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Doctor dog: how our canine companions can help us detect COVID and other diseases

Dogs love to sniff, and they’re good at it.

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While we humans generally experience the world through sight, dogs use scent to learn about the environment around them. What their nose knows is crucial for finding food, mates and safe spaces.

Our furry friends can also use their sniffing power to learn how people are feeling. For example, they can detect the scent of fear in human sweat.

Given this, it’s perhaps not surprising that pooches’ super-smelling skills can extend to monitoring human health – including, potentially, by detecting infectious diseases such as COVID. In a recent study undertaken in Californian schools, dogs were found to detect the virus with 95% sensitivity in a controlled laboratory setting and 83% in schools.


Read more: Human catches COVID from a cat – here's why this new evidence is not cause for panic


The olfactory capability of dogs far exceeds our own. Estimates suggest that dogs’ smelling ability might be up to 10,000 times better than ours, thanks to having more than 100 million scent receptors in their nose (compared to six million in people). Dogs can detect a wide range of different smells at much lower concentrations than humans or even hi-tech laboratory instruments – sometimes as low as at one part per trillion.

Interestingly, dogs use their nostrils separately. They start sniffing with their right nostril, and if the smell is familiar and “safe”, they switch to using their left nostril.

Dogs differ in the shape and size of their noses, of course, but all have an impressive ability to detect scent in a range of situations. And not only are dogs good at sniffing, they love to do it. Allowing dogs to sniff can actually improve their welfare and make them more optimistic.

Pandemic partners

Dogs have shown they can accurately identify a variety of infectious diseases via scent. For example, children infected with malaria parasites were successfully identified by dogs sniffing their foot odour. Dogs can also detect bacterial urinary tract infections, and gastrointestinal infections caused by the bacteria Clostridium difficle, which can be life-threatening in vulnerable patients.

Early in the COVID pandemic, it became clear that there was a need for extensive, real-time, accurate detection of infection. Respiratory infections cause the release of a range of substances that each have their own distinct smell.

Given dogs’ success in detecting other infectious diseases, the potential role of dogs as “lab partners” during the pandemic was quickly explored.

Initial research revealed that after just one week of training on COVID-specific odour, dogs were able to identify infections in bodily fluids from the respiratory system, correctly identifying positive cases 83% of the time. Once trained on respiratory samples, dogs were also capable of generalising their COVID detection skills to other bodily fluids, such as sweat and urine.

The potential for real-time screening with a high degree of sensitivity offers several advantages over traditional COVID testing methods, such as lateral flow and PCR testing, including cost and efficiency.

Screening by sniffing

In the recent study, two dogs already trained to detect the scent of COVID in the lab were taken into 27 Californian schools and completed 3,897 screenings, mostly among students, by sniffing their ankles and feet. For comparison and to check accuracy of detection, participants also undertook lateral flow tests.

After initial training, the dogs were detecting the virus in the lab with 95% sensitivity (correctly identifying positive cases) and 95% specificity (correctly identifying those who did not have COVID).

Screening people directly saw a slight drop in sensitivity to 83% and specificity to 90%. This is slightly lower than some estimates of the sensitivity and specificity of lateral flow tests, though their reported effectiveness has varied in different studies and between tests.

But even considering that the dogs made a small number of errors, given that screening could be completed within seconds, efficiency was high.

A woman sits with her dog on the couch.
Dogs have far superior olfactory skills compared with their human companions. MT-R/Shutterstock

In the same way that dogs routinely screen people for substances such as drugs or explosives as part of safety and security measures, they could offer effective medical screening services too. In high throughput environments such as schools or colleges, fast and effective screening would have distinct advantages.

However, all medical and health technology needs to be thoroughly evaluated for safety, cost and effectiveness, as well as any legal and ethical implications. Widespread health screening using dogs similarly requires ongoing review and careful consideration, while also ensuring the welfare of the dogs.

Doctor dog?

COVID is just one medical condition our canine companions could potentially help detect.

Along with infectious diseases, they have successfully detected certain forms of cancer in biological samples, the onset of epileptic seizures, and hypoglycemia (low blood sugar) in diabetes patients.


Read more: Were wolves dependent on humans long before they became man’s best friend?


Dogs and humans have lived together for thousands of years, and dogs have become constant human companions in many parts of the world.

The fact that they love to sniff, and are so good at it, has also made them important working partners in a range of roles. Using their innate skills to support human health and wellbeing through medical detection might be another way by which the human-dog relationship is deepened.

Jacqueline Boyd is affiliated with The Kennel Club (UK) through membership, as Chair of the Activities Health and Welfare Subgroup, member of the Dog Health Group and Chair of the Heelwork to Music Working Party. Jacqueline also writes, consults and coaches on canine matters on an independent basis in addition to her academic affiliation.

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DNAmFitAge: Biological age indicator incorporating physical fitness

“We expect DNAmFitAge will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions.”…

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“We expect DNAmFitAge will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions.”

Credit: 2023 McGreevy et al.

“We expect DNAmFitAge will be a useful biomarker for quantifying fitness benefits at an epigenetic level and can be used to evaluate exercise-based interventions.”

BUFFALO, NY- June 7, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 15, Issue 10, entitled, “DNAmFitAge: biological age indicator incorporating physical fitness.”

Physical fitness is a well-known correlate of health and the aging process and DNA methylation (DNAm) data can capture aging via epigenetic clocks. However, current epigenetic clocks did not yet use measures of mobility, strength, lung, or endurance fitness in their construction. 

In this new study, researchers Kristen M. McGreevy, Zsolt Radak, Ferenc Torma, Matyas Jokai, Ake T. Lu, Daniel W. Belsky, Alexandra Binder, Riccardo E. Marioni, Luigi Ferrucci, Ewelina Pośpiech, Wojciech Branicki, Andrzej Ossowski, Aneta Sitek, Magdalena Spólnicka, Laura M. Raffield, Alex P. Reiner, Simon Cox, Michael Kobor, David L. Corcoran, and Steve Horvath from the University of California Los Angeles, University of Physical Education, Altos Labs, Columbia University Mailman School of Public Health, University of Hawaii, University of Edinburgh, National Institute on Aging, Jagiellonian University, Pomeranian Medical University in Szczecin, University of Łódź, Central Forensic Laboratory of the Police in Warsaw, Poland, University of North Carolina at Chapel Hill, University of Washington, and University of British Columbia develop blood-based DNAm biomarkers for fitness parameters including gait speed (walking speed), maximum handgrip strength, forced expiratory volume in one second (FEV1), and maximal oxygen uptake (VO2max) which have modest correlation with fitness parameters in five large-scale validation datasets (average r between 0.16–0.48). 

“These parameters were chosen because handgrip strength and VO2max provide insight into the two main categories of fitness: strength and endurance [23], and gait speed and FEV1 provide insight into fitness-related organ function: mobility and lung function [8, 24].”

The researchers then used these DNAm fitness parameter biomarkers with DNAmGrimAge, a DNAm mortality risk estimate, to construct DNAmFitAge, a new biological age indicator that incorporates physical fitness. DNAmFitAge was associated with low-intermediate physical activity levels across validation datasets (p = 6.4E-13), and younger/fitter DNAmFitAge corresponds to stronger DNAm fitness parameters in both males and females. 

DNAmFitAge was lower (p = 0.046) and DNAmVO2max is higher (p = 0.023) in male body builders compared to controls. Physically fit people had a younger DNAmFitAge and experienced better age-related outcomes: lower mortality risk (p = 7.2E-51), coronary heart disease risk (p = 2.6E-8), and increased disease-free status (p = 1.1E-7). These new DNAm biomarkers provide researchers a new method to incorporate physical fitness into epigenetic clocks.

“Our newly constructed DNAm biomarkers and DNAmFitAge provide researchers and physicians a new method to incorporate physical fitness into epigenetic clocks and emphasizes the effect lifestyle has on the aging methylome.”
 

Read the full study: DOI: https://doi.org/10.18632/aging.204538 

Corresponding Authors: Kristen M. McGreevy, Zsolt Radak, Steve Horvath

Corresponding Emails: kristenmae@ucla.edu, radak.zsolt@tf.hu, shorvath@mednet.ucla.edu 

Keywords: epigenetics, aging, physical fitness, biological age, DNA methylation

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204538

 

About Aging-US:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Martha Stewart Has a Spicy Take on Americans Who Want to Work From Home

This half-baked take might need to stay in the oven a little longer.

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Lifestyle icon Martha Stewart has been on a roll when it comes to representing vivacious women over 60. Whether she's teaming up to charm audiences alongside her BFF Snoop Dogg, poking fun at Elon Musk, or starring as Sports Illustrated's Swimsuit Issue cover model, Martha stays busy. 

Her most recent publicity moment, however, doesn't have the same wholesome feeling Stewart brings to the table. In an interview with Footwear News, the DIY-queen had some choice words about Americans who want to continue working from home after covid-19 lockdown shut down offices.

“You can’t possibly get everything done working three days a week in the office and two days remotely," the cozy-home guru said. "Look at the success of France with their stupid … you know, off for August, blah blah blah. That’s not a very thriving country. Should America go down the drain because people don’t want to go back to work?”

Well, that's certainly a viewpoint. A lot to unpack there. Many online were confused--after all, didn't Stewart basically make her career by "working from home?"

Sitting down with The Today Show, Stewart elaborated on her controversial stance. It seems she's confusing "work from home" with a three-day workweek. 

"I'm having this argument with so many people these days. It's just that my kind of work is very creative and is very collaborative. And I cannot really stomach another zoom. [...But] I hate going to an office, it's empty. During COVID I took every precaution. We [...] set up an office at [...] my home[...] Now we're our offices and our three day work week, I just don't agree with it," Stewart tells viewers. 

"It's frightening because if you read the economic news and look at what's happening everywhere in the world, a three-day workweek doesn't get the work done, doesn't get the productivity up. It doesn't help with the economy and I think that's very important."

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How cashless societies can boost financial inclusion — with the right safeguards

The UK could learn a lot from developing economies about using digital payments to boost financial inclusion.

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Accepting digital payments. WESTOCK PRODUCTIONS/Shutterstock

Cashless societies, where transactions are entirely digital, are gaining traction in many parts of the world, particularly after a pandemic-era boom in demand for online banking.

Improvements in digital payment infrastructure such as mobile payments, digital currencies and online banking, make it more convenient for people and businesses to buy and sell things without using cash. Even the Bank of England is looking into how a digital pound might work, showing the potential for a significant shift from physical cash to digital payments in the UK.


Read more: How a digital pound could work alongside cryptocurrencies


Fintech companies have accelerated the transition towards cashless payments with innovations including mobile payment apps, digital wallets, cryptocurrencies and online banking services. The COVID pandemic was also a tipping point that created unprecedented appetite for digital transactions. Fintechs emerged as a life line for many during lockdowns, particularly vulnerable populations that needed emergency lines of credit and ways to make and receive payments.

By 2021, approximately 71% of adults in developing countries had bank accounts. But this leaves nearly 30% of the population still needing access to essential financial products and services. Fintechs can provide more affordable and accessible financial services and products. This helps boost financial inclusion, particularly for the “unbanked”, or those without a bank account.

In the UK, around 1.3 million people, roughly 4% of the population, lack access to banking services. The government and financial institutions have worked together to promote the adoption of digital payments, and the UK’s Request to Pay service allows people and businesses to request and make payments using digital channels such as Apple Pay and Google Pay.

But other countries are moving faster towards a cashless society. In Sweden, only about 10% of all payments were made in cash in 2020. This move towards cashless payments in the country has been facilitated by mobile payment solutions like Swish, which people can use to send and receive money via mobile phone.

Boosting financial inclusion

India has gone even further. In less than a decade, the country has become a digital finance leader. It has also made significant progress in promoting digital financial inclusion, mainly through the government’s flagship programme, the Pradhan Mantri Jan Dhan Yojana (PMJDY).

India’s banks also participate in mobile payment solutions like Unified Payments Interface (UPI), which can connect multiple accounts via one app. India’s digital infrastructure, known as the India Stack also aims to expand financial inclusion by encouraging companies to develop fintech solutions.

Many developing economies are using digitalisation to boost financial inclusion in this way. Kenya introduced its M-Pesa mobile money service in 2007. While microfinance institutions that provide small loans to low-income individuals and small businesses were first introduced in Bangladesh in the 1970s via the Grameen Bank project.

Digital lending has also grown in India in recent years. Its fintechs use algorithms and data analytics to assess creditworthiness and provide loans quickly and at a lower cost than traditional banks.

These innovative platforms have helped to bridge the gap between the formal financial system and underserved populations – those with low or no income – providing fast access to financial services. By removing barriers such as high transaction costs, lack of physical branches and some credit history requirements, fintech companies can reach a wider range of customers and provide financial services that are tailored to their needs.

It’s the tech behind these systems that helps fintechs connect with their customers. The increased use of digital payment methods generates a wealth of data to gain insights into consumer behaviour, spending patterns and other relevant information that can be used to further support a cashless society.

Helping the UK’s unbanked

Countries like the UK could also promote digital financial inclusion to help unbanked people. But this would require a combination of government support, innovation and the widespread adoption of mobile payment solutions.

There are some significant challenges to overcome to create a true – and truly fair – cashless economy. For example, a cashless system could exclude people who do not have access to digital payment methods, such as the elderly or low-income populations. According to a recent study by Age UK, 75% of over 65s with a bank account said they wanted to conduct at least one banking task in person at a bank branch, building society or post office.

Providing more cashless options could also increase the risk of cybercrime, digital fraud such as phishing scams and data breaches – particularly among people that aren’t as financially literate.

There is a dark side to fintech: algorithm biases and predatory lending practices negatively affect vulnerable and minority groups as well as women. Even major financial firms such as Equifax, Visa and Mastercard can get compromised by data breaches, creating valid concerns about data security for many people.

Cross-border transfer of personal data by fintech companies also concerns regulators, but there is still a lack of internationally recognised data protection standards. This should be addressed as the trend towards cashless societies continues.

Two hands hold a fan of GBP banknotes: £5, £10, £20, £50.
Paying with cash. Nieves Mares/Shutterstock

Building guardrails

Regulations affect how fintech companies can provide financial services but ensure they operate within the law. Since fintech companies generally aim to disrupt markets, however, this can create a complex relationship with regulators.

Collaboration between regulators and fintech companies will boost understanding of these innovative business models and help shape future regulatory frameworks. Countries like India have shown the way in this respect. An innovation hub run by UK regulator the Financial Conduct Authority is a good start. It supports product and service launches and offers access to synthetic data sets for testing and development.

Fintech can help finance become more inclusive. But it needs policies and regulations that support innovation, promote competition, ensure financial stability and – most importantly – to help protect the citizens of these new cashless societies.

Thankom Arun does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond their academic appointment.

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