Nearly 6 percent of children who presented to the Emergency Department (ED) with COVID-19 reported symptoms of long COVID 90 days later, according to a study conducted in eight countries and published in JAMA Network Open. Initial hospitalization of 48 or more hours, four or more symptoms at the initial ED visit, and age 14 years or older were associated with long COVID.
“We found that in some children, illness with COVID-19 is associated with reporting persistent symptoms after 3 months,” said Principal Investigator Stephen Freedman, MDCM, MSc, with the Cumming School of Medicine at University of Calgary, and Alberta Health Services. “Our results suggest that appropriate guidance and follow-up are needed, especially for children at high risk for long COVID.”
The study included 1,884 children with COVID-19 who had 90-day follow-up. Long COVID was found in nearly 10 percent of hospitalized children and 5 percent in children discharged from the ED.
“Reported rates of long COVID in adults are substantially higher than what we found in children,” said Co-Principal Investigator Nathan Kuppermann, MD, MPH, from University of California, Davis School of Medicine, Sacramento. “Our findings can inform public health policy decisions regarding COVID-19 mitigation strategies for children and screening approaches for long COVID among those with severe infections.”
The most reported persistent symptoms in children were fatigue or weakness, cough, difficulty breathing or shortness of breath.
“Our finding that children who had multiple COVID-19 symptoms initially were at higher risk for long COVID is consistent with studies in adults,” said Co-Principal Investigator Todd Florin, MD, MSCE, from Ann & Robert H. Lurie Children’s Hospital of Chicago and Northwestern University Feinberg School of Medicine. “Unfortunately, there are no known therapies for long COVID in children and more research is needed in this area. However, if symptoms are significant, treatment targeting the symptoms is most important. Multidisciplinary care is warranted if symptoms are impacting quality of life.”
About the Cumming School of Medicine
The University of Calgary’s Cumming School of Medicine (CSM) is driven to create the future of health. We are a proud leader with seven world-class research institutes and 2,900 students, as well as faculty and staff, working to advance education and research in precision medicine and precision public health, improving lives in our community and around the world. Visit cumming.ucalgary.ca and follow us @UCalgaryMed.
About University of California, Davis School of Medicine
The UC Davis School of Medicine is among the nation’s leading medical schools, recognized for its research and primary-care programs. The school offers fully accredited master’s degree programs in public health and in informatics, and its combined M.D.-Ph.D. program is training the next generation of physician-scientists to conduct high-impact research and translate discoveries into better clinical care. Along with being a recognized leader in medical research, the school is committed to serving underserved communities and advancing rural health. For more information, visit UC Davis School of Medicine at medschool.ucdavis.edu.
About Ann & Robert H. Lurie Children’s Hospital of Chicago
Research at Ann & Robert H. Lurie Children’s Hospital of Chicago is conducted through Stanley Manne Children’s Research Institute. The Manne Research Institute is focused on improving child health, transforming pediatric medicine and ensuring healthier futures through the relentless pursuit of knowledge. Lurie Children’s is ranked as one of the nation’s top children’s hospitals by U.S. News & World Report. It is the pediatric training ground for Northwestern University Feinberg School of Medicine. Emergency medicine-focused research at Lurie Children’s is conducted through the Grainger Research Program in Pediatric Emergency Medicine.
JAMA Network Open
Method of Research
Subject of Research
Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection
Article Publication Date
Dr Kuppermann reported receiving grants from University of Califonia, Davis during the conduct of the study. Dr Florin reported receiving grants from Cincinnati Children’s Hospital Medical Center Division of Emergency Medicine Small Grant Program during the conduct of the study. Dr Tancredi reported receiving personal fees from International Flavors & Fragrances Inc for statistical consulting outside the submitted work. Dr Ambroggio reported receiving grants from Pfizer Inc outside the submitted work. Dr Morris reported having a patent pending for therapies for the treatment of coronoviruses. Dr Freedman reported receiving grants from the Canadian Institutes of Health Research, the Alberta Health Services–University of Calgary, the Alberta Children’s Hospital Research Institute, and the Alberta Children’s Hospital Foundation during the conduct of the study. No other disclosures were reported.