells, generated from a diverse range of tissues, preclinical models, and clinical patient material in health and disease. Her studies have shed new light on the degree of vessel subtype heterogeneity in different tissues, as well as the altered composition and rewired molecular circuitries of endothelial cell subtypes in disease. Moreover, her efforts led to the discovery of previously unknown vascular subtypes and functions, including endothelial cells with a lipid-processing phenotype and potential prognostic relevance in breast cancer, and endothelial cells with a putative pro-fibrotic function in COVID-19. At CeMM, her lab focuses on deciphering the transcriptomic landscape and role of circulating endothelial cells in health and aging.
Read more about Laura de Rooij’s research

André Rendeiro is a Principal Investigator at CeMM since June 2022. He leads a group studying how cells interact to generate complex physiology in the human body, and how this changes over the lifespan of individuals and gives rise to disease. To do that, his group develops computational methods for the analysis of spatial data (spatial transcriptomics, highly multiplexed imaging, histopathological images), and its integration with various modalities of molecular, demographic, and clinical data of individuals along their lifespan. Prior to starting his group, André studied in Portugal, Austria, and Norway and earned his PhD in Molecular Medicine at CeMM in Vienna. During his PhD he developed methods for high-throughput cellular profiling and perturbation at single-cell resolution, applying them to leukemia, in the lab of Christoph Bock at CeMM. Between 2020 and 2022 he was a Postdoctoral Associate at the Institute for Precision Medicine and the Institute for Computational Biomedicine at Weill Cornell Medicine in New York. There he developed computational methods for the analysis of highly-multiplexed imaging that incorporate expression, morphology, micro-anatomy, and clinical covariates, in the lab of Olivier Elemento. He led the first tissue-level, single-cell resolution maps of lung pathology during COVID-19, and also contributed to the study of cancer, lung development, and disease, as well as COVID-19 immunology.
Read more about André Rendeiro’s research

The CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences is an international, independent, and interdisciplinary research institution for molecular medicine under the scientific direction of Giulio Superti-Furga. CeMM is oriented toward medical needs and integrates basic research and clinical expertise to develop innovative diagnostic and therapeutic approaches for precision medicine. Research focuses on cancer, inflammation, metabolic and immune disorders, and rare diseases. The Institute’s research building is located on the campus of the Medical University and the Vienna General Hospital. www.cemm.at

Angelini Ventures, the venture capital arm of Angelini Industries, is an early-stage investment firm focused on accelerating disruptive innovations and trends in digital health and life sciences. The group will invest €300M across a global portfolio led by investment professionals and advisors in Europe, North America, and Asia. Angelini Ventures has deep domain expertise and leverages a global team, advisors, and strategic partners to help entrepreneurs scale their businesses into transformative category-leading companies. www.angeliniventures.com

Angelini Industries is a multinational industrial group originally founded in Ancona (Italy) in 1919 by Francesco Angelini. Today it is a solid, structured industrial business with around 5,800 employees operating in 21 countries.  Angelini Industries operates in the health, industrial technology, and consumer goods businesses. Its investment strategy aimed at growth, constant commitment to research and development, and deep knowledge of markets and business sectors make Angelini Industries an Italian leader in the industries in which it operates.  The group is committed to reducing its environmental impact and finding increasingly cutting-edge circular economy solutions. It adopts the most advanced health and safety standards for workers and the most rigorous processes to ensure the highest quality by verifying the entire supply chain: from supplier certification to the control of raw materials, the production process, the finished product, and packaging, to spot checks at the point of sale.  For over 100 years, the Angelini family has steered the development of Angelini Industries with an entrepreneurial style typical of Italian family businesses. www.angeliniindustries.com

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