Connect with us

Uncategorized

Exclusive: Backed by former Google CEO’s VC, a Colorado biotech hatches platform to evolve degraders

It was 2012, and Doug Chapnick was fed up with traditional biochemistry research.
That kind of thinking first led him to a Department of Defense-funded…

Published

on

It was 2012, and Doug Chapnick was fed up with traditional biochemistry research.

That kind of thinking first led him to a Department of Defense-funded project, which involved white powders and Rube Goldberg-esque experiments, and then to founding a biotech company called BioLoomics, which is trying to develop new protein degraders via directed evolution, or lab-based natural selection, in human cell experiments.

On Tuesday morning, BioLoomics announced an $8.7 million seed raise led by Innovation Endeavors, the Silicon Valley VC started by former Google CEO Eric Schmidt.

Famed Harvard University geneticist George Church also serves as a scientific advisor to the Boulder, CO-based company.

After finishing his PhD at the University of Colorado a decade ago, Chapnick sought out a non-traditional postdoc job at the university as the lead researcher on a research grant from the Defense Advanced Research Projects Agency (DARPA) that aimed to develop a system to quickly identify bioterrorism threats.

“They would send us white powders — these bioterrorism threat simulants — and then we would stitch together existing technologies to make essentially a Rube Goldberg device … to figure out the mechanism of action of these drugs in 30 days,” Chapnick said. “You didn’t need to know anything about the drugs. You could make a bunch of measurements and say what it does and maybe what an antidote is.”

Over the years, those experiments evolved into what would become BioLoomics, which Chapnick describes as a “SynBio hardware-software company.” The biotech uses a machine learning program to look at millions of single cells — each essentially an individual experiment with the antibody — which is then picked, sorted and labeled with unique molecular barcodes.

“In one day, we go from a pot of 10 million tries of how an antibody should work to five- or six-barcoded that we know exactly, and we can track what that sequence does,” Chapnick said.

While the DARPA grant mostly dealt with small molecules (pills, powders and the like), BioLoomics will focus on protein degraders in cancer. Chapnick said the company has an early pipeline, and it also sees drug discovery partnerships as a major future business.

Chapnick said BioLoomics’ goal is to make a degrader from an antibody in one month; right now, BioLoomics has done so in about six months.

Last year, Innovation Endeavors hired Joel Dudley — formerly the CSO at Tempus and a lead researcher​​ in a Mount Sinai study that found problems with Theranos’ blood tests — to steer its biotech investments. Dudley joined the BioLoomics board as part of the seed round.

Joel Dudley

Dudley said that Innovation Endeavors invested $4 million in BioLoomics. Dudley, who lives outside of Boulder, highlighted that the company was Innovation Endeavors’ second investment in the city after co-leading a $17 million seed round for Think Bioscience in July.

“Everybody’s only looking at the Bay Area and Boston — and maybe San Diego —  for these kinds of companies,” Dudley said. “But I think it’s interesting that there are these other clusters emerging, and Boulder is one of the more interesting ones.”

Other investors in BioLoomics’ seed round included Horizons Ventures, TechU Ventures, Boom Capital Ventures, Hummingbird Nomads Fund, Cooley’s GC&H, BoxOne Ventures and Viswa Colluru — the founder of Boulder-based Enveda Biosciences and a scientific advisor to BioLoomics.

Read More

Continue Reading

Uncategorized

SEC initiates legal action against FTX’s auditor

The SEC alleges that Prager Metis, an accounting firm engaged by bankrupt crypto exchange FTX in 2021, committed hundreds of violations related to auditor…

Published

on

The SEC alleges that Prager Metis, an accounting firm engaged by bankrupt crypto exchange FTX in 2021, committed hundreds of violations related to auditor independence.

The United States Securities and Exchange Commission (SEC) has commenced legal proceedings against an accounting firm that had provided services to cryptocurrency exchange FTX before its bankruptcy declaration.

According to a Sept. 29 statement, the SEC alleged that accounting firm Prager Metis provided auditing services to its clients without maintaining the necessary independence as it continued to offer accounting services. This practice is prohibited under the auditor independence framework.

Extract from the SEC's September 29 statement. Source: SEC

To prevent conflicts of interest, accounting and audit tasks must be kept clearly separate. However, the SEC claims that these entwined activities spanned over a period of approximately three years:

“As alleged in our complaint, over a period of nearly three years, Prager’s audits, reviews, and exams fell short of these fundamental principles. Our complaint is an important reminder that auditor independence is crucial to investor protection.”

While the statement doesn't explicitly mention FTX or any other clients, it does emphasize that there were allegedly "hundreds" of auditor independence violations throughout the three-year period.

Furthermore, a previous court filing pointed out that the FTX Group engaged Metis to audit FTX US and FTX at some point in 2021. Subsequently, FTX declared bankruptcy in November 2022. 

The filing alleged that since former FTX CEO Sam Bankman-Fried publicly announced previous FTX audit results, Metis should have recognized that its work would be used by FTX to bolster public trust.

Related: FTX founder’s plea for temporary release should be denied, prosecution says

Concerns were previously reported about the material presented in FTX audit reports.

On Jan. 25, current FTX CEO John J. Ray III told a bankruptcy court that he had “substantial concerns as to the information presented in these audited financial statements.”

Furthermore, Senators Elizabeth Warren and Ron Wyden raised concerns about Prager Metis' impartiality. They argued that it functioned as an advocate for the crypto industry.

Meanwhile, a law firm that provided services to FTX has come under scrutiny in recent times.

In a Sept. 21 court filing, plaintiffs allege that U.S. based law firm, Fenwick & West, should be held partially liable for FTX's collapse because it reportedly exceeded the norm when it came to its service offerings to the exchange.

However, Fenwick & West asserts that it cannot be held accountable for a client's misconduct as long as its actions remain within the bounds of the client's representation.

Magazine: Blockchain detectives: Mt. Gox collapse saw birth of Chainalysis

Read More

Continue Reading

Uncategorized

DOJ readies witnesses in Bankman-Fried trial, highlights FTX asset management

The DOJ intends to highlight the experiences of retail and institutional clients who entrusted substantial assets to FTX.
The Department…

Published

on

The DOJ intends to highlight the experiences of retail and institutional clients who entrusted substantial assets to FTX.

The Department of Justice (DOJ) has confirmed its intention to summon former FTX clients, investors and staff as witnesses in the upcoming trial involving Sam Bankman-Fried, the former FTX CEO.

The DOJ submitted a letter motion in limine on Sept. 30 describing the witnesses it intends to call concerning FTX’s treatment of customer assets.

The testimonies intend to provide perspectives on the interactions between the accused and the witnesses. It also aims to get the witnesses’ understanding of Bankman-Fried’s remarks and conduct, particularly regarding FTX’s asset management. The DOJ intends to highlight the experiences of retail and institutional clients who entrusted substantial assets to FTX, believing that the platform would safeguard them securely.

Court filing in the United States District Court for the Southern District of New York. Source: CourtListener

Furthermore, a situation has emerged concerning one of the DOJ’s witnesses, “FTX Customer-1,” who resides in Ukraine. Given the ongoing conflict in Ukraine, traveling to the U.S. to provide testimony is associated with difficulties. The DOJ has suggested using video conferencing as a viable alternative. However, Bankman-Fried’s defense has not yet approved this proposal.

Nonetheless, the legal team representing Bankman-Fried, led by lawyer Mark Cohen, has voiced concerns about the jury questions put forth by the DOJ. According to Bankman-Fried’s defense, these interrogations insinuate guilt on Bankman-Fried’s part, potentially undermining the principle of “innocent until proven guilty.“

Additionally, the defense contends that these inquiries may not effectively uncover the jurors’ inherent biases, especially related to their encounters with cryptocurrencies. Moreover, specific questions could inadvertently guide the jury’s perspective instead of eliciting authentic insights, possibly compromising the trial’s impartiality.

Related: Sam Bankman-Fried’s lawyer challenges US gov’t proposed jury questions

With the jury selection scheduled to start on Oct. 3, closely followed by the trial, the spotlight is firmly on this high-stakes legal confrontation. This case underscores not only its immediate consequences but also underscores the vital importance of transparent communication and unbiased questioning in upholding the principles of justice.

Magazine: Deposit risk: What do crypto exchanges really do with your money?

Read More

Continue Reading

Uncategorized

DOJ readies witnesses in Bankman-Fried trial, spotlight on FTX assets

This initiative also encompasses their comprehension of Sam Bankman-Fried’s remarks and conduct, particularly regarding FTX’s asset management.

Published

on

This initiative also encompasses their comprehension of Sam Bankman-Fried's remarks and conduct, particularly regarding FTX's asset management.

The Department of Justice (DOJ) has affirmed its plan to summon former FTX clients, investors, and staff as witnesses in the upcoming trial involving Sam Bankman-Fried, the former FTX executive. This will shed light on how these individuals viewed their interactions with Bankman-Fried and his company. 

The DOJ submitted a letter motion in limine on Sept. 30, to enable them to get the interpretation of the witnesses on FTX’s treatment of customer assets, which will hold significant importance.

Importantly, these testimonies are intended to provide valuable perspectives on the interactions between the accused and these witnesses. This initiative also encompasses their comprehension of Bankman-Fried's remarks and conduct, particularly regarding FTX's asset management. The DOJ intends to emphasize the experiences of both retail and institutional clients who entrusted substantial assets to FTX with the belief that the platform would safeguard them securely.

Court filing in the U.S. District Court for the Southern District of New York. Source: CourtListener

Furthermore, a distinctive situation has emerged concerning one of the DOJ's witnesses, referred to as "FTX Customer-1," who resides in Ukraine. Given the ongoing conflict, there are difficulties associated with traveling to the United States to provide testimony. Consequently, the DOJ has suggested using video conferencing as a viable alternative. However, Bankman-Fried's defense has not yet approved this proposal.

Nonetheless, the legal team representing Bankman-Fried, led by lawyer Mark Cohen, has voiced concerns about the jury questions put forth by the DOJ. According to Bankman-Fried’s defense, these interrogations insinuate guilt on Bankman-Fried's part, potentially undermining the principle of "innocent until proven guilty."

Additionally, the defense contends that these inquiries may not effectively uncover the jurors' inherent biases, especially if related to their personal encounters with cryptocurrencies. Moreover, certain questions could inadvertently guide the jury's perspective instead of eliciting authentic insights, possibly compromising the trial's impartiality.

Related: Sam Bankman-Fried’s lawyer challenges US gov’t proposed jury questions

With the jury selection scheduled to start on Oct. 3, closely followed by the trial, the spotlight is firmly on this high-stakes legal confrontation. This case underscores not only its immediate consequences but also underscores the vital importance of transparent communication and unbiased questioning in upholding the principles of justice.

Magazine: Deposit risk: What do crypto exchanges really do with your money?

Read More

Continue Reading

Trending