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Amazon debuts a fully autonomous warehouse robot

You can’t discuss fulfillment robots without mentioning Amazon. Over the past decade, the retail juggernaut has become the 800-pound gorilla in the category,…

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You can’t discuss fulfillment robots without mentioning Amazon. Over the past decade, the retail juggernaut has become the 800-pound gorilla in the category, courtesy of several key acquisitions and seemingly endless resources. And while warehouse robotics and automation have been accelerated amid the pandemic and resulting employment crunch, Amazon Robotics has been driving these categories for years now.

This week at its annual Re:Mars conference in Las Vegas, the company celebrated a decade of its robotics division, which was effectively born with its acquisition of Kiva Systems. Over the course of its life, Amazon Robotics has deployed more than 520,000 robotic drive units, across its fulfillment and sort centers. From the outside, it’s been a tremendous success in the company’s push toward same- and next-day package delivery, and its driven the competition to look for their own third-party robotics solutions, bolstering startups like Locus, Fetch and Berkshire Grey.

Amazon Robotics head Tye Brady took to the stage at today’s event to offer a glimpse at what the future will look like for its in-house automated systems. At the heart of the news are two new robots: Proteus and Cardinal, an autonomous floor system and a robotic arm, respectively. The new robots are being integrated into the same shelf/cell system that’s been in place since Kiva.

Now, however, Proteus brings full autonomy to the floor. The company notes in a blog post,

Proteus autonomously moves through our facilities using advanced safety, perception, and navigation technology developed by Amazon. The robot was built to be automatically directed to perform its work and move around employees—meaning it has no need to be confined to restricted areas. It can operate in a manner that augments simple, safe interaction between technology and people—opening up a broader range of possible uses to help our employees—such as the lifting and movement of GoCarts, the non-automated, wheeled transports used to move packages through our facilities.

If I had to venture an educated guess, I’d say that Proteus is likely the result of the company’s 2019 acquisition of Boulder, Colorado-based autonomous cart company, Canvas. As I noted at the time, “Canvas […] brings its own built-in safety with its autonomous vision system. The hardware is designed to more directly interact with workers on the floor. It’s easier to imagine the company adopting the technology for some of its existing systems, as well.”

Image Credits: Amazon

From the looks of it, some of that Canvas technology was integrated into a Kiva form factor, so these robots can work with Amazon’s existing systems, with minimal retrofitting. What the additional autonomy brings is the ability to operate in less controlled environments, which means the technology can be implemented into additional environments outside of the current cages that the Kiva systems are relegated to.

The company notes,

Proteus will initially be deployed in the outbound GoCart handling areas in our fulfillment centers and sort centers. Our vision is to automate GoCart handling throughout the network, which will help reduce the need for people to manually move heavy objects through our facility and instead let them focus on more rewarding work.

Cardinal, meanwhile, is a robotic work cell that sorts heavy packages of up to 50 pounds, during the shipping process. The company is testing a pilot of the system right now and expects to deploy into to its sorting facilities at some point next year.

Also demoed on the stage today was the Amazon Robotics Identification system. The device looks a bit like an airport scanner, allowing employees to quickly input packages using “natural movements.” The company notes, “AR ID removes the manual scanning process by using a unique camera system that runs at 120 frames per second, giving employees greater mobility and helping reduce the risk of injury.”

Lastly is another arm-based picking system. It’s effectively a large, mobile, shelf-based system that utilizes the arm to retrieve containers to hand to the human employee. The company notes, “Our new Containerized Storage System puts employees in a safer and more ergonomic position through a highly choreographed dance of robotics and software.”

What’s most interesting viewing these updates from a far is the integration Amazon has managed, across a range of different tasks. Of course, Amazon has the marked advantage of being able to develop its own systems for its own warehouse — that, along with its huge resources, are going to prove extremely difficult for smaller companies to keep up.

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Aging-US | Time makes histone H3 modifications drift in mouse liver

BUFFALO, NY- June 30, 2022 – A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, “Time makes histone…

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BUFFALO, NY- June 30, 2022 – A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, “Time makes histone H3 modifications drift in mouse liver.”

Credit: Hillje et al.

BUFFALO, NY- June 30, 2022 – A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, “Time makes histone H3 modifications drift in mouse liver.”

Aging is known to involve epigenetic histone modifications, which are associated with transcriptional changes, occurring throughout the entire lifespan of an individual.

“So far, no study discloses any drift of histone marks in mammals which is time-dependent or influenced by pro-longevity caloric restriction treatment.”

To detect the epigenetic drift of time passing, researchers—from Istituto di Ricovero e Cura a Carattere Scientifico, University of Urbino ‘Carlo Bo’, University of Milan, and University of Padua—determined the genome-wide distributions of mono- and tri-methylated lysine 4 and acetylated and tri-methylated lysine 27 of histone H3 in the livers of healthy 3, 6 and 12 months old C57BL/6 mice. 

“In this study, we used chromatin immunoprecipitation sequencing technology to acquire 108 high-resolution profiles of H3K4me3, H3K4me1, H3K27me3 and H3K27ac from the livers of mice aged between 3 months and 12 months and fed 30% caloric restriction diet (CR) or standard diet (SD).”

The comparison of different age profiles of histone H3 marks revealed global redistribution of histone H3 modifications with time, in particular in intergenic regions and near transcription start sites, as well as altered correlation between the profiles of different histone modifications. Moreover, feeding mice with caloric restriction diet, a treatment known to retard aging, reduced the extent of changes occurring during the first year of life in these genomic regions.

“In conclusion, while our data do not establish that the observed changes in H3 modification are causally involved in aging, they indicate age, buffered by caloric restriction, releases the histone H3 marking process of transcriptional suppression in gene desert regions of mouse liver genome most of which remain to be functionally understood.”

DOI: https://doi.org/10.18632/aging.204107 

Corresponding Author: Marco Giorgio – marco.giorgio@unipd.it 

Keywords: epigenetics, aging, histones, ChIP-seq, diet

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About Aging-US:

Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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FDA asks for COVID boosters to fight Omicron’s BA.4, BA.5 subvariants

The U.S. Food and Drug Administration on Thursday recommended booster doses of COVID-19 vaccines be modified beginning this fall to include components…

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FDA asks for COVID boosters to fight Omicron’s BA.4, BA.5 subvariants

By Michael Erman

June 30 (Reuters) – The U.S. Food and Drug Administration on Thursday recommended booster doses of COVID-19 vaccines be modified beginning this fall to include components tailored to combat the currently dominant Omicron BA.4 and BA.5 subvariants of the coronavirus.

The FDA said manufacturers would not need to change the vaccine for the primary vaccination series, saying the coming year will be “a transitional period when this modified booster vaccine may be introduced.”

FILE PHOTO: Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, U.S., August 29, 2020. REUTERS/Andrew Kelly/File Photo

The new booster shots would be bivalent vaccines, meaning doses would target both the original virus as well as the Omicron subvariants.

The decision follows a recommendation by the agency’s outside advisers to change the design of the shots this fall in order to combat more prevalent versions of the coronavirus. read more

BA.4 and BA.5 are now estimated to account for more than 50% of U.S. infections, according the U.S. Centers for Disease Control and Prevention, and have also become dominant elsewhere.

The FDA said in a statement on Thursday that it hoped the modified vaccines could be used in early to mid-fall.

Pfizer Inc (PFE.N) with partner BioNTech SE (22UAy.DE) and Moderna Inc (MRNA.O) have been testing versions of their vaccines modified to combat the BA.1 Omicron variant that caused the massive surge in cases last winter.

Although they have said those vaccines worked against BA.1 and the more recently circulating variants, they did see a lower immune response against BA.4 and BA.5.

The companies had already been manufacturing their BA.1 vaccines, and said on Tuesday that swapping to a BA.4/BA.5 version could slow the rollout.

Pfizer/BioNTech, which on Wednesday announced a $3.2 billion contract to supply more COVID vaccine doses to the United States, said they would have a substantial amount of BA.4/BA.5 vaccine ready for distribution by the first week of October. read more

Moderna said it would be late October or early November before it would have the newly modified vaccine ready.

Reporting by Michael Erman in New Jersey and Leroy Leo in Bengaluru; Editing by Jonathan Oatis and Bill Berkrot

Our Standards: The Thomson Reuters Trust Principles.

Source: Reuters

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Marketing automation startup Retail Rocket nabs $24M for expansion

Retail Rocket, a retention management platform for brands, today announced that it raised $24 million in a Series A round led by Cyprus-based private equity…

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Retail Rocket, a retention management platform for brands, today announced that it raised $24 million in a Series A round led by Cyprus-based private equity fund Flintera. In addition to the fundraising, Retail Rocket revealed that it acquired SailPlay, a startup developing software to help retailers build loyalty programs and send mass message campaigns.

New York-based SailPlay had raised $3.3 million prior to the acquisition. Founded in 2013 by Leonid Shangin and Yakov Filippenko, the company offered services to collect customer data and leverage it to create games, texts, and tasks designed to encourage repeat business.

As for Retail Rocket, it launched in 2012 headed by Moscow Business School of Management classmates, Nick Khlebinsky and Andrey Chizh, who’d attempted but failed to gain traction with several startups. The learnings from their previous efforts were the springboard for Retail Rocket, which after multiple pivots eventually grew its customer base to over 1,000 companies including Nintendo, Puma, and Decathlon.

“The digital marketing world is growing very fast and the demand for highly-skilled professionals is constantly increasing,” CEO Khlebinsky said. “The complexity of digital marketing tools is booming too — just several years ago we couldn’t imagine the technologies we use today.”

According to Khlebinsky, Retail Rocket uses a mathematical model to segment first-time buyers of a company’s product. By analyzing their actions — for example, the links they click on — the platform attempts to figure out their wants and preferences.

Image Credits: Retail Rocket

Retail Rocket also offers tools for campaign management like email marketing and web-based push notifications, as well as an engine that attempts to identify the best timing and communication channel (e.g., SMS) to make personalized offers. The goal is to create a “system of loyalty and retention management” for both online and offline customers, Khlebinsky said, that ultimately boosts business.

“We work with ecommerce on a performance-based pricing model,” Khlebinsky explained. “In most countries, the pandemic lockdowns spiked online sales, thus we experienced a temporary revenue increase. After the lockdown ended, there was a decrease, but to levels exceeding the pre-lockdown months, because a lot of people were forced to change their buying habits towards online shoppings.”

Absent independent reviews of Retail Rocket’s platform, it’s unclear whether its approach might beat out rivals like SalesForce, SAP, Bloomreach, and Dynamic Yield. But the promise of software that predictably drives repeat business is alluring. According to HubSpot, a mere 5% increase in customer retention can boost profits by 25% to 95%.

Retail Rocket has around 150 employees spread across offices in the Netherlands, Germany, Spain, Italy, and Chile, and it plans to double down on mergers and purchases in the coming months. Sources close to the company tell TechCrunch that Retail Rocket has $50 million set aside for acquisitions alone.

“Retail Rocket popped on our radars thanks to their international expansion and ability to set up sales teams in Europe and Latin America,” Flintera partner Sergey Vasin said in a statement. “We were impressed with the company’s results given the limited amount of investment they raised. The company was bootstrapping its growth after the seed round. Despite that, the efficiency of Retail Rocket products surpasses those of international competitors. We expect that the global e-commerce market will continue its growth at more than 10% per annum, with Latin America leading the race.”

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