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ASMBS Foundation awards research grants for studies related to COVID-19 & obesity

Credit: ASMBS Foundation Newberry, FL – July19, 2021– The American Society for Metabolic and Bariatric Surgery (ASMBS) Foundation today announced it has awarded two research grants totaling $50,000 to study the effects of obesity on COVID-19 infections…

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Credit: ASMBS Foundation

Newberry, FL – July19, 2021– The American Society for Metabolic and Bariatric Surgery
(ASMBS) Foundation today announced it has awarded two research grants totaling $50,000 to
study the effects of obesity on COVID-19 infections in adolescents and the increasing use of
adult cannabis during and after the pandemic and its potential impact on weight loss outcomes
following bariatric surgery.

“These latest grants are for studies on the impact of COVID-19 and emerging areas of interest
that have thus far received little scientific study,” said Paul Enochs, MD, President, ASMBS
Foundation. “Our support for them reflects our enduring commitment, and that of our donors,
to help fuel innovative research that advances the scientific understanding of the disease of
obesity and its treatment.”

The ASMBS Foundation has been sponsoring important research on obesity and bariatric
surgery since 2004. Previous grant recipients have studied the short-term impact of bariatric
surgery on systemic inflammation in asthma patients, the effect of sleeve gastrectomy on
obesity-induced heart failure, and the determinants of Type 2 diabetes remission after bariatric
surgery. This year’s recipients will each receive $25,000 for their studies.

“I am so honored to have been chosen for this year’s ASMBS Foundation research grant. It will
support a study that will help both providers and patients better understand the influence of
cannabis use after bariatric surgery and whether it impacts eating behaviors and long-term
weight loss outcomes,” said Lisa R. Matero, Ph.D., ABPP, Director, Health Psychology Fellowship
Program at Henry Ford Hospital in Detroit.

“Pediatric and adolescent populations with obesity are at high risk for severe COVID-19
infection and novel therapeutic interventions are lacking. This study aims to reveal the
molecular and cellular underpinnings that influence increased viral susceptibility in these
individuals to aid in the future development of effective therapies,” said Christine Finck, MD,
Chief, Division of Pediatric General and Thoracic Surgery at Connecticut Children’s Hospital in
Hartford. “The grant for this study will help us accomplish our long-term goal of improving the
overall quality of life for pediatric patients with obesity.”

Metabolic/bariatric surgery has been shown to be the most effective and long-lasting treatment
for severe obesity, resulting in significant weight loss and resolution or improvements in
diabetes, heart disease, sleep apnea, and many other obesity-related diseases. Its safety profile
is comparable to some of the safest and most commonly performed surgeries in the U.S.
including gallbladder surgery, appendectomy, and knee replacement. An estimated 256,000
bariatric surgeries were performed in 2019, according to the ASMBS, which represents less than
1% of the currently eligible surgical population-based on body mass index (BMI).

The CDC reports 42.4% of adults in the U.S. had obesity in 2017-2018. Another 9.2% had
severe obesity. Obesity is linked to more than 40 diseases including type 2 diabetes,
hypertension, heart disease, stroke, sleep apnea, and at least 13 different types of cancer.

###

About ASMBS Foundation

The mission of the ASMBS Foundation is to raise funds for conducting research and education,
increasing public and scientific awareness and understanding, and improving access to quality
care and treatment of obesity and severe obesity. The ASMBS Foundation shares the vision of
the American Society for Metabolic and Bariatric Surgery (ASMBS) to improve public health
and well-being by lessening the burden of the disease of obesity and related diseases
throughout the world. For more information, visit http://www.asmbsfoundation.org.

Media Contact
Michael Votta
michael@asmbsfoundation.org

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International

Are We Falling As Rome Did?

Are We Falling As Rome Did?

Authored by Julie Ponese via The Epoch Times,

3, 2, 1… Timber! A Philosopher’s Take on the Collapse of Our…

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Are We Falling As Rome Did?

Authored by Julie Ponese via The Epoch Times,

3, 2, 1... Timber! A Philosopher’s Take on the Collapse of Our Civilization

The clock seems to be ticking.

Growing disparities in wealth, a housing and gas crisis, transhumanism galloping over the horizon, heroized incivility, and the constant threat of viruses, the “cures” for which may be worse than the diseases. Global politics feels eerily apocalyptic these days and, in our own little worlds, many of us are so lost, so unmoored from the comforts of our pre-pandemic lives, that we don’t know which end is up or what the future will hold. Investigative journalist Trish Wood recently wrote that we are living the fall of Rome (though it’s being pushed on us as a virtue).

I wonder, are we falling as Rome did? Is it possible that our civilization is on the verge of collapse? Not imminent collapse, perhaps, but are we taking the initial steps that civilizations before ours took before their eventual downfalls? Will we suffer the fates of the Indus, the Vikings, the Mayans, and the failed dynasties of China?

As a philosopher, I need first to understand what we mean by “civilization” and what it would mean for that thing to collapse.

This is a significant conceptual hurdle. “Civilization” (from the Latin civitas, meaning a body of people) was first used by anthropologists to refer to a “society made up of cities” (Mycenae’s Pylos, Thebes, and Sparta, for example). Ancient civilizations were typically non-nomadic settlements with concentrated complexes of persons who divided labor. They had monumental architecture, hierarchical class structures, and significant technological and cultural developments.

But just what is our civilization? There isn’t a tidy line between it and the next in the way the Mayans’ and the Greeks’ coexistence was defined by the ocean between them. Is the concept of Western civilization—rooted in the culture that emerged from the Mediterranean basin over 2,000 years ago—still meaningful, or has globalization made any distinction between contemporary civilizations meaningless? “I am a citizen of the world,” wrote Diogenes in the fourth century B.C. But of course, his world wasn’t quite as vast as our own.

Now for the second issue: civilization collapse. Anthropologists typically define it as a rapid and enduring loss of population, socio-economic complexity, and identity.

Will we suffer a mass loss of population or socio-economic complexity? Perhaps. But that isn’t what concerns me. What I really worry about is our loss of identity. I worry that we’ve lost the plot, as they say, and that with all our focus on the ability of science to save us, we’ve lost our ideals, our spirit, our reasons for being. I worry we are suffering what Betty Friedan called “a slow death of the mind and spirit.” I worry that our nihilism, our façadism, our progressivism are incurring a debt that we may not be able to pay.

As the eminent anthropologist Sir John Glubb wrote (pdf), “The life-expectation of a great nation, it appears, commences with a violent, and usually unforeseen, outburst of energy, and ends in a lowering of moral standards, cynicism, pessimism and frivolity.”

Think of a civilization as the top step on a staircase, with each stair below having fallen away. Western civilization today is built largely on the foundational ideals of ancient Greece and Rome that endure long after their physical structures and governments disappeared. But they endure because we find them meaningful. They endure through literature and art and conversation and ritual. They endure in how we marry, how we write about one another, and how we care for our sick and aging.

One lesson history tries to teach us is that civilizations are complex systems—of technology, economics, foreign relations, immunology, and civility—and complex systems regularly give way to failure. The collapse of our civilization is almost certainly inevitable; the only questions are when, why, and what will replace us.

But this brings me to another point. Early in its usage, anthropologists started using “civilization” as a normative term, distinguishing “civilized society” from those who are tribal or barbaric. Civilizations are sophisticated, noble, and morally good; other societies are uncivilized, backward, and unvirtuous.

But the old distinction between civilization and barbarism has taken on a new form in the 21st century. It is from within our own “civilized” culture that emerges an inversion of the concepts of civility and brutishness. It is our leaders, our journalists, and our professionals who ignore the standards of rational discourse, who institutionalize hatred and incite division. Today, it is the elites who are the true barbarians among us.

Taking a cue from Walt Whitman, who thought his own 19th century America was waning, “We had best look our times and lands searchingly in the face, like a physician diagnosing some deep disease.”

If our civilization collapses, it won’t be because of an outside attack, like Bedouin charging in from the desert. It will be because of those among us who, like parasites, destroy us from within. Our civilization may collapse and it could be due to any number of factors—war, the economy, natural disasters—but the silent killer, the one that may get us in the end, is our own moral catastrophe.

The ultimate problem, therefore, is not interpersonal; it’s inner-personal. If our civilization is collapsing, it’s because something in each of us is collapsing. And we need to rebuild ourselves first, brick by brick, if we are to have a chance of rebuilding ourselves together.

Tyler Durden Wed, 09/28/2022 - 22:20

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Economics

DryEyeRhythm: A reliable, valid, and non-invasive app to assess dry eye disease

Dry eye disease (DED) is a condition characterized by an array of different symptoms, including dryness, ocular discomfort, fatigue, and visual disturbances….

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Dry eye disease (DED) is a condition characterized by an array of different symptoms, including dryness, ocular discomfort, fatigue, and visual disturbances. This condition has become increasingly common in recent years owing to an aging society, increased screen time, and a highly stressful social environment. There are about 1 billion people, worldwide, who have DED. Undiagnosed and untreated DED can lead to a variety of symptoms, including ocular fatigue, sensitivity to light, lower vision quality, and a lower quality of life. Given the widespread prevalence of the condition, this can further lead to reduced work productivity and economic loss.

Credit: Juntendo University

Dry eye disease (DED) is a condition characterized by an array of different symptoms, including dryness, ocular discomfort, fatigue, and visual disturbances. This condition has become increasingly common in recent years owing to an aging society, increased screen time, and a highly stressful social environment. There are about 1 billion people, worldwide, who have DED. Undiagnosed and untreated DED can lead to a variety of symptoms, including ocular fatigue, sensitivity to light, lower vision quality, and a lower quality of life. Given the widespread prevalence of the condition, this can further lead to reduced work productivity and economic loss.

 

Despite the obvious disadvantages of DED, a large portion of the population remains undiagnosed, which ultimately leads to increased disease severity. DED is currently diagnosed through a series of questionnaires and ocular examinations (which can be invasive). But this method of diagnosis is not ideal. DED examinations do not always correspond with  patients’ subjective DED symptoms. Furthermore, non-invasive and non-contact dry eye examinations are required in the COVID-19 pandemic. These flaws point to a need for a simple, reliable, and accessible screening method for DED to improve diagnosis and prognosis of the disease.

 

To answer this need, a research group, led by Professor Akira Murakami and Associate Professor Takenori Inomata of the Juntendo University Graduate School of Medicine, developed a smartphone application called DryEyeRhythm. “DryEyeRhythm leverages the cameras in smartphones to measure users’ blink characteristics and determine maximum blink interval (MBI)—a substitute for tear film breakup time, an important diagnostic criterion of DED,” explains Associate Prof. Inomata. “The app also administers Ocular Surface Disease Index (OSDI) questionnaires, which are also a crucial component of DED diagnosis.

 

To validate the usefulness of the app, the research team conducted a prospective, cross-sectional, observational, single-center study, the results of which have been published in

The Ocular Surface (available online on 25 April 2022 and published in volume 25 in July 2022).

 

For their study, the team recruited 82 patients, aged 20 years or older, who visited the ophthalmology outpatient clinic at the Juntendo University Hospital between July 2020 and May 2021. The participants completed the Japanese version of the OSDI questionnaire (J-OSDI) and underwent examinations for MBI, both via the app and via other analysis techniques.

 

The study revealed that the J-OSDI collected with DryEyeRhythm showed good internal consistency. Moreover, the app-based questionnaire and MBI yielded significantly higher discriminant validity. The app also showed good positive and negative predictive values, with 91.3% and 69.1%, respectively. The area under the Receiver operating characteristic (ROC) curve—a measure of clinical sensitivity and specificity—for the concurrent use of the app-based J-OSDI and MBI was also high, with a value of 0.910. These results demonstrate that the app is a reliable, valid, and moreover non-invasive, instrument for assessing DED.

 

Non-contact and non-invasive DED diagnostic assistance, like the kind provided by DryEyeRhythm, could help facilitate the early diagnosis and treatment of patients, as well as, DED treatment through telemedicine and online medical care,” says Associate Prof. Inomata. The research team plans to further validate its results by conducting a multi-institutional collaborative study in the future. They are also planning to obtain medical device approval and insurance reimbursement for the smartphone application.

 

The development of DryEyeRhythm is crucial step forward toward the management of DED and improving vision and quality of life among the population.


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Spread & Containment

A rapid, highly sensitive method to measure SARS-CoV-2 in wastewater

Wastewater-based epidemiology (WBE) has been shown to be an excellent means of understanding the spread of SARS-CoV-2 in communities. It is now used in…

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Wastewater-based epidemiology (WBE) has been shown to be an excellent means of understanding the spread of SARS-CoV-2 in communities. It is now used in multiple areas across the world to track the prevalence of the virus, serving as a proxy for determining the status of COVID-19. Of particular importance is that WBE can be used to estimate the prevalence of COVID-19, including asymptomatic cases. However, one of the major drawbacks of WBE for SARS-CoV-2 has been that the traditional method was not very sensitive, and low viral loads could not be reliably detected.

Credit: Hiroki Ando, et al. Science of the Total Environment. August 8, 2022

Wastewater-based epidemiology (WBE) has been shown to be an excellent means of understanding the spread of SARS-CoV-2 in communities. It is now used in multiple areas across the world to track the prevalence of the virus, serving as a proxy for determining the status of COVID-19. Of particular importance is that WBE can be used to estimate the prevalence of COVID-19, including asymptomatic cases. However, one of the major drawbacks of WBE for SARS-CoV-2 has been that the traditional method was not very sensitive, and low viral loads could not be reliably detected.

A team of scientists from Hokkaido University and Shionogi & Co, Ltd., have developed a simple, rapid, highly sensitive method for the detection of SARS-CoV-2 in wastewater. The method, EPISENS-S, which does not require specialised equipment, was described in the journal Science of the Total Environment.

During the COVID-19 pandemic, Japan has had the lowest number of cases per capita. Thus, the viral loads in sewage have also been lower, and much more difficult to evaluate using established WBE methods—due to their low sensitivity. Prior work by the research team showed that the SARS-CoV-2 virus was associated with solids in sewage, so they focused on developing a method to analyse the solid phase of wastewater.

The method they developed, EPISENS-S, involves centrifuging collected wastewater samples to separate all the solids in the samples. The solids were then treated with a commercially available kit to extract all the RNA; the RNA was then reverse transcribed and amplified to obtain a substantial amount of DNA copies. A separate set of samples was subjected to treatment with polyethylene glycol followed by RNA extraction and reverse transcription to synthesize DNA: the method that is currently widely implemented in Japan. The DNA obtained from each of these methods was subjected to quantitative PCR (qPCR).

The team found that the EPISENS-S method is approximately 100 times more sensitive than the polyethylene glycol method. They used EPISENS-S to conduct a long-term analysis of wastewater from two sewage treatment plants in Sapporo city, and found that there was a high correlation between changes in RNA concentrations in the collected samples and changes in the number of reported cases in the city. EPISENS-S can also detect and quantify the Pepper mild mottle virus (PMMoV), which is associated with fecal matter and is used as an internal control.

EPISENS-S provides a way to track COVID-19 cases that are asymptomatic, as well as those that have not been clinically confirmed. In addition, it has great potential to continue tracking the prevalence of SARS-CoV-2 as vaccination rates increase. Finally, EPISENS-S could also be adapted to track other viral diseases with low infection numbers and viral loads.


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