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3 Monster Growth Stocks With Still Plenty of Gas in the Tank

3 Monster Growth Stocks With Still Plenty of Gas in the Tank



The market is on the move, and this time stocks took off on an upward trajectory. On Wednesday April 29, all three of the major U.S. stock indexes posted gains at the closing bell, climbing higher on encouraging data from the government trial for Gilead Sciences’ COVID-19 treatment, remdesivir. The antiviral therapy met its primary endpoint, and while there’s still a long way to go until it could be available for use, it’s exciting progress. Stocks were also helped by the Federal Reserve’s statement that it will keep rates close to zero for as long as it takes and provide the economy with additional help.

However, it should be noted that this surge came as investors brushed off weak U.S. gross domestic product, with the figure’s first quarter decline bigger than expected and marking the largest contraction of economic activity since the financial crisis.

So, is it still possible to find stocks going up, up and away? Wall Street pros say yes. They argue that in spite of COVID-19's impact on the broader market, several healthcare names are undervalued as they have held up strong and are set to deliver even more returns in the long run.

Heeding this advice, we used TipRanks’ database to zero in on three healthcare stocks that are poised to rip higher and handsomely reward investors over the long-term. Not only have all of the tickers amassed enough bullish calls from analysts to be given “Strong Buy” consensus ratings, but each could also see substantial share price appreciation in the next year. Here’s the lowdown.

Fate Therapeutics (FATE)

Fate Therapeutics is at the forefront of the cellular immunotherapy space, with it taking healthy donor cells, which are then modified ex vivo using pharmacologic modulators, to improve the cells’ biological properties and therapeutic function. Despite already rising 48% year-to-date, several analysts believe its growth story is only just beginning.

Part of the excitement surrounding this name is related to its collaboration with Janssen to develop iPSC NK and T-cell therapies against four tumor-associated antigens. As per the terms of the agreement, FATE will be paid $50 million in cash up front and receive a $50 million equity investment. In addition, FATE is eligible for as much as $1.8 billion in developmental and regulatory milestones and $1.2 billion in commercial milestones, with $898 million applying to the first candidate.

Only when the company gets reimbursed for preclinical development going as far as the IND filing will Janssen get an exclusive option to assume development and commercialization. It should also be noted that FATE will have an option for U.S. co-commercialization or mid-teen royalties when proof-of-concept data is available for each candidate.

Weighing in for Piper Sandler, five-star analyst Edward Tenthoff also sees potential stemming from its FT596 asset. “Encouragingly, the first patient was dosed with FT596 in a Phase I study of B-cell malignancies and chronic lymphocytic leukemia... We could see first-ever data at ASH in December pending enrollment impact with respect to COVID-19,” he wrote.

To top it all off, Tenthoff thinks there are additional potential catalysts that could be capable of catapulting shares. FATE is focusing FT500 on non-small-cell lung carcinoma (NSCLC) with stable disease in 4/8 monotherapy and 2/3 CPI combo patients initially and data for its FT516 candidate in AML and B-cell lymphoma could be released in December.

While management stated that COVID-19 could affect clinical trial enrollment, Tenthoff points out that FATE remains on-course to file INDs for FT538 and FT819. To this end, he stayed with the bulls, reiterating an Overweight rating. He also bumped up the price target from $57 to $63, implying 117% upside potential. (To watch Tenthoff’s track record, click here)

Meanwhile, the rest of the Street also likes what it’s seeing. 11 Buys and a single Hold add up to a Strong Buy consensus rating. At $39.08, the average price target puts the upside potential at 35%. (See Fate Therapeutics stock analysis on TipRanks)

Cytokinetics Inc. (CYTK)

Using its differentiated muscle biology platform, Cytokinetics develops therapies for cardiac and skeletal muscle diseases. Since the start of 2020, shares have climbed 53% higher, and market watchers want to know if there’s more fuel left in the tank.

Cantor Fitzgerald’s Charles Duncan says yes. The five-star analyst tells investors that ahead of the Phase 3 GALACTIC-HF readout for its Omecamtiv mecarbil (ome’) drug in heart failure, he sees a significant opportunity, with the “binary and potentially transformational milestone” potentially coming earlier than he expected in Q4 2020.

Expounding on this, Duncan stated, “Additionally, we believe that the probability of success (PoS) for GALACTIC-HF, which is being conducted by partner Amgen, is underappreciated and that current powering assumptions provide a degree of ‘immunity’ against potential confounding results with CV-driven death/hospitalizations due to COVID-19... To us, robust powering suggests that a risk-mitigating buffer is in place if the pandemic drives missing data or adjudicated events that reduce the number of patients used in per-protocol primary or secondary efficacy analysis. In addition, we note that the FDA recently issued guidance on clinical trial conduct, including amended data management and/or statistical analysis plans, protocol-specified clinical visits and method of drug/pbo distribution, which can further mitigate COVID-19 risk.”

Speaking to the trial’s design, Duncan is also optimistic when comparing it to two other heart failure studies, the VICTORIA-HF trial for vericiguat and PARADIGM-HF trial for ENTRESTO. “We believe that the GALACTIC-HF study has enrolled an at-risk population that falls between the two other studies, which will facilitate a clear signal-to-noise readout and clinical interpretation, in our view. We believe that this factor, in combination with the nuanced patient inclusion/exclusion criteria, including NT-proBNP cutoff specifically for pts with atrial fibrillation/flutter and systolic blood pressure cutoffs among others, increases the PoS for this study, which we believe should enhance PoS for a positive readout,” he commented.

Both the study’s design and overall patient population prompted Duncan to increase the PoS, and thus the price target also gets a boost. In addition to his Overweight call, he lifted the target from $12 to $23, suggesting 41% upside potential. (To watch Duncan’s track record, click here)

Looking at the consensus breakdown, the stock has earned 100% Street support, or 4 Buy ratings to be exact. Therefore, the message is clear: CYTK is a Strong Buy. Based on the $25.50 average price target, shares could rise 57% in the next year. (See Cytokinetics stock analysis on TipRanks)

Iovance Biotherapeutics (IOVA)

Fighting the good fight against cancer, Iovance is developing transformative immuno-oncology tumor-infiltrating lymphocytes (TIL) therapies that harness a patient's own immune system. Up 21% year-to-date, several members of the Street think that IOVA’s future is only going to get brighter.

Writing for H.C. Wainwright, five-star analyst Joseph Pantginis points to the Moffitt study results as renewing his confidence. On April 28, Moffitt Cancer Center, IOVA’s partner, provided an updated glimpse at the Phase 1 trial evaluating TILs plus nivolumab in CKI-naïve metastatic NSCLC patients. Delivering strong results, efficacy was seen in 25% of patients, with the therapy demonstrating two complete responses (CRs). Additionally, ongoing clinical responses were witnessed in half of patients and one active response is pending.

The outcome gets even better. “Although TIL clonotype persistence declines with time in the blood of these patients, persistent and stable levels of infused T cells associated with higher tumor killing and response. Thus, we believe that methods to enrich for these TIL populations, such as Iovance’s next generation TILs could be critical to drive better clinical responses,” Pantginis said. It should also be noted that TILs were capable of spurring an immune response against several cancer clones, which could produce better clinical outcomes.

Even though some investors expected data from a larger number of patients with a longer follow-up date, Pantginis argues that the results should be viewed as encouraging. He added, “We remind investors that metastatic NSCLC is not an easy indication: (1) most patients rapidly progress; and (2) low activity of CKI. Thus, achieving a DCR of 50% is still meaningful, in our belief. More importantly, the study is ongoing with 8 clinical responses underway.”

It should come as no surprise, then, that Pantginis left a Buy recommendation on the stock. Along with his bullish call, he attached a new $48 price target, up from $36. Should this target be met, a twelve-month gain of 44% could be in store. (To watch Pantginis’ track record, click here)

Turning now to the rest of the Street, other analysts have also been impressed with IOVA. Only Buy ratings have been assigned, 9 in the last three months. As a result, the healthcare name gets a unanimous Strong Buy consensus rating. With a $47 average price target, the upside potential comes in just below Pantginis’ forecast at 41%. (See Iovance stock analysis on TipRanks)

  To find good ideas for stocks trading at attractive valuations, visit TipRanks’ Best Stocks to Buy, a newly launched tool that unites all of TipRanks’ equity insights.

The post 3 Monster Growth Stocks With Still Plenty of Gas in the Tank appeared first on TipRanks Financial Blog.

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Comments on February Employment Report

The headline jobs number in the February employment report was above expectations; however, December and January payrolls were revised down by 167,000 combined.   The participation rate was unchanged, the employment population ratio decreased, and the …



The headline jobs number in the February employment report was above expectations; however, December and January payrolls were revised down by 167,000 combined.   The participation rate was unchanged, the employment population ratio decreased, and the unemployment rate was increased to 3.9%.

Leisure and hospitality gained 58 thousand jobs in February.  At the beginning of the pandemic, in March and April of 2020, leisure and hospitality lost 8.2 million jobs, and are now down 17 thousand jobs since February 2020.  So, leisure and hospitality has now essentially added back all of the jobs lost in March and April 2020. 

Construction employment increased 23 thousand and is now 547 thousand above the pre-pandemic level. 

Manufacturing employment decreased 4 thousand jobs and is now 184 thousand above the pre-pandemic level.

Prime (25 to 54 Years Old) Participation

Since the overall participation rate is impacted by both cyclical (recession) and demographic (aging population, younger people staying in school) reasons, here is the employment-population ratio for the key working age group: 25 to 54 years old.

The 25 to 54 years old participation rate increased in February to 83.5% from 83.3% in January, and the 25 to 54 employment population ratio increased to 80.7% from 80.6% the previous month.

Both are above pre-pandemic levels.

Average Hourly Wages

WagesThe graph shows the nominal year-over-year change in "Average Hourly Earnings" for all private employees from the Current Employment Statistics (CES).  

There was a huge increase at the beginning of the pandemic as lower paid employees were let go, and then the pandemic related spike reversed a year later.

Wage growth has trended down after peaking at 5.9% YoY in March 2022 and was at 4.3% YoY in February.   

Part Time for Economic Reasons

Part Time WorkersFrom the BLS report:
"The number of people employed part time for economic reasons, at 4.4 million, changed little in February. These individuals, who would have preferred full-time employment, were working part time because their hours had been reduced or they were unable to find full-time jobs."
The number of persons working part time for economic reasons decreased in February to 4.36 million from 4.42 million in February. This is slightly above pre-pandemic levels.

These workers are included in the alternate measure of labor underutilization (U-6) that increased to 7.3% from 7.2% in the previous month. This is down from the record high in April 2020 of 23.0% and up from the lowest level on record (seasonally adjusted) in December 2022 (6.5%). (This series started in 1994). This measure is above the 7.0% level in February 2020 (pre-pandemic).

Unemployed over 26 Weeks

Unemployed Over 26 WeeksThis graph shows the number of workers unemployed for 27 weeks or more.

According to the BLS, there are 1.203 million workers who have been unemployed for more than 26 weeks and still want a job, down from 1.277 million the previous month.

This is down from post-pandemic high of 4.174 million, and up from the recent low of 1.050 million.

This is close to pre-pandemic levels.

Job Streak

Through February 2024, the employment report indicated positive job growth for 38 consecutive months, putting the current streak in 5th place of the longest job streaks in US history (since 1939).

Headline Jobs, Top 10 Streaks
Year EndedStreak, Months
6 tie194333
6 tie198633
6 tie200033
1Currrent Streak


The headline monthly jobs number was above consensus expectations; however, December and January payrolls were revised down by 167,000 combined.  The participation rate was unchanged, the employment population ratio decreased, and the unemployment rate was increased to 3.9%.  Another solid report.

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Immune cells can adapt to invading pathogens, deciding whether to fight now or prepare for the next battle

When faced with a threat, T cells have the decision-making flexibility to both clear out the pathogen now and ready themselves for a future encounter.

Understanding the flexibility of T cell memory can lead to improved vaccines and immunotherapies. Juan Gaertner/Science Photo Library via Getty Images

How does your immune system decide between fighting invading pathogens now or preparing to fight them in the future? Turns out, it can change its mind.

Every person has 10 million to 100 million unique T cells that have a critical job in the immune system: patrolling the body for invading pathogens or cancerous cells to eliminate. Each of these T cells has a unique receptor that allows it to recognize foreign proteins on the surface of infected or cancerous cells. When the right T cell encounters the right protein, it rapidly forms many copies of itself to destroy the offending pathogen.

Diagram depicting a helper T cell differentiating into either a memory T cell or an effector T cell after exposure to an antigen
T cells can differentiate into different subtypes of cells after coming into contact with an antigen. Anatomy & Physiology/SBCCOE, CC BY-NC-SA

Importantly, this process of proliferation gives rise to both short-lived effector T cells that shut down the immediate pathogen attack and long-lived memory T cells that provide protection against future attacks. But how do T cells decide whether to form cells that kill pathogens now or protect against future infections?

We are a team of bioengineers studying how immune cells mature. In our recently published research, we found that having multiple pathways to decide whether to kill pathogens now or prepare for future invaders boosts the immune system’s ability to effectively respond to different types of challenges.

Fight or remember?

To understand when and how T cells decide to become effector cells that kill pathogens or memory cells that prepare for future infections, we took movies of T cells dividing in response to a stimulus mimicking an encounter with a pathogen.

Specifically, we tracked the activity of a gene called T cell factor 1, or TCF1. This gene is essential for the longevity of memory cells. We found that stochastic, or probabilistic, silencing of the TCF1 gene when cells confront invading pathogens and inflammation drives an early decision between whether T cells become effector or memory cells. Exposure to higher levels of pathogens or inflammation increases the probability of forming effector cells.

Surprisingly, though, we found that some effector cells that had turned off TCF1 early on were able to turn it back on after clearing the pathogen, later becoming memory cells.

Through mathematical modeling, we determined that this flexibility in decision making among memory T cells is critical to generating the right number of cells that respond immediately and cells that prepare for the future, appropriate to the severity of the infection.

Understanding immune memory

The proper formation of persistent, long-lived T cell memory is critical to a person’s ability to fend off diseases ranging from the common cold to COVID-19 to cancer.

From a social and cognitive science perspective, flexibility allows people to adapt and respond optimally to uncertain and dynamic environments. Similarly, for immune cells responding to a pathogen, flexibility in decision making around whether to become memory cells may enable greater responsiveness to an evolving immune challenge.

Memory cells can be subclassified into different types with distinct features and roles in protective immunity. It’s possible that the pathway where memory cells diverge from effector cells early on and the pathway where memory cells form from effector cells later on give rise to particular subtypes of memory cells.

Our study focuses on T cell memory in the context of acute infections the immune system can successfully clear in days, such as cold, the flu or food poisoning. In contrast, chronic conditions such as HIV and cancer require persistent immune responses; long-lived, memory-like cells are critical for this persistence. Our team is investigating whether flexible memory decision making also applies to chronic conditions and whether we can leverage that flexibility to improve cancer immunotherapy.

Resolving uncertainty surrounding how and when memory cells form could help improve vaccine design and therapies that boost the immune system’s ability to provide long-term protection against diverse infectious diseases.

Kathleen Abadie was funded by a NSF (National Science Foundation) Graduate Research Fellowships. She performed this research in affiliation with the University of Washington Department of Bioengineering.

Elisa Clark performed her research in affiliation with the University of Washington (UW) Department of Bioengineering and was funded by a National Science Foundation Graduate Research Fellowship (NSF-GRFP) and by a predoctoral fellowship through the UW Institute for Stem Cell and Regenerative Medicine (ISCRM).

Hao Yuan Kueh receives funding from the National Institutes of Health.

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President Biden Delivers The “Darkest, Most Un-American Speech Given By A President”

President Biden Delivers The "Darkest, Most Un-American Speech Given By A President"

Having successfully raged, ranted, lied, and yelled through…



President Biden Delivers The "Darkest, Most Un-American Speech Given By A President"

Having successfully raged, ranted, lied, and yelled through the State of The Union, President Biden can go back to his crypt now.

Whatever 'they' gave Biden, every American man, woman, and the other should be allowed to take it - though it seems the cocktail brings out 'dark Brandon'?

Tl;dw: Biden's Speech tonight ...

  • Fund Ukraine.

  • Trump is threat to democracy and America itself.

  • Abortion is good.

  • American Economy is stronger than ever.

  • Inflation wasn't Biden's fault.

  • Illegals are Americans too.

  • Republicans are responsible for the border crisis.

  • Trump is bad.

  • Biden stands with trans-children.

  • J6 was the worst insurrection since the Civil War.

(h/t @TCDMS99)

Tucker Carlson's response sums it all up perfectly:

"that was possibly the darkest, most un-American speech given by an American president. It wasn't a speech, it was a rant..."

Carlson continued: "The true measure of a nation's greatness lies within its capacity to control borders, yet Bid refuses to do it."

"In a fair election, Joe Biden cannot win"

And concluded:

“There was not a meaningful word for the entire duration about the things that actually matter to people who live here.”

Victor Davis Hanson added some excellent color, but this was probably the best line on Biden:

"he doesn't care... he lives in an alternative reality."

*  *  *

Watch SOTU Live here...

*   *   *

Mises' Connor O'Keeffe, warns: "Be on the Lookout for These Lies in Biden's State of the Union Address." 

On Thursday evening, President Joe Biden is set to give his third State of the Union address. The political press has been buzzing with speculation over what the president will say. That speculation, however, is focused more on how Biden will perform, and which issues he will prioritize. Much of the speech is expected to be familiar.

The story Biden will tell about what he has done as president and where the country finds itself as a result will be the same dishonest story he's been telling since at least the summer.

He'll cite government statistics to say the economy is growing, unemployment is low, and inflation is down.

Something that has been frustrating Biden, his team, and his allies in the media is that the American people do not feel as economically well off as the official data says they are. Despite what the White House and establishment-friendly journalists say, the problem lies with the data, not the American people's ability to perceive their own well-being.

As I wrote back in January, the reason for the discrepancy is the lack of distinction made between private economic activity and government spending in the most frequently cited economic indicators. There is an important difference between the two:

  • Government, unlike any other entity in the economy, can simply take money and resources from others to spend on things and hire people. Whether or not the spending brings people value is irrelevant

  • It's the private sector that's responsible for producing goods and services that actually meet people's needs and wants. So, the private components of the economy have the most significant effect on people's economic well-being.

Recently, government spending and hiring has accounted for a larger than normal share of both economic activity and employment. This means the government is propping up these traditional measures, making the economy appear better than it actually is. Also, many of the jobs Biden and his allies take credit for creating will quickly go away once it becomes clear that consumers don't actually want whatever the government encouraged these companies to produce.

On top of all that, the administration is dealing with the consequences of their chosen inflation rhetoric.

Since its peak in the summer of 2022, the president's team has talked about inflation "coming back down," which can easily give the impression that it's prices that will eventually come back down.

But that's not what that phrase means. It would be more honest to say that price increases are slowing down.

Americans are finally waking up to the fact that the cost of living will not return to prepandemic levels, and they're not happy about it.

The president has made some clumsy attempts at damage control, such as a Super Bowl Sunday video attacking food companies for "shrinkflation"—selling smaller portions at the same price instead of simply raising prices.

In his speech Thursday, Biden is expected to play up his desire to crack down on the "corporate greed" he's blaming for high prices.

In the name of "bringing down costs for Americans," the administration wants to implement targeted price ceilings - something anyone who has taken even a single economics class could tell you does more harm than good. Biden would never place the blame for the dramatic price increases we've experienced during his term where it actually belongs—on all the government spending that he and President Donald Trump oversaw during the pandemic, funded by the creation of $6 trillion out of thin air - because that kind of spending is precisely what he hopes to kick back up in a second term.

If reelected, the president wants to "revive" parts of his so-called Build Back Better agenda, which he tried and failed to pass in his first year. That would bring a significant expansion of domestic spending. And Biden remains committed to the idea that Americans must be forced to continue funding the war in Ukraine. That's another topic Biden is expected to highlight in the State of the Union, likely accompanied by the lie that Ukraine spending is good for the American economy. It isn't.

It's not possible to predict all the ways President Biden will exaggerate, mislead, and outright lie in his speech on Thursday. But we can be sure of two things. The "state of the Union" is not as strong as Biden will say it is. And his policy ambitions risk making it much worse.

*  *  *

The American people will be tuning in on their smartphones, laptops, and televisions on Thursday evening to see if 'sloppy joe' 81-year-old President Joe Biden can coherently put together more than two sentences (even with a teleprompter) as he gives his third State of the Union in front of a divided Congress. 

President Biden will speak on various topics to convince voters why he shouldn't be sent to a retirement home.

According to CNN sources, here are some of the topics Biden will discuss tonight:

  • Economic issues: Biden and his team have been drafting a speech heavy on economic populism, aides said, with calls for higher taxes on corporations and the wealthy – an attempt to draw a sharp contrast with Republicans and their likely presidential nominee, Donald Trump.

  • Health care expenses: Biden will also push for lowering health care costs and discuss his efforts to go after drug manufacturers to lower the cost of prescription medications — all issues his advisers believe can help buoy what have been sagging economic approval ratings.

  • Israel's war with Hamas: Also looming large over Biden's primetime address is the ongoing Israel-Hamas war, which has consumed much of the president's time and attention over the past few months. The president's top national security advisers have been working around the clock to try to finalize a ceasefire-hostages release deal by Ramadan, the Muslim holy month that begins next week.

  • An argument for reelection: Aides view Thursday's speech as a critical opportunity for the president to tout his accomplishments in office and lay out his plans for another four years in the nation's top job. Even though viewership has declined over the years, the yearly speech reliably draws tens of millions of households.

Sources provided more color on Biden's SOTU address: 

The speech is expected to be heavy on economic populism. The president will talk about raising taxes on corporations and the wealthy. He'll highlight efforts to cut costs for the American people, including pushing Congress to help make prescription drugs more affordable.

Biden will talk about the need to preserve democracy and freedom, a cornerstone of his re-election bid. That includes protecting and bolstering reproductive rights, an issue Democrats believe will energize voters in November. Biden is also expected to promote his unity agenda, a key feature of each of his addresses to Congress while in office.

Biden is also expected to give remarks on border security while the invasion of illegals has become one of the most heated topics among American voters. A majority of voters are frustrated with radical progressives in the White House facilitating the illegal migrant invasion. 

It is probable that the president will attribute the failure of the Senate border bill to the Republicans, a claim many voters view as unfounded. This is because the White House has the option to issue an executive order to restore border security, yet opts not to do so

Maybe this is why? 

While Biden addresses the nation, the Biden administration will be armed with a social media team to pump propaganda to at least 100 million Americans. 

"The White House hosted about 70 creators, digital publishers, and influencers across three separate events" on Wednesday and Thursday, a White House official told CNN. 

Not a very capable social media team... 

The administration's move to ramp up social media operations comes as users on X are mostly free from government censorship with Elon Musk at the helm. This infuriates Democrats, who can no longer censor their political enemies on X. 

Meanwhile, Democratic lawmakers tell Axios that the president's SOTU performance will be critical as he tries to dispel voter concerns about his elderly age. The address reached as many as 27 million people in 2023. 

"We are all nervous," said one House Democrat, citing concerns about the president's "ability to speak without blowing things."

The SOTU address comes as Biden's polling data is in the dumps

BetOnline has created several money-making opportunities for gamblers tonight, such as betting on what word Biden mentions the most. 

As well as...

We will update you when Tucker Carlson's live feed of SOTU is published. 

Tyler Durden Fri, 03/08/2024 - 07:44

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