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NTU spin-off ARTICARES launches portable arm rehabilitation device

NTU spin-off ARTICARES launches portable arm rehabilitation device

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Credit: Tan Tock Seng Hospital

A new portable arm rehabilitation robot will help patients to carry out robot-aided therapy at home, allowing them to perform intensive exercises without visiting hospitals or clinics, which can possibly reduce the risk of exposure to infectious diseases such as COVID-19. The robot can also be used in hospitals and outpatient facilities such as nursing homes and clinics.

The compact robot, known as the H-Man, has demonstrated its efficacy in helping patients improve their upper-limb mobility in a clinical trial involving 60 stroke patients undergoing rehabilitation therapy.

Currently, most robots that are used for rehabilitation purposes weigh up to 70 kgs, require special reinforced housing, are very costly, and are located at hospitals where their operation is managed by occupational therapists.

In comparison, H-Man weighs 14 kgs and can be placed on a normal table. Consisting of a handle shaped like a joystick and a large screen, the patient performs prescribed tasks shown on the screen such as playing a game, while the robot evaluates his or her progress and sends feedback to therapists wirelessly.

The smart robot was developed over eight years by scientists from Nanyang Technological University, Singapore (NTU Singapore) in collaboration with rehabilitation physicians and occupational therapists from the Centre for Advanced Rehabilitation Therapeutics (CART) at Tan Tock Seng Hospital (TTSH) Rehabilitation Centre.

With the successful completion of the clinical trials, the technology was commercialised and spun off into ARTICARES by NTUitve, NTU’s enterprise and innovation company. In the short span of three years, ARTICARES has grown into a successful company with strong international presence including in Australia, Germany and China.

Leader of the NTU research team, Associate Professor Domenico Campolo, co-founder of ARTICARES, said their initial aim was to develop an affordable and portable robot that post-stroke patients could use for rehabilitation therapy at home or in community-based settings at their own pace with minimal supervision, as a complement to conventional therapy.

“With an ageing population in Singapore, we can expect to see more elderly people with upper-limb movements affected by stroke or other injuries,” said Assoc Prof Campolo, who is the Director of the NTU Robotics Research Centre. “Our smart robot is designed to allow patients to practise in the comfort of their own home with minimal help from therapists. It also improves the reach of rehabilitation physicians and occupational therapists, as they can supervise more patients this way than through one-to-one visits at the hospital.”

Adjunct Associate Professor Karen Chua, Senior Consultant at the Department of Rehabilitation Medicine, TTSH and at NTU’s Lee Kong Chian School of Medicine, who led the clinical trials for the H-Man from 2014 to 2018, said, “The machine targeted smart intensive, training to help stroke patients regain sensorimotor control and strength, and translate these to functional use of their arms in combination with conventional therapy by occupational therapists. Furthermore, lasting gains up to 19 weeks were observed after training, implying sustainability of the training and this was associated with high levels of patient safety and self-reported satisfaction in trained subjects. Potential to upskill rehabilitation professionals and enhance their productivity are also plus points to use robots in the clinic.

“As ARTICARES is locally headquartered, this has facilitated our next phase of collaboration, to foster a smooth and effective translation to the clinic,” said A/Prof Chua.

Enabling continued rehabilitation care in the community

Chief Executive Officer and co-founder of ARTICARES Dr Asif Hussain, said that while there are other technological solutions for motor rehabilitation, most of them still require the patient to be present at the hospital and under constant supervision.

“When the patient is in hospital, they can receive therapy and quality care daily. However, once they are discharged, there will be gaps in between each hospital therapy session with limited to no options to continue therapy with the same quality, intensity and frequency from outpatient settings” said Dr Hussain, a former research fellow at the NTU Robotics Research Centre.

“For post-stroke or brain injury patients, it is challenging for them to make the journey from home to hospital and back, so they often require a family member or helper to assist them. Our hope is that the H-Man robot can help bridge this gap by allowing them to do therapy in the nearby day rehabilitation centre, clinic or even at home, since we have clinically demonstrated its therapeutic efficacy and safety.”

In the clinical trials, patients using H-man successfully improved in their mobility at the same rate as conventional therapy. An assessment of their Fugl-Meyer Assessment (FMA) scores showed an average increase over 6 weeks of training of 46% for H-Man compared to conventional therapy and long-term retention of learning observed at follow-up stage with FMA was also on average observed to be 20% higher. Four of the subjects, successfully trained with the H-Man in their own home for three days, this time, under the supervision of their carers.

How the H-Man works

Specially designed games for helping patients stay motivated and learn in a fun way are displayed on the H-Man screen. Patients play the games using a joystick-shaped handle that can sense the patient’s arm strength and increase or decrease the difficulty of performing tasks in a lot of different therapeutically beneficial ways, based on the patient’s individual needs, thus helping them to relearn sensorimotor control and apply it to activities for daily living.

The device is easy to set up and use and H-Man can be equipped with a variety of soft-touch handles, including sensor-embedded handles, to suit the needs of the user and his/her therapist.

To control the games and programming on the H-Man, a digital platform called CARE has been designed based on inputs and feedback from TTSH rehabilitation physicians and occupational therapists. An automatic reporting feature also allows clinicians to track their patients’ recovery remotely.

Moving forward, ARTICARES plans to further harness technologies such as robotics and AI to improve healthcare delivery and to improve the lives of people.

“It does not stop here. It is our vision to make rehabilitation more accessible and affordable so that we can reach out to as many patients as possible and help them maximise their rehabilitation potential. This is now even more important with the current situation we are facing with COVID-19 where social distancing is becoming the new normal. We hope that by using our technologies, they can regain their mobility in a shorter time and resume their normal daily lives. This would not have been possible without the tremendous support from NTU, TTSH and the National Medical Research Council,” adds Dr Asif Hussain.

Dr Alex Lin, Interim CEO of NTUitive, said: “The H-Man by ARTICARES is a prime example of how technologies from the university are successfully being brought from the lab to the marketplace to serve real and pressing needs of society. We are proud to have guided the team through the commercialisation process to make the H-Man available for stroke patients as part of their rehabilitation journey.”

Speaking on the long-standing collaboration between ARTICARES, the National Healthcare Group’s (NHG) Centre for Medical Technologies and Innovations (CMTi), and TTSH’s Department of Rehabilitative Medicine, Associate Professor Thomas Lew, Clinical Director, NHG CMTi; and Group Chief Data and Strategy Officer, NHG, said, “This partnership was first forged when CMTi facilitated a research project between TTSH and NTU to develop a manpower-efficient rehabilitative solution for patients suffering from neurological injuries. It contributed to the successful spin-off of ARTICARES to introduce H-Man to patient care and the research community, both locally and internationally. We will continue to work together on a pipeline of devices for dedicated upper and lower limb rehabilitation, and systems for remote tele-rehabilitation therapy.”

###

Media contact:

Jasmine Singh

Marketing & Communications

ARTICARES Pte. Ltd.

Email: jasmine.singh@articares.com

Lester Kok

Assistant Director

Corporate Communications Office

Nanyang Technological University

Email: lesterkok@ntu.edu.sg

Ms Charlene Tan

Senior Executive, Communications

Tan Tock Seng Hospital

Email: Charlene_Se_TAN@ttsh.com.sg

About Nanyang Technological University, Singapore

A research-intensive public university, Nanyang Technological University, Singapore (NTU Singapore) has 33,000 undergraduate and postgraduate students in the Engineering, Business, Science, Humanities, Arts, & Social Sciences, and Graduate colleges. It also has a medical school, the Lee Kong Chian School of Medicine, established jointly with Imperial College London.

NTU is also home to world-renowned autonomous institutes – the National Institute of Education, S Rajaratnam School of International Studies, Earth Observatory of Singapore, and Singapore Centre for Environmental Life Sciences Engineering – and various leading research centres such as the Nanyang Environment & Water Research Institute (NEWRI) and Energy Research Institute @ NTU (ERI@N).

Ranked amongst the world’s top universities by QS, NTU has also been named the world’s top young university for the past seven years. The University’s main campus is frequently listed among the Top 15 most beautiful university campuses in the world and it has 57 Green Mark-certified (equivalent to LEED-certified) building projects, of which 95% are certified Green Mark Platinum. Apart from its main campus, NTU also has a campus in Singapore’s healthcare district.

Under the NTU Smart Campus vision, the University harnesses the power of digital technology and tech-enabled solutions to support better learning and living experiences, the discovery of new knowledge, and the sustainability of resources.

For more information, visit http://www.ntu.edu.sg

Media Contact
Lester Kok
lesterkok@ntu.edu.sg

Original Source

https://media.ntu.edu.sg/NewsReleases/Pages/newsdetail.aspx?news=deef219a-2632-4253-86a6-3814033bfa8f

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http://dx.doi.org/10.1177/2055668319881583

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Buried Project Veritas Recording Shows Top Pfizer Scientists Suppressed Concerns Over COVID-19 Boosters, MRNA Tech

Buried Project Veritas Recording Shows Top Pfizer Scientists Suppressed Concerns Over COVID-19 Boosters, MRNA Tech

Submitted by Liam Cosgrove

Former…

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Buried Project Veritas Recording Shows Top Pfizer Scientists Suppressed Concerns Over COVID-19 Boosters, MRNA Tech

Submitted by Liam Cosgrove

Former Project Veritas & O’Keefe Media Group operative and Pfizer formulation analyst scientist Justin Leslie revealed previously unpublished recordings showing Pfizer’s top vaccine researchers discussing major concerns surrounding COVID-19 vaccines. Leslie delivered these recordings to Veritas in late 2021, but they were never published:

Featured in Leslie’s footage is Kanwal Gill, a principal scientist at Pfizer. Gill was weary of MRNA technology given its long research history yet lack of approved commercial products. She called the vaccines “sneaky,” suggesting latent side effects could emerge in time.

Gill goes on to illustrate how the vaccine formulation process was dramatically rushed under the FDA’s Emergency Use Authorization and adds that profit incentives likely played a role:

"It’s going to affect my heart, and I’m going to die. And nobody’s talking about that."

Leslie recorded another colleague, Pfizer’s pharmaceutical formulation scientist Ramin Darvari, who raised the since-validated concern that repeat booster intake could damage the cardiovascular system:

None of these claims will be shocking to hear in 2024, but it is telling that high-level Pfizer researchers were discussing these topics in private while the company assured the public of “no serious safety concerns” upon the jab’s release:

Vaccine for Children is a Different Formulation

Leslie sent me a little-known FDA-Pfizer conference — a 7-hour Zoom meeting published in tandem with the approval of the vaccine for 5 – 11 year-olds — during which Pfizer’s vice presidents of vaccine research and development, Nicholas Warne and William Gruber, discussed a last-minute change to the vaccine’s “buffer” — from “PBS” to “Tris” — to improve its shelf life. For about 30 seconds of these 7 hours, Gruber acknowledged that the new formula was NOT the one used in clinical trials (emphasis mine):


“The studies were done using the same volume… but contained the PBS buffer. We obviously had extensive consultations with the FDA and it was determined that the clinical studies were not required because, again, the LNP and the MRNA are the same and the behavior — in terms of reactogenicity and efficacy — are expected to be the same.

According to Leslie, the tweaked “buffer” dramatically changed the temperature needed for storage: “Before they changed this last step of the formulation, the formula was to be kept at -80 degrees Celsius. After they changed the last step, we kept them at 2 to 8 degrees celsius,” Leslie told me.

The claims are backed up in the referenced video presentation:

I’m no vaccinologist but an 80-degree temperature delta — and a 5x shelf-life in a warmer climate — seems like a significant change that might warrant clinical trials before commercial release.

Despite this information technically being public, there has been virtually no media scrutiny or even coverage — and in fact, most were told the vaccine for children was the same formula but just a smaller dose — which is perhaps due to a combination of the information being buried within a 7-hour jargon-filled presentation and our media being totally dysfunctional.

Bohemian Grove?

Leslie’s 2-hour long documentary on his experience at both Pfizer and O’Keefe’s companies concludes on an interesting note: James O’Keefe attended an outing at the Bohemian Grove.

Leslie offers this photo of James’ Bohemian Grove “GATE” slip as evidence, left on his work desk atop a copy of his book, “American Muckraker”:

My thoughts on the Bohemian Grove: my good friend’s dad was its general manager for several decades. From what I have gathered through that connection, the Bohemian Grove is not some version of the Illuminati, at least not in the institutional sense.

Do powerful elites hangout there? Absolutely. Do they discuss their plans for the world while hanging out there? I’m sure it has happened. Do they have a weird ritual with a giant owl? Yep, Alex Jones showed that to the world.

My perspective is based on conversations with my friend and my belief that his father is not lying to him. I could be wrong and am open to evidence — like if boxer Ryan Garcia decides to produce evidence regarding his rape claims — and I do find it a bit strange the club would invite O’Keefe who is notorious for covertly filming, but Occam’s razor would lead me to believe the club is — as it was under my friend’s dad — run by boomer conservatives the extent of whose politics include disliking wokeness, immigration, and Biden (common subjects of O’Keefe’s work).

Therefore, I don’t find O’Keefe’s visit to the club indicative that he is some sort of Operation Mockingbird asset as Leslie tries to depict (however Mockingbird is a 100% legitimate conspiracy). I have also met James several times and even came close to joining OMG. While I disagreed with James on the significance of many of his stories — finding some to be overhyped and showy — I never doubted his conviction in them.

As for why Leslie’s story was squashed… all my sources told me it was to avoid jail time for Veritas executives.

Feel free to watch Leslie’s full documentary here and decide for yourself.

Fun fact — Justin Leslie was also the operative behind this mega-viral Project Veritas story where Pfizer’s director of R&D claimed the company was privately mutating COVID-19 behind closed doors:

Tyler Durden Tue, 03/12/2024 - 13:40

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Association of prenatal vitamins and metals with epigenetic aging at birth and in childhood

“[…] our findings support the hypothesis that the intrauterine environment, particularly essential and non-essential metals, affect epigenetic aging…

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“[…] our findings support the hypothesis that the intrauterine environment, particularly essential and non-essential metals, affect epigenetic aging biomarkers across the life course.”

Credit: 2024 Bozack et al.

“[…] our findings support the hypothesis that the intrauterine environment, particularly essential and non-essential metals, affect epigenetic aging biomarkers across the life course.”

BUFFALO, NY- March 12, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 4, entitled, “Associations of prenatal one-carbon metabolism nutrients and metals with epigenetic aging biomarkers at birth and in childhood in a US cohort.”

Epigenetic gestational age acceleration (EGAA) at birth and epigenetic age acceleration (EAA) in childhood may be biomarkers of the intrauterine environment. In this new study, researchers Anne K. Bozack, Sheryl L. Rifas-Shiman, Andrea A. Baccarelli, Robert O. Wright, Diane R. Gold, Emily Oken, Marie-France Hivert, and Andres Cardenas from Stanford University School of Medicine, Harvard Medical School, Harvard T.H. Chan School of Public Health, Columbia University, and Icahn School of Medicine at Mount Sinai investigated the extent to which first-trimester folate, B12, 5 essential and 7 non-essential metals in maternal circulation are associated with EGAA and EAA in early life. 

“[…] we hypothesized that OCM [one-carbon metabolism] nutrients and essential metals would be positively associated with EGAA and non-essential metals would be negatively associated with EGAA. We also investigated nonlinear associations and associations with mixtures of micronutrients and metals.”

Bohlin EGAA and Horvath pan-tissue and skin and blood EAA were calculated using DNA methylation measured in cord blood (N=351) and mid-childhood blood (N=326; median age = 7.7 years) in the Project Viva pre-birth cohort. A one standard deviation increase in individual essential metals (copper, manganese, and zinc) was associated with 0.94-1.2 weeks lower Horvath EAA at birth, and patterns of exposures identified by exploratory factor analysis suggested that a common source of essential metals was associated with Horvath EAA. The researchers also observed evidence of nonlinear associations of zinc with Bohlin EGAA, magnesium and lead with Horvath EAA, and cesium with skin and blood EAA at birth. Overall, associations at birth did not persist in mid-childhood; however, arsenic was associated with greater EAA at birth and in childhood. 

“Prenatal metals, including essential metals and arsenic, are associated with epigenetic aging in early life, which might be associated with future health.”

 

Read the full paper: DOI: https://doi.org/10.18632/aging.205602 

Corresponding Author: Andres Cardenas

Corresponding Email: andres.cardenas@stanford.edu 

Keywords: epigenetic age acceleration, metals, folate, B12, prenatal exposures

Click here to sign up for free Altmetric alerts about this article.

 

About Aging:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

  • Facebook
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Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

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A beginner’s guide to the taxes you’ll hear about this election season

Everything you need to know about income tax, national insurance and more.

Cast Of Thousands/Shutterstock

National insurance, income tax, VAT, capital gains tax, inheritance tax… it’s easy to get confused about the many different ways we contribute to the cost of running the country. The budget announcement is the key time each year when the government shares its financial plans with us all, and announces changes that may make a tangible difference to what you pay.

But you’ll likely be hearing a lot more about taxes in the coming months – promises to cut or raise them are an easy win (or lose) for politicians in an election year. We may even get at least one “mini-budget”.

If you’ve recently entered the workforce or the housing market, you may still be wrapping your mind around all of these terms. Here is what you need to know about the different types of taxes and how they affect you.

The UK broadly uses three ways to collect tax:

1. When you earn money

If you are an employee or own a business, taxes are deducted from your salary or profits you make. For most people, this happens in two ways: income tax, and national insurance contributions (or NICs).

If you are self-employed, you will have to pay your taxes via an annual tax return assessment. You might also have to pay taxes this way for interest you earn on savings, dividends (distribution of profits from a company or shares you own) received and most other forms of income not taxed before you get it.

Around two-thirds of taxes collected come from people’s or business’ incomes in the UK.

2. When you spend money

VAT and excise duties are taxes on most goods and services you buy, with some exceptions like books and children’s clothing. About 20% of the total tax collected is VAT.

3. Taxes on wealth and assets

These are mainly taxes on the money you earn if you sell assets (like property or stocks) for more than you bought them for, or when you pass on assets in an inheritance. In the latter case in the UK, the recipient doesn’t pay this, it is the estate paying it out that must cover this if due. These taxes contribute only about 3% to the total tax collected.

You also likely have to pay council tax, which is set by the council you live in based on the value of your house or flat. It is paid by the user of the property, no matter if you own or rent. If you are a full-time student or on some apprenticeship schemes, you may get a deduction or not have to pay council tax at all.


Quarter life, a series by The Conversation

This article is part of Quarter Life, a series about issues affecting those of us in our 20s and 30s. From the challenges of beginning a career and taking care of our mental health, to the excitement of starting a family, adopting a pet or just making friends as an adult. The articles in this series explore the questions and bring answers as we navigate this turbulent period of life.

You may be interested in:

If you get your financial advice on social media, watch out for misinformation

Future graduates will pay more in student loan repayments – and the poorest will be worst affected

Selling on Vinted, Etsy or eBay? Here’s what you need to know about paying tax


Put together, these totalled almost £790 billion in 2022-23, which the government spends on public services such as the NHS, schools and social care. The government collects taxes from all sources and sets its spending plans accordingly, borrowing to make up any difference between the two.

Income tax

The amount of income tax you pay is determined by where your income sits in a series of “bands” set by the government. Almost everyone is entitled to a “personal allowance”, currently £12,570, which you can earn without needing to pay any income tax.

You then pay 20% in tax on each pound of income you earn (across all sources) from £12,570-£50,270. You pay 40% on each extra pound up to £125,140 and 45% over this. If you earn more than £100,000, the personal allowance (amount of untaxed income) starts to decrease.

If you are self-employed, the same rates apply to you. You just don’t have an employer to take this off your salary each month. Instead, you have to make sure you have enough money at the end of the year to pay this directly to the government.


Read more: Taxes aren't just about money – they shape how we think about each other


The government can increase the threshold limits to adjust for inflation. This tries to ensure any wage rise you get in response to higher prices doesn’t lead to you having to pay a higher tax rate. However, the government announced in 2021 that they would freeze these thresholds until 2026 (extended now to 2028), arguing that it would help repay the costs of the pandemic.

Given wages are now rising for many to help with the cost of living crisis, this means many people will pay more income tax this coming year than they did before. This is sometimes referred to as “fiscal drag” – where lower earners are “dragged” into paying higher tax rates, or being taxed on more of their income.

National insurance

National insurance contributions (NICs) are a second “tax” you pay on your income – or to be precise, on your earned income (your salary). You don’t pay this on some forms of income, including savings or dividends, and you also don’t pay it once you reach state retirement age (currently 66).

While Jeremy Hunt, the current chancellor of the exchequer, didn’t adjust income tax meaningfully in this year’s budget, he did announce a cut to NICs. This was a surprise to many, as we had already seen rates fall from 12% to 10% on incomes higher than £242/week in January. It will now fall again to 8% from April.


Read more: Budget 2024: experts explain what it means for taxpayers, businesses, borrowers and the NHS


While this is charged separately to income tax, in reality it all just goes into one pot with other taxes. Some, including the chancellor, say it is time to merge these two deductions and make this simpler for everyone. In his budget speech this year, Hunt said he’d like to see this tax go entirely. He thinks this isn’t fair on those who have to pay it, as it is only charged on some forms of income and on some workers.

I wouldn’t hold my breath for this to happen however, and even if it did, there are huge sums linked to NICs (nearly £180bn last year) so it would almost certainly have to be collected from elsewhere (such as via an increase in income taxes, or a lot more borrowing) to make sure the government could still balance its books.

A young black man sits at a home office desk with his feet up, looking at a mobile phone
Do you know how much tax you pay? Alex from the Rock/Shutterstock

Other taxes

There are likely to be further tweaks to the UK’s tax system soon, perhaps by the current government before the election – and almost certainly if there is a change of government.

Wealth taxes may be in line for a change. In the budget, the chancellor reduced capital gains taxes on sales of assets such as second properties (from 28% to 24%). These types of taxes provide only a limited amount of money to the government, as quite high thresholds apply for inheritance tax (up to £1 million if you are passing on a family home).

There are calls from many quarters though to look again at these types of taxes. Wealth inequality (the differences between total wealth held by the richest compared to the poorest) in the UK is very high (much higher than income inequality) and rising.

But how to do this effectively is a matter of much debate. A recent study suggested a one-off tax on total wealth held over a certain threshold might work. But wealth taxes are challenging to make work in practice, and both main political parties have already said this isn’t an option they are considering currently.

Andy Lymer and his colleagues at the Centre for Personal Financial Wellbeing at Aston University currently or have recently received funding for their research work from a variety of funding bodies including the UK's Money and Pension Service, the Aviva Foundation, Fair4All Finance, NEST Insight, the Gambling Commission, Vivid Housing and the ESRC, amongst others.

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