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Dictators turn delegates: Former CEOs grapple with DAO governance

"A DAO is merely a formalizing of very deep and instinctive human bonds that I think have been suppressed."
One morning in July of 2019, Kain Warwick awoke at 6:30 to a grim phone call from his co-founder and CTO, Justin Moses.We have.

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"A DAO is merely a formalizing of very deep and instinctive human bonds that I think have been suppressed."

One morning in July of 2019, Kain Warwick awoke at 6:30 to a grim phone call from his co-founder and CTO, Justin Moses.

We have a problem, said Moses.

Synthetix, the synthetic asset protocol that Warwick, Moses, and their team had been building for over two years, had fallen victim to a crippling exploit: an attacker with the pseudonym Onyx had created $11 billion of synthetic asset debt over 275 times what Synthetix was worth and was taunting team members and sowing chaos in public channels.

These days, time and success seem to have tempered what Warwick freely admits is a fiery disposition. Still witty and pugnacious, hes prone to ribbing his competitors and critics on Twitter, but otherwise presents as affable and charming; sometimes even wise.

In the Australian winter of 2019, however, he was raging.

Synthetix blog posts from the period maintain a thin veneer of professionalism, but are laced with fury. In them, Warwick equates communicating with the exploiter with a hostage negotiation, and says that paying a bug bounty to Onyx is a form of extortion. He gets dragged into a war of words, at one point smearing Onyx with a terrible curse in programmer circles, branding the attacker a script kiddie.

In context, Warwicks anger is easy to empathize with. The young decentralized finance (DeFi) platform was in the nascent stages of what is now considered a legendary run, having successfully attracted $40 million in total value locked just a fraction of an eventual over $1 billion peak. Such an exploit can cripple growth for a fledgling project, and over the next few months the hyper-competitive Kain went on the offensive: deploying a mechanism that slashed funds from user wallets attempting to exploit the protocol, a mechanism that eventually gave Kain the last laugh as Onyxs funds were drained.

Warwick wanted to go even further, too: instituting harsh slashing penalties in perpetuity for anyone attempting to undermine his protocol.

In the end, however, what Warwick wanted was no longer relevant.

Control over the protocol had previously been handed over to a multi-signature scheme, part of a larger, 18-month process of decentralizing Synthetixs governance through the use of a series of decentralized autonomous organizations (DAOs). The majority of signatories controlling the protocol decided on a more reserved course of action, avoiding a slashing policy entirely.

It was at that moment Warwick says he first faced the confronting realization hed lost the traditional dictatorial power of a CEO.

He could no longer throw a tantrum and say, This is the way were going to do this because I feel this way.

I was in the minority internally, and what I wanted to do was not going to happen, and I just had to come to terms with it.

The dictator had become just another delegate.

A new kind of unicorn

To those uninitiated in the tenets of DeFi and Web3, the decision to decentralize governance over a billion-dollar protocol likely seems insane.

Founder/CEOs like Elon Musk are worshiped with cult-like devotion and aside from the fame, helming a unicorn grants founders the potential to reap historic levels of wealth: all the fortune of King Solomons mines can be earned from the IPO of a simple social app.

Billion-dollar protocols like Synthetix and lending platform Aave stand out in particular for their active revenue streams, growing user bases, and proven models, as well as their involvement in both the fintech and blockchain industries two of the hottest for speculators and investors. If the regulatory knots could ever be unwound, a Wall Street suit in the underwriting business would no doubt want to institutionalize anyone who suggested handing over control of such a protocol to a DAO.

That is true, that is actually true, says Aave co-founder Stani Kulechov, laughing at the accusations of lunacy.

The suits aren’t the only ones who think its crazy. Even those ideological adherents who truly and deeply believe in decentralized governance admit that, as of today, the tooling for DAOs is highly limited.

Since October 29th and July 28th respectively, the entirety of Aave and Synthetixs administrative infrastructure has been operated by DAOs. The process is, at best, rudimentary: AAVE and SNX token holders vote on Improvement Proposals with boolean outcomes, and participants votes are weighted relative to the quantity of tokens they hold. While certain departments/administrative bodies might be split into separate DAOs, the structure largely remains the same across the respective networks.

Token-weighted yes/no votes: this is the mechanism that dictates payroll, treasury holdings, protocol upgrades, long term strategy, business operations, and all other forms of governance for two of the largest and most successful DeFi platforms a pair of sprawling, high-stakes experiments being undertaken in real time.

Embracing ideology over practicality can often be a tricky affair, as anyone who has led a revolution can attest. But even for all the uncertainty, the decision to decentralize was an easy one for both Warwick and Kulechov.

At some point we noticed that there is so much value in the protocol that we practically have to decentralize, said Kulechov. We can’t, as a team, continue to hold this responsibility for something that is highly decentralized except for us.

Warwick was more succinct on the matter:

Its just better for everybody if theres not dictators.

In a series of wide-ranging interviews with Cointelegraph, Warwick, Kulechov, and some of the leading minds in the DAO engineering and organization space discussed the practicalities of decentralized governance, competitive advantages and disadvantages, the unique value capture decentralized governance provides, attracting talent to a nontraditional work environment, and the future of DAOs moving forward.

Centralized versus decentralized

Just as, twelve years on, Bitcoin is still proving the value of a decentralized ledger, it might take time for skeptics of decentralized or distributed governance to come around to the concept.

They have every right to be skeptical. Were not quite at the point where this is adding value, said Patrick Rawson, a co-founder at DAO engineering think tank Curve Labs.

Eventually decentralized governance will become a nexus of contracts making everyones time more efficient, lowering operator costs, Rawson argued, but currently the optimizations arent there yet.

Rawson pointed to authoritarian Chinas response to Covid-19 as an example of the optimizations centralized bodies can currently provide. China was able to shut down the spread of the virus within its own borders because they could put screws in doors and fully lock people down.

Similarly, theres a warranted folk wisdom that projects should start out centralized for the optimizational benefits, and then progressively decentralize over time. He concludes that:

The people who are skeptical are skeptical because centralized structures have proven themselves time and time again.

However, DAOs do come with certain built-in competitive edges, argues Eric Arsenault, head of growth and DAO design at DAOstack.

In certain aspects, you absolutely can compete, and theres not even an alternative, he said. When it comes to questionable legal activities or things involving securities, having a DAO is absolutely more competitive and in fact is the only valid option, potentially.

Both Aave and Synthetix occupy decidedly grey legal territory. But legalities aside, Arsenault argues that in the long run a well-coordinated, well-incentivized decentralized organization will always out-compete a centralized one.

At the end of the day, a DAO allows for open innovation permissionless innovation and collaboration. A traditional siloed corporation will always be bound by its hierarchy, and the ladders and your ability to contribute to that will always be limited to a certain extent, said Arsenault.

A combination of the open innovation and the legal leeway is part of what drew Warwick to decentralizing Synthetixs governance.

I love this idea that you can have people that arent even in the same building coordinating, or are not all tied to a single legal entity the governance system can be the coordinating mechanism, he said. Even if we may not know how to optimize for that, ideologically that was the thing that attracted me towards [decentralizing Synthetix].

User ownership is also not a force to overlook, says Rawson. He offered the example of Uber: the parent company reaps the profits generated by drivers, and drivers notably have limited voice and rights.

But if that were inverted, where drivers slowly gain ownership over time, thats where the drivers will naturally gravitate towards, said Rawson.

Sharif Sakr, an analyst for blockchain investment firm BR Capital and a member of Free TON DAO, agrees that DAOs have a unique appeal and set of reward structures for certain people especially those disaffected with the whimsy of traditional hierarchies.

When I joined Free TON, I think it completely changed my view of incentivization. And it started to make me think differently about incentivization and motivation, as two sort of separate but hopefully parallel things. They were motivated, they were young even if they werent younger than me, they felt younger. I thought, whatever they have, I want some of that.

Sakr initially joined Free TON to perform reconnaissance for BR Capital as they weighed investing in the project. He quickly found himself enchanted with the unique DAO structure, and now jokes that his Free TON work is cutting into time reserved for his BR Capital duties, occasionally getting him into trouble.

Through Free TON, I have seen people create something, deliver something, be paid for that thing, receive community applause for that thing, and then see that thing deployed for a bigger goal that they believed in from the start.

Its a very fulfilling cycle, and I think the normal world has denied younger people that feeling for far too long […] And thats kind of a miracle from which theres no turning back.

Aside from offering top talent a different kind of workplace experience, Rawson believes that eventually the centralized/decentralized competition will come down to who can offer the most robust and compelling ecosystem and thats where centralized entities simply wont be able to keep up.

Once you can launch the equivalent of a mutual fund or a credit union in 15 minutes, then the competition moves away from who has the best tech and towards who has the best, most loyal network? Thats when you start to play a game of ecosystems rather than a game of innovation, said Rawson.

A spectrum of power

Another question that skeptics of decentralized governance frequently raise is to what degree the governance is truly decentralized after all, if the vast majority of governance tokens (and therefore voting power) are retained by a founding team, how dissimilar are DAO operations from that of a normal company?

Aave is not a decentralized protocol, I would say, said Pet3rpan, a semi-anon DAO organizer and member of the Meta Cartel and Venture DAOs. There may be token governance, but theres still huge centralization on [the founding team] itself.

Rawson agreed, saying that users should be cautious about blindly accepting the decentralized label.

If we look at the mechanics, perhaps theyre not [really giving up control], Rawson said.

 

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Maybe behind-the-scenes this is all plotted out, with a cabal of actors, the right people, and mechanisms in place where theyre not giving up control theyre theatrically giving up control.

This would boil down to decentralized theater, a show granting founders like Warwick and Kulechov the legitimacy of claiming decentralization while surrendering none of the power.

Rawson quickly cautioned that he doesnt know the inner workings of either project, however, and is simply advocating for a healthy dose of skepticism.

If theyre doing this really, really well, then I wouldnt have insight thats the point, Rawson laughed.

Warwick and Kulechov both acknowledged that, as founders, they retain a soft power that elevates their voices above others and that they still hold a portion of tokens large enough to keep them incentivized to continue working on the protocol.

However, founders retaining soft power is nothing new in the crypto space. Though Vitalik Buterin has claimed he no longer has any true control over Ethereum, he remains a figurehead in the eyes of many.

Kulechov also mentioned the founder of Linux, Linus Torvalds, as someone whose example he aims to follow:

I love the way Linus Torvald is doing it at Linux. He practically deployed the very first software of Linux, Kernels, and even Git, and to this day he follows whats happening in the community and is actively involved. I really like that kind of approach when building protocols. Its hard to build something, that you get it right where people are using your protocol and you have sustainability thats something thats difficult to leave.

Warwick, meanwhile, made it clear that his soft power does have clear limits:

If I turned up tomorrow in Discord and said, Hey, Im writing a SIP to change the monetary policy of the token to divert all of the fees to 0x0 address (which would burn the funds), for example, I cant see a scenario where I get that over the line no matter how persuasive I am.

Sakr also pointed out that there are different kinds of soft power, some of which occupy an important role in a DAO. Social hierarchies are a naturally occurring phenomenon in any human organization, and theres nothing wrong with certain people commanding soft power by way of respect for instance, product managers.

A product manager only operates through soft power. They are rarely top of a hierarchy, but usually on the side — theyre not the head of engineering, theyre not the head of design, not the head of commercial, theyre not the head of anything. They often have a big personality, and they are not revered at all, but respected due to the force of personality, imagination, gravitas, vision.

Where soft power goes wrong is when it becomes overly reverential, says Sakr, granting an individual disproportionate sway and cult-like status status which founders often command.

Warwick also seems to resent whatever degree of reverential soft power he commands, wishing he could participate without the cloud of his own influence hanging over him. He talked through a hypothetical where he would leave Synthetix publicly, rejoin anonymously, and build up credibility in the DAO through a new persona.

In the end, though, such an undertaking would be too complicated.

As someone who is, ultimately, a crypto-anarchist, centralized power is bad, Warwick sighed. The fact that a founder retains soft power, but not hard power, is probably a good balance.

Pet3rpan agrees. While the Synthetix and Aave DAOs could stand to have a greater degree of token decentralization, founders retaining soft power ultimately makes sense.

Its just reality, he said. I don’t see anything wrong with it. The rhetoric of, these people still have influence, well yeah, no shit […] You want to listen to people who have done the most. If a leader of a project is the person who has done the most well, thats not the greatest conspiracy ever.

Fresh blood

While founders maintain some of their stature, who is actually doing the work day-to-day? Though some models have emerged, an unanswered question remains as to how decentralized governments attract new talent.

I personally like the idea that when you give the keys to the community, you can walk away and say, My work is done, said Kulechov.

However, he acknowledged that the unfortunate reality is that the majority of smart contract engineering still comes from Aaves founding team. While he speculated that one day more third-party developers might come on as employees of the DAO, so far it hasn’t happened at scale.

That said, lots of small features have come from the community, he says. The changes might be very small, but very useful.

He described one example where a community member proposed that users in certain legal jurisdictions would have the option not to take on new, wrapped tokens upon depositing funds into Aave a minor operational change that would yield significant tax and efficiency benefits for depositors.

Warwick also said that the majority of technical improvements and changes to the protocol still come from the core team and that the team is keeping to a five year plan mapped out before Synthetix decentralized its governance but upwards of 80% of operational changes to the protocol, such as adjusting collateralization ratios, now come from the community.

The community is on top of it more. They see where something isnt optimal, they can monitor on-chain and see if theres something inefficient with the peg or something, and so those are increasingly coming more from the community, he said.

Pet3rpan emphasizes that DAOs offloading major responsibilities from the core team to the community is a key step in long-term success.

Its like a mother and her child: you dont want to coddle the child because it will become this useless thing that always needs help, he said. If you really removed the core team from Compound right now, or even Aave, […] they wouldnt really exist.

He pointed to Yearn.finance as an example of a DAO that has successfully invested in developing and attracting new talent.

Maybe if Andre [Cronje] didnt exist anymore we wouldnt get these mergers and cool innovations like Deriswap, but the core YFI product would keep going because theyve built up the team and trained a team of really great engineers.

However, Pet3rpan also suggested that progress might be a process and not an event.

It makes sense that the first proposers and the first people who are involved are the core team. The other people, the workers and the contributors, they will come. Money, and having a large treasury in the DAO, that takes time but it will come.

Sakr also believes that the talent migration from centralized entities to decentralized ones is just a matter of time.

I am coming from a world where energy and young people have been repeatedly, almost psychically crushed […] Ive seen so much failure from the centralized world. I just can’t see anything in this world for DAOs to compete against that has been so amazing or impressive.

Into the unknown

Few of the experts that spoke to Cointelegraph for this piece could offer historical analogues for successful decentralized governance. It is new, largely unexplored territory.

This means, of course, that there are heaps of developmental work to be done but according to Rawson, scholars have already laid the bulk of the theoretical groundwork.

Scholarship usually predates technological change, he said. Everyone sees this coming, everyone knows its coming. The folks who are doing this thing every day, having this empirical experience… time might seem slower to us because a day in DeFi is 20 years in the real world, but its moving along. Its moving along and it wont be long before businesses start out as DAOs.

He points to The Handbook for Computational Social Choice, a sprawling, 600-page tome that games out a vast array of possible computational governance and voting structures. According to Rawson, DeFi has only scratched 2% of what the academic theory has to offer.

Additionally, according to Sakr, the process of advancing DAO tooling might be less of a technological push forward, but rather a social step back toward more traditional community structures.

Some people have called it civic fabric the invisible, informal, nonofficial relationships that bind, for example, neighbors that cause someone young to do the shopping for someone older. These sort of layers of trust that have been there, perhaps have been damaged by the industrial revolution.

He compared the Free TON community to another he encountered as he moved his family to rural France to escape the Covid-19 outbreak: an idyllic town bound by loose, but powerful, collectivist bonds:

A DAO is merely a formalizing of very deep and instinctive human bonds that I think have been suppressed.

From a market perspective, the tooling might rapidly improve as the time is already approaching when DeFi users demand some degree of decentralization from the projects they use at the governance layer, and not just at the protocol layer. Arsenault hopes that day comes soon.

I would hope that the market would move in that direction, he said. Youve seen hacks, youve seen issues with rugpulls [] The more these types of things happen, the more people are going to be requiring some form of governance mechanism to ensure their funds are safe.

The consensus among the founders and experts is that a true DeFi requires decentralization at both layers. For the founders especially, even if it means giving up certain privileges, they seem eager to move forward.

Youre saying goodbye to a power you have, but youre saying at the same time, Welcome! to a new kind of power, said Kulechov. Youre accepting that the model you had was there for a reason, but for where you need to go, you need the new thing.

Likewise, Warwick implied that the governance development now takes precedence for him over the protocol.

I think the specifics of how Synthetix works are, to me, far less important to me than how its coordinated, and how weve built these primitives to scale it up, he said. I think the incentive structure and the governance structure are, to me, more important than even what it does.

And is there any advice for the young founder who wishes to brave the decentralized frontier and start their enterprise as a DAO?

I think the most important thing is, theres no reason to be afraid to give up this power, said Warwick. As long as youre supporting the community while youre doing it, and making sure that theyre good custodians stepping into that role and power as you give it up, the people who youre handing that power to will typically surprise you and be very dedicated and conscientious about how they manage things.

Its not something to be afraid of, its something to be excited about to be able to take these decentralized systems to fruition.


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Germany Is Running Out Of Money And Debt Levels Are Exploding, Finance Minister Warns

Germany Is Running Out Of Money And Debt Levels Are Exploding, Finance Minister Warns

By John Cody of Remix News

German Finance Minister…

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Germany Is Running Out Of Money And Debt Levels Are Exploding, Finance Minister Warns

By John Cody of Remix News

German Finance Minister Christian Lindner is warning his own government that state finances are quickly growing out of hand, and the government needs to change course and implement austerity measures. However, the dispute over spending is only expected to escalate, with budget shortfalls causing open clashes among the three-way left-liberal coalition running the country.

With negotiations kicking off for the 2025 budget, much is at stake. However, the picture has been complicated after the country’s top court ruled that the government could not shift €60 billion in money earmarked for the coronavirus crisis to other areas of the budget, with the court noting that the move was unconstitutional.

Since then, the government has been in crisis mode, and sought to cut the budget in a number of areas, including against the country’s farmers. Those cuts already sparked mass protests, showcasing how delicate the situation remains for the government.

German Finance Minister Christian Lindner attends the cabinet meeting of the German government at the chancellery in Berlin, Germany. (AP Photo/Markus Schreiber)

Lindner, whose party has taken a beating in the polls, is desperate to create some distance from his coalition partners and save his party from electoral disaster. The finance minster says the financial picture facing Germany is dire, and that the budget shortfall will only grow in the coming years if measures are not taken to rein in spending.

“In an unfavorable scenario, the increasing financing deficits lead to an increase in debt in relation to economic output to around 345 percent in the long term,” reads the Sustainability Report released by his office. “In a favorable scenario, the rate will rise to around 140 percent of gross domestic product by 2070.”

Under EU law, Germany has limited its debt levels to 60 percent of economic output, which requires dramatic savings. A huge factor is Germany’s rapidly aging population, with a debt explosion on the horizon as more and more citizens head into retirement while tax revenues shrink and the social welfare system grows — in part due to the country’s exploding immigrant population.

Lindner’s partners, the Greens and Social Democrats (SPD), are loath to cut spending further, as this will harm their electoral chances. In fact, Labor Minister Hubertus Heil is pushing for a new pension package that will add billions to the country’s debt, which remarkably, Lindner also supports.

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Tyler Durden Mon, 03/18/2024 - 05:00

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Artificial mucus identifies link to tumor formation

NEW ORLEANS, March 18, 2024 – During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential…

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NEW ORLEANS, March 18, 2024 – During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health. To better understand its many roles, researchers synthesized the major component of mucus, the sugar-coated proteins called mucins, and discovered that changing the mucins of healthy cells to resemble those of cancer cells made healthy cells act more cancer-like.

Credit: American Chemical Society

NEW ORLEANS, March 18, 2024 – During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health. To better understand its many roles, researchers synthesized the major component of mucus, the sugar-coated proteins called mucins, and discovered that changing the mucins of healthy cells to resemble those of cancer cells made healthy cells act more cancer-like.

The researcher will present her results today at the spring meeting of the American Chemical Society (ACS). ACS Spring 2024 is a hybrid meeting being held virtually and in person March 17-21; it features nearly 12,000 presentations on a range of science topics.

“For hundreds of years, mucus was considered a waste material or just a simple barrier,” says Jessica Kramer, a professor of biomedical engineering who led the study. And indeed, it does serve as a barrier, regulating the transport of small molecules and particulates to underlying epithelial cells that line the respiratory and digestive tracts. But it also does much more. Studies show that mucus and mucins are biologically active, playing roles in immunity, cell behavior and defense against pathogens and cancer. Kramer’s team at the University of Utah, for example, recently found that specific sugars attached to mucins inhibited coronavirus infection in cell culture.

“Part of the challenge of studying mucus and mucins in general is that they have quite a variety of protein structures,” Kramer explains. Although humans share more than 20 mucin genes, those genes are expressed differently in different tissues and are spliced to generate a range of proteins. In addition, cells modify those proteins in myriad ways with different sugars to meet the body’s needs.

Complicating the picture, genetic factors alone don’t determine mucin composition. Dietary and environmental factors can also influence which sugars become attached to these proteins. Thus, mucus composition can vary significantly from person to person, from day to day, and from tissue to tissue, all of which makes it difficult to identify the biological effects of any given mucin.

To study mucin properties, researchers can collect mucus from animals in slaughterhouses, Kramer says. “But ultimately, it’s quite labor intensive and difficult to purify. And in the process of doing the harvesting, usually the sticky, slimy properties are disrupted.”

As an alternative, mucins can be purchased off-the-shelf, Kramer explains. But because batch-to-batch variability can lead to problems with experimental reproducibility, methods are needed to reliably produce synthetic mucins at scale and at a reasonable price.

In the absence of a simple genetic method to produce individual mucins, Kramer’s lab combined synthetic chemistry and bacterial enzymes to generate the core polypeptides and then selectively add sugars to create unique synthetic mucins. This allows the researchers to test the physical, chemical and biological properties of individual types of mucin molecules and identify the impact of changing individual sugars or protein sequences.

Kramer, along with the lab of collaborator Jody Rosenblatt at King’s College London, is applying her team’s mucins to questions of cancer biology. In particular, the scientists are exploring the influence of mucins on the earliest stages of tumor formation. Previous studies in other labs have shown that mucins embedded in the surface of cancer cells promote metastasis, the spread of cancer to other tissues in the body. These mucins can also help the cancer cells evade immune system defenses by blocking immune cell activation.

“We are building synthetic mucins to understand how the chemical aspects of these proteins affect the behavior of cancer cells,” Kramer explains. “It hasn’t been possible to study these things before because we can’t control the molecular properties of mucins using traditional genetic and biochemical methods.”

Normally, as non-cancerous epithelial cells grow, they crowd together, with some getting eliminated from the epithelial layer to maintain a consistent and stable tissue structure. When Kramer’s team engineered the cells to have a bulky mucin-rich surface similar to that of cancer cells, the cells stopped extruding normally and piled up, forming what looked like the start of tumors.

Kramer is quick to note, however, that her team has not determined whether the genetics of the cells have changed, so they cannot yet state definitively whether the healthy cells were transformed into cancer cells. Those studies are ongoing.

The insights will be pivotal for the development of possible cancer treatments targeting mucins, as they will help highlight which parts of the mucin molecules are most important to tumor formation.

Scientists have been trying to make mucin-targeting therapeutics for decades, but that hasn’t worked well, in part because the sugar groups on the molecules weren’t fully taken into account, Kramer says. “For a vaccine, we can’t only consider the protein sequence because that’s not what the molecule looks like to the immune system. Instead, when an immune cell bumps into the surface of a cancer cell it’s going to see the sugars first, not the protein backbone.” So she believes an effective vaccine will need to target those mucin sugars.

Beyond cancer, the ability to reliably modify the protein sequence and sugars and produce scalable quantities of synthetic mucins offers opportunities to develop these molecules as anti-infectives, probiotics and therapies to support reproductive and women’s health, Kramer says.

The research was funded by the National Institute of General Medical Science, National Science Foundation and Marion Milligan Mason Fund.

Visit the ACS Spring 2024 program to learn more about this presentation, “Synthetic mucins: From new chemical routes to engineered cells,” and more scientific presentations. 

###

The American Chemical Society (ACS) is a nonprofit organization chartered by the U.S. Congress. ACS’ mission is to advance the broader chemistry enterprise and its practitioners for the benefit of Earth and all its people. The Society is a global leader in promoting excellence in science education and providing access to chemistry-related information and research through its multiple research solutions, peer-reviewed journals, scientific conferences, eBooks and weekly news periodical Chemical & Engineering News. ACS journals are among the most cited, most trusted and most read within the scientific literature; however, ACS itself does not conduct chemical research. As a leader in scientific information solutions, its CAS division partners with global innovators to accelerate breakthroughs by curating, connecting and analyzing the world’s scientific knowledge. ACS’ main offices are in Washington, D.C., and Columbus, Ohio.

To automatically receive news releases from the American Chemical Society, contact newsroom@acs.org.

Note to journalists: Please report that this research was presented at a meeting of the American Chemical Society. ACS does not conduct research, but publishes and publicizes peer-reviewed scientific studies.

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Title
Synthetic mucins: From new chemical routes to engineered cells

Abstract
Mucin glycoproteins are the major component of mucus and the epithelial glycocalyx. Mucins are essential for life, serving roles as a physical barrier, a lubricant, and a biochemical moderator of infection, immunity, and cancer. There are more than 20 known mucin genes with variable expression patterns, splicing, and post-translational glycosylation patterns. Such diversity has challenged study of structure-function relationships. We are developing scalable methods, based on polymerization of amino acid N-carboxyanhydrides, to synthesize glycan-bearing polypeptides that capture the chemical and physical properties of native mucins. We are utilizing these synthetic mucins to form fully synthetic mucus hydrogels and to engineer the glycocalyx of live cells to shed light on the role of glycans in health and disease. This talk will focus on advances in chemical synthesis along with application of synthetic mucins in study of tumorigenesis.


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International

You can strike gold and silver investment opportunities at Costco

Costco (NDAQ:COST), known for its wide array of products, also offers a distinct opportunity for investors: gold and silver.
The post You can strike gold…

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Costco known for its wide array of products ranging from groceries to electronics and sporting goods, also offers a distinct opportunity for investors: precious metals Costco began selling 1-ounce 24-karat gold bars, in the United States in October 2023 and sold more than US$100 million by November Investors are looking for inflation-proof opportunities and as Stockhouse’s recent Thematic Insights report details, the gold supply has remained essentially flat over time, so it is never diluted Costco Wholesale Corp. stock last traded at US$725.63 on the NASDAQ and C$34.01 per share on the NEO Exchange

With gold prices hovering around all-time highs, one of the top warehouse retailers and Canada’s favourite grocer has brought the precious metal to its consumers.

Costco (NDAQ:COST), known for its wide array of products ranging from groceries to electronics and sporting goods, also offers a distinct opportunity for investors: precious metals. While the retail giant might not be the first place that comes to mind when thinking about gold and silver investments, Costco’s offerings in Canada have caught the attention of savvy investors looking to diversify their portfolios.

Let’s delve into what Costco Canada has to offer in terms of gold and silver investments and explore the potential benefits and considerations.

Gold and silver bullion at Costco

Costco began selling 1-ounce 24-karat gold bars, in the United States in October 2023 priced around US$2,000 and sold more than US$100 million by November.

Observing Costco shoppers can provide interesting economic and cultural indicators. Just like the early days of COVID-19 in 2020 when consumers emptied pallets of toilet paper, the supplies of gold and silver at Costco might reveal how confident the public is in Canadian currency and the economy.

Costco Canada stocks a selection of gold and silver bullion available online at Costco.ca, providing investors with the opportunity to add physical precious metals to their investment portfolios. Gold and silver bullion are typically offered in the form of bars or coins, each carrying intrinsic value based on the metal content.

(Source: Costco.ca) Benefits of investing in gold and silver Portfolio diversification: Gold and silver have historically served as a hedge against inflation and economic uncertainty. By adding precious metals to their portfolios, investors can diversify risk and potentially protect their wealth during times of market volatility. Tangible assets: Unlike stocks or bonds, which exist only as digital entries or paper certificates, gold and silver bullion offer investors tangible assets they can hold in their hands. This physical presence can provide a sense of security and stability, especially during turbulent economic times. Liquidity: Gold and silver are globally recognized as valuable commodities, making them liquid assets. Investors can easily buy and sell gold and silver bullion in various markets around the world, providing flexibility and accessibility. Store of value: Throughout history, gold and silver have maintained their value over the long term. While fiat currencies may depreciate because of factors such as inflation, political instability or economic crises, precious metals have proven to retain their purchasing power over time. Considerations when investing in precious metals Price volatility: Like any investment, the prices of gold and silver can fluctuate based on supply and demand dynamics, geopolitical events, and macroeconomic factors. Investors should be prepared for price volatility and hold a long-term perspective. Storage and security: Owning physical precious metals requires adequate storage and security measures to protect against theft or damage. Investors might opt for secure vault storage services or invest in home safes to safeguard their bullion. Transaction costs: When buying and selling gold and silver bullion, investors might incur transaction costs such as premiums, commissions or storage fees. It’s essential to factor these expenses into investment decisions to accurately assess potential returns. Costco also marks up its precious metals at a few hundred dollars above its market value, but you will likely find it slightly cheaper than what the big Canadian banks offer, if their stock isn’t sold out. Market timing: Timing the market is notoriously difficult, and attempting to predict short-term price movements in gold and silver can be challenging. Instead, focus on the long-term fundamentals and consider dollar-cost averaging as a strategy to mitigate market timing risk. Why buy gold and silver at Costco?

Already up more than 5 per cent since the beginning of the year, the value of gold is expected to continue to climb this year. Earlier this month it hit record highs above $2,181/oz. as speculation rises around the prospects of June interest rate cuts.

… but is it a good investment?

In an interview with CBC Radio’s The Current, Will Huggins, an associate professor of finance and economics at McMaster University’s DeGroote School of Business called this a good marketing strategy by Costco, but believed that buying gold from Costco doesn’t offer any advantage compared with the big Canadian banks.

“It’s not like a herd of cattle or some land or a corporate entity that we can keep bringing new people into,” he said. “It’s just a yellow rock.”

(Source: Costco Wholesale Corp.) Final thoughts on buying gold and silver

Costco Canada’s offering of gold and silver bullion presents an intriguing opportunity for investors seeking to diversify their portfolios with tangible assets.

Investors are looking for inflation-proof opportunities and as Stockhouse’s recent Thematic Insights report details, the gold supply has remained essentially flat over time, so it is never diluted and is essentially immune to inflation.

Whether you’re a seasoned investor looking to bolster your portfolio’s resilience or a newcomer exploring alternative investment avenues, the availability of gold and silver bullion at Costco Canada may offer a convenient and accessible option to incorporate precious metals into your investment strategy.

While investing in precious metals carries certain benefits and considerations, it is important for investors to conduct due diligence, assess their risk tolerance, and consult with financial professionals before making investment decisions. As with any investment, prudent decision-making and a long-term perspective are key to navigating the complexities of the financial markets.

Costco Wholesale Corp. (NDAQ:COST) stock last traded at US$725.63 on the NASDAQ and C$34.01 per share on the NEO Exchange.

Join the discussion: Find out what everybody’s saying about this stock on the Costco Wholesale Corp. Bullboard, and check out the rest of Stockhouse’s stock forums and message boards.

The material provided in this article is for information only and should not be treated as investment advice. For full disclaimer information, please click here.

The post You can strike gold and silver investment opportunities at Costco appeared first on The Market Online Canada.

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