Acta Pharmaceutica Sinica B publishes a special column on ‘Novel Peptides and Peptidomimetics in Drug Discovery’ edited by Jianfeng Cai and Lulu Wei from the Department of Chemistry, University of South Florida, Tampa, FL, USA. Topics include current research accomplishments and current challenges in the field of peptidomimetics.
In 2021 Acta Pharmaceutica Sinica B (APSB) is celebrating its 10th anniversary. The journal was founded with the goal of creating a global high-level forum centred around drug discovery and pharmaceutical research/application. APSB was included by Chemical Abstracts in 2011, accepted by PubMed Central in 2015, indexed by Science Citation Index in 2017 and has evolved to become one of the most important international journals in the field of pharmaceutical sciences.
APSB is a monthly journal, in English, which publishes significant original research articles, rapid communications and high quality reviews of recent advances in all areas of pharmaceutical sciences — including pharmacology, pharmaceutics, medicinal chemistry, natural products, pharmacognosy, pharmaceutical analysis and pharmacokinetics.
Featured papers in this special column are:
Peptidomimetic-based antibody surrogate for HER2 by Mengmeng Zheng, Chunpu Lia, Mi Zhou, et al. (https://doi.org/10.1016/j.apsb.2021.04.016). Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive cancers. Although monoclonal antibodies are currently used as marketed drugs, their large molecular weight, high cost of production and susceptibility to proteolysis could be a hurdle for long-term application. In this study, we reported a strategy for the development of artificial antibody based on γ-AApeptides to target HER2 extracellular domain (ECD).
Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for P53 activation and tumor suppression by authors Chenglong Gao, Yazhou Xu, Zhuangzhuang Liang et al. (https://doi.org/10.1016/j.apsb.2021.06.010). LFHP-1c directly binding to PGAM5 inhibits PGAM5 enzyme activity and impairs PGAM5 interaction with NRF2, promoting NRF2 transcription activity to protect against blood–brain barrier disruption and ischemic brain injury.
Regular articles of interest in this issue:
Repurposing carrimycin as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2 by Xiang Lia, Neelakshi Gohain, Si Chen et al. (https://doi.org/10.1016/j.apsb.2021.02.024). CFDA-approved drug carrimycin is repurposed as an antiviral agent against human coronaviruses, including the currently pandemic SARS-CoV-2, through inhibition of post-entry replication events of human coronavirus infection.
Design, synthesis, and biological evaluation of multiple targeting antimalarials by authors Yiqing Yang, TongkeTang, Xiaolu Li et al. (https://doi.org/10.1016/j.apsb.2021.05.008). A highly potent antimalarial compound, RYL-581, has a potential multi-targeting mechanism of action by simultaneously binding to three pockets (allosteric site of PfNDH2, Qo and Qi sites of Pfbc1).
Other articles published in the issue include:
Special Column “Novel Peptides and Peptidomimetics in Drug Discovery”
“Novel Peptides and Peptidomimetics in Drug Discovery”
Membrane-disruptive peptides/peptidomimetics-based therapeutics: Promising systems to combat bacteria and cancer in the drug-resistant era
Liming Lin, Jiaying Chi, Yilang Yan, Rui Luo et al.
Apoptosis-inducing activity of synthetic hydrocarbon-stapled peptides in H358 cancer cells expressing KRASG12C
Cuicui Li, Ni Zhao, Luyan An, Zhen Dai et al.
A novel ω-conotoxin Bu8 inhibiting N-type voltage-gated calcium channels displays potent analgesic activity
Jinqin Chen, Xinhong Liu, Shuo Yu, Jia Liu et al.
An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation
Mirja Harms, Monica M.W. Habib, Simona Nemska, Antonella Nicolò et al.
Discovery of a potent and dual-selective bisubstrate inhibitor for protein arginine methyltransferase 4/5
Ayad A. Al-Hamashi, Dongxing Chen, Youchao Deng, Guangping Dong, Rong Huang
Facile synthesis of insulin fusion derivatives through sortase A ligation
Maria M. Disotuar, Jake A. Smith, Jinze Li, Steve Alam et al.
Integrins as attractive targets for cancer therapeutics
Meng Li, Ying Wang, Mengwei Li, Xuezhen Wu et al.
Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
Kailin Li, Jieqiong You, Qian Wu, Wen Meng et al.
Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management
Guoyi Tang, Sha Li, Cheng Zhang, Haiyong Chen et al.
Gasdermin D in pyroptosis
Brandon E. Burdette, Ashley N. Esparza, Hua Zhu, Shanzhi Wang
The biology, function, and applications of exosomes in cancer
Jinyi Liu, Liwen Ren, Sha Li, Wan Li et al.
Receptor-mediated targeted drug delivery systems for treatment of inflammatory bowel disease: Opportunities and emerging strategies
Peng Liu, Caifang Gao, Hongguo Chen, Chi Teng Vong et al.
Combination therapy with miR34a and doxorubicin synergistically inhibits Dox-resistant breast cancer progression via down-regulation of Snail through suppressing Notch/NF-κB and RAS/RAF/MEK/ERK signaling pathway
Xiaoxia Yang, Pengfei Shang, Bingfang Yu, Qiuyang Jin et al.
Tryptophan 2,3-dioxygenase 2 controls M2 macrophages polarization to promote esophageal squamous cell carcinoma progression via AKT/GSK3β/IL-8 signaling pathway
Yumiao Zhao, Jiaxin Sun, Yin Li, Xiuman Zhou et al.
Novel compound FLZ alleviates rotenone-induced PD mouse model by suppressing TLR4/MyD88/NF-κB pathway through microbiota–gut–brain axis
Zhe Zhao, Fangyuan Li, Jingwen Ning, Ran Peng et al.
Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation
Qi Lv, Yao Xing, Jian Liu, Dong Dong et al.
Simultaneous improvement to solubility and bioavailability of active natural compound isosteviol using cyclodextrin metal-organic frameworks
Xiaojin Chen, Tao Guo, Kaikai Zhang, Jiacai Chen et al.
Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis
Wenqi Yu, Ruyi Lin, Xueqin He, Xiaotong Yang et al.
Transdermal delivery of Chinese herbal medicine extract using dissolvable microneedles for hypertrophic scar treatment
Xiaoyu Ning, Christian Wiraja, Wan Ting Sharon Chew, Chen Fan, Chenjie Xu
Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new “non-natural” analogues
Ke Ma, Yuting Zhang, Cui Guo, Yanlong Yang et al.
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