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MLB trade rumors and news: MLB and MLBPA set to meet for first time since lockout on Thursday

Troy Taormina-USA TODAY SportsRob Manfred and Tony Clark are headed back to the bargaining table. The MLB Daily Dish is a daily feature we’re running here at MLBDD that rounds up roster-impacting news, rumors, and analysis. Have feedback or have someth…

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Troy Taormina-USA TODAY Sports

Rob Manfred and Tony Clark are headed back to the bargaining table.

The MLB Daily Dish is a daily feature we’re running here at MLBDD that rounds up roster-impacting news, rumors, and analysis. Have feedback or have something that should be shared? Hit us up at @mlbdailydish on Twitter or @MLBDailyDish on Instagram.

  • MLB and the MLBPA are set to hold their first bargaining session since the lockout began last month on Thursday, according to ESPN’s Jeff Passan. The league is expected to make a proposal that addresses economic and competitive issues. Given the league’s negotiation tactics during the COVID-19 shutdown in 2020 and in the lead-up to the lockout, it’s unlikely that much if anything will come out of this session, but at least the two sides are coming back to the table with just about a month until spring training is scheduled to begin.
  • In an unbelievably unfortunate development, Rays bullpen catcher Jean Ramirez passed away unexpectedly Tuesday at the age of 28. Ramirez joined the Rays organization in 2016 as a player and had been part of their major league coaching staff since 2019. Our condolences go out to his family and friends.
  • The Yankees have hired Rachel Balkovec as manager for their low-A team, the Tampa Tarpons, making her the first female skipper in affiliated professional baseball. The 34-year old has already made a massive name for herself in the baseball world, starting out as a strength and conditioning coach for the St. Louis Cardinals in 2012. In 2016, she made the jump to the Houston Astros as Latin American strength and conditioning coordinator—a position she learned Spanish for. From there she moved on to become the strength and conditioning coach for Double-A Corpus Christi and has served as a hitting coach in the Yankees organization for the last three seasons.
  • While it looks like it will be a while before we see roster moves start back up because of the (very) stalled CBA negotiations, teams and and have been working on upgrading their coaching staffs and front offices. Case in point: the Mets. After hiring Billy Eppler and Buck Showalter for their general manager and manager position respectively, the Mets continued to overhaul their leadership roles as they managed to snag Eric Chavez as their hitting coach. Chavez had JUST agreed to be the Yankees’ assistant hitting coach, but it looks like the higher level position with the Mets was too good to pass up.
  • Aside from some minor league moves, transactions involving players have been nonexistent across Major League Baseball for the last month as the lockout drags on. Luckily for the baseball obsessed, Buck Showalter continues to make transactions on his new Mets coaching staff. The Mets are set to hire Joey Cora, the older brother of Red Sox manager Alex Cora, as their new third base coach according to the New York Post. Cora spent the last five seasons in the same position with the Pirates.
  • Apparently, Ron Manfred and MLB were none too happy when veteran reporter Ken Rosenthal was critical of Manfred during the 2020 season. Not only did they sideline Rosenthal from MLB Network broadcasts for months during that season, but the rift was apparently so large that they decided to not bring back Rosenthal at all for next season.
  • When Fanatics came somewhat out of nowhere to snag the MLB license to make baseball cards out from under Topps, the writing was on the wall for the future of Topps as a company. Without the MLB license, Topps did not really have anything going for it except name recognition and that would not be able to compete with actual licensed cards. As a result, it was announced that Fanatics is buying Topps outright, which should make the transition much smoother and could preserve many of the Topps brands fans have grown to love.
  • The Dodgers have signed infielder Eddy Alvarez, which he announced himself via his Instagram page (eat your heart out, Jon Heyman). You might be saying to yourself, “But there’s a lockout, how is this possible?” Why you’re technically right, Alvarez was a minor league free agent at the beginning of this offseason, thus allowing him to sign a minor league deal. If the Miami native will stay a minor leaguer after the lockout is over is another story. The 32-year old has also achieved what only six other athletes in the world have: medaling in different sports at both the Summer and Winter Olympics. Alvarez won a silver medal as part of the Team USA baseball team in the 2021 Tokyo Summer Games, and had also previously won a silver medal as part of the U.S. 5000m relay speed-skating team at the 2014 Winter Games in Sochi. Not for nothing, a speed skating medalist is totally someone I’d want on my team (even if his slash line for his last two major league seasons was .188/.287/.287 over 115 plate appearances.)
  • The Athletics have hired Mark Kotsay as the team’s latest manager. Kotsay played for the team from 2004-2007, diving into coaching after retiring in 2013. After spending some time as San Diego’s hitting coach, Kotsay took on the bench coach role for Oakland, following that up with positions as quality control coach and first base coach.
  • In fun historic things that might have gotten swept under the rug, the Pirates have hired Caitlyn Callahan, the team’s first in-uniform female coach.
  • A possibly drunk umpire in Mexico flipped off fans and tried to fight players mid-game, and it’s sad this is the kind of baseball Robert Manfred is keeping from us.
  • The Mets have hired Buck Showalter as their new manager. The 65-year old has a 1,551-1,517 career record, and will be taking his place in Queens for the next three years. He’ll be the Mets third manager in five years, and just like he was able to do in Baltimore, can hopefully bring some hope to a team whose has fighting chance potential.
  • The Phillies announced a flurry of minor league deals with invitations to major league spring training. Headlining those signings was eight-year major league veteran Cam Bedrosian, who will return to the Phillies organization after posting a 4.35 ERA in 11 relief appearances with them last season. It’s unclear why Bedrosian, who finished the 2021 season on Philadelphia’s 40-man roster, was allowed to sign during the lockout or why the team was allowed to announce it. The Phillies added two more pitchers who appeared at the major league level in 2021, Andrew Bellatti and Jake Newberry, along with career minor leaguers Tyler Cyr, Joe Gatto, and Michael Kelly.
  • As we wait for news on the continuing CBA negotiations during the lockout, we got some sad news. Roland Hemond, former front office executive for several MLB teams over a nearly 70 year career, passed away at the age of 92. You will struggle to find another person in the game of baseball who worked in baseball as long as he did and was as beloved as him.
  • Infielder Freddy Galvis is packing his bags to head overseas, reports Yahoo Japan. The 32-year old has signed a two-year contract with the Fukuoka SoftBank Hawks of Nippon Professional Baseball. While Galvis wasn’t creating the buzz that other free agents were this offseason, he still seemed likely to earn a major league contract from someone.
  • Six new members have been elected to the National Baseball Hall Of Fame, revealed by today’s special selection committee meetings. Cooperstown will now have new residents Bud Fowler, Gil Hodges, Jim Kaat, Minnie Miñoso, Tony Oliva, and Buck O’Neil, who will be officially inducted on July 24 along with the players to be voted in by the standard writers’ ballot.
  • Right-hander Tomoyuki Sugano has declined the international opt-out clause in his contract and instead will remain with the Yomiuri Giants. Sugano told media outlets, including Yahoo Japan, that his goal was to help the Giants win a championship in 2022, so he will remain in Japan for at least one more season.
  • While a lockout was widely expected in MLB this offseason, the hope was that the two sides could at least make some movement in the closing days before the expiration of the CBA to give some hope that there could be a fairly quick resolution during the work stoppage. However, a 30 minute meeting followed by a seven minute meeting is essentially all we got and when the clock struck midnight, the lockout officially began with little cause for optimism...at least not yet.
  • In case you’re still confused about the logistics of the lockout, here’s your five minute breakdown on what’s going on.
  • One of the easier types of deals to do when faced with a hard deadline like the expiration of the CBA is to bring back a player that was on your team last year. Without concerns about medicals or background checks, there are far fewer hurdles for the moves like the Dodgers bringing back Chris Taylor on a four year deal to overcome with a tight window.
  • The Angels brought back closer Raisel Iglesias, signing him to a four-year deal. It’s a bold move for the Halos, who still have a lot of areas to address despite having arguably the two best players in baseball in Mike Trout and Shohei Ohtani.
  • After signing Michael Wacha over the weekend, the Red Sox again added to their rotation with another one-year gamble, signing lefty James Paxton to a $10 million deal. Paxton has a career 3.59 ERA but has made just six starts over the past two years, including one in 2021 before undergoing Tommy John surgery.
  • The Giants continued assembling their 2022 rotation, signing right-hander Alex Cobb to a two-year, $20 million deal with a club option for 2024. Cobb has largely struggled since leaving the Rays following the 2017 season, but he was pretty good over 18 starts for the Angels in 2021, throwing for a 3.76 ERA with 98 strikeouts and 33 walks in 93.1 innings. The Giants are betting on Cobb getting the same San Francisco boost that pitchers like Kevin Gausman, Drew Smyly, Anthony DeSclafani, and Alex Wood have received over the past two seasons.
  • The Marlins’ surprisingly active offseason took another turn as they acquired All-Star infielder Joey Wendle from the Rays in exchange for 2019 first-rounder Kameron Misner. While more work still needs to be done, the additions of Wendle, Jacob Stallings, and Avisaíl García put the pitching-rich Marlins in better position to contend for a playoff spot in 2022.
  • The Rangers have been arguably the most aggressive team in free agency this offseason. After already locking in Marcus Semien to a seven year deal among other moves, the Rangers got another high profile infielder as they signed Corey Seager to a massive 10 year, $325 million deal.
  • Everyone has been waiting for months for the fate of Marcell Ozuna in the wake of the domestic violence charges against him. After a winding tale during the legal process that saw his charges downgraded and saw him enter a diversion program, the league finally weighed in as they gave him a 20 game retroactive suspension. He will not miss a game during the 2022 season.
  • Normally, the reigning Cy Young award winner signing with a new team would be the headline for most baseball news cycles. That it wasn’t on Monday speaks volumes to how crazy it was on the transaction front. Robbie Ray does, in fact, have a new squad as the Mariners inked him to a five year, $115 million.
  • The Rangers are close to signing Jon Gray to four-year deal. The 30-year old showcased some amazing breaking pitches before his success trailed off at the end of the 2021 season. But for the Rangers right now, any kind of pitching is good pitching.
  • Kevin Gausman has agreed to a five-year, $110 million deal with Blue Jays. While Gausman struggled in the second half of last season, posting a concerning 4.42 ERA after the All-Star Break, he still finished sixth in Cy Young voting and was undoubtably the Giants’ ace at one point. We all go through rough patches, right?
  • Marcus Semien has signed a seven-year deal with the Rangers. The star infielder put on quite the show last season, slashing .265/.334/.538 with 45 home runs. Now, the Rangers have locked him down until 2028 — the year he turns 38.
  • The Twins signed Byron Buxton to a massive seven year, $100 million extension,because ‘tis the season for astronomical contracts. The Twins are rolling the dice on their homegrown talent — while Buxton is a powerhouse of a player, he is beyond injury prone. If Minnesota can keep him healthy for more than 90 games a season, their risk will be well worth it.
  • The Rays and Wander Franco both took major gambles, agreeing to an 11-year extension with a club option for a 12th year that will pay Franco a guaranteed $182 million. If all goes right for the Rays, they’ll control a generational superstar through his age-33 season. They’re betting big on a player who has played in just 70 major league games, though, while Franco is sacrificing the possibility of signing a deal that could be twice as big in exchange for more financial certainty now.
  • The White Sox signed reliever Kendall Graveman to a three-year, $24 million deal. They could have a three-headed monster at the back of their bullpen in 2022 with Graveman, Liam Hendriks, and Craig Kimbrel, though GM Rick Hahn has said they’re open to trading Kimbrel this offseason after he struggled down the stretch as a setup man in 2021.
  • The Giants had themselves a busy day as they, at least partially, sought to get the band back together for next season. They were successful on a couple fronts as they inked starting pitcher Anthony DeSclafani to a three-year deal and shortly after that, his fellow member of the Giants’ 2021 rotation, Alex Wood, joined him on a two-year deal.
  • The candidates for the Comeback Players of the Year were fairly clear this season, and that is exactly how the awards played out as Buster Posey, who battled injuries in 2019 and didn’t play in 2020, and Trey Mancini, famously coming back from colon cancer to play at a high level, took home the Comeback Player of the Year awards in each league.
  • Despite all of the drama surrounding the tenure of manager Alex Cora with regards to the sign stealing scandal that impacted both his time with the Astros and Red Sox, Boston seems very keen on keep the manager on that won them a World Series title AND helped them put together a surprising run this season deep into the playoffs as they went ahead and exercised their options on his deal for 2023 and 2024.
  • Giants first baseman Brandon Belt was the only player in the majors to accept the one-year, $18.4 million qualifying offer from his previous club, and he’ll return to a San Francisco team that he helped propel to 107 wins in 2020. 13 players rejected qualifying offers, so their previous clubs will receive compensation if they sign elsewhere.
  • Justin Verlander was one of those players who rejected the qualifying offer, but he quickly re-upped with the Astros, agreeing to a one-year, $25 million deal with a $25 million player option for 2023. That’s an impressive commitment on the part of the Astros, who will bring back a future Hall of Fame but will gamble on an aging starter who has pitched in just one game over the past two seasons.
  • The Mets tendered the one-year, $18.4 million qualifying offer to Noah Syndergaard, but instead of sticking with the club he’s spent his entire major league career with, the oft-injured starter opted to take on a new challenge and a slightly more lucrative deal, signing a one-year, $21 million deal with the Angels. After making just two appearances over the last two years, Syndergaard is gambling that he can stay healthy in 2022 and help turn around a franchise that has struggled badly at evaluating free agent pitchers in recent seasons.
  • The Blue Jays turned some heads when they gave up highly-regarded prospects Simeon Woods-Richardson and Austin Martin to acquire starter José Berríos at the trade deadline this year, but now they’re in it for the long haul with the former Twins starter after signing him to a seven-year, $131 million extension. The Berríos deal stabilizes Toronto’s rotation moving forward and should serve as a reference point for teams looking to sign free agent starters like Kevin Gausman, Robbie Ray, and Marcus Stroman this winter.
  • The Mets have pretty famously struggled to find someone to take their general manager job. After getting turned down by a number of candidates, New York offered the position to former Angels GM Billy Eppler, and he accepted the job.
  • The Giants have extended Gabe Kapler’s contract through 2024. It makes sense for the Giants to keep the party going with Kapler; he’s taken a team that was seemingly short on talent in 2020 and transformed them into the most winning team in 2021 (107, to be exact).
  • Joakim Soria has long been a productive reliever for nine different organizations over the course of his 14 season career. While his heyday was with the Royals where he made a couple of All-Star teams, he remained a solid reliever throughout his career. Soria has decided to call it a career.
  • The Dodgers are taking a gamble on a starter who struggled significantly in 2021, signing lefty Andrew Heaney to a one-year, $8.5 million deal. Heaney posted a 5.83 ERA between the Angels and Yankees this past season, but with his high strikeout rate and spin rate, the Dodgers evidently think they can turn his career around.
  • The Cardinals were quick to bring back one of the key contributors to their late-season turnaround, signing lefty reliever T.J. McFarland to a new one-year, $2.5 million deal. The 32-year-old McFarland posted a 2.56 ERA and induced a 63.7% ground-ball rate after joining the Cardinals in July.
  • J.D. Martinez has opted into his final year of his deal with the Red Sox. He’ll earn $19.35M in his last year of the $110M contract. After a turbulent 2020, the All-Star bounced back with a slash line of .286/.349/.518 and 28 home runs, shaking off any previous indication of his age.
  • Starting in the 2022 season, all 30 teams will now be required to provide housing to all minor league players, ESPN.com’s Jeff Passan reports. Last month team owners held a vote on the subject that passed unanimously. The intricacies are still being worked out on if teams will be giving players stipends for housing or if they will provide it directly. Considering the conditions that an overwhelming amount of minor leaguers have been subject to, this is a welcome improvement to the quality of their lives.

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Type-I interferon stops immune system ‘going rogue’ during viral infections

Hamilton, ON (May 17, 2022) – McMaster University researchers have found not only how some viral infections cause severe tissue damage, but also how…

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Hamilton, ON (May 17, 2022) – McMaster University researchers have found not only how some viral infections cause severe tissue damage, but also how to reduce that damage.

Credit: Georgia Kirkos/McMaster University

Hamilton, ON (May 17, 2022) – McMaster University researchers have found not only how some viral infections cause severe tissue damage, but also how to reduce that damage.

 

They have discovered how Type I interferon (IFN) stops the immune system ‘going rogue’ and attacking the body’s own tissues when fighting viral infections, including COVID-19.

 

Their paper was published in the journal PLOS Pathogens today.

  

Senior author Ali Ashkar said IFN is a well-known anti-viral signalling molecule released by the body’s cells that can trigger a powerful immune response against harmful viruses.

 

“What we have found is that it is also critical to stop white blood cells from releasing protease enzymes, which can damage organ tissue. It has this unique dual function to kick start an immune response against a viral infection on the one hand, as well as restrain that same response to prevent significant bystander tissue damage on the other,” he said.

 

The research team investigated IFN’s ability to regulate a potentially dangerous immune response by testing it on both flu and the HSV-2 virus, a highly prevalent sexually transmitted pathogen, using mice. Data from COVID-19 patients in Germany, including post-mortem lung samples, was also used in the study.

 

“For many viral infections, it is not actually the virus that causes most of the tissue damage, it is our heightened immune activation towards the virus,” said Ashkar, a professor of medicine at McMaster.

  

First co-author of the study and PhD student Emily Feng said: “Our body’s immune response is trying to fight off the virus infection, but there’s a risk of damaging innocent healthy tissue in the process. IFNs regulates the immune response to only target tissues that are infected.

 

“By discovering the mechanisms the immune system uses that can inadvertently cause tissue damage, we can intervene during infection to prevent this damage and not necessarily have to wait until vaccines are developed to develop life-saving treatments,” she added.

 

“This applies not just to COVID-19, but also other highly infectious viruses such as flu and Ebola, which can cause tremendous and often life-threatening damage to the body’s organs,” said first study co-author Amanda Lee, a family medicine resident. 

 

Ashkar said the release of harmful proteases is the result of a ‘cytokine storm’, which is life-threatening inflammation sometimes triggered by viral infections. It has been a common cause of death in patients with COVID-19, but treatment has been developed to prevent and suppress the cytokine storm.

 

Ashkar said that steroids like dexamethasone are already used to rein in an extreme immune response to viral infections. The authors used doxycycline in their study, an antibiotic used for bacterial infections and as an anti-inflammatory agent, inhibits the function of proteases causing the bystander tissue damage.

 

Lee added: “This has the potential in the future to be used to alleviate virus-induced life-threatening inflammation and warrants further research.” 

 

The study was funded by the Canadian Institutes of Health Research.

 

-30-

 

Editors:

Pictures of Ali Ashkar and Emily Feng may be found at https://bit.ly/3wmSw0D

  

 

 


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mRNA vaccines like Pfizer and Moderna fare better against COVID-19 variants of concern

A comparison of four COVID-19 vaccinations shows that messenger RNA (mRNA) vaccines — Pfizer-BioNTech and Moderna — perform better against the World…

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A comparison of four COVID-19 vaccinations shows that messenger RNA (mRNA) vaccines — Pfizer-BioNTech and Moderna — perform better against the World Health Organization’s variants of concern (VOCs) than viral vector vaccines — AstraZeneca and J&J/Janssen. Although they all effectively prevent severe disease by VOCs, the research, publishing May 17th in the open access journal PLOS Medicine, suggests that people receiving a viral vector vaccine are more vulnerable to infection by new variants.

Credit: Carlos Reusser Monsalvez, Flickr (CC0, https://creativecommons.org/publicdomain/zero/1.0/)

A comparison of four COVID-19 vaccinations shows that messenger RNA (mRNA) vaccines — Pfizer-BioNTech and Moderna — perform better against the World Health Organization’s variants of concern (VOCs) than viral vector vaccines — AstraZeneca and J&J/Janssen. Although they all effectively prevent severe disease by VOCs, the research, publishing May 17th in the open access journal PLOS Medicine, suggests that people receiving a viral vector vaccine are more vulnerable to infection by new variants.

By March 2022, COVID-19 had caused over 450 million confirmed infections and six million reported deaths. The first vaccines approved in the US and Europe that protect against serious infection are Pfizer-BioNTech and Moderna, which deliver genetic code, known as mRNA, to the bodies’ cells, whereas Oxford/AstraZeneca and J&J/Janssen are viral vector vaccines that use a modified version of a different virus — a vector — to deliver instructions to our cells. Three vaccines are delivered as two separate injections a few weeks apart, and J&J/Janssen as a single dose.

Marit J. van Gils at the University of Amsterdam, Netherlands, and colleagues, took blood samples from 165 healthcare workers, three and four weeks after first and second vaccination respectively, and for J&J/Janssen at four to five and eight weeks after vaccination. Samples were collected before, and four weeks after a Pfizer-BioNTech booster.

Four weeks after the initial two doses, antibody responses to the original SARS-CoV-2 viral strain were highest in recipients of Moderna, followed closely by Pfizer-BioNTech, and were substantially lower in those who received viral vector vaccines. Tested against the VOCs – Alpha, Beta, Gamma, Delta and Omicron – neutralizing antibodies were higher in the mRNA vaccine recipients compared to those who had viral vector vaccines. The ability to neutralize VOCs was reduced in all vaccine groups, with the greatest reduction against Omicron. The Pfizer-BioNTech booster increased antibody responses in all groups with substantial improvement against VOCs, including Omicron.

The researchers caution that their AstraZeneca group was significantly older, because of safety concerns for the vaccine in younger age groups. As immune responses tend to weaken with age, this could affect the results. This group was also smaller because the Dutch government halted use for a period.

van Gils concludes, “Four COVID-19 vaccines induce substantially different antibody responses.”

#####

In your coverage, please use this URL to provide access to the freely available paper in PLOS Medicine:

http://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003991

Citation: van Gils MJ, Lavell A, van der Straten K, Appelman B, Bontjer I, Poniman M, et al. (2022) Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study. PLoS Med 19(5): e1003991. https://doi.org/10.1371/journal.pmed.1003991

 

Author Countries: The Netherlands, United States

 

Funding: This work was supported by the Netherlands Organization for Scientific Research (NWO) ZonMw (Vici grant no. 91818627 to R.W.S., S3 study, grant agreement no. 10430022010023 to M.K.B.; RECoVERED, grant agreement no. 10150062010002 to M.D.d.J.), by the Bill & Melinda Gates Foundation (grant no. INV002022 and INV008818 to R.W.S. and INV-024617 to M.J.v.G.), by Amsterdam UMC through the AMC Fellowship (to M.J.v.G.) and the Corona Research Fund (to M.K.B.), and by the European Union’s Horizon 2020 program (RECoVER, grant no. 101003589 to M.D.d.J). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.


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Japanese yen remains directionless

The Japanese yen has posted slight gains on Tuesday. In the North American session, USD/JPY is trading at 129.32, up 0.17% on the day. The US dollar pummelled…

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The Japanese yen has posted slight gains on Tuesday. In the North American session, USD/JPY is trading at 129.32, up 0.17% on the day.

The US dollar pummelled the yen in the months of March and April, but the yen has held its own in May. Still, USD/JPY remains at high levels and the 130 line, which has psychological significance, remains vulnerable. If there is a line in the sand for the Japanese government or the BoJ to intervene and prop up the yen, it certainly is not the 130 level, as the dollar broke through this line without a response. The yen is extremely sensitive to the US/Japan rate differential, and with the BoJ demonstrating that it will tenaciously defend its yield curve, the yen is at the mercy of Powell & Co.

Japan releases GDP for Q1 on Thursday. The markets are braced for a decline of 0.4%, after a respectable gain of 1.1% in Q4 of 2020. Investors never like to see negative growth, and a lower-than-expected GDP report will put downward pressure on the yen.

 

US retail sales within expectations

Over in the US, retail sales for April came in at 0.9%, just shy of the consensus estimate of 1.0%. Core retail sales rose 1.0%, above the forecast of 0.7% and close to the 1.1% gain in March. The numbers were not spectacular by any stretch, but were respectable, given that consumer confidence has weakened – the UoM Consumer Sentiment index fell to 59.42 in May, its lowest level since October 2011. US households continue to spend, despite a deterioration in consumer confidence. Wages are not keeping up with the cost of living, but consumers appear to be using savings which accumulated during the Covid pandemic.

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USD/JPY Technical

  • USD/JPY is testing resistance at 1.2938, followed by resistance at 1.3123
  • There is support at 1.3000 and 1.2918

 

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