Connect with us

Spread & Containment

Futures Flat As Traders Freak Over Jackson Hawk

Futures Flat As Traders Freak Over Jackson Hawk

After Monday’s furious selloff which sent stocks tumbling the most in two months when the…

Published

on

Futures Flat As Traders Freak Over Jackson Hawk

After Monday's furious selloff which sent stocks tumbling the most in two months when the yield on 10-year Treasuries breached 3%, S&P futures have stabilized overnight, and after earlier dropping as low as 4,120 - or some 200 points below last week's 200DMA resistance - have since rebounded to unchanged, if near the bottom of Monday’s range as nervous traders increasingly fear Powell will unleash a Hawk-ano during his Friday Jackson Hole speech. The 10-year Treasury yield held above 3% and the Bloomberg dollar index hovered at a five-week high as the EUR briefly dropped to 0.99, a fresh 20-year low, amid exponentially increasing energy costs. Oil futures climbed another 2% amid fears OPEC+ will cut output, as the market finally grasped what we were saying back in July 8 in "Inside The Oil Market's Jekyll-And-Hyde Moment" after the Saudi Energy minister said that "The paper and physical markets have become increasingly more disconnected."

In US premarket trading, Zoom Video Communications tumbled 9% after the communications software company cut its full-year forecast. Meanwhile, Palo Alto Networks rallied 8.7% after the security software company reported fiscal fourth- quarter results that beat expectations and gave a full-year forecast that is ahead of the analyst consensus. Here are some of the biggest US movers today:

  • Bed Bath & Beyond (BBBY US) shares rise as much as 6.6% in US premarket trading, set to end three days of losses, as a rout in retail-trader favorites eases, though worries over more challenging economic conditions remain
  • Dlocal (DLO US) shares fall as much as 9.5% in US premarket trading after the Uruguay payments firm reported second-quarter earnings that Morgan Stanley said were “good,” but not an “outright beat.”
  • Ocugen (OCGN US) shares rise as much as 6.8% in US premarket trading as Mizuho initiates the biopharma firm with a buy rating and $5 PT
  • Grocery Outlet (GO US) slips 4% after Morgan Stanley cut to underweight with the risk-reward on the grocery stores operator now looking negative
  • Kohl’s (KSS US) rose 2.1% in extended trading after a filing with the SEC showed Chairman Peter Boneparth bought $750,130 of shares

As discussed countless times before, the J-Hole symposium starting Friday with a keynote speech from J-Powell will be a key catalyst for equities, which have started pulling back again amid renewed fears of a more hawkish Fed. The Nasdaq has been under the most pressure after its valuation climbed above the 10-year average as higher rates weigh on the present value of future profits, hurting pricier growth stocks, like tech.

“For the moment, global sentiment is both skittish and volatile,” said Richard Hunter, head of markets at Interactive Investor. “There is little cause for optimism on the immediate horizon, with any glimmers of economic hope yet to take hold on a sustainable basis.”

“We expect equity markets to remain volatile as investor sentiment oscillates between hopes that the Fed will succeed in steering the US economy to a ‘soft landing,’ and fears that it will not,” said Mark Haefele, chief investment officer at UBS Global Wealth Management. “Against this uncertain backdrop, we have recommended that investors retain a selective approach toward equities, and we believe this remains the right strategy.”

Meanwhile, looking at market technicals, Citi's Chris Montagu said that the disjointed set of flows from both exchange-traded funds and futures last week paint a “muddled picture,” reflecting various assessments of whether the current rally has reached its near-term peak. The recent bullish sentiment appears weak and investors are uncertain with muted flows, they wrote in a note.

In Europe, the Stoxx 600 fluctuated near a three-week low after euro-area economic activity declined for a second month, signaling that fears of a recession may already be coming to pass as record inflation saps demand. While German PMIs came in a little stronger, a gauge of French private-sector activity dropped in August to its lowest level since the pandemic-related disruptions of early 2021, suggesting France is joining Germany in recession. It fell more than economists had expected, dipping below the threshold that separates expansion from contraction.

Energy stocks advanced thanks to a boost for crude oil from the possibility of OPEC+ output cuts. The euro hovered near a two-decade through, and only stronger than expected German PMI data prevented the EURUSD from sliding below 0.99; bond yields edged higher.

The looming European recession and the drop in the euro-area PMIs presents a dilemma for the ECB, which is raising interest rates to curb the hottest inflation in decades, even as uncertainty about the outlook is high and economic momentum fades. Meanwhile, the surge in European electricity prices continued and investors are finally waking up to the prospect that German stocks have further to fall due to the spiraling energy crisis according to Bloomberg. In the panic over Russian supplies, German power surged to above 700 euros a megawatt-hour for the first time and the Belgian prime minister said Europe could face up to 10 difficult winters.

European stocks tumbled, with the DAX a notable laggard, down over 2% Monday although it steadied on Tuesday.  The DAX is now the worst-performing major Western European equity benchmark so far this month. Investors may be coming to realize that the energy crisis will put long-term strain on economies and companies, with the official start of the winter heating season just over a month away. Equities, especially in Germany, have not fully priced the energy stew. Cyclical German stocks are particularly at risk from this cocktail of soaring energy, inflation and recession risk, with chemicals, autos and industrials making up about 45% of the DAX, whose negative 30-day correlation with nat gas prices is the highest since April. That month German stocks fell 2.2%, more than the Stoxx 600. The correlation was most negative in late February/early March, when Russia invaded Ukraine. The DAX slumped 6.5% in February, also more than the Stoxx 600. European 2Q earnings were better than feared but there are signs conditions will get tougher from this cocktail of soaring energy, inflation and recession risk.

Here are some of the biggest European movers today:

  • On the Beach shares rose as much as 6.6% after CEO Simon Cooper notified the company he had increased his stake in the company with a purchase of ~1.53m shares at 129.54 pence per share
  • TAG Immobilien shares gained as much as 4.8% before paring gains after the German real estate company reported 2Q earnings following a capital increase in July
  • Zurich Airport shares rose as much as 3.9% and was among the top performers on the Stoxx 600 Industrial Goods and Services index as analysts praised 1H results that came in ahead of consensus expectations
  • BT shares rose as much as 1.7% after the telecom firm said the UK government decided to take no action on Altice UK’s stake in the company, after announcing in May that it would review it under the national security act
  • Virgin Money UK shares rose as much as 1% after Liberum increased the price target on the stock, saying the company is delivering on its accelerated digital strategy
  • Wood shares dropped as much as 12% before paring declines, with Jefferies saying the engineering services firm’s outlook “looks light”
  • Halfords shares slid as much as 11%, dropping to the lowest since July 2020, after Panmure Gordon cut the retailer of auto parts and bicycles to hold from buy and halved its price target to a Street-low
  • Grieg Seafood shares fell as much as 6%, to the lowest intraday since May 13, after the salmon and trout farmer cut its harvest guidance for the year
  • Dermapharm shares declined as much as 4.4% after the company posted 1H results that Jefferies called “solid but still not exciting”
  • Evotec shares fell as much as 3.8%, the worst performer in the Stoxx 600 Health Care index. RBC (outperform) cuts its PT on the German pharma firm, though says it still sees upside for the stock
  • Bakkafrost shares fell as much as 2.8%, hitting the lowest since June, with DNB saying the salmon farmer’s 2Q results were weaker than anticipated

Earlier in the session, Asian shares dropped as investors reduced bets on tech and other growth stocks amid receding expectations of slower monetary tightening by the Federal Reserve. The MSCI Asia Pacific Index fell as much as 1.2% to the lowest level in five weeks. TSMC, Sony and Samsung were among the biggest contributors to the drop. Benchmarks in most countries were in the red, with key measures in Japan, South Korea, Australia and the Philippine tumbling more than 1%. Expectations are building ahead of this week’s Jackson Hole central banker meeting that Federal Reserve Chair Jerome Powell will double down on the need to tame inflation. That’s helped cool the recent equity rally that was fueled by bets on slower interest rate hikes. 

“It’s hard to profit more from here -- the dollar is strengthening again on views that the rate hike pace won’t slow down,” said Heo Pil-Seok, chief executive officer at Midas International Asset Management in Seoul. “Risk-off sentiment is spreading again.” In addition to currency, traders were monitoring the impact of expected tighter Fed policy on bonds, with the 10-year Treasury yield holding above 3%. Corporate earnings are also in focus, with more than 340 members of the MSCI Asian benchmark reporting this week.

Japanese stocks tumbled amid deepening investor concerns over the Federal Reserve’s monetary policy plans as the Jackson Hole meeting draws near.  The Topix fell 1.1% to close at 1,971.44, while the Nikkei declined 1.2% to 28,452.75. Sony Group Corp. contributed the most to the Topix decline, decreasing 3.3%. Out of 2,170 stocks in the index, 453 rose and 1,624 fell, while 93 were unchanged. “For the time being, we will have to wait and see what Powell has to say throughout the week, as Jackson Hole is still the most important factor to watch,” said Hideyuki Suzuki, general manager at SBI securities. “However, it’s also difficult to take a position since it’s the end of the month, and there should be more moves in the beginning of September with employment statistics and the major SQ.”

India’s benchmark equities index ended higher after fluctuating between gains and losses for much of the session, with heavyweight Reliance Industries among the winners.  The S&P BSE Sensex rose 0.4% to 59,031.30 in Mumbai, after falling as much as 1% earlier in the session. The measure had lost 2.5% in previous two days. The NSE Nifty 50 Index climbed 0.5% on Tuesday.  Traders are bracing for hawkish talks at the Federal Reserve’s Jackson Hole symposium later this week amid concerns that the central bank may not slow the pace of monetary tightening to tackle price pressures.   “Markets may witness bouts of volatility in coming days as global factors will continue to keep investors on tenterhooks,” said Shrikant Chouhan, head of research at Kotak Securities Ltd. Reliance Industries advanced 1.5%, the most in over a week. Among the 30 stocks in the Sensex, 21 ended higher. All but two of 19 sectoral sub-indexes compiled by BSE Ltd. gained, led by a gauge of metal companies.

In FX, the Bloomberg Dollar Spot Index was little changed as the greenback traded mixed against its Group-of-10 peers. Risk- sensitive Scandinavian and Antipodean currencies advanced along with the yen. Two-year Treasury yields rose by 2bps, while 10- year yields were little changed. The euro briefly erased losses against the dollar and German benchmark 10-year bonds erased earlier gains, following stronger-than-forecast German manufacturing PMI data. The common currency was earlier on the verge of falling below the $0.99 handle. One-month implied volatility in euro-dollar is up for an eighth day, for the first time since April 2017. The pound fell against a broadly stronger dollar, slipping below $1.18 to approach its lowest since March 2020. China’s onshore and offshore yuan extend declined to their lowest level in two years as the currency continued to be weighed by the dollar’s strength. Additional policies to support the nation’s property sector did little to alleviate growth concerns.

In rates, Treasuries extended flattening with long-end yields slightly richer on the day, front-end cheaper led by 2-year sector with yields ~2bp higher on the day ahead of $44BN auction at 1pm. 10-year are yields little changed around 3.015% with bunds and gilts in the sector cheaper by ~1bp and ~3bp; long-end outperforms, flattening 2s10s, 5s30s spreads by ~2bp each. Bunds, gilts underperformed following stronger-than-forecast German manufacturing PMI. US S&P Global PMIs are due later in the session. The yield on bunds 10-year is up about 1 bp to 1.31%; gilts curve flattens, with belly underperforming. Peripheral spreads widen to Germany with 10y BTP/Bund adding 2.1bps to 233.9bps. The Treasury auction cycle begins with $44b 2-year note sale at 1pm ET, followed by $45b five-year Wednesday and $37b seven-year Thursday.

In commodities, WTI drifts 1.5% higher to trade below $92. Base metals are mixed; LME nickel falls 1.6% while LME aluminum gains 1%. Spot gold rises roughly $4 to trade near $1,740/oz

To the day ahead now, flash PMIs from around the world will be the main data highlight. Otherwise, there’s also the Euro Area’s preliminary consumer confidence reading for August, and in the US there’s new home sales for July and the Richmond Fed’s manufacturing index for August. From central banks, the ECB’s Panetta will speak, and earnings releases include Intuit and Medtronic.

Market Snapshot

  • S&P 500 futures up 0.3% to 4,153.00
  • MXAP down 0.9% to 158.27
  • MXAPJ down 0.7% to 515.06
  • Nikkei down 1.2% to 28,452.75
  • Topix down 1.1% to 1,971.44
  • Hang Seng Index down 0.8% to 19,503.25
  • Shanghai Composite little changed at 3,276.22
  • Sensex up 0.4% to 59,011.72
  • Australia S&P/ASX 200 down 1.2% to 6,961.81
  • Kospi down 1.1% to 2,435.34
  • STOXX Europe 600 little changed at 433.29
  • German 10Y yield little changed at 1.31%
  • Euro little changed at $0.9939
  • Gold spot up 0.3% to $1,741.69
  • U.S. Dollar Index down 0.11% to 108.92

Top Overnight News from Bloomberg

  • Hedge funds are unleashing record bets the Federal Reserve will stick to its hawkish script at Jackson Hole to rein in the fastest inflation in four decades. The group has collectively placed a big short across futures for a key overnight rate that moves in line with the Fed’s benchmark. The position, which has more than tripled in the past month, will benefit if Fed Chair Jerome Powell effectively rules out a dovish pivot when he speaks at this week’s symposium
  • The Global Inflation-Linked Bond Index has plunged 17% in 2022 -- the worst-performing of the 20 key fixed-income benchmarks offered by Bloomberg. The reason has everything to do with the kind of bonds that make up the benchmark. Linker indexes are concentrated in longer-maturity debt that have absorbed the worst losses as central banks around the world lift interest rates.
  • The UK economy almost ground to a halt in August as falling demand and a shortage of labor and materials disrupted work of all kinds, a closely-watched survey showed. S&P Global said its index of private-sector growth fell to 50.9 this month. That’s the worst reading since the height of the UK lockdown in February 2021 and close to the level of 50 that separates expansion from contraction
  • Swedish home prices continued to fall last month as the surging cost of living threatens to upend what has been one of Europe’s hottest housing markets. The downturn has raised fears that what currently looks like a correction may accelerate into a crash with more wide- ranging implications. Prices had dropped the most since the financial crisis in June
  • China’s property market crisis is testing whether central bank Governor Yi Gang can stick to his stimulus-lite strategy. Over the past couple of weeks, Yi has cut key lending rates, announced special loans to struggling property developers via policy banks and urged state-owned lenders to extend more credit. Meantime, speculation of a cut to reserve requirement ratios grows

A more detailed look at global markets courtesy of Newsquawk

APAC stocks were mostly lower after the negative mood rolled over from global counterparts amid growth and energy-related concerns. ASX 200 was subdued as losses in financials and the consumer sectors overshadowed the gains in the mining and energy industries, while sentiment was also dampened after Flash PMI data weakened from the previous month in which Services and Composite PMIs slipped into contraction territory. Nikkei 225 declined as Japan suffered a similar fate on the data front which showed factory activity cooled to its slowest pace in 19 months. Hang Seng and Shanghai Comp weakened at the open amid a slew of earnings although the mainland gradually recovered as developers benefitted from China’s plans to offer CNY 200bln in special loans to troubled developers, while the PBoC also recently called on the major financial institutions to maintain stable growth of loans and pledged support for the platform industry and infrastructure construction.

Top Asian News

  • PBoC could reduce RRR this year to compensate for MLF maturities and further RRR cuts could lower lending prime rates, according to Security Times.
  • Japan's government is preparing to increase the daily cap of arrivals to Japan to 50k from 20k, according to FNN. In relevant news, Japanese Chief Cabinet Secretary Matsuno said border controls will be lightened in a way to prevent COVID spread and aid economic activity, while he added that they cannot comment on the timing of new measures but will respond appropriately based on conditions at home and abroad.
  • Shimao Group (0813 HK) is proposing offshore creditors to repay USD 11.8bln over three-eight years as part of a restructuring plan, according to Reuters sources; proposes payment based on a two-tier structure.

European bourses have reversed initial pressure following EZ Flash PMIs, Euro Stoxx 50 +0.2%, which were mostly mixed though noted of less intense price pressures. FTSE 100 -0.3% lags following its respective measures which posted a surprise manufacturing drop into contractionary territory. Stateside, futures are firmer, ES +0.2%, and have been in-fitting with European peers throughout the morning awaiting their own Flash PMI metrics. "Twitter has major security problems that pose a threat to its own users' personal information, to company shareholders, to national security, and to democracy", according to CNN citing a whistle-blower.

Top European News

  • French S&P Global Composite Flash PMI (Aug) 49.8 vs. Exp. 50.8 (Prev. 51.7); Manufacturing Flash PMI (Aug) 49.0 vs. Exp. 49.0 (Prev. 49.5); Services Flash PMI (Aug) 51.0 vs. Exp. 53.0 (Prev. 53.2)
  • German S&P Global Composite Flash PMI (Aug) 47.6 vs. Exp. 47.4 (Prev. 48.1); Manufacturing Flash PMI (Aug) 49.8 vs. Exp. 48.2 (Prev. 49.3); Services Flash PMI (Aug) 48.2 vs. Exp. 49.0 (Prev. 49.7)
  • EU S&P Global Composite Flash PMI (Aug) 49.2 vs. Exp. 49.0 (Prev. 49.9); Manufacturing Flash PMI (Aug) 49.7 vs. Exp. 49.0 (Prev. 49.8); Services Flash PMI (Aug) 50.2 vs. Exp. 50.5 (Prev. 51.2)
  • UK Flash Composite PMI (Aug) 50.9 vs. Exp. 51.1 (Prev. 52.1); Services PMI (Aug) 52.5 vs. Exp. 52.0 (Prev. 52.6); Manufacturing PMI (Aug) 46.0 vs. Exp. 51.1 (Prev. 52.1)

FX

  • DXY reversed earlier gains after coming close to the YTD peak at 109.29 before pulling back.
  • EUR has been in focus; EUR/USD tested 0.9900 to the downside before rebound post-PMI.
  • The JPY has remained in the green vs the USD throughout the European session thus far as the earlier soured sentiment improved and the Dollar pulled back from near-YTD highs.
  • CAD and NZD lead the G10 gains whilst the EUR and CHF lag vs the USD.

Fixed Income

  • Pronounced two-way action on the French and German Flash PMI metrics, resulting in a ~200 tick range for Bunds thus far.
  • Initial upside was driven on the French release though this reversed in short-order and session lows then printed following the German figures.
  • Gilts were comparably contained on a surprise Manufacturing contraction, currently near the lower-end of 112.86-111.89 parameters.
  • USTs have been dictated by EGB action thus far but, now that the morning’s risk events have passed, have detached themselves somewhat and regained a positive foothold.
  • UK DMO says Gilt dealers suggested 2039 or 2073 I/L Gilts for November syndication, investors had mixed views on the November syndication some believe the current risk appetite for ultra-long I/L Gilt could be muted.

Commodities

  • WTI and Brent October contracts have been edging higher since the resumption of futures trading overnight.
  • Spot gold is choppy under USD 1,750/oz and moving in tandem with the Dollar.
  • Base metals are mixed but 3M LME copper maintains its head above USD 8,000/t.
  • Caspian Pipeline Consortium (CPC) says it will take a month to repair each mooring point in suitable weather, according to Interfax.
  • China's Agricultural Ministry cautions that drought and high temperatures poses a "serious threat" to autumn crops; necessary to do everything possible to expand water source and relieve drought.

US Event Calendar

  • 09:45: Aug. S&P Global US Manufacturing PM, est. 51.8, prior 52.2
  • 09:45: Aug. S&P Global US Services PMI, est. 49.8, prior 47.3
  • 09:45: Aug. S&P Global US Composite PMI, prior 47.7
  • 10:00: Aug. Richmond Fed Index, est. -4, prior 0
  • 10:00: July New Home Sales MoM, est. -2.5%, prior -8.1%
  • 10:00: July New Home Sales, est. 575,000, prior 590,000

DB's Jim Reid concludes the overnight wrap

Yesterday was a sea of red for risk assets and sovereign bonds, as the energy crisis intensified in Europe, contributing to the specter of global central bank tightening already weighing on asset markets. Diving right in …

Starting in Europe, the energy crisis intensified yet further, after news over the weekend that Nord Stream would be shut for maintenance at the end of the month introduced fresh fears it would not re-open. European natural gas prices ratcheted +14.59% higher to €280/MWH, a record high. German power prices surged +18.60% to another record as well, closing at €663 and breaching €700/MWH intraday for the first time ever. The threat of climbing prices drove 10yr bund yields +7.6bps higher, led by a +5.9bp widening in 10yr breakevens to 2.54%, their widest levels since early May. 10yr OATs were +9.0bps higher, while BTPs increased +13.3bps, widening their spread to bunds to 230bps, the widest in nearly a month. In turn, the front end also climbed as additional ECB tightening was factored into market pricing, with the amount of tightening expected by March 2023 increasing +10.5bps.

Tighter policy and growing energy fears naturally weighed on risk sentiment, with the STOXX 600 falling -0.96%, while the DAX fared even worse, falling -2.32%. It was the worst daily performance in more than a month for both indices. The poor sentiment weighed on the euro as well, which, despite short-dated nominal (if not real) yield differentials keeping pace with Treasury markets (more below), broke parity again with the dollar, closing at $0.9943, the first close below parity in 20 years.

The story was much the same in the United States. 2yr Treasury yields increased +7.6bps while fed fund futures moved to price a terminal rate above 3.75% in the second quarter next year. 10yr yields were +4.3bps higher. Another day, another day flatter. More of the 10yr move came in real yields (+3.0bps), as sentiment is building toward a potentially hawkish rebuke of recent financial conditions easing from Chair Powell at Jackson Hole this week. Futures positioning is matching sentiment, where short positions in Eurodollar and SOFR futures (that is, positioning for higher short-term rates), has been building. That sentiment is already impacting rates markets, but it caught up with risk yesterday, as well, as the S&P 500 fell -2.14%, with the more rate sensitive NASDAQ underperforming, down -2.55%. It was the worst daily return for both indices since mid-June. . Yields on the 10yr USTs (-0.19 bps) are fairly stable as we go to print, trading at 3.01%.

Brent crude futures were as much as -4.52% lower intraday following cautious optimism around continued progress on the Iran negotiations and weaker broader risk sentiment. However, futures recovered to touch green before finishing -0.25% lower after the Saudi Arabian Energy Minister said the disconnect between volatile and illiquid markets and underlying fundamentals may force OPEC+ to cut production. The rally in oil helped drive medium-term breakevens wider; 5yr breakevens were around 2bps narrower before the remarks, and ended the day +2.4bps wider at 2.77%, their widest in almost a month. The next OPEC meeting is scheduled for September 5. Elsewhere, oil prices continue to gain momentum in early Asian session trading with Brent futures +0.81% higher at $97.26/bbl.

It was very light on the data front, but the Chicago National Activity Index for July printed at 0.27 versus expectations of a -0.25 print. The positive print of the comprehensive index indicated economic activity was still in expansionary territory despite recent growth jitters.

Asian equity markets are tracking sharp losses on Wall Street amid mounting rate hike concerns. The Nikkei (-1.24%) is leading losses across the region with the Kospi (-0.89%), the Hang Seng (-0.84%), the CSI (-0.61%) and the Shanghai Composite (-0.35%) all trading in the red. Elsewhere, the S&P/ASX 200 (-0.55%) is also sliding as Australia’s private sector activity contracted. Moving ahead, US equity futures are indicating a slight rebound with the contracts on the S&P 500 (+0.16%) and NASDAQ 100 (+0.20%) inching upwards.

Early morning data showed that the S&P Global Inc’s Flash Australia composite PMI fell to 49.8 in August from 51.1 in July while at the same time the services PMI Index dropped to a contractionary 49.6 from 50.9 indicating that the nation’s services sector is struggling. There was some encouraging data on the manufacturing activity with the headline index remaining in expansionary territory but eased slightly from 55.7 to 54.5.

Moving to Japan, factory activity decelerated to a 19-month low as the Jibun Bank manufacturing PMI dropped to 51.0 in August from 52.1 in July as output and new order declines deepened amid weakening global demand. Also, the nation’s services sector activity contracted for the first time in five months with the services PMI slipping to 49.2 in August from July's final of 50.3 because of a lackluster demand at home.

To the day ahead now, and the flash PMIs from around the world will be the main data highlight. Otherwise, there’s also the Euro Area’s preliminary consumer confidence reading for August, and in the US there’s new home sales for July and the Richmond Fed’s manufacturing index for August. From central banks, the ECB’s Panetta will speak, and earnings releases include Intuit and Medtronic.

Tyler Durden Tue, 08/23/2022 - 08:04

Read More

Continue Reading

Government

FDA’s drug shortages leader wants companies to start reporting increases in demand

It is no secret that drug shortages have been prevalent in 2022. Several major drug products, such as amoxicillin and Adderall, have been in short supply…

Published

on

It is no secret that drug shortages have been prevalent in 2022. Several major drug products, such as amoxicillin and Adderall, have been in short supply for several months and have led to members of Congress applying pressure on the FDA and HHS to resolve the situation.

Valerie Jensen

Speaking at a webinar hosted by the Alliance for a Stronger FDA, Valerie Jensen, the associate director of the FDA’s Drug Shortage Staff, noted both the rise in quality-related issues and increased demand for some products. She called on companies to report such demand increases, even though they are not currently required to do so.

During the Covid-19 pandemic, she said, the agency has seen new challenges mainly related to these increases in demand.

“During the pandemic as well, we had competition on manufacturing lines and that’s still occurring due to vaccine production and other Covid products,” Jensen said. “So, the same products are being made on those lines that are making the vaccines and Covid-related products, and then that creates a competition situation.”

Jensen added that an increase in demand for manufacturing commodities due to large-scale vaccine production is also leading to shortages. Items such as glass, filters and vial hoppers are in short supply. And now the increased demand is centered around the increase in drugs to counter respiratory illnesses.

She said the physical number of drug shortages currently sits at 123, which is “a little above normal,” but there have been around 100 shortages at any given time over the past seven years. Some of those can be chalked up to companies not producing the volumes required to meet market demand. She also added that there were 38 new shortages in 2021, but the FDA is still dealing with them this year.

For some temporary solutions, Jensen said that she has been coordinating with international regulatory authorities more often, to find out what is being marketed and to see if they can import a drug in short supply in the US. She is also coordinating experts to try to mitigate the situation, providing the public with widely available information as well as expediting the review of anything that manufacturers need to boost supplies.

However, Jensen said that the increase in the demand for drugs is not something that will be going away anytime soon.

“One thing that we really see going forward are these demand increases, this is something that is fairly new to us. It’s something that we’re looking at closely,” she said. “We would really want companies to inform us if they’re seeing spikes in demand because that’s currently not required.”

While producers do need to let the FDA know of supply disruption, companies do not need to let the FDA know of spikes in demand, and Jensen would like to see this changed. Also, she would like to apply different uses for supply chain data to look for signals or patterns and ultimately predict shortages.

Jensen added that in some cases it is impossible to prevent a shortage, but she stresses that better notification of when companies are seeing a spike in demand can be a key solution:

In those cases, when we can prevent (a shortage), we are using those same tools to prevent it. So, we’re expediting review, we’re looking at potential ways that we can use flexibility to allow a product to be on the market while the company fixes a problem. All of those tools are really the same for prevention and mitigation. But I think that really the key is early notification. The earlier companies let us know about an issue the earlier we can deal with it.

With the uptick in respiratory illnesses and shortages of drugs such as amoxicillin, Jensen noted that it’s a matter of reaching out and monitoring the market to see what manufacturers are contending with. Also, Jensen will look to work with pharmacy associations and other trade groups to see what is occurring at the pharmacy level and then “put all of those pieces together” to try and help end the shortage.

Read More

Continue Reading

International

Scientists reveal encouraging findings in first-in-human clinical trial evaluating HIV vaccine approach

NEW YORK and LA JOLLA, CA—While scientists have struggled in the past to create an effective vaccine against HIV, a novel vaccine design strategy being…

Published

on

NEW YORK and LA JOLLA, CA—While scientists have struggled in the past to create an effective vaccine against HIV, a novel vaccine design strategy being pursued by researchers at Scripps Research, IAVI, Fred Hutchinson Cancer Center (Fred Hutch) and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center (VRC) shows new promise, according to data from a first-in-human clinical trial.

Credit: CHRISTOPHER COTTRELL, CREATED WITH BIORENDER.COM

NEW YORK and LA JOLLA, CA—While scientists have struggled in the past to create an effective vaccine against HIV, a novel vaccine design strategy being pursued by researchers at Scripps Research, IAVI, Fred Hutchinson Cancer Center (Fred Hutch) and the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIAID) Vaccine Research Center (VRC) shows new promise, according to data from a first-in-human clinical trial.

In a paper published in Science on December 2, 2022, the scientists reveal critical new insights into their novel vaccine strategy, which involves a stepwise approach to producing antibodies capable of targeting a wide range of HIV variants. 

“The data we are publishing in Science demonstrates for the first time that one can design a vaccine that elicits made-to-order antibodies in humans. We specified in advance certain molecular properties of the antibodies that we wanted to elicit, and the results of this trial show that our vaccine antigen consistently induced precisely those types of antibodies,” says co-senior author William Schief, PhD, a professor and immunologist at Scripps Research and executive director of vaccine design at IAVI’s Neutralizing Antibody Center, whose laboratory developed the vaccine antigen. “We believe this vaccine design strategy will be essential to make an HIV vaccine and may help the field create vaccines for other difficult pathogens.”

The Phase 1 trial, known as IAVI G001, tested the first stage in a multi-stage HIV vaccine regimen the researchers are developing. The trial results show that the vaccine had a favorable safety profile and induced the targeted response in 97% of people who were vaccinated. Importantly, the Science study also provides a detailed immunological analysis of the vaccine responses.

“HIV represents an area of dire unmet need across the world, which is what makes the findings from our Phase 1 clinical trial so encouraging,” says Mark Feinberg, MD, PhD, president and CEO of IAVI. “Through the close-knit collaboration of many different scientists, disciplines and institutions, we are that much closer to designing an effective vaccine that could help end the HIV pandemic.”  

Priming the Immune System

Broadly neutralizing antibodies (bnAbs) are a rare type of antibody that can fight and protect against many different variants of a virus—including HIV. This is why scientists have tried to develop an HIV vaccine that induces bnAbs, but thus far without success.   

The researchers in the study are using a strategy known as ‘germline targeting’ to eventually produce bnAbs that can protect against HIV. The first step of germline targeting involves stimulating the rare immune cells—known as bnAb-precursor B cells—that can eventually evolve into the cells that produce the bnAbs needed to block the virus. To accomplish this first step, the researchers designed a customized molecule—known as an immunogen—that would “prime” the immune system and elicit responses from these rare bnAb-precursor cells.

The overarching goal of the IAVI G001 trial was to determine if the vaccine had an acceptable safety profile and could induce responses from these bnAb-precursor B cells.

“Through extensive safety and tolerability monitoring during the trial, we showed the vaccine had a favorable safety profile, while still inducing the necessary target cells,” says study author Dagna Laufer, MD, vice president and head of clinical development at IAVI. “This represents a large step forward in developing an HIV vaccine that is both safe and effective.”

To determine if the targeted bnAb-precursor B cells were induced, the researchers carried out a sophisticated analytical process.

“The workflow of multidimensional immunological analyses has taken clinical trial evaluation to the next level,” says co-senior author Adrian B. McDermott, PhD, former chief of the Vaccine Immunology Program at the NIAID VRC. “In evaluating these important immunological factors, we helped show why the vaccine antigen was able to induce the targeted response in 97% of vaccine recipients.” 

IAVI G001 was sponsored by IAVI and took place at two sites: George Washington University (GWU) in Washington, D.C., and Fred Hutch in Seattle, enrolling 48 healthy adult volunteers. Participants received either a placebo or two doses of the vaccine antigen, eOD-GT8 60mer, along with an adjuvant developed by the pharmaceutical company GSK. Julie McElrath, MD, PhD, co-senior author, senior vice president and director of Fred Hutch’s Vaccine and Infectious Disease Division, and David Diemert, MD, professor of medicine at GWU School of Medicine and Health Sciences, were lead investigators at the trial sites.

A Deeper Immunological Dive

The study also carefully examined the properties of the antibodies and B cells induced by the vaccine antigen, in what Schief likens to “looking under the car hood” to understand how the immune system operated in response to the vaccine. One analysis showed that the vaccine antigen first stimulated an average of 30 to 65 different bnAb precursors per person vaccinated, and then caused those cells to multiply. This helped explain why the vaccine induced the desired response in almost all participants.

Other analyses delved into the specific mutations the bnAb-precursor B cells acquired over time and how tightly they bound to the vaccine antigen. These investigations showed that that after each dose of the vaccine, the bnAb-precursor B cells gained affinity and continued along favorable maturation pathways.

One concern for this type of vaccine approach is the notion of “competitors”—in other words, the B cells induced by the vaccine antigen that are not bnAb precursors. The researchers extensively studied the “competitor” responses, and the results were very encouraging. Although the majority of the B cells triggered by vaccination were, in fact, “competitors”, these undesired B cells could not match the binding strength of the desired bnAb precursors and did not seem to impede maturation of the bnAb-precursor responses.

“These findings were very encouraging, as they indicated that immunogen design principles we used could be applied to many different epitopes, whether for HIV or even other pathogens,” adds Schief.

With these promising data in hand spanning both safety and immune responses, the researchers will continue to iterate and design boosting immunogens that could eventually induce the desired bnAbs and provide protection against the virus. These findings also come shortly after two additional studies in Immunity published in September 2022, which helped validate the germline-targeting approach for vaccinating against HIV.

“Working together with IAVI, Scripps Research, the VRC, GWU, additional investigators at Fred Hutch and many others, this trial and additional analyses will help inform design of the remaining stages of a candidate HIV vaccine regimen—while also enabling others in the field to develop vaccine strategies for additional viruses,” says McElrath of Fred Hutch.

IAVI, Scripps Research, NIAID, the Bill & Melinda Gates Foundation and the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) through the United States Agency for International Development (USAID) are partnering with the biotechnology company Moderna to develop and test mRNA delivery of these HIV vaccine antigens. Two Phase I clinical trials are underway that build on IAVI G001, one (IAVI G002) at four sites in the U.S. and another (IAVI G003) at the Center for Family Health Research in Kigali, Rwanda, and The Aurum Institute in Tembisa, South Africa. Both are testing mRNA delivery of the eOD-GT8 60mer that was evaluated as recombinant protein in IAVI G001, and the U.S. trial includes a boost antigen designed by the Schief lab and delivered with Moderna mRNA technology. A third trial (HVTN302), at ten sites in the U.S., is testing mRNA delivery of three different stabilized HIV trimers designed in the Schief laboratory that are candidates for late-stage boosters in multi-stage vaccines aiming to induce bnAbs. Using mRNA technology could significantly accelerate the pace of HIV vaccine development as it allows for faster production of clinical trial material.

This work was supported by the Bill & Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery; the IAVI Neutralizing Antibody Center; NIAID; Scripps Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery and Scripps Consortium for HIV/AIDS Vaccine Development; and the Ragon Institute of MGH, MIT, and Harvard. Other collaborating organizations include Duke Human Vaccine Institute, Karolinska Institutet, and La Jolla Institute. 

Research at the IAVI Neutralizing Antibody Center that contributed to the development of the vaccine antigen eOD-GT8 60mer was also made possible by the government of the Netherlands through the Minister of Foreign Trade & Development Cooperation and through the generous support of the American people through PEPFAR through USAID. The contents are the responsibility of IAVI and Scripps Research and do not necessarily reflect the views of PEPFAR, USAID, or the United States government.

About IAVI

IAVI is a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges including HIV and tuberculosis. Its mission is to translate scientific discoveries into affordable, globally accessible public health solutions. Read more at iavi.org.

About Scripps Research

Scripps Research is an independent, nonprofit biomedical institute ranked the most influential in the world for its impact on innovation by Nature Index. We are advancing human health through profound discoveries that address pressing medical concerns around the globe. Our drug discovery and development division, Calibr, works hand-in-hand with scientists across disciplines to bring new medicines to patients as quickly and efficiently as possible, while teams at Scripps Research Translational Institute harness genomics, digital medicine and cutting-edge informatics to understand individual health and render more effective healthcare. Scripps Research also trains the next generation of leading scientists at our Skaggs Graduate School, consistently named among the top 10 US programs for chemistry and biological sciences. Learn more at www.scripps.edu.


Read More

Continue Reading

Government

Futures Flat Ahead Of Worst Payrolls Report Since 2020

Futures Flat Ahead Of Worst Payrolls Report Since 2020

US stock futures were muted, trading in a narrow 5 point range and unchanged for the…

Published

on

Futures Flat Ahead Of Worst Payrolls Report Since 2020

US stock futures were muted, trading in a narrow 5 point range and unchanged for the second day in a row after a blistering post-Powell rally, as investors awaited the latest jobs report for clues around the strength of the domestic economy (with consensus expecting a +200K print, it will be the weakest monthly gain since Dec 2020) as well as its impact on the outlook for rate hikes. Contracts on the Nasdaq 100 and the S&P 500 were little changed 745 a.m. ET. The underlying indexes were also subdued Thursday after a sharp rally that was fueled by signals from Federal Reserve Chair Jerome Powell that the central bank could slow the pace of rate hikes at this month’s meeting.

Among notable movers in premarket trading, Marvell Technology dropped after the US chipmaker issued a tepid sales forecast for the fourth quarter. Zscaler Inc. also slumped after the cloud security company gave a forecast for calculated billings that fell slightly short of the average analyst estimate at the midpoint. Here are all the notable premarket movers:

  • Marvell Technology shares drop 7% in premarket trading after the US chipmaker issued a tepid sales forecast for the fourth quarter. Analysts note that weakness stemmed from the company’s data-center business, as well as a broad softening in demand from China. This indicates that the decline in demand for chips continues to spread outside of the computer and smartphone industries, they said.
  • Opendoor shares fall as much as 2.2% in premarket trading, after the real estate platform provider’s CEO Eric Wu stepped down to become president of its marketplace business to be replaced as CEO by Carrie Wheeler. Analysts said that the CEO change came as a surprise and raised questions around its timing amid a tough backdrop for the real estate market.
  • Zscaler shares are down 9% in premarket, after the cloud security company gave a forecast for calculated billings that fell slightly short of the average analyst estimate at the midpoint. Analysts noted that revenue and billings growth decelerated as macro headwinds intensified.
  • Asana shares slumped as much as 17% in premarket, after the software firm’s revenue forecast for the fourth quarter disappointed, with analysts cautious on the stock given its greater exposure to job losses in the technology industry, which could put pressure on future growth.
  • Veeva shares drop 4.2% in postmarket trading after the company’s adjusted EPS and billings guidance for the fourth quarter missed Street estimate.
  • Smartsheet’s strong quarterly results beat across the board and set the work-management software firm up well to deliver durable growth into next year, analysts say. Shares in the firm were up more than 9% in after-hours trading.
  • Samsara rose 20% postmarket after the software company boosted its year revenue outlook. The company also posted 3Q sales that topped expectations and delivered a narrower-than-expected loss

US stocks have rallied since mid-October, with the S&P 500 posting its first two-month gain since August 2021, on bets that inflation has peaked. The blue-chip Dow is back in a technical bull market, but market strategists have warned equities could see further declines in the first half of next year amid the specter of a recession. Data from Bank of America, citing EPFR Global, showed US stock funds had their biggest outflows since April in the week through Nov. 30. US large cap funds had the largest redemptions at $14.5 billion. Among sectors, utilities and health care attracted inflows, while $600 million exited financials.

All eyes today are on the November non-farm payrolls report, with economists expecting it to show signs that labor demand is ebbing. Still, they say a bigger slowdown is needed to bring that more in line with labor supply in order to contain the wage growth that’s helped fuel inflation. We have posted a full preview here, but the median estimate for November jobs report’s employment change is 200k; crowd-sourced whisper number is 187k. Nonfarm payrolls change has exceeded the median estimate for seven months running; 2-year yield’s YTD high 4.799% was reached on Nov. 4 following October jobs report. 

In terms of the market's reaction to the headline jobs print, this is what Goldman expects:

  • >261k (aka higher than last print) S&P down at least 2%
  • 175k – 261k S&P down 1 – 2%
  • 125k – 175k S&P up 50bps - 1%
  • 0 – 125k S&P up 1 - 2%

Many economists reckon Friday’s employment report may fall short of the turning point Fed officials are seeking in their battle to beat back inflation. The median projection in a Bloomberg survey calls for payrolls to rise 200,000 in November, cooling only slightly from the previous month. Other market watchers point to signs that steep rate hikes will tip more economies into a downturn.

“Nervous Fed-watchers will be hoping that the non-farms number comes in somewhat below consensus to strengthen the case for a moderation of aggressive rate hikes so far,” said Richard Hunter, head of markets at Interactive Investor. “On the other hand, a stronger-than-expected reading, while positive for the economy, would be damaging for that case in another example of good news being bad news for investors.”

“Consensus is that recession is coming but equities cannot bottom before it starts, inflation won’t fall quickly so central banks can’t blink, China reopening will be a messy process, and Europe remains tricky,” Barclays Plc strategist Emmanuel Cau wrote in a note.

And speaking of that, recession concerns have become more pronounced after data on Thursday showed November factory activity sliding in a range of countries, with American manufacturing contracting for the first time since May 2020. Recent company reports also hint at mounting pressure on company earnings, and companies, ranging from Amazon.com to Ford Motor Co., have announced thousands of job cuts.

In Europe, the Stoxx 50 is little changed before the release of US payroll data.  Here are the top European movers:

  • Credit Suisse shares rise as much as 6.9%, halting a 13-day losing streak, as Chairman Axel Lehmann said the bank has mostly stemmed the huge outflow of client assets.
  • AJ Bell jumps as much as 12% to its highest level in a year after Jefferies upgraded its rating to buy from hold, praising the strategy of the firm’s trading platform.
  • Goldman Sachs upgrades both AB Foods and H&M to neutral. AB Foods shares rise as much as 4.3%, touching the highest since August, while H&M gains as much as 3.1%.
  • Separately, Morgan Stanley sees a “perfect storm” ahead for apparel retail as revenue and cost pressures collide, in a note putting an overweight rating on AB Foods, equal-weights on Next and Inditex and underweight on H&M.
  • Trigano hits the highest level since April, rising as much as 3.6% in a third straight day of gains since the French caravan maker announced results on Tuesday evening.
  • Sanofi is the worst performer across France’s SBF 120 index on Friday, losing as much as 2.5%, after the French pharmaceutical group confirmed that any offer it would make for Horizon Therapeutics would be solely in cash.
  • PolyPeptide falls as much as 37%, the most since July, after the Swiss peptides maker issued its second profit warning of 2022. The update casts a “very negative shadow” on the company’s strategic alignment and management, ZKB says, downgrading the stock to underperform from market perform.
  • Kerry Group falls as much as 3.8% in Dublin, heading for a seventh daily drop, after Citi downgraded to neutral from buy, expecting the food company to face volume headwinds in 2023 as customers reduce inventory levels.
  • DOF shares drop as much as 53% in Oslo, the most since 2016, after the firm said it will petition for reconstruction proceedings with Hordaland district court.

Earlier in the session, Asia stocks fell, trimming their weekly gain, as investors sold off some positions ahead of a key jobs report in the US. The MSCI Asia Pacific Index declined as much as 0.9%, with most sectors in the red, led by energy and utility stocks. Benchmarks in Japan and South Korea were among the worst performers as investors await more signs of China’s reopening and economic policy at an upcoming meeting of the country’s top leaders. Chinese stocks edged lower. Read: China Watchers See Shift to Growth at Politburo Meeting (1) All eyes will also be on the payrolls and employment data due in the US Friday. 

“The US job report will be the key risk event today,” said Jun Rong Yeap, market strategist at IG Asia in a note. “Current expectations are pointing to job gains of 200,000, which is a step closer to pre-Covid levels.” The Asian measure is poised to advance more than 2% this week, set for its fifth weekly gain. Bullish indicators are growing, with the index testing its 200-day moving average for the first time since September 2021, as global funds dip back into the region. Foreign funds pumped about $15.7 billion into emerging Asia shares outside China last month, the biggest inflows in two years, Bloomberg-compiled data shows.

Japanese stocks dropped as investors weighed data showing US manufacturing contracted in November for the first time since May 2020 and as the yen strengthened against the dollar.  The Topix fell 1.6% to close at 1,953.98, while the Nikkei declined 1.6% to 27,777.90. The Japanese currency slightly extended against the greenback, up nearly 3% on the week. Daiichi Sankyo Co. contributed the most to the Topix decline, decreasing 4.2%. Out of 2,164 stocks in the index, 201 rose and 1,919 fell, while 44 were unchanged. The yen has been gaining strength against the dollar and investors are cautious ahead of the monthly US employment report, creating a double-whammy for stocks, said Ercan Serdar Armutcu, head of electronic trading at Mita Securities. 

Australian stocks snapped a 3-day rally: the S&P/ASX 200 index fell 0.7% to close at 7,301.50, taking a breather after three consecutive days of advances. Banks and some commodity stocks dragged the benchmark most.  Still, the index posted a weekly advance of 0.6%, ending a second week in the green. In New Zealand, the S&P/NZX 50 index fell 0.1% to 11,641.85.

In FX, the Bloomberg Dollar Spot Index gave up an early Asia session gain as the greenback traded mixed versus its Group-of-10 peers.

  • The euro rose to touch $1.0545, the highest level since June, and its volatility skew shifted higher as leveraged desks unwind long-term bearish bets.
  • The yen led G-10 gains. The Japanese currency briefly strengthened beyond 134 per dollar and is set for its longest rising streak since April 2021. BOJ’s new board member Naoki Tamura said “it would be appropriate to conduct a review at the right time, including the monetary policy framework and inflation target”.
  • Australian and New Zealand bonds rally as a drop in stocks boosts demand for haven assets and ahead of the key US employment report later Friday. Scandinavian currencies were the worst G-10 performers

In rates, treasuries twist-steepened, with the 2-year yield falling around 4bps and the 30-year yield rising by about 2bps; the 2- to 5-year yields declined to lowest levels in several weeks; 2s10s approaches Wednesday’s high.  Front-end yields are richer by 2bp-3bp curve, 10-year cheaper by ~1bp at 3.51%, steepening 2s10s by ~3bp; bunds outperform by 4bp, gilts by 6bp in the 10-year sector.  Bunds outperform in bull-steepening price action. Bund and gilt curves bull steepen. Peripheral spreads widen to Germany with 10y BTP/Bund narrowing 1.1bps to 187.2bps.  Dollar issuance slate empty so far, while no issuers announced bond sales on Thursday; December is expected to be slow for issuance with just $20b expected vs November tally of $102b

In commodities, oil headed for its biggest weekly gain in almost two months, benefiting from looser Chinese curbs, calls by the Biden administration to halt sales from US strategic reserves and an OPEC producers’ group decision to cut crude supply by the most since 2020. Crude futures were steady. WTI trades within Thursday’s range at near $81.22. Most base metals trade in the green. WTI and Brent futures are subdued in early European hours as market participants await the next catalyst, and with the clock ticking down to the US jobs report.  The G7 price cap coalition official said they are 'very very close' to an agreement on a USD 60/bbl price cap for Russian oil exports and there is some flexibility in determining the market price of Russian crude for the price cap. The official said oil markets seem pretty comfortable with a cap mechanism and noted uncertainty on how Russia will react to a USD 60/bbl cap but added that Russia has no good options, according to Reuters. Spot gold is flat in pre-NFP trade and probes the USD 1,800/oz mark with the 200 DMA today at USD 1,795/oz. Base metal futures are similarly flat/mixed with 3M copper off session highs of around USD 8,418/t and closer to session lows.

To the day ahead now, and the main highlight will be the US jobs report for November. Otherwise, we’ll get data on French industrial production and Euro Area PPI for October. Elsewhere, central bank speakers include ECB Vice President de Guindos, the ECB’s Villeroy and Nagel, along with the Fed’s Barkin and Evans.

Market Snapshot

  • S&P 500 futures down 0.1% to 4,076.75
  • STOXX Europe 600 down 0.1% to 443.62
  • MXAP down 0.5% to 158.53
  • MXAPJ down 0.6% to 513.09
  • Nikkei down 1.6% to 27,777.90
  • Topix down 1.6% to 1,953.98
  • Hang Seng Index down 0.3% to 18,675.35
  • Shanghai Composite down 0.3% to 3,156.14
  • Sensex down 0.7% to 62,851.92
  • Australia S&P/ASX 200 down 0.7% to 7,301.46
  • Kospi down 1.8% to 2,434.33
  • German 10Y yield down 1.2% to 1.79%
  • Euro little changed at $1.0520
  • Brent Futures little changed at $86.82/bbl
  • Gold spot down 0.1% to $1,801.49
  • U.S. Dollar Index down 0.13% to 104.59

Top Overnight News from Bloomberg

  • ECB President Christine Lagarde said inflation expectations need to remain anchored and that the public needs to know price gains will be brought back to target
  • The global economy may be headed for a new era of volatile inflation, making it even more crucial to anchor expectations for where prices are headed, central bank governors warned Friday
  • There’s been a “significant” improvement in relations between the European Union and UK, and a landing zone in their Brexit negotiations is possible in the next few weeks, Ireland’s foreign minister said, even though there has been “no major breakthroughs” over the Northern Ireland Protocol
  • Italy will meet all its second semester objectives for the Next Generation EU program by the end of this year, Economy and Finance Minister Giancarlo Giorgetti said
  • Option traders are growing less concerned about potential dollar strength as the drivers of the US currency’s world-beating rally fade away
  • A rush by Japan’s life insurers to protect themselves against a stronger yen may have the paradoxical effect of accelerating gains in the currency
  • Central banks are facing their first test in a new world of more variable inflation that they must pass in order to re-establish confidence in the community, Reserve Bank of Australia Governor Philip Lowe said
  • South African President Cyril Ramaphosa’s allies closed ranks behind him as the governing party’s top leaders prepared to discuss his fate over an independent panel’s findings that there may be grounds for his impeachment. The rand rallied and government bond yields fell

A more detailed look at global markets courtesy of Newsquawk

Asian stocks were subdued following the uninspired lead from the US where the major indices took a breather from the Powell-induced rally and finished relatively flat amid soft data releases and ahead of the looming NFP jobs report. ASX 200 was pressured as weakness in real estate, energy and the top-weighted financials sector overshadowed the resilience in defensives. Nikkei 225 underperformed and fell back below the 28,000 level, while there were notable comments from BoJ’s Tamura who called for a review of the BoJ’s ultra-easy monetary policy framework. Hang Seng and Shanghai Comp were indecisive but with downside stemmed following the recent slight easing of China’s COVID rules.

Top Asian News

  • China's top leaders will likely signal a more reasonable approach to COVID controls at the upcoming meeting of the CPC's Politburo which usually takes place in early December, according to economists cited by Bloomberg.
  • China's Beijing City to allow passengers without a 48-hour COVID nucleic acid negative certificate to take buses and subways from Monday; busses and subways cannot reject people with no COVID test results, according to Bloomberg.
  • PBoC Governor Yi said the forecast for China's inflation in 2023 is in a moderate range, while he noted the current focus is on growth and that monetary policy has been pretty accommodative.
  • Chinese Finance Minister Liu Kun said they will keep the economy within a reasonable range and strive to realise better results, while Liu added that China's economy will keep growing at a reasonable speed with stable employment and prices, according to Reuters.
  • China's top four banks intend to issue offshore loans for domestic developers overseas debt repayments, via Reuters citing sources.

Equities in Europe are mostly mildly softer with the ranges particularly narrow ahead of the US jobs report; US futures in-fitting. DXY is under pressure with peers modestly firmer and JPY outpacing given yield differentials and Tamura's remarks. Bunds are modest bid but failed to breach 143.00 with USTs essentially unchanged pre-NFP. Crude benchmarks similarly contained awaiting oil cap/OPEC+ developments. Beijing City is to ease its COVID travel restrictions from Monday while reports indicate the Politburo could signal a more reasonable approach. Looking ahead, highlights include US & Canadian Jobs Reports, Speakers from ECB's de Guindos, Fed's Barkin & Evans.

Top European News

  • ECB President Lagarde said monetary policy is complicated by three uncertainties including the global economy and CPI outlook, while she added that all policies need to act in concert for sustainable growth.
  • US President Biden and French President Macron made major progress in talks on how to alleviate the impact of the Inflation Reduction Act on Europe in which the US could use executive orders to give European allies the same level of exemptions on local content as countries with a free-trade deal, according to a source at the French Finance Ministry
  • EU Commissioner Breton withdrew from EU-US Trade and Technology Council discussions and believed that talks will not provide enough space to EU concerns, according to Politico.

Fixed Income

  • Modest overnight Bund pressure proved shortlived and appeared more of a pause for breath rather than a concerted pullback.
  • Instead, the German benchmark has tested but failed to breach 143.00 while USTs are essentially unchanged in 10tick parameters pre-NFP.
  • NFP aside, newsflow has been limited and of insufficient magnitude thus far to impact the above price action.

Commodities

  • WTI and Brent futures are subdued in early European hours as market participants await the next catalyst, and with the clock ticking down to the US jobs report.
  • Spot gold is flat in pre-NFP trade and probes the USD 1,800/oz mark with the 200 DMA today at USD 1,795/oz.
  • Base metal futures are similarly flat/mixed with 3M copper off session highs of around USD 8,418/t and closer to session lows.
  • G7 price cap coalition official said they are 'very very close' to an agreement on a USD 60/bbl price cap for Russian oil exports and there is some flexibility in determining the market price of Russian crude for the price cap. The official said oil markets seem pretty comfortable with a cap mechanism and noted uncertainty on how Russia will react to a USD 60/bbl cap but added that Russia has no good options, according to Reuters.
  • Just one of these three ministries/ministers handling the oil price cap is yet to okay it, according to WSJ's Norman's sources.
  • Turkish media says a fire broke out in the port of Samsun due to the explosion of an oil depot, according to Al Arabiya.
  • India will continue to buy oil from wherever possible, including Russia, according to a source cited by Reuters; adds that India will continue to get oil, even beyond January 19th.

FX

  • DXY sees another session of early European weakness for the broader Dollar and index as the JPY continues to strengthen.
  • JPY is again the marked outperformer with gains fuelled by further narrowing yield differentials post-Powell, and with BoJ’s board member Tamura yesterday striking somewhat of a hawkish tone; USD/JPY down to 133.64 at worst.
  • NZD, AUD, CHF, EUR, GBP are all modestly firmer against the USD and to varying degrees, whilst the CAD lags ahead of the Canadian jobs report.
  • PBoC set USD/CNY mid-point at 7.0542 vs exp. 7.0563 (prev. 7.1225)
  • Chairman of South Africa's ANC has denied that President Ramaphosa has considered resigning.

Geopolitics

  • Military analysts claimed that satellite images suggested Russia is planning an 'imminent' large-scale missile strike on Ukraine, according to Sky News Australia.
  • Belarusian border guards shot down a Ukrainian march that conducted reconnaissance and photographing operations over the border areas with Ukraine, according to Al Jazeera.
  • US imposed additional North Korea-related sanctions on three individuals and Japan imposed additional sanctions on 3 entities and 1 individual from North Korea, while South Korea imposed sanctions on 8 individuals and 7 agencies over North Korea's weapons programme, according to Reuters.

US Event Calendar

  • 08:30: Nov. Change in Nonfarm Payrolls, est. 200,000, prior 261,000
    • Change in Private Payrolls, est. 185,000, prior 233,000
    • Change in Manufact. Payrolls, est. 18,000, prior 32,000
    • Unemployment Rate, est. 3.7%, prior 3.7%
    • Underemployment Rate, prior 6.8%
    • Labor Force Participation Rate, est. 62.3%, prior 62.2%
    • Nov. Average Weekly Hours All Emplo, est. 34.5, prior 34.5
    • Average Hourly Earnings MoM, est. 0.3%, prior 0.4%
    • Average Hourly Earnings YoY, est. 4.6%, prior 4.7%

Central Bank Speakers

  • 09:15: Fed’s Barkin Speaks in Richmond
  • 10:15: Fed’s Evans Speaks at Event on Financial Regulation
  • 14:00: Fed’s Evans Gives Welcome Remarks at Economic Symposium

DB's Jim Reid concludes the overnight wrap

After the massive surge on Wednesday following Fed Chair Powell’s speech, the rally in risk assets stalled out yesterday thanks to weak US data that sparked growing concern about the state of the economy. There were lots of releases to digest, but in many ways the most notable was the ISM manufacturing print, which fell into contractionary territory for the first time since May 2020, coming in beneath expectations at 49.0, and crucially beneath the 50-mark that separates expansion from contraction. The sub-components didn’t look too promising either, with the employment reading at 48.4, and new orders down to 47.2.

Of course, we should add the usual caveats this is just one data release, but it fits into a declining trend for the ISM over the last year, and only added to fears about a potential recession. In addition, it comes on the back of some other pretty negative data over recent days. For instance, last week’s flash PMIs for November were also in contractionary territory, and Wednesday’s Chicago PMI release came in at levels that have historically been consistent with recessions.

This gloomy backdrop meant that investors once again put increasing emphasis on a dovish pivot from the Fed. Indeed, terminal rate pricing fell back to 4.86%, which is the lowest it’s been in a couple of weeks and is noticeably beneath the 5% levels before Powell’s Wednesday speech. In turn, this led to a further rally in Treasuries, with the 10yr yield coming down by a sizeable -10.1bps on the day to 3.50%, which is its lowest level in a couple of months, although we’ve had a slight +3.4bps pullback this morning. Bear in mind that the 10yr Treasury yield hit an intraday peak of 4.34% in late-October, so we’re now down by around -80bps from those levels. Furthermore, the decline yesterday was driven by real yields, with the 10yr real yield down -10.7bps on the day to 1.14%.

Those hopes for a dovish pivot from investors were given added support by the latest PCE inflation data for October, which is the measure the Fed officially target. That showed the month-on-month numbers coming in beneath expectations, with headline PCE up +0.3% (vs. +0.4% expected), and core PCE up +0.2% (vs. +0.3% expected). There were also signs that inflationary pressures were waning in the ISM release, since the prices paid indicator fell to 43.0 (vs. 45.9 expected), marking the lowest level for that reading since May 2020.

Whilst this environment proved a great backdrop for Treasuries, equities had a tougher time yesterday, with the S&P 500 (-0.09%) ending the session modestly lower as investors considered the tough outlook. Banks (-1.77%) were one of the worst-performing sectors as bond yields continued their decline, but tech was a relative outperformer and the FANG+ index (+0.55%) of megacap tech stocks even hit a 2-month high. Over in Europe the major indices advanced for the most part, but that was more a reflection of them catching up to the previous day’s rally following Powell’s speech. That saw the STOXX 600 (+0.89%) hit its highest level in nearly 5 months, with the index now on track for a 7th consecutive weekly advance.

As investors mull over the prospects for a dovish Fed pivot, attention today will turn to the US jobs report, which is out at 13:30 London time. Our US economists expect that growth in nonfarm payrolls will have slowed to +200k in November, which is in line with consensus and would mark the weakest number since December 2020. That should still be enough to lower the unemployment rate by a tenth to 3.6%, but clearly a downside surprise would only add to the jitters in markets given the negative survey data for November that we’ve already had.

Speaking of the Fed, yesterday we heard from a few officials, including New York President Williams, who said “I still think we have a ways to go” on raising rates. He added that he felt “we need to get the federal funds rate above the inflation rate”, and the two still remain some way apart even with the recent series of 75bp hikes. Remember as well that today is the last opportunity for FOMC officials to comment before their blackout period begins ahead of the next meeting, so these comments are some of the last clues we’ll get ahead of the next decision and the December dot plot. Elsewhere, we also heard that the new Chicago Fed President would be Austan Goolsbee, a former chair of the Council of Economic Advisers under President Obama. Goolsbee will have a vote on the FOMC in 2023, and has previously said on October 31 that a peak fed funds rate around 5% “kind of makes sense to me.”

Back in Europe, sovereign bonds rallied alongside US Treasuries as investors caught up with Chair Powell’s speech and priced in a more dovish outcome for the ECB as well. For instance, the hike priced in for this month’s meeting fell to 54.1bps, which is the lowest since mid-September as investors became increasingly sceptical that the ECB will continue to hike at a 75bps pace. That triggered a big rally across the continent, with yields on 10yr bunds (-11.7bps), OATs (-14.0bps) and BTPs (-17.6bps) all moving lower on the day. In the meantime, the continued weakness for the US Dollar meant that the Euro surpassed the $1.05 mark in trading for the first time since June, yesterday, where it remains this morning.

Overnight in Asia, equity markets have continued that trend lower from the US, with the Nikkei (-1.72%), the KOSPI (-1.45%), the Hang Seng (-0.60%), the CSI 300 (-0.49%) and the Shanghai Composite (-0.24%) all trading lower. The moves came in spite of further signs of waning inflationary pressures, with South Korean CPI falling to +5.0% in November (vs. +5.2% expected). That’s been echoed by US futures, with those on the S&P 500 (-0.19%) and the NASDAQ 100 (-0.33%) both in negative territory ahead of today’s jobs report.

Finally, with all the data releases yesterday, there were plenty of numbers that got relatively less attention than usual, but still told an interesting story. First, the Nationwide house price index in the UK saw a monthly drop of -1.4% in November, which is the steepest decline since early 2009 if you exclude the pandemic months of April and May 2020. Second, the Euro Area unemployment rate fell to a record low of 6.5% in October (vs. 6.6% expected). And back in the US, the weekly initial jobless claims came in at 225k in the week ending November 26 (vs. 235k expected).

To the day ahead now, and the main highlight will be the US jobs report for November. Otherwise, we’ll get data on French industrial production and Euro Area PPI for October. Elsewhere, central bank speakers include ECB Vice President de Guindos, the ECB’s Villeroy and Nagel, along with the Fed’s Barkin and Evans.

Tyler Durden Fri, 12/02/2022 - 08:05

Read More

Continue Reading

Trending