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Haut.AI OU announced residency at JLABS @ Shanghai

The modern skincare and personal care field is science-driven and based on continuous innovation and product development through R&D. To keep pace…

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The modern skincare and personal care field is science-driven and based on continuous innovation and product development through R&D. To keep pace with the ever-expanding expectations and consumer preferences, cosmetics manufacturers and brands are encouraged to embrace the shift toward hyper-personalized, inclusive, and claims-supported products. This puts a lot of pressure on companies’ R&D teams to create new products and formulations tailored to a range of different skin and hair types. Moreover, the pandemic has put its weight on the already complex and multifaceted process of conducting consumer studies and product testing.  All of these factors have contributed significantly to the growing demand for innovative tools that help R&D teams with their cosmetic claims collection processes.

Credit: JLABS

The modern skincare and personal care field is science-driven and based on continuous innovation and product development through R&D. To keep pace with the ever-expanding expectations and consumer preferences, cosmetics manufacturers and brands are encouraged to embrace the shift toward hyper-personalized, inclusive, and claims-supported products. This puts a lot of pressure on companies’ R&D teams to create new products and formulations tailored to a range of different skin and hair types. Moreover, the pandemic has put its weight on the already complex and multifaceted process of conducting consumer studies and product testing.  All of these factors have contributed significantly to the growing demand for innovative tools that help R&D teams with their cosmetic claims collection processes.

Established in 2018, Haut.AI initially emerged as a skin research organization focused on image-based methods for skin evaluation. Haut.AI has supported the R&D activities of major skincare players and enabled the collection of thousands of data points in remote consumer and in-vivo product evaluations.

Haut.AI currently provides a wide range of innovative AI-based software solutions for cosmetic and dermatocosmetic R&D, consumer-facing applications, and patient support programs. HautAI utilizes a unique, proprietary, inclusive artificial intelligence and computer vision technology for the analysis of skin, hair and nails with more than 100 image-based visual biomarkers. This technology was developed in collaboration with exceptional data scientists, skin scientists and industry leaders in dermatology. It has been validated on a diverse dataset of more than three million images to ensure it performs equally well on a wide spectrum of people.

Haut.AI’s digital innovation platform allows beauty and wellness brands to conduct various types of consumer studies remotely, without any significant loss of efficiency or accuracy. Haut.AI’s solution for remote standardized data collection has been shown to increase the number of high-quality pictures and survey data collected during remote studies from 32% to 81%. The platform is also secured with end-to-end encryption.

Haut.AI has recently declared its strategic goals for 2022.  Of particular note, the company aims to expand its presence in the Asian market. The Asian skincare market is currently valued at over $62 billion, with facial skincare accounting for 74% of total revenue, according to market research carried out by Statista in November 2021. This market is expected to grow annually by 7.42% and reach $89 billion by 2026. To date, Haut.AI has provided its services in South Korea, Vietnam and Indonesia, and it has recently entered the Chinese market.

Four of the five top countries in the sale of skincare products are based in Asia (Japan, China, South Korea and India). And while the US is the global skincare market leader right now, Japan is not far behind and is expected to outperform it in 2024. To successfully compete on the global market, Asian cosmetics companies must gain an advantage by staying ahead of emerging trends. This is achieved by creating new hyper-personalized and highly effective products. Thus, the demand for Haut.AI’s technology in Asia will certainly continue to grow.

Haut.AI plans to seize these emerging opportunities and aspires to become the world’s leading provider of skin analysis services.

About Haut.AI OU

Based in Estonia, Haut.AI is a cutting-edge technology company specializing in the development and application of next-generation platforms for skin health and longevity research. Haut.AI’s software is backed by state-of-the-art computer vision technology and inspired by the principles of biophysical skin analysis. Since its inception in 2018, the company’s R&D team has published multiple research papers in peer-reviewed journals. The company’s mission is to develop fully autonomous recommendation systems and AI-driven research tools to maximize the health and longevity of human skin.

Haut.AI helps cosmetics and wellness brands around the world to leverage the open innovation model, allowing them to focus on their core business, while Haut.AI’s devoted team of expert AI scientists and machine learning engineers lead the development of skin and hair analysis technology.


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Why Is The VIX So Low? A Surprising Answer Emerges In The Market’s Microstructure

Why Is The VIX So Low? A Surprising Answer Emerges In The Market’s Microstructure

One of the most frequent questions tossed around Wall Street…

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Why Is The VIX So Low? A Surprising Answer Emerges In The Market's Microstructure

One of the most frequent questions tossed around Wall Street trading desks (and strip clubs), and which was duly covered by Bloomberg recently in "Fear Has Gone Missing in Wall Street’s Slow-Motion Bear Market", is why despite the crushing bear market and the coming recession, does the VIX refuse to rise sustainably above 30, or in other words, why is the VIX so low?

As Goldman's Rocky Fishman wrote in a recent note "Option Markets Take the SPX Bear Market in Stride" (available to professional subs), "one of the most popular questions we have received is why the VIX hasn't surpassed its March peak (36) despite the SPX being lower than it was in March and realized vol being higher than it was in March."

Here, Fishman notes that implied volatility was unusually high in March, and the current VIX level (29) is only slightly low for the current level of realized vol. Furthermore, a VIX around 30 typically happens with the 5Y CDX HY spread above 600, and although it has risen steadily it's currently in the mid 500's.

Meanwhile, even as the VIX has fallen moderately since late April, both vol risk premium and skew have both fallen dramatically.

Picking up on this quandary, overnight JMorgan also joined the discussion with its analyst Peng Cheng laying out his own thoughts on why the VIX remains so low (note is also available to professional subs), and similar to Goldman notes that the current bear market, despite being deeper in magnitude, has produced VIX levels well below the peak observed during previous market sell-offs:

However, unlike Goldman which mostly analyzes the VIX in the context of a macro framework, JPM's Cheng offers observations based on his analysis of market microstructure in both equity and options markets.

Cheng starts with the previously noted low realized volatility: as the JPM strategist writes, YTD, the SPX realized vol, measured on a close to close basis, is only 25.5, which means that delta-hedged put options would have lost money in the gamma component. From a technical perspective, JPM believes that return volatility is dampened by a lack of intraday price momentum and increasingly frequent occurrences of intraday price reversal. As seen in the next chart, intraday reversal has only started to become noticeable in the last two years. Prior to that, intraday momentum was the dominant market behavior.

This diminishing intraday price momentum has had a non-trivial impact on realized volatility, according to JPM which estimates that if the intraday return correlation remained the same as pre-pandemic, YTD volatility would be close to 28.8, or 3.3 vol points higher than realized.

As an aside, those asking for the reason behind this change in intraday patterns in the last couple of years, Cheng notes that "this is a complex topic" but in short, his view is that it is a result of 1) crowding in intraday momentum trading strategies and 2) a potential shift in option gamma dynamics as discussed below.

Supply/demand of S&P 500 options: Although the estimation of market level option gamma profile is highly dependent on many factors, including assumptions on open interest, OTC options, and leveraged ETFs, etc., in a report published earlier this year, JPM's quants presented a more dynamic estimation of the gamma profile by using tick level data. Specifically, they assigned directions to SPX and SPY option trades based on their distance to the best bid/offer at the tick level, rather than the constant assumption of investors being outright long puts and short calls. The updated results are shown below.

Tha chart shows that starting in 2020, the put gamma imbalance has fallen meaningfully. This is the result of investors’ changing preference from buying outright puts to put spreads for protection, in JPM's view. And year to date, the decline in gamma demand has not improved. Moreover, and echoing what we have said on several recent occasions, JPM notes that judging from the outright negative put gamma imbalance in early 2022, it appears that investors have been monetizing hedges that had been held since 2021 - note the consistently positive and relatively elevated put gamma imbalance throughout 2021, which suggests that protections were put on during this period.

More in the full note available to pro subs

Tyler Durden Wed, 06/29/2022 - 15:05

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Dr. Stephen Kingsmore receives prestigious Precision Medicine World Conference 2022 Luminary Award

SAN DIEGO, Calif. – June 29, 2022 – Rady Children’s Institute for Genomic Medicine® (RCIGM) today announced that Stephen Kingsmore, MD, DSc, President…

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SAN DIEGO, Calif. – June 29, 2022 – Rady Children’s Institute for Genomic Medicine® (RCIGM) today announced that Stephen Kingsmore, MD, DSc, President and CEO, was presented with the Precision Medicine World Conference (PMWC) 2022 Luminary Award at this year’s conference in the Silicon Valley region of California for his innovation in rapid neonatal molecular diagnoses using whole-genome sequencing.

Credit: Rady Children’s Institute for Genomic Medicine

SAN DIEGO, Calif. – June 29, 2022 – Rady Children’s Institute for Genomic Medicine® (RCIGM) today announced that Stephen Kingsmore, MD, DSc, President and CEO, was presented with the Precision Medicine World Conference (PMWC) 2022 Luminary Award at this year’s conference in the Silicon Valley region of California for his innovation in rapid neonatal molecular diagnoses using whole-genome sequencing.

The Luminary Award recognizes the recent contributions of prominent figures who have accelerated precision medicine into the clinic. Additional PMWC 2022 honorees included Dr. Albert Bourla, Pfizer, for his extraordinary achievement in leading the record-time development of a vaccine and antiviral drug against the coronavirus and Dr. Stephen Hoge, Moderna, for overseeing R&D of the first antiviral synthetic mRNA vaccines ever created, including the one against COVID-19.

“I am honored to receive this award and be among this extraordinary group of past and present recipients focused on the clinical adoption of precision medicine,” said Dr. Kingsmore. “At RCIGM, we are transforming pediatric healthcare through the power of Rapid Precision Medicine™ by offering the fastest delivery of rapid Whole Genome Sequencing™ to enable prompt diagnosis and targeted treatment of critically ill newborns and children in intensive care. We know that time matters – a fast, molecular diagnosis can make the difference between improved outcomes and a lifetime of disability, or even life itself.”

Dr. Kingsmore leads a multi-disciplinary team of scientists, physicians, genetic counselors, software engineers and bioinformaticians who are pioneering the use of rWGS® to enable precise diagnoses for critically ill newborns. In 2021, he led the RCIGM team to set a new record of 13.5 hours for achieving the fastest molecular diagnosis using rWGS, breaking his previous 2018 world record of 19.5 hours. 

PMWC is the largest and original annual conference dedicated to precision medicine. PMWC’s mission is to bring together recognized leaders, top global researchers and medical professionals, and innovators across healthcare and biotechnology sectors to showcase practical content that helps close the knowledge gap between different sectors, thereby catalyzing cross-functional fertilization and collaboration in an effort to accelerate the development and spread of precision medicine.

Rady Children’s Institute for Genomic Medicine

Rady Children’s Institute for Genomic Medicine is transforming neonatal and pediatric health care by harnessing the power of Rapid Precision Medicine™ to improve the lives of children and families facing rare genetic disease. Founded by Rady Children’s Hospital and Health Center, the Institute offers the fastest delivery of rapid Whole Genome Sequencing™ to enable prompt diagnosis and targeted treatment of critically ill newborns and children in intensive care. The Institute now provides clinical genomic diagnostic services for a growing network of more than 70 children’s hospitals. The vision is for this life-changing technology to become standard of care and enable clinicians nationwide to provide rapid, personalized care. Learn more about the non-profit Institute at RadyGenomics.org. Follow us on Twitter and LinkedIn.

Media Contact:

Ben Metcalf
bmetcalf@rchsd.org
+1 (619) 822-8593
 


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Fauci Suffers “Much Worse” COVID Symptoms After ‘Paxlovid Rebound’

Fauci Suffers "Much Worse" COVID Symptoms After ‘Paxlovid Rebound’

Fully-vaxx’d and double-boosted mask-admirer Anthony Fauci is suffering.

Two…

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Fauci Suffers "Much Worse" COVID Symptoms After 'Paxlovid Rebound'

Fully-vaxx'd and double-boosted mask-admirer Anthony Fauci is suffering.

Two weeks ago, we reported that President Biden's chief medical adviser had COVID.

The 81-year-old reportedly had 'mild symptoms' and of course he 'said the words'...

Of course, Fauci followed the CDC guidelines and ingested the government-blessed treatment - Paxlovid - due to his age and possible risks from the virus.

So, that should have been it right?

But no. During an event at Foreign Policy’s Global Health Forum, Fauci admitted he had not had a good experience:

“After I finished the five days of Paxlovid, I reverted to negative on an antigen test for three days in a row,” Fauci said Tuesday .

“And then on the fourth day, just to be absolutely certain, I tested myself again. I reverted back to positive.”

Interestingly, Fauci admitted:

"...this is becoming more and more typical based on more clinical studies..."

As Bloomberg reports, large numbers of patients have reported the phenomenon, often called Covid rebound or Paxlovid rebound, of returning symptoms after taking a full course of Pfizer’s drug.

While Pfizer Chief Executive Officer Albert Bourlasaid in May that doctors could prescribe a second course of treatment to such patients, US drug regulators have said there’s no evidence that a repeat will help.

However, Fauci said he started taking a second course of Paxlovid after experiencing symptoms “much worse than in the first go around.”

Now near completion of the five-day oral treatment, he said he was still enduring symptoms but felt “reasonably good.”

Finally, as we reported less than two weeks ago, Pfizer stopped enrolling in a clinical trial for Paxlovid for standard-risk COVID-19 patients after the latest results suggested the drug did not reduce symptoms or hospitalizations and deaths to a statistically significant degree.

Watch the full interview below: (forward to around 5:26:00):

Not exactly encouraging news...

Tyler Durden Wed, 06/29/2022 - 11:45

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